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BRCA Challenge
Melissa S Cline, Rachel G Liao, Michael T Parsons, Benedict Paten, Faisal Alquaddoomi, Antonis Antoniou, Samantha Baxter, Larry Brody, Robert Cook-Deegan, Amy Coffin, Fergus J Couch, Brian Craft, Robert Currie, Chloe C Dlott, Lena Dolman, Johan T den Dunnen, Stephanie OM Dyke, Susan M Domchek, Douglas Easton, Zachary Fischmann, William D Foulkes, Judy Garber, David Goldgar, Mary J Goldman, Peter Goodhand, Steven Harrison, David Haussler, Kazuto Kato, Bartha Knoppers, Charles Markello, Robert Nussbaum, Kenneth Offit, Sharon E Plon, Jem Rashbass, Heidi L Rehm, Mark Robson, Wendy S Rubinstein, Dominique Stoppa-Lyonnet, Sean Tavtigian, Adrian Thorogood, Can Zhang, Marc Zimmermann, BRCA Challenge Authors, John Burn, Stephen Chanock, Gunnar Rätsch, Amanda B Spurdle
Jan 08, 2019
The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to...
Understanding of BRCA VUS genetic results by breast cancer specialists.
BACKGROUND: Mainstreaming genetic medicine, increased media coverage and clinical trials for BRCA mutation carriers are leading oncologists into more patient discussions about BRCA genetic testing. BRCA variants of uncertain...
Current detection rates and time-to-detection of all identifiable BRCA carriers in the Greater London population.
Ranjit Manchanda, Oleg Blyuss, Faiza Gaba, Vladimir Sergeevich Gordeev, Chris Jacobs, Matthew Burnell, Carmen Gan, Rohan Taylor, Clare Turnbull, Rosa Legood, Alexey Zaikin, Antonis C Antoniou, Usha Menon, Ian Jacobs
Jun 18, 2018
BACKGROUND: BRCA carrier identification offers opportunities for early diagnoses, targeted treatment and cancer prevention. We evaluate BRCA- carrier detection rates in general and Ashkenazi Jewish (AJ) populations across...
Authors
List of contributing authors.
Published by: The Morning Watch: Educational and Social Analysis
Association between CT-texture-derived tumor heterogeneity, outcomes, and BRCA mutation status in patients with high-grade serous ovarian cancer.
Andreas Meier, Harini Veeraraghavan, Stephanie Nougaret, Yulia Lakhman, Ramon Sosa, Robert A Soslow, Elizabeth J Sutton, Hedvig Hricak, Evis Sala, Hebert A Vargas
Jan 02, 2019
PURPOSE: To assess the associations between inter-site texture heterogeneity parameters derived from computed tomography (CT), survival, and BRCA mutation status in women with high-grade serous ovarian cancer (HGSOC). MATERIALS...
BRCA mutation status high-grade serous ovarian cancer Radiomics texture analysis Tumor heterogeneity Adult Aged Aged 80 and over Cystadenocarcinoma Serous Female Humans Middle Aged Mutation Neoplasm Grading Ovarian Neoplasms Radiographic Image Interpretation Computer-Assisted Retrospective Studies Tomography X-Ray Computed Ubiquitin-Protein Ligases
Authors
List of contributing authors.
Published by: The Morning Watch: Educational and Social Analysis
Germline BRCA mutation and outcome in young-onset breast cancer (POSH)
Ellen R Copson, Tom C Maishman, Will J Tapper, Ramsey I Cutress, Stephanie Greville-Heygate, Douglas G Altman, Bryony Eccles, Sue Gerty, Lorraine T Durcan, Louise Jones, D Gareth Evans, Alastair M Thompson, Paul Pharoah, Douglas F Easton, Alison M Dunning, Andrew Hanby, Sunil Lakhani, Ros Eeles, Fiona J Gilbert, Hisham Hamed, Shirley Hodgson, Peter Simmonds, Louise Stanton, Diana M Eccles
Feb 02, 2018
BACKGROUND: Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The primary aim of this study was to determine the effect of a...
Adult Age Factors Breast Neoplasms Cohort Studies Combined Modality Therapy Disease-Free Survival Female Genes BRCA1 Genes BRCA2 Genetic Predisposition to Disease Germ-Line Mutation Humans Multivariate Analysis Patient Outcome Assessment Prognosis Proportional Hazards Models Prospective Studies Survival Analysis Triple Negative Breast Neoplasms United Kingdom Young Adult
Evaluating stress as a challenge is associated with superior attentional control and motor skill performance
The biopsychosocial model of challenge and threat (Blascovich, 2008) suggests that individuals who evaluate a performance situation as a challenge will perform better than those who evaluate it as a threat. However, limited...
Evaluating stress as a challenge is associated with superior attentional control and motor skill performance
The biopsychosocial model of challenge and threat (Blascovich, 2008) suggests that individuals who evaluate a performance situation as a challenge will perform better than those who evaluate it as a threat. However, limited...
Challenge funds in international development
The use of challenge funds to promote economic and social development continues to grow but has been the subject of relatively little research. This article draws on institutional economics (particularly principal-agent theory)...
Challenge funds in international development
The use of challenge funds to promote economic and social development continues to grow but has been the subject of relatively little research. This article draws on institutional economics (particularly principal-agent theory)...
A Grand Challenge
Alexander Ball, Manjula Patel, Christopher McMahon, Stuart Green, John Clarkson, Stephen Culley
Nov 01, 2006
‘Immortal information and through-life knowledge management: strategies and tools for the emerging product-service business paradigm’, is a Grand Challenge project involving eleven different UK universities and incorporating...
Winthrop Giving Challenge Raises More Than $100K to Support Scholarships
Winthrop University
Jan 01, 0001
The Winthrop Chimney Challenge, a holiday-themed giving challenge, has raised more than $100,000 to support the Winthrop Fund, an unrestricted fund that provides student scholarships. The holiday-themed challenge, which began at...
Published by: Winthrop University
Nonverbal behavior accompanying challenge and threat states under pressure
Objectives
This study examined if challenge and threat states predicted nonverbal behavior during a pressurized soccer penalty task.
Design
A predictive design was employed.
Method
Forty-two...
This study examined if challenge and threat states predicted nonverbal behavior during a pressurized soccer penalty task.
Design
A predictive design was employed.
Method
Forty-two...
Mobile Learning as a Tool for Indigenous Language Revitalization and Sustainability in Canada
In this article, the authors explore how mobile learning can complement the Certificate of Indigenous Languages program at the University of Saskatchewan in Western Canada. Through the FRAME model analysis, the authors extract...
Published by: IGI Global Scientific Publishing
A Grand Challenge
Alexander Ball, Manjula Patel, Christopher McMahon, Stuart Green, John Clarkson, Stephen Culley
Nov 01, 2006
‘Immortal information and through-life knowledge management: strategies and tools for the emerging product-service business paradigm’, is a Grand Challenge project involving eleven different UK universities and incorporating...
The relationship between challenge and threat states and performance:
The biopsychosocial model of challenge and threat states specifies that these states engender different physiological and behavioral responses in potentially stressful situations. This model has received growing interest in the...
The relationship between challenge and threat states and performance:
The biopsychosocial model of challenge and threat states specifies that these states engender different physiological and behavioral responses in potentially stressful situations. This model has received growing interest in the...
Higher Education
P Gregg, Alan Milburn, Gillian Shephard, Paul Cleal, Tom Attwood, David Johnston, Douglas Hamilton, Anne Marie Carrie, Christian Guy, Catriona Williams
Jun 17, 2013
Last year the Independent Reviewer on Social Mobility published a report on higher education access, focused mainly on England.
‘University Challenge: How Higher Education Can Advance Social Mobility’ made wide-ranging...
‘University Challenge: How Higher Education Can Advance Social Mobility’ made wide-ranging...
Published by: Social Mobility & Child Poverty (SMCP) Commission
Higher Education
P Gregg, Alan Milburn, Gillian Shephard, Paul Cleal, Tom Attwood, David Johnston, Douglas Hamilton, Anne Marie Carrie, Christian Guy, Catriona Williams
Jun 17, 2013
Last year the Independent Reviewer on Social Mobility published a report on higher education access, focused mainly on England.
‘University Challenge: How Higher Education Can Advance Social Mobility’ made wide-ranging...
‘University Challenge: How Higher Education Can Advance Social Mobility’ made wide-ranging...
Published by: Social Mobility & Child Poverty (SMCP) Commission
My Nail-biting Challenge
Abena Boachie
Oct 01, 2018
This paper is a three-week journey of gathering personal data about my nail-biting challenge. It borrows the idea from the “Dear data Project” by Georgia Lupi and Stefanie Posavec to frame a personal experience with nail-biting...
Published by: The Morning Watch: Educational and Social Analysis
Nonverbal behavior accompanying challenge and threat states under pressure
Objectives
This study examined if challenge and threat states predicted nonverbal behavior during a pressurized soccer penalty task.
Design
A predictive design was employed.
Method
Forty-two...
This study examined if challenge and threat states predicted nonverbal behavior during a pressurized soccer penalty task.
Design
A predictive design was employed.
Method
Forty-two...
Winthrop Kicks Off 48-Hour THANKSgiving Fundraising Challenge Nov. 18
Winthrop University
Jan 01, 0001
The THANKSgiving Challenge kicked off at 9 a.m. today. The goal: Collect 480 gifts in 48 hours to benefit student scholarships. Visit http://www.winthropalumni.com/thanksgiving to join the challenge now.
Published by: Winthrop University
My Nail-biting Challenge
Abena Boachie
Oct 01, 2018
This paper is a three-week journey of gathering personal data about my nail-biting challenge. It borrows the idea from the “Dear data Project” by Georgia Lupi and Stefanie Posavec to frame a personal experience with nail-biting...
Published by: The Morning Watch: Educational and Social Analysis
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