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Results: 4204
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies.
Sophia A Wild, Ian G Cannell, Ashley Nicholls, Katarzyna Kania, Dario Bressan, CRUK IMAXT Grand Challenge Team, Gregory J Hannon, Kirsty Sawicka
Dec 16, 2022
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies.
Sophia A Wild, Ian G Cannell, Ashley Nicholls, Katarzyna Kania, Dario Bressan, CRUK IMAXT Grand Challenge Team, Gregory J Hannon, Kirsty Sawicka
Jan 22, 2023
Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to...
A Grand Challenge
Alexander Ball, Manjula Patel, Christopher McMahon, Stuart Green, John Clarkson, Stephen Culley
Nov 01, 2006
‘Immortal information and through-life knowledge management: strategies and tools for the emerging product-service business paradigm’, is a Grand Challenge project involving eleven different UK universities and incorporating...
A Grand Challenge
Alexander Ball, Manjula Patel, Christopher McMahon, Stuart Green, John Clarkson, Stephen Culley
Nov 01, 2006
‘Immortal information and through-life knowledge management: strategies and tools for the emerging product-service business paradigm’, is a Grand Challenge project involving eleven different UK universities and incorporating...
New modes of managing grand challenges
Grand challenges are complex, large-scale problems requiring collaborative, multidisciplinary attention. Cross-sector collaboration can potentially play a significant role in addressing these challenges by capturing the diverse...
grand challenges Accountability Accounting adaptive governance collaborative governance cross-sector collaboration Management refugees structural governance /dk/atira/pure/subjectarea/asjc/1400/1400 name=General Business,Management and Accounting /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Creating inclusive teams through perceptions of supplementary and complementary person-team fit
Using a multi-wave, multi-level design, this study unravels the impact of subjective (dis)similarities in teams on team effectiveness. Based on optimal distinctiveness theory and the social inclusion model, we assume combined...
Creating inclusive teams through perceptions of supplementary and complementary person-team fit
Using a multi-wave, multi-level design, this study unravels the impact of subjective (dis)similarities in teams on team effectiveness. Based on optimal distinctiveness theory and the social inclusion model, we assume combined...
Pakistan’s Grand Strategy
This article is concerned with a significant grand strategic choice that Pakistan faces concerning its relations with China. The relationship between Pakistan and the United States has deteriorated since the US Special Forces...
BRI CPEC China Pakistan Quad grand strategy /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/3300/3303 name=Development /dk/atira/pure/subjectarea/asjc/3300/3320 name=Political Science and International Relations /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Grand challenges, covid‐19 and the future of organizational scholarship
J Howard‐Grenville
Oct 07, 2020
Grand challenges are “formulations of global problems that can be plausibly addressed through coordinated and collaborative effort” (George et al., 2016: 1880). By this definition, the Covid-19 pandemic certainly registers as a...
Pakistan’s Grand Strategy
This article is concerned with a significant grand strategic choice that Pakistan faces concerning its relations with China. The relationship between Pakistan and the United States has deteriorated since the US Special Forces...
BRI CPEC China Pakistan Quad grand strategy /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/3300/3303 name=Development /dk/atira/pure/subjectarea/asjc/3300/3320 name=Political Science and International Relations /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
The Grand Coalition and the party system
Charles Lees
Sep 01, 2010
This article examines the formation of the Grand Coalition in the context of the German party system and draws upon a synthetic analytical framework derived from formal coalition theory. It argues that both the SPD and CDU/CSU...
Winthrop Team Places in 2017 National Financial Planning Challenge
Winthrop University
Jan 01, 0001
The Winthrop team placed fifth out of the eight teams that made it to the national level.
Published by: Winthrop University
New modes of managing grand challenges
Grand challenges are complex, large-scale problems requiring collaborative, multidisciplinary attention. Cross-sector collaboration can potentially play a significant role in addressing these challenges by capturing the diverse...
grand challenges Accountability Accounting adaptive governance collaborative governance cross-sector collaboration Management refugees structural governance /dk/atira/pure/subjectarea/asjc/1400/1400 name=General Business,Management and Accounting /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
BRCA Challenge
Melissa S Cline, Rachel G Liao, Michael T Parsons, Benedict Paten, Faisal Alquaddoomi, Antonis Antoniou, Samantha Baxter, Larry Brody, Robert Cook-Deegan, Amy Coffin, Fergus J Couch, Brian Craft, Robert Currie, Chloe C Dlott, Lena Dolman, Johan T den Dunnen, Stephanie OM Dyke, Susan M Domchek, Douglas Easton, Zachary Fischmann, William D Foulkes, Judy Garber, David Goldgar, Mary J Goldman, Peter Goodhand, Steven Harrison, David Haussler, Kazuto Kato, Bartha Knoppers, Charles Markello, Robert Nussbaum, Kenneth Offit, Sharon E Plon, Jem Rashbass, Heidi L Rehm, Mark Robson, Wendy S Rubinstein, Dominique Stoppa-Lyonnet, Sean Tavtigian, Adrian Thorogood, Can Zhang, Marc Zimmermann, BRCA Challenge Authors, John Burn, Stephen Chanock, Gunnar Rätsch, Amanda B Spurdle
Jan 08, 2019
The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to...
The Grand Coalition and the party system
Charles Lees
Sep 01, 2010
This article examines the formation of the Grand Coalition in the context of the German party system and draws upon a synthetic analytical framework derived from formal coalition theory. It argues that both the SPD and CDU/CSU...
Bridging Brain and Cognition
Ivan L. Simpson-Kent, Eiko I. Fried, Danyal Akarca, Silvana Mareva, Edward T. Bullmore, the CALM Team the CALM Team, Rogier A. Kievit
Jun 17, 2021
Network analytic methods that are ubiquitous in other areas, such as systems neuroscience, have recently been used to test network theories in psychology, including intelligence research. The network or mutualism theory of...
Team building
Team building has been identified as an important method of improving the psychological climate in which teams operate, as well as overall team functioning. Within the context of sports, team building interventions have...
Understanding and tackling societal grand challenges through management research
“Grand challenges” are formulations of global problems that can be plausibly addressed through coordinated and collaborative effort. In this Special Research Forum, we showcase management research that examines societal problems...
A Bayesian spatio-temporal model for precipitation extremes - STOR team contribution to the EVA2017 challenge
This paper concerns our approach to the EVA2017 challenge, the aim of which was to predict extreme precipitation quantiles across several sites in the Netherlands. Our approach uses a Bayesian hierarchical structure, which...
A Bayesian spatio-temporal model for precipitation extremes - STOR team contribution to the EVA2017 challenge
This paper concerns our approach to the EVA2017 challenge, the aim of which was to predict extreme precipitation quantiles across several sites in the Netherlands. Our approach uses a Bayesian hierarchical structure, which...
Evaluating stress as a challenge is associated with superior attentional control and motor skill performance
The biopsychosocial model of challenge and threat (Blascovich, 2008) suggests that individuals who evaluate a performance situation as a challenge will perform better than those who evaluate it as a threat. However, limited...
Team building
Team building has been identified as an important method of improving the psychological climate in which teams operate, as well as overall team functioning. Within the context of sports, team building interventions have...
Ice Scour Risk and Protection on the Grand Banks
Mark Flynn
Apr 09, 2013
Hydrocarbons were first discovered offshore Newfoundland in the late 1970s and full-scale production of these discoveries began in earnest in 1997 with the Hibernia oil field. The estimated total recoverable oil reserves on the...
Ocean and Naval Architectural Engineering Coastal Engineering, 8751 CASE STUDY OCEAN and NAVAL ICE SCOUR EDC GRAND BANKS TERRA NOVA
Published by: Memorial University of Newfoundland
Evaluating stress as a challenge is associated with superior attentional control and motor skill performance
The biopsychosocial model of challenge and threat (Blascovich, 2008) suggests that individuals who evaluate a performance situation as a challenge will perform better than those who evaluate it as a threat. However, limited...
“The Team Behind The Team”
Rachel Arnold, Samuel Collington, Hannah Manley, Samuel Rees, James Soanes, Matthew Williams
Jan 01, 0001
This study explored the organizational stressors encountered by the “team behind the team” (viz., those operating in sport science and management roles) in elite sport and the consequences these can have. Forty support...
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