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High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
Steve Eyre, John Bowes, Dorothée Diogo, Annette Lee, Anne Barton, Paul Martin, Alexandra Zhernakova, Eli Stahl, Sebastien Viatte, Kate McAllister, Christopher I Amos, Leonid Padyukov, Rene EM Toes, Tom WJ Huizinga, Cisca Wijmenga, Gosia Trynka, Lude Franke, Harm-Jan Westra, Lars Alfredsson, Xinli Hu, Cynthia Sandor, Paul IW de Bakker, Sonia Davila, Chiea Chuen Khor, Khai Koon Heng, Robert Andrews, Sarah Edkins, Sarah E Hunt, Cordelia Langford, Deborah Symmons, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Wellcome Trust Case Control Consortium, Pat Concannon, Suna Onengut-Gumuscu, Stephen S Rich, Panos Deloukas, Miguel A Gonzalez-Gay, Luis Rodriguez-Rodriguez, Lisbeth Ärlsetig, Javier Martin, Solbritt Rantapää-Dahlqvist, Robert M Plenge, Soumya Raychaudhuri, Lars Klareskog, Peter K Gregersen, Jane Worthington
May 28, 2021
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoid arthritis (cases) of European...
Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach
Shang-Ming Zhou, Fabiola Fernandez-Gutierrez, Jonathan Kennedy, Roxanne Cooksey, Mark Atkinson, Spiros Denaxas, Stefan Siebert, William G Dixon, Terence W O'Neill, Ernest Choy, Cathie Sudlow, UK Biobank Follow-up and Outcomes Group, Sinead Brophy
Nov 20, 2017
OBJECTIVES: 1) To use data-driven method to examine clinical codes (risk factors) of a medical condition in primary care electronic health records (EHRs) that can accurately predict a diagnosis of the condition in secondary care...
Fostering autonomous motivation, physical activity and cardiorespiratory fitness in rheumatoid arthritis
Peter C Rouse, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Nikos Ntoumanis, Chen-an Yu, Yiannis Koutedakis, Sally A M Fenton, Joanna Coast, Hema Mistry, George D Kitas, Joan L Duda
Dec 19, 2014
BACKGROUND: People with rheumatoid arthritis are at greater risk of morbidity and mortality from cardiovascular disease than the general population. Sustained physical activity increases cardio-respiratory fitness and reduces...
Perioperative Considerations in Rheumatoid Arthritis Patients.
The pre-operative assessment is used to clarify issues prior to surgery that can change management provided by a multidisciplinary team. A high proportion of rheumatoid arthritis patients are elderly requiring orthopaedic...
Increased DNA methylation variability in rheumatoid arthritis discordant monozygotic twins
DS Paul
Jan 30, 2019
Background: Rheumatoid arthritis is a common autoimmune disorder influenced by both genetic and environmental factors. Epigenome-wide association studies can identify environmentally mediated epigenetic changes such as altered...
Motivation-related predictors of physical activity engagement and vitality in rheumatoid arthritis patients
C.-A. Yu, P. C. Rouse, J. V. J. Van Zanten, G. S. Metsios, N. Ntoumanis, G. D. Kitas, J. L. Duda
Aug 18, 2015
This study tests the Basic Psychological Needs Theory (within the Self-determination framework), in relation to the prediction of physical activity and well-being among rheumatoid arthritis patients. Motivation regulations for...
Motivation-related predictors of physical activity engagement and vitality in rheumatoid arthritis patients
C.-A. Yu, P. C. Rouse, J. V. J. Van Zanten, G. S. Metsios, N. Ntoumanis, G. D. Kitas, J. L. Duda
Aug 18, 2015
This study tests the Basic Psychological Needs Theory (within the Self-determination framework), in relation to the prediction of physical activity and well-being among rheumatoid arthritis patients. Motivation regulations for...
Fostering autonomous motivation, physical activity and cardiorespiratory fitness in rheumatoid arthritis
Peter C Rouse, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Nikos Ntoumanis, Chen-an Yu, Yiannis Koutedakis, Sally A M Fenton, Joanna Coast, Hema Mistry, George D Kitas, Joan L Duda
Dec 19, 2014
BACKGROUND: People with rheumatoid arthritis are at greater risk of morbidity and mortality from cardiovascular disease than the general population. Sustained physical activity increases cardio-respiratory fitness and reduces...
Gender stratified adjustment of the DAS28-CRP improves inter-score agreement with the DAS28-ESR in rheumatoid arthritis
Philip Hamann, Gavin Shaddick, Kimme L. Hyrich, Amelia Green, Neil McHugh, John D Pauling
Oct 03, 2018
Objectives: To evaluate determinants of discordance between DAS28-ESR and DAS28-CRP and resulting impact on disease activity stratification in rheumatoid arthritis (RA)Methods: Paired DAS28-ESR and DAS28-CRP readings (n=31,074)...
Gender stratified adjustment of the DAS28-CRP improves inter-score agreement with the DAS28-ESR in rheumatoid arthritis
Philip Hamann, Gavin Shaddick, Kimme L. Hyrich, Amelia Green, Neil McHugh, John D Pauling
Oct 03, 2018
Objectives: To evaluate determinants of discordance between DAS28-ESR and DAS28-CRP and resulting impact on disease activity stratification in rheumatoid arthritis (RA)Methods: Paired DAS28-ESR and DAS28-CRP readings (n=31,074)...
Risk factors for falls in adults with rheumatoid arthritis
Emma K Stanmore, Jackie Oldham, Dawn A Skelton, Terence O'Neill, Mark Pilling, A John Campbell, Chris Todd
May 31, 2018
OBJECTIVE: To investigate the association between potential risk factors and falls in community-dwelling adults with rheumatoid arthritis (RA). METHODS: We followed patients for 1 year of followup in a prospective cohort study...
A prospective cohort study measuring cost-benefit analysis of the Otago Exercise Programme in community dwelling adults with rheumatoid arthritis.
Siyar Abdulrazaq, Jackie Oldham, Dawn A Skelton, Terence O'Neill, Luke Munford, Brenda Gannon, Mark Pilling, Chris Todd, Emma K Stanmore
Jun 01, 2018
BACKGROUND: Falls are one of the major health problems in adults with Rheumatoid Arthritis (RA). Interventions, such as the Otago Exercise Programme (OEP), can reduce falls in community dwelling adults by up to 35%. The...
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
Autonomy support, light physical activity and psychological well-being in Rheumatoid Arthritis
Sally A M Fenton, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Peter C. Rouse, Chen-an Yu, George D Kitas, Joan L. Duda
Mar 01, 2018
Background Participation in physical activity may improve psychological well-being among people with Rheumatoid Arthritis (RA). This study examined the implications of autonomy support for physical activity, on objectively...
Perceived barriers, facilitators and benefits for regular physical activity and exercise in patients with rheumatoid arthritis
Jet J. C. S. Veldhuijzen Van Zanten, Peter C. Rouse, Elizabeth D. Hale, Nikos Ntoumanis, George S. Metsios, Joan L. Duda, George D. Kitas
Oct 01, 2015
Rheumatoid arthritis (RA) is an autoimmune disease, which not only affects the joints but can also impact on general well-being and risk for cardiovascular disease. Regular physical activity and exercise in patients with RA have...
Perceived barriers, facilitators and benefits for regular physical activity and exercise in patients with rheumatoid arthritis
Jet J. C. S. Veldhuijzen Van Zanten, Peter C. Rouse, Elizabeth D. Hale, Nikos Ntoumanis, George S. Metsios, Joan L. Duda, George D. Kitas
Oct 01, 2015
Rheumatoid arthritis (RA) is an autoimmune disease, which not only affects the joints but can also impact on general well-being and risk for cardiovascular disease. Regular physical activity and exercise in patients with RA have...
Composite Measures for Clinical Trials in Psoriatic Arthritis
William Tillett, Oliver FitzGerald, Laura C Coates, Jon Packham, Deepak R Jadon, Marco Massarotti, Mel Brook, Suzanne Lane, Paul Creamer, Anna Antony, Eleanor Korendowych, Adwaye Rambojun, Neil J McHugh, Philip S Helliwell, and Philip S. Helliwell on behalf of the PROMPT Study Group
Aug 02, 2021
OBJECTIVE: To test the addition of pain and fatigue to the Composite Psoriatic Arthritis Disease Activity (CPDAI) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) Composite Exercise (GRACE) composite...
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
Perioperative management of patients with rheumatoid arthritis undergoing orthopaedic surgery.
Rheumatoid arthritis is an autoimmune disease which is characterised by systemic inflammation. In the recent decades, the advent of disease modifying anti-rheumatic drugs have reduced the need for orthopaedic procedures....
Autonomy support, light physical activity and psychological well-being in Rheumatoid Arthritis
Sally A M Fenton, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Peter C. Rouse, Chen-an Yu, George D Kitas, Joan L. Duda
Mar 01, 2018
Background Participation in physical activity may improve psychological well-being among people with Rheumatoid Arthritis (RA). This study examined the implications of autonomy support for physical activity, on objectively...
Measuring the positive psychological well-being of people with rheumatoid arthritis
Peter C. Rouse, Jet J. J. C. S. Veldhuijzen Van Zanten, Nikos Ntoumanis, George S. Metsios, Chen-an Yu, George D. Kitas, Joan L. Duda
Nov 05, 2015
Introduction People with rheumatoid arthritis (RA) frequently suffer from compromised physical and psychological health, however, little is known about positive indicators of health, due to a lack of validated outcome measures....
Treating to target in psoriatic arthritis
Ines Rombach, William Tillett, Deepak Jadon, Laura Tucker, Marion Watson, Anne Francis, Yvonne Sinomati, Lucy Eldridge, Melina Dritsaki, Susan J Dutton, Hussein Al-Mossawi, Nicola Gullick, Ben Thompson, Laura C Coates
Apr 12, 2021
BACKGROUND: The Tight Control of psoriatic arthritis (TICOPA) trial confirmed improved clinical outcomes with a treat to target (T2T) strategy in psoriatic arthritis (PsA). This consisted of 4-weekly review and escalation of...
Treating to target in psoriatic arthritis
Ines Rombach, William Tillett, Deepak Jadon, Laura Tucker, Marion Watson, Anne Francis, Yvonne Sinomati, Lucy Eldridge, Melina Dritsaki, Susan J. Dutton, Hussein Al-Mossawi, Nicola Gullick, Ben Thompson, Laura C. Coates
Mar 04, 2021
Abstract: Background: The Tight Control of psoriatic arthritis (TICOPA) trial confirmed improved clinical outcomes with a treat to target (T2T) strategy in psoriatic arthritis (PsA). This consisted of 4-weekly review and...
A systematic review of randomised controlled trials in rheumatoid arthritis
BACKGROUND: Most reported outcome measures in rheumatoid arthritis (RA) trials are composite, whose components comprise single measures that are combined into one outcome. The aims of this review were to assess the range of...
Composite outcomes imputation missing data RA sensitivity analysis Arthritis Rheumatoid Data Accuracy Data Collection Data Interpretation Statistical Humans Intention to Treat Analysis Models Statistical Patient Dropouts Randomized Controlled Trials as Topic Research Design Sample Size Treatment Outcome
Published by: Trials
Tumour Necrosis Factor Inhibitor monotherapy versus combination therapy for the treatment of psoriatic arthritis
Matthew Thomas, Gavin Shaddick, Rachel Charlton, Charlotte Cavill, Richard Holland, Florenzo Iannone, Giovanni Lapadula, Simona Lopriore, Jakub Zavada, Michal Uher, Karel Pavelka, Lenka Szczukova, Prodromos Sidiropolous, Irini Flouri, Alexandros Drosos, Burkhard Möller, Michael Nissen, Rüdiger Müller, Almut Scherer, Neil McHugh, Alison Nightingale
Jan 01, 2021
Objective
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
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