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Results: 96603
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
Xueyi Shen, David M Howard, Mark J Adams, W David Hill, Toni-Kim Clarke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ian J Deary, Heather C Whalley, Andrew M McIntosh
May 08, 2021
Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a...
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Till FM Andlauer, Jose Guzman-Parra, Fabian Streit, Jana Strohmaier, Maria José González, Susana Gil Flores, Francisco J Cabaleiro Fabeiro, Francisco Del Río Noriega, Fermin Perez Perez, Jesus Haro González, Guillermo Orozco Diaz, Yolanda de Diego-Otero, Berta Moreno-Küstner, Georg Auburger, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffmann, Josef Frank, Jerome C Foo, Jens Treutlein, Stephanie H Witt, Sven Cichon, Manolis Kogevinas, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Fabio Rivas, Fermín Mayoral, Bertram Müller-Myhsok, Andreas J Forstner, Markus M Nöthen, Marcella Rietschel
Mar 22, 2021
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD...
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes
BP Prins, A Abbasi, A Wong, A Vaez, I Nolte, N Franceschini, PE Stuart, J Guterriez Achury, V Mistry, JP Bradfield, AM Valdes, J Bras, A Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, C Lu, B Han, S Raychaudhuri, S Bevan, MD Mayes, LC Tsoi, E Evangelou, RP Nair, SFA Grant, C Polychronakos, TRD Radstake, DA van Heel, ML Dunstan, NW Wood, A Al-Chalabi, A Dehghan, H Hakonarson, HS Markus, JT Elder, J Knight, DE Arking, TD Spector, BPC Koeleman, CM van Duijn, J Martin, AP Morris, RK Weersma, C Wijmenga, PB Munroe, JRB Perry, JG Pouget, Y Jamshidi, H Snieder, BZ Alizadeh
Jan 30, 2017
BACKGROUND: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. METHODS AND FINDINGS: We performed Mendelian...
Frontal networks in adults with autism spectrum disorder.
Marco Catani, Flavio Dell'Acqua, Sanja Budisavljevic, Henrietta Howells, Michel Thiebaut de Schotten, Seán Froudist-Walsh, Lucio D'Anna, Abigail Thompson, Stefano Sandrone, Edward T Bullmore, John Suckling, Simon Baron-Cohen, Michael V Lombardo, Sally J Wheelwright, Bhismadev Chakrabarti, Meng-Chuan Lai, Amber NV Ruigrok, Alexander Leemans, Christine Ecker, Mrc Aims Consortium, Michael C Craig, Declan GM Murphy
Aug 09, 2017
It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum...
Surveillance recommendations for DICER1 pathogenic variant carriers
Jette J Bakhuizen, Helen Hanson, Karin van der Tuin, Fiona Lalloo, Marc Tischkowitz, Karin Wadt, Marjolijn CJ Jongmans, SIOPE Host Genome Working Group, CanGene-CanVar Clinical Guideline Working Group, Expert Network Members
Oct 01, 2021
DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging because uncertainty exists about the clinical efficacy of surveillance...
Adapted cognitive behavior therapy for obsessive compulsive disorder with co-occurring autism spectrum disorder
Oskar Flygare, Erik Andersson, Helene Ringberg, Anna-Clara Hellstadius, Johan Edbacken, Jesper Enander, Matti Dahl, Kristina Aspvall, Indra Windh, Ailsa Russell, David Mataix-Cols, Christian Ruck
Jan 31, 2020
Obsessive–compulsive disorder and autism spectrum disorder commonly co-occur. Adapted cognitive behavior therapy for obsessive–compulsive disorder in adults with autism spectrum disorder has not previously been evaluated...
Deficits in metacognitive monitoring in mathematics assessments in learners with autism spectrum disorder
Mark Brosnan, Hilary Johnson, Beate Grawemeyer, Emma Chapman, Konstantina Antoniadou, Melissa Hollinworth
May 01, 2016
Children and adults with autism spectrum disorder have been found to have deficits in metacognition that could impact upon their learning. This study explored metacognitive monitoring in 28 (23 males and 5 females) participants...
Deficits in metacognitive monitoring in mathematics assessments in learners with autism spectrum disorder
Mark Brosnan, Hilary Johnson, Beate Grawemeyer, Emma Chapman, Konstantina Antoniadou, Melissa Hollinworth
May 01, 2016
Children and adults with autism spectrum disorder have been found to have deficits in metacognition that could impact upon their learning. This study explored metacognitive monitoring in 28 (23 males and 5 females) participants...
Adapted cognitive behavior therapy for obsessive compulsive disorder with co-occurring autism spectrum disorder
Oskar Flygare, Erik Andersson, Helene Ringberg, Anna-Clara Hellstadius, Johan Edbacken, Jesper Enander, Matti Dahl, Kristina Aspvall, Indra Windh, Ailsa Russell, David Mataix-Cols, Christian Ruck
Jan 31, 2020
Obsessive–compulsive disorder and autism spectrum disorder commonly co-occur. Adapted cognitive behavior therapy for obsessive–compulsive disorder in adults with autism spectrum disorder has not previously been evaluated...
Early Motor Differences in Infants at Elevated Likelihood of Autism Spectrum Disorder and/or Attention Deficit Hyperactivity Disorder.
Jannath Begum Ali, Tony Charman, Mark H Johnson, Emily JH Jones, and the BASIS/STAARS Team
Apr 23, 2021
We investigated infant's manual motor behaviour; specifically behaviours crossing the body midline. Infants at elevated likelihood of Autism Spectrum Disorder (ASD) and/or Attention Deficit Hyperactivity Disorder (ADHD) produced...
Parental inflammatory bowel disease and autism in children.
Aws Sadik, Christina Dardani, Panagiota Pagoni, Alexandra Havdahl, Evie Stergiakouli, iPSYCH Autism Spectrum Disorder Working Group, Golam M Khandaker, Sarah A Sullivan, Stan Zammit, Hannah J Jones, George Davey Smith, Christina Dalman, Håkan Karlsson, Renee M Gardner, Dheeraj Rai
Jul 23, 2022
The SPECTRUM Consortium
M Horton, PR Perman-Howe, C Angus, J Bishop, I Bogdanovica, A Brennan, J Britton, LS Brose, J Brown, J Collin, M Dockrell, N Fitzgerald, S Friel, D Gillespie, AB Gilmore, SE Hill, C Knai, T Langley, S Martin, A McNeill, G Moore, MR Munafò, RL Murray, M Opazo Breton, J Pearce, M Petticrew, G Reid, D Robson, H Rutter, L Shahab, N Shortt, K Smith, K Syrett, L Bauld
Dec 31, 2021
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures...
Alcohol Commercial determinants Inequalities Non-communicable disease Policy Prevention Public Health Tobacco Unhealthy commodities /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The SPECTRUM Consortium
M Horton, PR Perman-Howe, C Angus, J Bishop, I Bogdanovica, A Brennan, J Britton, LS Brose, J Brown, J Collin, M Dockrell, N Fitzgerald, S Friel, D Gillespie, AB Gilmore, SE Hill, C Knai, T Langley, S Martin, A McNeill, G Moore, MR Munafò, RL Murray, M Opazo Breton, J Pearce, M Petticrew, G Reid, D Robson, H Rutter, L Shahab, N Shortt, K Smith, K Syrett, L Bauld
Dec 31, 2021
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures...
Alcohol Commercial determinants Inequalities Non-communicable disease Policy Prevention Public Health Tobacco Unhealthy commodities /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder.
Derek Sayre Andrews, Thomas A Avino, Maria Gudbrandsen, Eileen Daly, Andre Marquand, Clodagh M Murphy, Meng-Chuan Lai, Michael V Lombardo, Amber NV Ruigrok, Steven C Williams, Edward T Bullmore, The Mrc Aims Consortium, John Suckling, Simon Baron-Cohen, Michael C Craig, Declan GM Murphy, Christine Ecker
Aug 17, 2017
Atypical cortical organization and reduced integrity of the gray-white matter boundary have been reported by postmortem studies in individuals with autism spectrum disorder (ASD). However, there are no in vivo studies that...
Experiences of autism spectrum disorder and policing in England and Wales
An online survey gathered the experiences and views of 394 police officers (from England and Wales) regarding autism spectrum disorder (ASD). Just 42% of officers were satisfied with how they had worked with individuals with ASD...
Shared and Disorder-Specific Neurocomputational Mechanisms of Decision-Making in Autism Spectrum Disorder and Obsessive-Compulsive Disorder.
Christina O Carlisi, Luke Norman, Clodagh M Murphy, Anastasia Christakou, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, Declan G Murphy, David Mataix-Cols, Katya Rubia, MRC AIMS Consortium
May 14, 2019
Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) often share phenotypes of repetitive behaviors, possibly underpinned by abnormal decision-making. To compare neural correlates underlying decision-making...
Autism spectrum disorder computational modeling decision-making fMRI Obsessive-Compulsive Disorder Adolescent Autism spectrum disorder Brain Brain Mapping Child Computer Simulation Decision Making Feedback Psychological Formative Feedback Gambling Humans Magnetic Resonance Imaging Male Models Neurological Neural Pathways Neuropsychological Tests Obsessive-Compulsive Disorder Reinforcement psychology
Emotion awareness and cognitive behavioural therapy in young people with autism spectrum disorder
Young people with autism spectrum disorder experience high levels of emotional problems, including anxiety and depression. Adapted cognitive behavioural therapy is recommended for such difficulties. However, no evidence...
Emotion awareness and cognitive behavioural therapy in young people with autism spectrum disorder
Young people with autism spectrum disorder experience high levels of emotional problems, including anxiety and depression. Adapted cognitive behavioural therapy is recommended for such difficulties. However, no evidence...
EU-AIMS Longitudinal European Autism Project (LEAP)
Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K Buitelaar, Eva Loth, Declan GM Murphy, Will Spooren, Sven Bölte, EU-AIMS LEAP group
May 09, 2019
EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has...
Gray matter covariations and core symptoms of autism
Ting Mei, Alberto Llera, Dorothea L Floris, Natalie J Forde, Julian Tillmann, Sarah Durston, Carolin Moessnang, Tobias Banaschewski, Rosemary J Holt, Simon Baron-Cohen, Annika Rausch, Eva Loth, Flavio Dell'Acqua, Tony Charman, Declan GM Murphy, Christine Ecker, Christian F Beckmann, Jan K Buitelaar, EU-AIMS LEAP group
Dec 07, 2020
BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of...
Mental imagery scanning in autism spectrum disorder
Navigational impairments have previously been reported in autism spectrum disorder (ASD). The present study examined the ability of individuals with ASD to generate and scan their mental image of a previously viewed map....
Policy Gaps and Opportunities
Dylan Cooper, Disha Uppal, Kirsten Railey, Amy Blank Wilson, Katie Maras, Emily Zimmerman, Juan Bornman, Lindsay Shea
Jul 31, 2022
Autism spectrum disorder prevalence is rising, and as this population enters adulthood, preliminary research has identified high rates of contact with the criminal justice system. Policy and programmatic reform are crucial given...
Mental imagery scanning in autism spectrum disorder
Navigational impairments have previously been reported in autism spectrum disorder (ASD). The present study examined the ability of individuals with ASD to generate and scan their mental image of a previously viewed map....
The cognitive interview for eyewitnesses with autism spectrum disorder
The cognitive interview (CI) is one of the most widely accepted forms of interviewing techniques for eliciting the most detailed, yet accurate reports from witnesses. No research, however, has examined its effectiveness with...
Experiences of autism spectrum disorder and policing in England and Wales
An online survey gathered the experiences and views of 394 police officers (from England and Wales) regarding autism spectrum disorder (ASD). Just 42% of officers were satisfied with how they had worked with individuals with ASD...
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