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Results: 7051
Mitochondrial mutations and metabolic adaptation in pancreatic cancer.
Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V Pearson, Sean M Grimmond, Australian Pancreatic Cancer Genome Initiative, Leonid Sazanov, Andrew V Biankin, Silas Villas-Boas, Andrew J Hoy, Nigel Turner, Darren N Saunders
Jan 31, 2017
BACKGROUND: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy...
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Alison P Klein, Brian M Wolpin, Harvey A Risch, Rachael Z Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J Childs, Jason W Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A Arslan, Ana Babic, William R Bamlet, Laura Beane-Freeman, Sonja I Berndt, Amanda Blackford, Michael Borges, Ayelet Borgida, Paige M Bracci, Lauren Brais, Paul Brennan, Hermann Brenner, Bas Bueno-de-Mesquita, Julie Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G Chaffee, Charles C Chung, Sean Cleary, Michelle Cotterchio, Frederike Dijk, Eric J Duell, Lenka Foretova, Charles Fuchs, Niccola Funel, Steven Gallinger, J Michael M Gaziano, Maria Gazouli, Graham G Giles, Edward Giovannucci, Michael Goggins, Gary E Goodman, Phyllis J Goodman, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Peter Hegyi, Kathy J Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A Holly, Robert Hoover, Rayjean J Hung, Eric J Jacobs, Krzysztof Jamroziak, Vladimir Janout, Rudolf Kaaks, Kay-Tee Khaw, Eric A Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H Kulke, Juozas Kupcinskas, Robert J Kurtz, Daniel Laheru, Stefano Landi, Rita T Lawlor, I-Min Lee, Loic Lemarchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Mannisto, Roger L Milne, Beatrice Mohelníková-Duchoňová, Rachel E Neale, John P Neoptolemos, Ann L Oberg, Sara H Olson, Irene Orlow, Claudio Pasquali, Alpa V Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X Real, Nathaniel Rothman, Ghislaine Scelo, Howard D Sesso, Gianluca Severi, Xiao-Ou Shu, Debra Silverman, Jill P Smith, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Francesca Tavano, Mark D Thornquist, Geoffrey S Tobias, Stephen K Van Den Eeden, Yogesh Vashist, Kala Visvanathan, Pavel Vodicka, Jean Wactawski-Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen Chanock, Ofure Obazee, Gloria M Petersen, Laufey T Amundadottir
Jul 31, 2018
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040...
Carcinoma Pancreatic Ductal Databases Genetic Genetic Predisposition to Disease Genome-Wide Association Study Hepatocyte Nuclear Factor 1-beta Hepatocyte Nuclear Factor 4 Humans Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins Pancreatic Neoplasms Polymorphism Single Nucleotide Proteins Repressor Proteins Tensins
Signatures of mutational processes in human cancer.
Ludmil B Alexandrov, Serena Nik-Zainal, David C Wedge, Samuel AJR Aparicio, Sam Behjati, Andrew V Biankin, Graham R Bignell, Niccolò Bolli, Ake Borg, Anne-Lise Børresen-Dale, Sandrine Boyault, Birgit Burkhardt, Adam P Butler, Carlos Caldas, Helen R Davies, Christine Desmedt, Roland Eils, Jórunn Erla Eyfjörd, John A Foekens, Mel Greaves, Fumie Hosoda, Barbara Hutter, Tomislav Ilicic, Sandrine Imbeaud, Marcin Imielinski, Natalie Jäger, David TW Jones, David Jones, Stian Knappskog, Marcel Kool, Sunil R Lakhani, Carlos López-Otín, Sancha Martin, Nikhil C Munshi, Hiromi Nakamura, Paul A Northcott, Marina Pajic, Elli Papaemmanuil, Angelo Paradiso, John V Pearson, Xose S Puente, Keiran Raine, Manasa Ramakrishna, Andrea L Richardson, Julia Richter, Philip Rosenstiel, Matthias Schlesner, Ton N Schumacher, Paul N Span, Jon W Teague, Yasushi Totoki, Andrew NJ Tutt, Rafael Valdés-Mas, Marit M van Buuren, Laura van 't Veer, Anne Vincent-Salomon, Nicola Waddell, Lucy R Yates, Australian Pancreatic Cancer Genome Initiative, ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, ICGC PedBrain, Jessica Zucman-Rossi, P Andrew Futreal, Ultan McDermott, Peter Lichter, Matthew Meyerson, Sean M Grimmond, Reiner Siebert, Elías Campo, Tatsuhiro Shibata, Stefan M Pfister, Peter J Campbell, Michael R Stratton
Nov 01, 2018
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the...
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation.
Tim DD Somerville, Giulia Biffi, Juliane Daßler-Plenker, Stella K Hur, Xue-Yan He, Krysten E Vance, Koji Miyabayashi, Yali Xu, Diogo Maia-Silva, Olaf Klingbeil, Osama E Demerdash, Jonathan B Preall, Michael A Hollingsworth, Mikala Egeblad, David A Tuveson, Christopher R Vakoc
Nov 16, 2020
A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-differentiation into the squamous lineage during disease progression. Here, we investigated whether squamous trans-differentiation of human and mouse...
TP63 cancer biology Cancer-Associated Fibroblasts human human biology Inflammation Medicine MOUSE pancreatic cancer Squamous trans-differentiation Animals Cancer-Associated Fibroblasts Carcinoma Pancreatic Ductal Cell Lineage Cell Transdifferentiation Cytokines Humans Inflammation Membrane Proteins Mice Mice Inbred C57BL Neutrophil Infiltration Pancreatic Neoplasms Stromal Cells Tumor Microenvironment
Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.
Mingfeng Zhang, Zhaoming Wang, Ofure Obazee, Jinping Jia, Erica J Childs, Jason Hoskins, Gisella Figlioli, Evelina Mocci, Irene Collins, Charles C Chung, Christopher Hautman, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Julie Buring, Eric J Duell, Steven Gallinger, Graham G Giles, Gary E Goodman, Phyllis J Goodman, Aruna Kamineni, Laurence N Kolonel, Matthew H Kulke, Núria Malats, Sara H Olson, Howard D Sesso, Kala Visvanathan, Emily White, Wei Zheng, Christian C Abnet, Demetrius Albanes, Gabriella Andreotti, Lauren Brais, H Bas Bueno-De-Mesquita, Daniela Basso, Sonja I Berndt, Marie-Christine Boutron-Ruault, Maarten F Bijlsma, Hermann Brenner, Laurie Burdette, Daniele Campa, Neil E Caporaso, Gabriele Capurso, Giulia Martina Cavestro, Michelle Cotterchio, Eithne Costello, Joanne Elena, Ugo Boggi, J Michael Gaziano, Maria Gazouli, Edward L Giovannucci, Michael Goggins, Myron Gross, Christopher A Haiman, Manal Hassan, Kathy J Helzlsouer, Nan Hu, David J Hunter, Elzbieta Iskierka-Jazdzewska, Mazda Jenab, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Eric A Klein, Manolis Kogevinas, Vittorio Krogh, Juozas Kupcinskas, Robert C Kurtz, Maria T Landi, Stefano Landi, Loic Le Marchand, Andrea Mambrini, Satu Mannisto, Roger L Milne, Rachel E Neale, Ann L Oberg, Salvatore Panico, Alpa V Patel, Petra Hm Peeters, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Mark Purdue, J Ramón Quiros, Elio Riboli, Nathaniel Rothman, Aldo Scarpa, Ghislaine Scelo, Xiao-Ou Shu, Debra T Silverman, Pavel Soucek, Oliver Strobel, Malin Sund, Ewa Małecka-Panas, Philip R Taylor, Francesca Tavano, Ruth C Travis, Mark Thornquist, Anne Tjønneland, Geoffrey S Tobias, Dimitrios Trichopoulos, Yogesh Vashist, Pavel Vodicka, Jean Wactawski-Wende, Nicolas Wentzensen, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Charles Kooperberg, Harvey A Risch, Eric J Jacobs, Donghui Li, Charles Fuchs, Robert Hoover, Patricia Hartge, Stephen J Chanock, Gloria M Petersen, Rachael S Stolzenberg-Solomon, Brian M Wolpin, Peter Kraft, Alison P Klein, Federico Canzian, Laufey T Amundadottir
Nov 23, 2018
Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation...
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.
Roman Maresch, Sebastian Mueller, Christian Veltkamp, Rupert Öllinger, Mathias Friedrich, Irina Heid, Katja Steiger, Julia Weber, Thomas Engleitner, Maxim Barenboim, Sabine Klein, Sandra Louzada, Ruby Banerjee, Alexander Strong, Teresa Stauber, Nina Gross, Ulf Geumann, Sebastian Lange, Marc Ringelhan, Ignacio Varela, Kristian Unger, Fengtang Yang, Roland M Schmid, George S Vassiliou, Rickmer Braren, Günter Schneider, Mathias Heikenwalder, Allan Bradley, Dieter Saur, Roland Rad
Oct 14, 2020
Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited by the long duration of allele/model generation. Here we show transfection-based multiplexed delivery of CRISPR/Cas9 to the pancreas of...
Animals BRCA2 Protein CRISPR-Cas Systems Carcinogenesis Chromosome Deletion Electroporation Genetic Engineering Genome High-Throughput Nucleotide Sequencing Immunohistochemistry Magnetic Resonance Imaging Mice Mutation Neoplasms Experimental Pancreas Pancreatic Neoplasms Phylogeny Polymerase Chain Reaction Proto-Oncogene Proteins p21(ras) Sequence Analysis DNA Transfection Translocation Genetic
Plasma concentrations of persistent organic pollutants and pancreatic cancer risk.
Miquel Porta, Magda Gasull, José Pumarega, Hannu Kiviranta, Panu Rantakokko, Ole Raaschou-Nielsen, Ingvar A Bergdahl, Torkjel Manning Sandanger, Antoni Agudo, Charlotta Rylander, Therese Haugdahl Nøst, Carolina Donat-Vargas, Dagfinn Aune, Alicia K Heath, Lluís Cirera, Fernando Goñi-Irigoyen, Juan Alguacil, Àlex Giménez-Robert, Anne Tjønneland, Malin Sund, Kim Overvad, Francesca Romana Mancini, Vinciane Rebours, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Matthias B Schulze, Antonia Trichopoulou, Domenico Palli, Sara Grioni, Rosario Tumino, Alessio Naccarati, Salvatore Panico, Roel Vermeulen, J Ramón Quirós, Miguel Rodríguez-Barranco, Sandra M Colorado-Yohar, María-Dolores Chirlaque, Eva Ardanaz, Nick Wareham, Tim Key, Mattias Johansson, Neil Murphy, Pietro Ferrari, Inge Huybrechts, Veronique Chajes, Carlos Alberto Gonzalez, Bas Bueno-de-Mesquita, Marc Gunter, Elisabete Weiderpass, Elio Riboli, Eric J Duell, Verena Katzke, Paolo Vineis
Jul 20, 2021
BACKGROUND: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts. METHODS: We conducted a prospective...
The Role of Neuronal Pentraxin 1 in Promoting Pancreatic Cancer Progression
Yuehyi Gloria Wu
Jan 01, 0001
Pancreatic cancer is a deadly malignancy because it is usually diagnosed at an advanced stage and does not respond to the majority of treatments. More than 80% of patients present with advanced stage disease at the time of...
Published by: Rockefeller University
Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer
Jeffrey W Chen, Tess ME van Ramshorst, Sanne Lof, Bilal Al-Sarireh, Bergthor Bjornsson, Ugo Boggi, Fernando Burdio, Giovanni Butturini, Riccardo Casadei, Andrea Coratti, Mathieu D'Hondt, Safi Dokmak, Bjørn Edwin, Alessandro Esposito, Jean M Fabre, Giovanni Ferrari, Fadhel S Ftériche, Giuseppe K Fusai, Bas Groot Koerkamp, Thilo Hackert, Asif Jah, Jin-Young Jang, Emanuele F Kauffmann, Tobias Keck, Alberto Manzoni, Marco V Marino, Quintus Molenaar, Elizabeth Pando, Patrick Pessaux, Andrea Pietrabissa, Zahir Soonawalla, Robert P Sutcliffe, Lea Timmermann, Steven White, Vincent S Yip, Alessandro Zerbi, Mohammad Abu Hilal, Marc G Besselink, European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)
Apr 10, 2023
BACKGROUND: Robot-assisted distal pancreatectomy (RDP) is increasingly used as an alternative to laparoscopic distal pancreatectomy (LDP) in patients with resectable pancreatic cancer but comparative multicenter studies...
CA19-9 and apolipoprotein-A2 isoforms as detection markers for pancreatic cancer
Kazufumi Honda, Verena A Katzke, Anika Hüsing, Shinobu Okaya, Hirokazu Shoji, Kaoru Onidani, Anja Olsen, Anne Tjønneland, Kim Overvad, Elisabete Weiderpass, Paolo Vineis, David Muller, Kostas Tsilidis, Domenico Palli, Valeria Pala, Rosario Tumino, Alessio Naccarati, Salvatore Panico, Krasimira Aleksandrova, Heiner Boeing, H Bas Bueno-De-Mesquita, Petra H Peeters, Antonia Trichopoulou, Pagona Lagiou, Kay-Tee Khaw, Nick Wareham, Ruth C Travis, Susana Merino, Eric J Duell, Miguel Rodríguez-Barranco, María Dolores Chirlaque, Aurelio Barricarte, Vinciane Rebours, Marie-Chiristine Boutron-Ruault, Francesca Romana Mancini, Paul Brennan, Ghislaine Scelo, Jonas Manjer, Malin Sund, Daniel Öhlund, Federico Canzian, Rudolf Kaaks
Nov 21, 2018
Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. Our study provides a first prospective evaluation of an ApoA2 isoform ("ApoA2-ATQ/AT"), alone and in combination...
CA19-9 apolipoprotein A2 Early detection isoforms pancreatic cancer prospective study Adult Aged Apolipoprotein A-II CA-19-9 Antigen Case-Control Studies Early Detection of Cancer Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Pancreas Pancreatic Neoplasms Predictive Value of Tests Prospective Studies Protein Isoforms ROC Curve Time Factors
Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.
Tania Capeloa, Justine A Van de Velde, Donatienne d'Hose, Sara G Lipari, Françoise Derouane, Loïc Hamelin, Marie Bedin, Thibaut Vazeille, François P Duhoux, Michael P Murphy, Paolo E Porporato, Bernard Gallez, Pierre Sonveaux
Nov 16, 2022
At diagnosis, about 35% of pancreatic cancers are at the locally invasive yet premetastatic stage. Surgical resection is not a treatment option, leaving patients with a largely incurable disease that often evolves to the...
The SYMPTOM-upper gastrointestinal study
Napin Karnchanachari, Shakira Milton, Tjuntu Muhlen-Schulte, Riati Scarborough, Jennifer F Holland, Fiona M Walter, John Zalcberg, Jon Emery
May 09, 2022
OBJECTIVE: There is limited evidence on the development of pancreatic and oesophagogastric cancer, how patients decide to seek help and the factors impacting help-seeking. Our study, the first in Australia, aimed to explore...
Circulating Cell-Free Tumour DNA for Early Detection of Pancreatic Cancer.
Pancreatic cancer is a lethal disease, with mortality rates negatively associated with the stage at which the disease is detected. Early detection is therefore critical to improving survival outcomes. A recent focus of research...
Pan-cancer analysis of whole genomes.
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of...
Cell Proliferation Cellular Senescence Chromothripsis Cloud Computing DNA Mutational Analysis evolution Molecular Female Genome Human Genomics Germ-Line Mutation High-Throughput Nucleotide Sequencing Humans Information Dissemination Male Mutagenesis Mutation Neoplasms Oncogenes Promoter Regions Genetic RNA Splicing Reproducibility of Results Telomerase Telomere
DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors.
Minyuan Chen, Ee Ming Wong, Tuong L Nguyen, Gillian S Dite, Jennifer Stone, Pierre-Antoine Dugué, Graham G Giles, Melissa C Southey, Roger L Milne, John L Hopper, Shuai Li
Oct 20, 2020
DNA methylation-based biological age (DNAm age), as well as genome-wide average DNA methylation, have been reported to predict breast cancer risk. We aimed to investigate the associations between these DNA methylation-based risk...
Prediction and identification of synergistic compound combinations against pancreatic cancer cells.
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L Bramhall, Tai-Ping Fan, Andreas Bender
Nov 22, 2021
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations...
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Diagnosing cancer in primary care
Ruth Swann, Sean McPhail, Jana Witt, Brian Shand, Gary A Abel, Sara Hiom, Jem Rashbass, Georgios Lyratzopoulos, Greg Rubin, National Cancer Diagnosis Audit Steering Group
Mar 07, 2018
BACKGROUND: Continual improvements in diagnostic processes are needed to minimise the proportion of patients with cancer who experience diagnostic delays. Clinical audit is a means of achieving this. AIM: To characterise key...
Metabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model.
Tatiana J Carneiro, Joana Pinto, Eva M Serrao, António S Barros, Kevin M Brindle, Ana M Gil
Oct 13, 2022
Untargeted Nuclear Magnetic Resonance (NMR) metabolomics of polar extracts from the pancreata of a caerulin-induced mouse model of pancreatitis (Pt) and of a transgenic mouse model of pancreatic cancer (PCa) were used to find...
Consensus for the management of pancreatic exocrine insufficiency
Mary E Phillips, Andrew D Hopper, John S Leeds, Keith J Roberts, Laura McGeeney, Sinead N Duggan, Rajesh Kumar
Jul 28, 2021
INTRODUCTION: Pancreatic exocrine insufficiency is a finding in many conditions, predominantly affecting those with chronic pancreatitis, pancreatic cancer and acute necrotising pancreatitis. Patients with pancreatic exocrine...
Holistic cancer genome profiling for every patient.
Technological advances in the ability to read the human genome have accelerated the speed of sequencing, such that today we can perform whole genome sequencing (WGS) in one day. Until recently, genomic studies have largely been...
The Gene Ontology's Reference Genome Project
The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a...
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer.
Evangelina López de Maturana, Juan Antonio Rodríguez, Lola Alonso, Oscar Lao, Esther Molina-Montes, Isabel Adoración Martín-Antoniano, Paulina Gómez-Rubio, Rita Lawlor, Alfredo Carrato, Manuel Hidalgo, Mar Iglesias, Xavier Molero, Matthias Löhr, Christopher Michalski, José Perea, Michael O'Rorke, Victor Manuel Barberà, Adonina Tardón, Antoni Farré, Luís Muñoz-Bellvís, Tanja Crnogorac-Jurcevic, Enrique Domínguez-Muñoz, Thomas Gress, William Greenhalf, Linda Sharp, Luís Arnes, Lluís Cecchini, Joaquim Balsells, Eithne Costello, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Mirari Márquez, Josefina Mora, Damian O'Driscoll, Aldo Scarpa, Weimin Ye, Jingru Yu, PanGenEU Investigators, Montserrat García-Closas, Manolis Kogevinas, Nathaniel Rothman, Debra T Silverman, SBC/EPICURO Investigators, Demetrius Albanes, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Paul Brennan, Bas Bueno-de-Mesquita, Julie Buring, Federico Canzian, Margaret Du, Steve Gallinger, J Michael Gaziano, Phyllis J Goodman, Marc Gunter, Loic Lemarchand, Donghui Li, Rachael E Neale, Ulrika Peters, Gloria M Petersen, Harvey A Risch, Maria José Sánchez, Xiao-Ou Shu, Mark D Thornquist, Kala Visvanathan, Wei Zheng, Stephen J Chanock, Douglas Easton, Brian M Wolpin, Rachael Z Stolzenberg-Solomon, Alison P Klein, Laufey T Amundadottir, Marc A Marti-Renom, Francisco X Real, Núria Malats
Dec 16, 2020
BACKGROUND: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the...
3D genomic structure genetic susceptibility Genome-wide association analysis Local indices of genome spatial autocorrelation Pancreatic cancer risk Biomarkers Tumor Cell Line Tumor Computer Simulation Gene Regulatory Networks Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Linkage Disequilibrium Pancreatic Neoplasms Reproducibility of Results Signal Transduction
Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals
Genome-wide association studies (GWAS) have identified thousands of cancer risk loci revealing many 102 risk regions shared across multiple cancers. Characterizing the cross-cancer shared genetic basis can increase our...
Breast Cancer Association Consortium (BCAC) Colorectal Transdisciplinary Study (CORECT) Colon Cancer Family Registry Study (CCFR) Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) Endometrial Cancer Association Consortium (ECAC) Esophageal Cancer GWAS Consortium Glioma International Case Control Consortium (GICC) Head-Neck Cancer GWAS Consortium International Lung Cancer Consortium (ILCCO) Melanoma GWAS Consortium Ovarian Cancer Association Consortium (OCAC) Pancreatic Cancer Case-Control Consortium (PANC4) Pancreatic Cancer Cohort Consortium (PanScan) PRACTICAL consortium cruk BPC3 CAPS PEGASUS Renal Cancer GWAS Consortium
Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.
Hongjie Chen, Arunabha Majumdar, Lu Wang, Siddhartha Kar, Kevin M Brown, Helian Feng, Constance Turman, Joe Dennis, Douglas Easton, Kyriaki Michailidou, Jacques Simard, Timothy Bishop, Iona C Cheng, Jeroen R Huyghe, Stephanie L Schmit, Tracy A O'Mara, Amanda B Spurdle, Puya Gharahkhani, Johannes Schumacher, Janusz Jankowski, Ines Gocke, Melissa L Bondy, Richard S Houlston, Robert B Jenkins, Beatrice Melin, Corina Lesseur, Andy R Ness, Brenda Diergaarde, Andrew F Olshan, Christopher I Amos, David C Christiani, Maria T Landi, James D Mckay, Myriam Brossard, Mark M Iles, Matthew H Law, Stuart MacGregor, Jonathan Beesley, Michelle R Jones, Jonathan Tyrer, Stacey J Winham, Alison P Klein, Gloria Petersen, Donghui Li, Brian M Wolpin, Rosalind A Eeles, Christopher A Haiman, Zsofia Kote-Jarai, Fredrick R Schumacher, Paul Brennan, Stephen J Chanock, Valerie Gaborieau, Mark P Purdue, Paul Pharoah, Rayjean J Hung, Laufey T Amundadottir, Peter Kraft, Bogdan Pasaniuc, Sara Lindström
Sep 08, 2021
Genome-wide association studies (GWASs) have identified thousands of cancer risk loci revealing many risk regions shared across multiple cancers. Characterizing the cross-cancer shared genetic basis can increase our...
Published by: HGG advances
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