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Results: 3186
Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers
Daniel James Cooper, Sara Lear, Nyarie Sithole, Ashley Shaw, Hannah Stark, Mark Ferris, CITIID-NIHR BioResource COVID-19 collaboration consortium, John Bradley, Patrick Maxwell, Ian Goodfellow, Michael P Weekes, Shaun Seaman, Stephen Baker
Dec 09, 2022
OBJECTIVE: Healthcare workers (HCWs) are at higher risk of SARS-CoV-2 infection than the general population. This group is pivotal to healthcare system resilience during the COVID-19, and future, pandemics. We investigated...
Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers
Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID.
Benjamin A Krishna, Eleanor Y Lim, Lenette Mactavous, NIHR BioResource Team, Paul A Lyons, Rainer Doffinger, John R Bradley, Kenneth GC Smith, John Sinclair, Nicholas J Matheson, Paul J Lehner, Mark R Wills, Nyaradzai Sithole
Aug 01, 2022
BACKGROUND: There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. The diagnostic complexity of Long COVID is compounded in many patients who were or might have been infected...
Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.
Lisa Hurler, Erik JM Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo JMGE Brandwijk, Wieke de Bruin, Paul A Lyons, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka
Dec 24, 2022
The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and...
C1-INH complexes assay development and validation classical pathway activation early complement activation lectin pathway activation Adult Humans Complement C1 Inhibitor Protein Complement System Proteins covid-19 Lectins Mannose-Binding Protein-Associated Serine Proteases Enzyme-Linked Immunosorbent Assay
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
Edward J Needham, Alexander L Ren, Richard J Digby, Emma J Norton, Soraya Ebrahimi, Joanne G Outtrim, Doris A Chatfield, Anne E Manktelow, Maya M Leibowitz, Virginia FJ Newcombe, Rainer Doffinger, Gabriela Barcenas-Morales, Claudia Fonseca, Michael J Taussig, Rowan M Burnstein, Romit J Samanta, Cordelia Dunai, Nyarie Sithole, Nicholas J Ashton, Henrik Zetterberg, Magnus Gisslén, Arden Edén, Emelie Marklund, Peter JM Openshaw, Jake Dunning, Michael J Griffiths, Jonathan Cavanagh, Gerome Breen, Sarosh R Irani, Anne Elmer, Nathalie Kingston, Charlotte Summers, John R Bradley, Leonie S Taams, Benedict D Michael, Edward T Bullmore, Kenneth GC Smith, Paul A Lyons, Alasdair J Coles, David K Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility
Oct 06, 2022
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19...
A thermostable, closed SARS-CoV-2 spike protein trimer.
Xiaoli Xiong, Kun Qu, Katarzyna A Ciazynska, Myra Hosmillo, Andrew P Carter, Soraya Ebrahimi, Zunlong Ke, Sjors HW Scheres, Laura Bergamaschi, Guinevere L Grice, Ying Zhang, CITIID-NIHR COVID-19 BioResource Collaboration, James A Nathan, Stephen Baker, Leo C James, Helen E Baxendale, Ian Goodfellow, Rainer Doffinger, John AG Briggs
Oct 21, 2020
The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. It exhibits substantial conformational flexibility. It transitions from closed to open conformations...
Betacoronavirus COVID-19 Testing Clinical Laboratory Techniques Coronavirus Infections Cryoelectron Microscopy Disulfides Enzyme-Linked Immunosorbent Assay Flow Cytometry Humans Immunoglobulin G Models Molecular Mutation Protein Conformation Protein Engineering Protein Multimerization Protein Stability SARS-CoV-2 Spike Glycoprotein Coronavirus Temperature
Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients
Dami A Collier, Sonny M Assennato, Ben Warne, Nyarie Sithole, Katherine Sharrocks, Allyson Ritchie, Pooja Ravji, Matthew Routledge, Dominic Sparkes, Jordan Skittrall, Anna Smielewska, Isobel Ramsey, Neha Goel, Martin Curran, David Enoch, Rhys Tassell, Michelle Lineham, Devan Vaghela, Clare Leong, Hoi Ping Mok, John Bradley, Kenneth GC Smith, Vivienne Mendoza, Nikos Demiris, Martin Besser, Gordon Dougan, Paul J Lehner, Mark J Siedner, Hongyi Zhang, Claire S Waddington, Helen Lee, Ravindra K Gupta, CITIID-NIHR COVID BioResource Collaboration
Aug 10, 2020
There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined...
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.
Lucy Rivett, Sushmita Sridhar, Dominic Sparkes, Matthew Routledge, Nick K Jones, Sally Forrest, Jamie Young, Joana Pereira-Dias, William L Hamilton, Mark Ferris, M Estee Torok, Luke Meredith, CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, Richard J Samworth, John R Bradley, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Nicholas J Matheson, Giles Wright, Ian G Goodfellow, Stephen Baker, Michael P Weekes
May 11, 2020
covid-19 SARS-CoV-2 emerging pathogens EPIDEMIOLOGY Global Health human human biology infectious disease Medicine Occupational health Virology Virus Asymptomatic Infections Betacoronavirus covid-19 COVID-19 Testing COVID-19 Vaccines Clinical Laboratory Techniques Coronavirus Infections Female Health Personnel Humans infection control Male Pandemics Pneumonia Viral Real-Time Polymerase Chain Reaction SARS-CoV-2 United Kingdom
Ensuring that COVID-19 research is inclusive
Miles D Witham, Eleanor Anderson, Camille B Carroll, Paul M Dark, Kim Down, Alistair S Hall, Joanna Knee, Eamonn R Maher, Rebecca H Maier, Gail A Mountain, Gary Nestor, John T O'Brien, Laurie Oliva, James Wason, Lynn Rochester, NIHR CRN INCLUDE Steering Group
Oct 23, 2020
OBJECTIVE: To provide guidance to researchers, funders, regulators and study delivery teams to ensure that research on COVID-19 is inclusive, particularly of groups disproportionately affected by COVID-19 and who may have been...
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.
Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C James, Katarzyna A Ciazynska, Xiaoli Xiong, John AG Briggs, James A Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A Lyons, John Bradley, Steven Baker, Jean Pierre Allain, Kenneth GC Smith, Rachel Bousfield, Michael Wilson, Dominic Sparkes, Glenn Amoroso, Effrosyni Gkrania-Klotsas, Susie Hardwick, Adrian Boyle, Ian Goodfellow, Ravindra K Gupta, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration
Sep 29, 2020
Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%-50% of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (NAAT). Furthermore, the D614G spike mutant...
covid-19 D614G SARS-CoV-2 point of care testing rapid diagnoses Aged Aged 80 and over Antibodies Viral covid-19 COVID-19 Testing Female Humans Immunoassay Male Middle Aged Neutralization Tests Nucleic Acid Amplification Techniques Point-of-care testing SARS-CoV-2 Sensitivity and Specificity Spike Glycoprotein Coronavirus
Mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative
Jan 05, 2022
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of...
Autoimmunity Body Mass Index covid-19 Critical Illness Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Geographic Mapping Hospitalization Host-Pathogen Interactions Humans Inflammation Information Dissemination Male Multifactorial Inheritance Racial Groups SARS-CoV-2 Smoking
The impact of hypoxia on B cells in COVID-19.
Prasanti Kotagiri, Federica Mescia, Aimee L Hanson, Lorinda Turner, Laura Bergamaschi, Ana Peñalver, Nathan Richoz, Stephen D Moore, Brian M Ortmann, Benjamin J Dunmore, Michael D Morgan, Zewen Kelvin Tuong, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Berthold Göttgens, Mark Toshner, Christoph Hess, Patrick H Maxwell, Menna R Clatworthy, James A Nathan, John R Bradley, Paul A Lyons, Natalie Burrows, Kenneth GC Smith
Mar 28, 2022
Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19.
Nick K Jones, Lucy Rivett, Dominic Sparkes, Sally Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane Gray, Michael Gill, CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R Bradley, Gregory J Hannon, Ian G Goodfellow, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Giles Wright, Nicholas J Matheson, Stephen Baker, Michael P Weekes
Jun 24, 2020
Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus...
covid-19 SARS-CoV-2 emerging pathogens EPIDEMIOLOGY Global Health human human biology infectious disease Medicine Occupational health Virology Adult Asymptomatic Diseases Betacoronavirus covid-19 COVID-19 Testing Clinical Laboratory Techniques Community-Acquired Infections Contact Tracing Coronavirus Infections Disease Transmission Infectious England Family Characteristics Female Health Personnel Hospital Units Hospitals Teaching Hospitals University Humans infection control Infectious Disease Transmission Patient-to-Professional Male Mass Screening Middle Aged nasopharynx Occupational Diseases Pandemics Patient Admission Pneumonia Viral prevalence Program Evaluation Real-Time Polymerase Chain Reaction SARS-CoV-2 Symptom Assessment
A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital.
Daniel J Cooper, Sara Lear, Laura Watson, Ashley Shaw, Mark Ferris, Rainer Doffinger, Rachel Bousfield, Katherine Sharrocks, Michael P Weekes, Ben Warne, Dominic Sparkes, Nick K Jones, Lucy Rivett, Matthew Routledge, Afzal Chaudhry, Katherine Dempsey, Montgomery Matson, Adil Lakha, George Gathercole, Olivia O'Connor, Emily Wilson, Orthi Shahzad, Kieran Toms, Rachel Thompson, Ian Halsall, David Halsall, Sally Houghton, Sofia Papadia, Nathalie Kingston, Kathleen E Stirrups, Barbara Graves, Paul Townsend, Neil Walker, Hannah Stark, CITIID-NIHR BioResource COVID-19 Collaboration, Daniela De Angelis, Shaun Seaman, Gordon Dougan, John R Bradley, M Estée Török, Ian Goodfellow, Stephen Baker
Oct 05, 2022
OBJECTIVES: To describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs). METHODS: We conducted a prospective sero-epidemiological study of HCWs at a major UK teaching hospital using a SARS-CoV-2...
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.
Dami A Collier, Isabella ATM Ferreira, Prasanti Kotagiri, Rawlings P Datir, Eleanor Y Lim, Emma Touizer, Bo Meng, Adam Abdullahi, CITIID-NIHR BioResource COVID-19 Collaboration, Anne Elmer, Nathalie Kingston, Barbara Graves, Emma Le Gresley, Daniela Caputo, Laura Bergamaschi, Kenneth GC Smith, John R Bradley, Lourdes Ceron-Gutierrez, Paulina Cortes-Acevedo, Gabriela Barcenas-Morales, Michelle A Linterman, Laura E McCoy, Chris Davis, Emma Thomson, Paul A Lyons, Eoin McKinney, Rainer Doffinger, Mark Wills, Ravindra K Gupta
Sep 10, 2021
Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age1. Here we...
Adult Aged Aged 80 and over aging Antibodies Neutralizing Antibodies Viral Autoantibodies B-Lymphocytes BNT162 Vaccine COVID-19 Vaccines Female Health Personnel Humans Immunity Immunization Secondary Immunoglobulin A Immunoglobulin Class Switching Immunoglobulin G Immunologic Memory Inflammation Interferon-gamma Interleukin-2 Male Middle Aged SARS-CoV-2 Somatic Hypermutation Immunoglobulin Spike Glycoprotein Coronavirus T-Lymphocytes Vaccination vaccines Synthetic
A patient-centric modeling framework captures recovery from SARS-CoV-2 infection.
Hélène Ruffieux, Aimee L Hanson, Samantha Lodge, Nathan G Lawler, Luke Whiley, Nicola Gray, Tui H Nolan, Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aloka De Sa, Victoria S Pelly, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) BioResource COVID-19 Collaboration, Prasanti Kotagiri, Nathalie Kingston, John R Bradley, Elaine Holmes, Julien Wist, Jeremy K Nicholson, Paul A Lyons, Kenneth GC Smith, Sylvia Richardson, Glenn R Bantug, Christoph Hess
Mar 02, 2023
The biology driving individual patient responses to severe acute respiratory syndrome coronavirus 2 infection remains ill understood. Here, we developed a patient-centric framework leveraging detailed longitudinal phenotyping...
B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination.
Prasanti Kotagiri, Federica Mescia, William M Rae, Laura Bergamaschi, Zewen K Tuong, Lorinda Turner, Kelvin Hunter, Pehuén P Gerber, Myra Hosmillo, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Christoph Hess, Menna R Clatworthy, Ian G Goodfellow, Nicholas J Matheson, Eoin F McKinney, Mark R Wills, Ravindra K Gupta, John R Bradley, Rachael JM Bashford-Rogers, Paul A Lyons, Kenneth GC Smith
Mar 13, 2022
Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.
Lisa Hurler, Erik JM Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo JMGE Brandwijk, Wieke de Bruin, Paul A Lyons, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka
Nov 21, 2022
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease
Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators, Tim Raine, Miles Parkes, UK IBD Bioresource Investigators
Jul 20, 2020
OBJECTIVE: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date...
Germline mutations in the transcription factor IKZF5 cause thrombocytopenia.
Claire Lentaigne, Daniel Greene, Suthesh Sivapalaratnam, Remi Favier, Denis Seyres, Chantal Thys, Luigi Grassi, Sarah Mangles, Keith Sibson, Matthew Stubbs, Frances Burden, Jean-Claude Bordet, Corinne Armari-Alla, Wendy Erber, Samantha Farrow, Nicholas Gleadall, Keith Gomez, Karyn Megy, Sofia Papadia, Christopher J Penkett, Matthew C Sims, Luca Stefanucci, Jonathan C Stephens, Randy J Read, Kathleen E Stirrups, Willem H Ouwehand, Michael A Laffan, NIHR BioResource, Mattia Frontini, Kathleen Freson, Ernest Turro
Jan 02, 2020
To identify novel causes of hereditary thrombocytopenia, we performed a genetic association analysis of whole-genome sequencing data from 13 037 individuals enrolled in the National Institute for Health Research (NIHR)...
Treatment of COVID-19 with remdesivir in the absence of humoral immunity
Matthew S Buckland, James B Galloway, Caoimhe Nic Fhogartaigh, Luke Meredith, Nicholas M Provine, Stuart Bloor, Ane Ogbe, Wioleta M Zelek, Anna Smielewska, Anna Yakovleva, Tiffeney Mann, Laura Bergamaschi, Lorinda Turner, Frederica Mescia, Erik JM Toonen, Carl-Philipp Hackstein, Hossain Delowar Akther, Vinicius Adriano Vieira, Lourdes Ceron-Gutierrez, Jimstan Periselneris, Sorena Kiani-Alikhan, Sofia Grigoriadou, Devan Vaghela, Sara E Lear, M Estée Török, William L Hamilton, Joanne Stockton, Josh Quick, Peter Nelson, Michael Hunter, Tanya I Coulter, Lisa Devlin, CITIID-NIHR COVID-19 BioResource Collaboration, MRC-Toxicology Unit COVID-19 Consortium, John R Bradley, Kenneth GC Smith, Willem H Ouwehand, Lise Estcourt, Heli Harvala, David J Roberts, Ian B Wilkinson, Nick Screaton, Nicholas Loman, Rainer Doffinger, Paul A Lyons, B Paul Morgan, Ian G Goodfellow, Paul Klenerman, Paul J Lehner, Nicholas J Matheson, James ED Thaventhiran
Oct 13, 2020
Harmonising electronic health records for reproducible research
Hoda Abbasizanjani, Fatemeh Torabi, Stuart Bedston, Thomas Bolton, Gareth Davies, Spiros Denaxas, Rowena Griffiths, Laura Herbert, Sam Hollings, Spencer Keene, Kamlesh Khunti, Emily Lowthian, Jane Lyons, Mehrdad A Mizani, John Nolan, Cathie Sudlow, Venexia Walker, William Whiteley, Angela Wood, Ashley Akbari, CVD-COVID-UK/COVID-IMPACT Consortium
Jan 16, 2023
BACKGROUND: The CVD-COVID-UK consortium was formed to understand the relationship between COVID-19 and cardiovascular diseases through analyses of harmonised electronic health records (EHRs) across the four UK nations. Beyond...
Harmonising electronic health records for reproducible research
Hoda Abbasizanjani, Fatemeh Torabi, Stuart Bedston, Thomas Bolton, Gareth Davies, Spiros Denaxas, Rowena Griffiths, Laura Herbert, Sam Hollings, Spencer Keene, Kamlesh Khunti, Emily Lowthian, Jane Lyons, Mehrdad A Mizani, John Nolan, Cathie Sudlow, Venexia Walker, William Whiteley, Angela Wood, Ashley Akbari, CVD-COVID-UK/COVID-IMPACT Consortium
Feb 17, 2023
BACKGROUND: The CVD-COVID-UK consortium was formed to understand the relationship between COVID-19 and cardiovascular diseases through analyses of harmonised electronic health records (EHRs) across the four UK nations. Beyond...
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