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Results: 104
Somatic cancer genetics in the UK
JD Brenton
Oct 15, 2018
Critical questions in ovarian cancer research and treatment
James Derek Brenton
Feb 07, 2019
Substantial progress has been made in understanding ovarian cancer at the molecular and cellular level. Significant improvement in 5‐year survival has been achieved through cytoreductive surgery, combination platinum‐based...
PARP inhibitors Drug Resistance Early detection Heterogeneity Immunotherapy metabolism microenvironment ovarian cancer Prevention Antineoplastic Agents Congresses as Topic Drug Resistance Neoplasm Female Humans Immunotherapy Ovarian Neoplasms Patient-Centered Care Poly(ADP-ribose) Polymerase Inhibitors Societies Scientific Tumor Microenvironment
You won't believe this old test … that does cheap single-cell mutation detection.
Detecting mutations in single cells from cancer specimens is now a major area of translational research. In a recent article in this journal, Khalique et al validated an immunohistochemistry assay for ARID1A that reliably...
SPARC Regulates Transforming Growth Factor Beta Induced (TGFBI) Extracellular Matrix Deposition and Paclitaxel Response in Ovarian Cancer Cells.
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence.
Hepatocyte nuclear factor-1β (HNF1β) Importin-α Isothermal titration calorimetry Nuclear import pathway Nuclear localisation signal sequence (NLS) Site-directed mutagenesis X-ray crystallography Active Transport Cell Nucleus Animals Binding Sites Cell Line Tumor Cell Nucleus Crystallography X-Ray HEK293 Cells Hepatocyte Nuclear Factor 1-beta Humans Mice Models Molecular Nuclear Localization Signals Protein Binding Protein Conformation alpha-Helical Sequence Analysis Protein Xenopus Proteins Xenopus laevis alpha Karyopherins
Personalising Treatment for High-Grade Serous Ovarian Carcinoma.
Ovarian cancer is a heterogeneous group of cancers that differ by cell of origin and genomic features. High-grade serous ovarian cancer (HGSOC) is the commonest histiotype and is characterized by extreme genomic complexity and...
Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling.
Ali Naderi, Ahmed A Ahmed, Nuno L Barbosa-Morais, Samuel Aparicio, James D Brenton, Carlos Caldas
Jun 16, 2011
Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma.
Claire M King, Cynthia Barbara, Andrew Prentice, James D Brenton, D Stephen Charnock-Jones
Oct 07, 2015
animal model clear cell ovarian cancer endometrioid ovarian cancer endometriosis menstruation Adenocarcinoma Clear Cell Animals Carcinoma Ovarian Epithelial Cell Transformation Neoplastic Disease Models Animal Disease Progression Endometrial Neoplasms Endometriosis Female Humans Menstruation Neoplasms Glandular and Epithelial Ovarian Neoplasms Primates Rabbits Rodentia Transplantation Heterologous
Bcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer.
MH Lawson, NM Cummings, DM Rassl, SL Vowler, M Wickens, WJ Howat, JD Brenton, G Murphy, RC Rintoul
Sep 05, 2018
INTRODUCTION: Survival in small cell lung cancer (SCLC) is limited by the development of chemoresistance. Factors associated with chemoresistance in vitro have been difficult to validate in vivo. Both Bcl-2 and β(1)-integrin...
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors.
Ionut-Gabriel Funingana, Jacob S Bedia, Ying-Wen Huang, Antonio Delgado Gonzalez, Kenyi Donoso, Veronica D Gonzalez, James D Brenton, Alan Ashworth, Wendy J Fantl
Feb 28, 2023
Optimized p53 immunohistochemistry is an accurate predictor of TP53 mutation in ovarian carcinoma.
Martin Köbel, Anna M Piskorz, Sandra Lee, Shuhong Lui, Cecile LePage, Francesco Marass, Nitzan Rosenfeld, Anne-Marie Mes Masson, James D Brenton
Jul 01, 2016
Global mitigation efforts cannot neglect emerging emitters.
Can Cui, Dabo Guan, Daoping Wang, Jing Meng, Vicky Chemutai, Paul Brenton, Shaohui Zhang, Yuli Shan, Qiang Zhang, Steven J Davis
Jan 22, 2023
International efforts to avoid dangerous climate change have historically focused on reducing energy-related CO2 emissions from countries with either the largest economies (e.g. the EU and the USA) and/or the largest populations...
Feasibility of Quantitative Magnetic Resonance Fingerprinting in Ovarian Tumors for T1 and T2 Mapping in a PET/MR Setting.
Joshua D Kaggie, Surrin Deen, Dimitri A Kessler, Mary A McLean, Guido Buonincontri, Rolf F Schulte, Helen Addley, Evis Sala, James Brenton, Martin J Graves, Ferdia A Gallagher
Mar 25, 2020
Multiparametric magnetic resonance imaging (MRI) can be used to characterize many cancer subtypes including ovarian cancer. Quantitative mapping of MRI relaxation values, such as T 1 and T 2 mapping, is promising for improving...
A consensus prognostic gene expression classifier for ER positive breast cancer.
Andrew E Teschendorff, Ali Naderi, Nuno L Barbosa-Morais, Sarah E Pinder, Ian O Ellis, Sam Aparicio, James D Brenton, Carlos Caldas
Jan 03, 2018
BACKGROUND: A consensus prognostic gene expression classifier is still elusive in heterogeneous diseases such as breast cancer. RESULTS: Here we perform a combined analysis of three major breast cancer microarray data sets to...
Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer
Fiona R James, Mercedes Jiminez-Linan, Jennifer Alsop, Marie Mack, Honglin Song, James D Brenton, Paul D P Pharoah, H. R Ali
Sep 21, 2017
Abstract
Background
There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of...
Refined characterization of circulating tumor DNA through biological feature integration
Abstract Circulating tumor DNA (ctDNA) in blood plasma is present at very low concentrations compared to cell-free DNA (cfDNA) of non-tumor origin. To enhance ctDNA detection, recent studies have...
Havell Markus, Dineika Chandrananda, Elizabeth Moore, Florent Mouliere, James Morris, James D Brenton, Christopher G Smith, Nitzan Rosenfeld
Feb 04, 2022
Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer.
Fiona R James, Mercedes Jiminez-Linan, Jennifer Alsop, Marie Mack, Honglin Song, James D Brenton, Paul DP Pharoah, H Raza Ali
Nov 29, 2018
BACKGROUND: There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for...
A Bayesian adaptive design for biomarker trials with linked treatments.
James MS Wason, Jean E Abraham, Richard D Baird, Ioannis Gournaris, Anne-Laure Vallier, James D Brenton, Helena M Earl, Adrian P Mander
Oct 15, 2015
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
Mareike M Wiedmann, Yaw Sing Tan, Yuteng Wu, Shintaro Aibara, Wenshu Xu, Hannah F Sore, Chandra S Verma, Laura Itzhaki, Murray Stewart, James D Brenton, David R Spring
Nov 10, 2017
There is a lack of current treatment options for ovarian clear cell carcinoma (CCC) and the cancer is often resistant to platinum-based chemotherapy. Hence there is an urgent need for novel therapeutics. The transcription factor...
Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes.
Ina Schulte, Elizabeth M Batty, Jessica CM Pole, Katherine A Blood, Steven Mo, Susanna L Cooke, Charlotte Ng, Kevin L Howe, Suet-Feung Chin, James D Brenton, Carlos Caldas, Karen D Howarth, Paul AW Edwards
Jan 18, 2013
A metadata-aware application for remote scoring and exchange of tissue microarray images.
Lorna Morris, Andrew Tsui, Charles Crichton, Steve Harris, Peter H Maccallum, William J Howat, Jim Davies, James D Brenton, Carlos Caldas
May 20, 2013
Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
Charlotte L Sutherell, Cynthia Tallant, Octovia P Monteiro, Clarence Yapp, Julian E Fuchs, Oleg Fedorov, Paulina Siejka, Suzanne Müller, Stefan Knapp, James D Brenton, Paul E Brennan, Steven V Ley
May 17, 2016
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