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Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom.
M Estée Török, Benjamin R Underwood, Mark Toshner, Claire Waddington, Emad Sidhom, Katherine Sharrocks, Rachel Bousfield, Charlotte Summers, Caroline Saunders, Zoe McIntyre, Helen Morris, Jo Piper, Gloria Calderon, Sarah Dennis, Tracy Assari, Anita Marguerie de Rotrou, Ashley Shaw, John Bradley, John O'Brien, Robert C Rintoul, Ian Smith, Ed Bullmore, Krishna Chatterjee, Cambridge COVID Vaccine Trial Team
Aug 19, 2021
The COVID-19 pandemic has resulted in unprecedented challenges for healthcare systems worldwide. It has also stimulated research in a wide range of areas including rapid diagnostics, novel therapeutics, use of technology to...
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7)
Katherine RW Emary, Tanya Golubchik, Parvinder K Aley, Cristina V Ariani, Brian Angus, Sagida Bibi, Beth Blane, David Bonsall, Paola Cicconi, Sue Charlton, Elizabeth A Clutterbuck, Andrea M Collins, Tony Cox, Thomas C Darton, Christina Dold, Alexander D Douglas, Christopher JA Duncan, Katie J Ewer, Amy L Flaxman, Saul N Faust, Daniela M Ferreira, Shuo Feng, Adam Finn, Pedro M Folegatti, Michelle Fuskova, Eva Galiza, Anna L Goodman, Catherine M Green, Christopher A Green, Melanie Greenland, Bassam Hallis, Paul T Heath, Jodie Hay, Helen C Hill, Daniel Jenkin, Simon Kerridge, Rajeka Lazarus, Vincenzo Libri, Patrick J Lillie, Catherine Ludden, Natalie G Marchevsky, Angela M Minassian, Alastair C McGregor, Yama F Mujadidi, Daniel J Phillips, Emma Plested, Katrina M Pollock, Hannah Robinson, Andrew Smith, Rinn Song, Matthew D Snape, Rebecca K Sutherland, Emma C Thomson, Mark Toshner, David PJ Turner, Johan Vekemans, Tonya L Villafana, Christopher J Williams, Adrian VS Hill, Teresa Lambe, Sarah C Gilbert, Merryn Voysey, Maheshi N Ramasamy, Andrew J Pollard, COVID-19 Genomics UK Consortium, AMPHEUS Project, Oxford COVID-19 Vaccine Trial Group
May 06, 2021
BACKGROUND: A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19...
Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom
M Estée Török, Benjamin R Underwood, Mark Toshner, Claire Waddington, Emad Sidhom, Katherine Sharrocks, Rachel Bousfield, Charlotte Summers, Caroline Saunders, Zoe McIntyre, Helen Morris, Jo Piper, Gloria Calderon, Sarah Dennis, Tracy Assari, Anita Marguerie de Rotrou, Ashley Shaw, John Bradley, John O’Brien, Robert C Rintoul, Ian Smith, Ed Bullmore, Krishna Chatterjee, Carla Ribeiro, Lorinda Pickup, Ranalie de Jesus, Karen Brookes, Phoebe Vargas, Caroline McMahon, Chiara Macor, Ciro Pasquale, Areti Bermperi, Evgenia Kourampa, Marivic Fabiculcana, Julie Ann Zerudo, Vivien Mendoza, Stewart Fuller, Claire Glemas, Sharon Baker, Greta Lyons, Marina Bishop, Siobhan Coleman, Naomi Thomas, Vince Mlilo, Edward Stanton, Rachel Michel, Julie Philips, Heidi Rice, Lucie Garner, Francesca Rosa, Saji Victor, Julie Zamikula, Sue Mepham, Fatima Hajee, Juan Carlos Quijano-Campos, Laura Watson, Christopher Georgiou, Jieniean Worsley, Djamilla Shamtally-Amode, Ferishta Rahimi, Heather Jones, Isabel Cruz, Gayle Lindsay, Christian Sparke, Anna Chapman, Katie Keating-Fedders, Codie Fahey, Danielle Johnson, Lucy Worboys, Simone Hargreaves, Ashlea Bucke, Lindsay Carr, Jackie Hampshire, Tracy Richardson, Jenny Sharpe, Lynne Whitehead, Naval Vyse, Stephen Kelleher, Mary-Beth Sherwood, Vicki Hughes, Kim Giraud
Oct 01, 2021
The COVID-19 pandemic has resulted in unprecedented challenges for healthcare systems worldwide. It has also stimulated research in a wide range of areas including rapid diagnostics, novel therapeutics, use of technology to...
Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection.
Nick K Jones, Lucy Rivett, Shaun Seaman, Richard J Samworth, Ben Warne, Chris Workman, Mark Ferris, Jo Wright, Natalie Quinnell, Ashley Shaw, Cambridge COVID-19 Collaboration, Ian G Goodfellow, Paul J Lehner, Rob Howes, Giles Wright, Nicholas J Matheson, Michael P Weekes
Apr 09, 2021
The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection against symptomatic disease has encouraged some countries to opt for...
Impact of COVID-19 pandemic on surgical neuro-oncology multi-disciplinary team decision making
Stephen John Price, Alexis Joannides, Puneet Plaha, Fardad Taghizadeh Afshari, Erminia Albanese, Neil U Barua, Huan Wee Chan, Giles Critchley, Thomas Flannery, Daniel M Fountain, Ryan K Mathew, Rory J Piper, Michael TC Poon, Chittoor Rajaraman, Ola Rominiyi, Stuart Smith, Georgios Solomou, Anna Solth, Surash Surash, Victoria Wykes, Colin Watts, Helen Bulbeck, Peter Hutchinson, Michael D Jenkinson, COVID-CNSMDT study group
Aug 17, 2020
OBJECTIVES: Pressures on healthcare systems due to COVID-19 has impacted patients without COVID-19 with surgery disproportionally affected. This study aims to understand the impact on the initial management of patients with...
Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy
Daphne Day, Lisa Grech, Mike Nguyen, Nathan Bain, Alastair Kwok, Sam Harris, Hieu Chau, Bryan Chan, Richard Blennerhassett, Louise Nott, Nada Hamad, Annette Tognela, David Hoffman, Amelia McCartney, Kate Webber, Jennifer Wong, Craig Underhill, Brett Sillars, Antony Winkel, Mark Savage, Bao Sheng Loe, Daniel Freeman, Eva Segelov, On Behalf Of The Canvaccs Diabvaccs And Msvaccs Investigators
Jul 24, 2022
As COVID-19 vaccinations became available and were proven effective in preventing serious infection, uptake amongst individuals varied, including in medically vulnerable populations. This cross-sectional multi-site study...
Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy
Daphne Day, Lisa Grech, Mike Nguyen, Nathan Bain, Alastair Kwok, Sam Harris, Hieu Chau, Bryan Chan, Richard Blennerhassett, Louise Nott, Nada Hamad, Annette Tognela, David Hoffman, Amelia McCartney, Kate Webber, Jennifer Wong, Craig Underhill, Brett Sillars, Antony Winkel, Mark Savage, Bao Sheng Loe, Daniel Freeman, Eva Segelov, On Behalf Of The Canvaccs Diabvaccs And Msvaccs Investigators
May 30, 2022
As COVID-19 vaccinations became available and were proven effective in preventing serious infection, uptake amongst individuals varied, including in medically vulnerable populations. This cross-sectional multi-site study...
Vaccine Confidence and Hesitancy at the Start of COVID-19 Vaccine Deployment in the UK
Chrissy H Roberts, Hannah Brindle, Nina T Rogers, Rosalind M Eggo, Luisa Enria, Shelley Lees
Dec 15, 2021
Background: Approval for the use of COVID-19 vaccines has been granted in a number of countries but there are concerns that vaccine uptake may be low amongst certain groups. Methods: This study used a mixed methods approach...
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2
Merryn Voysey, Sue Ann Costa Clemens, Shabir A Madhi, Lily Y Weckx, Pedro M Folegatti, Parvinder K Aley, Brian Angus, Vicky L Baillie, Shaun L Barnabas, Qasim E Bhorat, Sagida Bibi, Carmen Briner, Paola Cicconi, Andrea M Collins, Rachel Colin-Jones, Clare L Cutland, Thomas C Darton, Keertan Dheda, Christopher JA Duncan, Katherine RW Emary, Katie J Ewer, Lee Fairlie, Saul N Faust, Shuo Feng, Daniela M Ferreira, Adam Finn, Anna L Goodman, Catherine M Green, Christopher A Green, Paul T Heath, Catherine Hill, Helen Hill, Ian Hirsch, Susanne HC Hodgson, Alane Izu, Susan Jackson, Daniel Jenkin, Carina CD Joe, Simon Kerridge, Anthonet Koen, Gaurav Kwatra, Rajeka Lazarus, Alison M Lawrie, Alice Lelliott, Vincenzo Libri, Patrick J Lillie, Raburn Mallory, Ana VA Mendes, Eveline P Milan, Angela M Minassian, Alastair McGregor, Hazel Morrison, Yama F Mujadidi, Anusha Nana, Peter J O'Reilly, Sherman D Padayachee, Ana Pittella, Emma Plested, Katrina M Pollock, Maheshi N Ramasamy, Sarah Rhead, Alexandre V Schwarzbold, Nisha Singh, Andrew Smith, Rinn Song, Matthew D Snape, Eduardo Sprinz, Rebecca K Sutherland, Richard Tarrant, Emma C Thomson, M Estée Török, Mark Toshner, David PJ Turner, Johan Vekemans, Tonya L Villafana, Marion EE Watson, Christopher J Williams, Alexander D Douglas, Adrian VS Hill, Teresa Lambe, Sarah C Gilbert, Andrew J Pollard, Oxford COVID Vaccine Trial Group
Dec 23, 2020
BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety...
'Be on the TEAM' Study (Teenagers Against Meningitis)
Jeremy Carr, Emma Plested, Parvinder Aley, Susana Camara, Kimberly Davis, Jenny M MacLennan, Steve Gray, Saul N Faust, Ray Borrow, Hannah Christensen, Caroline Trotter, Martin CJ Maiden, Adam Finn, Matthew D Snape, ‘Be on the TEAM’ investigators
Oct 27, 2020
INTRODUCTION: Capsular group B Neisseria meningitidis (MenB) is the most common cause of invasive meningococcal disease (IMD) in many parts of the world. A MenB vaccine directed against the polysaccharide capsule remains elusive...
Paediatric infectious disease and immunisation paediatric intensive and critical care Infectious Diseases Paediatrics Adolescent Adult Humans Meningitis Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Neisseria meningitidis Serogroup B Randomized Controlled Trials as Topic State Medicine Vaccination Young Adult
Injection fears and COVID-19 vaccine hesitancy.
Daniel Freeman, Sinéad Lambe, Ly-Mee Yu, Jason Freeman, Andrew Chadwick, Cristian Vaccari, Felicity Waite, Laina Rosebrock, Ariane Petit, Samantha Vanderslott, Stephan Lewandowsky, Michael Larkin, Stefania Innocenti, Helen McShane, Andrew J Pollard, Bao Sheng Loe
Jul 28, 2021
BACKGROUND: When vaccination depends on injection, it is plausible that the blood-injection-injury cluster of fears may contribute to hesitancy. Our primary aim was to estimate in the UK adult population the proportion of...
COVID-19 Vaccine Hesitancy in Australian Patients with Solid Organ Cancers.
Nathan Bain, Mike Nguyen, Lisa Grech, Daphne Day, Amelia McCartney, Kate Webber, Alastair Kwok, Sam Harris, Hieu Chau, Bryan Chan, Louise Nott, Nada Hamad, Annette Tognela, Craig Underhill, Bao Sheng Loe, Daniel Freeman, Eva Segelov, On Behalf Of The Canvaccs Investigators
Oct 24, 2022
BACKGROUND: Vaccination is the cornerstone of the global public health response to the COVID-19 pandemic. Excess morbidity and mortality of COVID-19 infection is seen in people with cancer. COVID-19 vaccine hesitancy has been...
COVID-19 and ANCA-associated vasculitis
Annette Bruchfeld, Andreas Kronbichler, Federico Alberici, Fernando C Fervenza, David RW Jayne, Mårten Segelmark, Vladimir Tesar, Wladimir M Szpirt
Nov 17, 2021
COVID-19 and ANCA-associated vasculitis - recommendations for vaccine preparedness and the use of rituximab.
Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments.
Caroline Cake, Emma Ogburn, Heather Pinches, Garry Coleman, David Seymour, Fran Woodard, Sinduja Manohar, Marjia Monsur, Martin Landray, Gaynor Dalton, Andrew D Morris, Patrick F Chinnery, UK COVID-19 National Core Studies Consortium, FD Richard Hobbs, Christopher Butler
Feb 21, 2022
BACKGROUND: The COVID-19 pandemic has presented unique challenges for rapidly designing, initiating, and delivering therapeutic clinical trials. PRINCIPLE (Platform Randomised Trial of Treatments in the Community for Epidemic...
Quantifying Efficiency Gains of Innovative Designs of Two-Arm Vaccine Trials for COVID-19 Using an Epidemic Simulation Model.
Clinical trials of a vaccine during an epidemic face particular challenges, such as the pressure to identify an effective vaccine quickly to control the epidemic, and the effect that time-space-varying infection incidence has on...
Impact of COVID-19-related disruptions to measles, meningococcal A, and yellow fever vaccination in 10 countries.
Katy AM Gaythorpe, Kaja Abbas, John Huber, Andromachi Karachaliou, Niket Thakkar, Kim Woodruff, Xiang Li, Susy Echeverria-Londono, VIMC Working Group on COVID-19 Impact on Vaccine Preventable Disease, Matthew Ferrari, Michael L Jackson, Kevin McCarthy, T Alex Perkins, Caroline Trotter, Mark Jit
Sep 13, 2021
BACKGROUND: Childhood immunisation services have been disrupted by the COVID-19 pandemic. WHO recommends considering outbreak risk using epidemiological criteria when deciding whether to conduct preventive vaccination campaigns...
covid-19 EPIDEMIOLOGY Global Health human Mathematical modelling Measles Medicine Meningococcal disease Vaccination Yellow Fever Adolescent Adult Africa Bangladesh covid-19 Child Child Preschool Disease Outbreaks Humans Immunization Programs Infant Measles Measles Vaccine Meningococcal Infections Meningococcal Vaccines Pandemics Risk Assessment SARS-CoV-2 Vaccination Yellow Fever Yellow Fever Vaccine Young Adult
Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments.
Caroline Cake, Emma Ogburn, Heather Pinches, Garry Coleman, David Seymour, Fran Woodard, Sinduja Manohar, Marjia Monsur, Martin Landray, Gaynor Dalton, Andrew D Morris, Patrick F Chinnery, UK COVID-19 National Core Studies Consortium, FD Richard Hobbs, Christopher Butler
Jan 28, 2022
BACKGROUND: The COVID-19 pandemic has presented unique challenges for rapidly designing, initiating, and delivering therapeutic clinical trials. PRINCIPLE (Platform Randomised Trial of Treatments in the Community for Epidemic...
COVID-19 Vaccine Hesitancy in Australian Patients with Solid Organ Cancers.
Nathan Bain, Mike Nguyen, Lisa Grech, Daphne Day, Amelia McCartney, Kate Webber, Alastair Kwok, Sam Harris, Hieu Chau, Bryan Chan, Louise Nott, Nada Hamad, Annette Tognela, Craig Underhill, Bao Sheng Loe, Daniel Freeman, Eva Segelov, On Behalf Of The Canvaccs Investigators
Aug 24, 2022
BACKGROUND: Vaccination is the cornerstone of the global public health response to the COVID-19 pandemic. Excess morbidity and mortality of COVID-19 infection is seen in people with cancer. COVID-19 vaccine hesitancy has been...
An Analysis of the Willingness to the COVID-19 Vaccine Booster Shots among Urban Employees
Many studies have shown that urban workers may have a higher acceptance rate of coronavirus disease (COVID-19) vaccine uptake compared to their rural counterparts. As Omicron spreads globally, the COVID-19 booster vaccination...
Analyzing Sentiments and Diffusion Characteristics of COVID-19 Vaccine Misinformation Topics in Social Media
Mohammad Daradkeh
Jul 01, 2022
This study presents a data analytics framework that aims to analyze topics and sentiments associated with COVID-19 vaccine misinformation in social media. A total of 40,359 tweets related to COVID-19 vaccination were collected...
Published by: IGI Global Scientific Publishing
COVID-19 Vaccine Ranking Using ANP Method
Wuhan Province in China reported the first case of novel corona virus as pneumonia outbreak during December 2019. The novel coronavirus was soon declared a pandemic by the World Health Organization. On 16th of July 2021, the...
Published by: IGI Global Scientific Publishing
An Analysis of the Willingness to the COVID-19 Vaccine Booster Shots among Urban Employees
Many studies have shown that urban workers may have a higher acceptance rate of coronavirus disease (COVID-19) vaccine uptake compared to their rural counterparts. As Omicron spreads globally, the COVID-19 booster vaccination...
Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection
Nick K Jones, Lucy Rivett, Shaun Seaman, Richard J Samworth, Ben Warne, Chris Workman, Mark Ferris, Jo Wright, Natalie Quinnell, Ashley Shaw, Cambridge COVID-19 Collaboration, Ian G Goodfellow, Paul J Lehner, Rob Howes, Giles Wright, Nicholas J Matheson, Michael P Weekes, Amy Amory, Stephen Baker, Emma Bateman, Aklima Begum, Moushima Begum, John Bradley, Michael Brennan, Helen Burn, Caroline Crofts, Afzal Chaudhry, Yasmin Chaudhry, Daniel J Cooper, Sharon Dawson, Gordon Dougan, Renny Feather, Louise Free, Katie Friel, Claire Gildea, Iliana Georgana, Lizz Grimwade, Ravi Gupta, Susan Hall, Sophie Hannan, James Hayes, Aleksandra Hosaja, Myra Hosmillo, Rhys Izuagbe, Aminu Jahun, Lidia James, Jill Jardin, Nathalie Kingston, Sara Lear, Paul A Lyons, Patrick H Maxwell, Sue Mott, Sarah Mugavin, Joyce Mwiya, Sharon Peacock, Ravi Prakash Nallattil, Kazeem Oloyede, Willem H Ouwehand, Elle Page, Marina Perez, Tim Raine, Matthew Routledge, Caroline Saunders, Kenneth GC Smith, Dominic Sparkes, Maria Stafford, Charlotte Summers, Despiona Tatsi, James ED Thaventhiran, Sharon Thomas Johnson, M Estée Török, Mark Toshner, Lesley Turner, Kate Wall, Karis Watson
Apr 23, 2021
The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection against symptomatic disease has encouraged some countries to opt for...
COVID-19 impact on routine immunisations for vaccine-preventable diseases
Jaspreet Toor, Xiang Li, Mark Jit, Caroline L Trotter, Susy Echeverria-Londono, Anna-Maria Hartner, Jeremy Roth, Allison Portnoy, Kaja Abbas, Neil M Ferguson, Katy Am Gaythorpe
Jul 08, 2022
Over the past two decades, vaccination programmes for vaccine-preventable diseases (VPDs) have expanded across low- and middle-income countries (LMICs). However, the rise of COVID-19 resulted in global disruption to routine...
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Mar 13, 2023
Background
While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service...
Vaccination Reminder Systems SMS mHealth Text Messaging Childhood immunisation Humans Bayes Theorem Child Australia Randomized Controlled Trials as Topic Vaccination Coverage Cell Phone
Published by: Trials
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