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The relationship between back pain and mortality in older adults varies with disability and gender
RE Docking, J Fleming, C Brayne, J Zhao, GJ Macfarlane, GT Jones, Cambridge City over-75s Cohort (CC75C) study collaboration
Jan 29, 2020
BACKGROUND: This study aims to determine whether older adults reporting back pain (BP) are at increased risk of premature mortality, specifically, to examine the association with disabling/non-disabling pain separately. METHODS...
Inability to get up after falling, subsequent time on floor, and summoning help
OBJECTIVES: To describe the incidence and extent of lying on the floor for a long time after being unable to get up from a fall among people aged over 90; to explore their use of call alarm systems in these circumstances....
Place of death for the 'oldest old'
Jane Fleming, Jun Zhao, Morag Farquhar, Carol Brayne, Stephen Barclay, Cambridge City over-75s Cohort (CC75C) study collaboration
Mar 01, 2019
BACKGROUND: Deaths are rising fastest among the oldest old but data on their transitions in place of care at the end of life are scarce. AIM: To examine the place of residence or care of > or =85 year-olds less than a year...
The oldest old in the last year of life
Jun Zhao, Stephen Barclay, Morag Farquhar, Ann Louise Kinmonth, Carol Brayne, Jane Fleming, Cambridge City over-75s Cohort Study collaboration
Feb 28, 2019
OBJECTIVES: To characterize people of advanced old age in their last year of life and compare those dying in their late 80s with those dying aged 90 and older to inform policy and planning. DESIGN: Retrospective analysis of...
Falls in advanced old age
Jane Fleming, Fiona E Matthews, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 16, 2011
BACKGROUND: The "oldest old" are now the fastest growing section of most western populations, yet there are scarcely any data concerning even the common problem of falls amongst the very old. Prospective data collection is...
Place of death and end-of-life transitions experienced by very old people with differing cognitive status
Anouk J Perrels, Jane Fleming, Jun Zhao, Stephen Barclay, Morag Farquhar, Hilde M Buiting, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 14, 2019
BACKGROUND: Despite fast-growing 'older old' populations, 'place of care' trajectories for very old people approaching death with or without dementia are poorly described and understood. AIM: To explore end-of-life transitions...
80 and over COGNITIVE IMPAIRMENT Aged Delivery of Health Care Dementia Frail Elderly Homes for the Aged Nursing Homes Patient Transfer residential characteristics Terminal Care Aged 80 and over Cognition Disorders Cohort Studies Female Hospital Mortality Humans Male Nursing Homes Terminal Care Terminally Ill United Kingdom
Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study.
Carol Brayne, Kathryn Richardson, Fiona E Matthews, Jane Fleming, Sally Hunter, John H Xuereb, Eugene Paykel, Elizabeta B Mukaetova-Ladinska, Felicia A Huppert, Angela O'Sullivan, Tom Dening, Cambridge City Over-75s Cohort Cc75c Study Neuropathology Collaboration
Feb 28, 2019
Key neuropathological changes associated with late-onset dementia are not fully understood. Population-based longitudinal studies offer an opportunity to step back and examine which pathological indices best link to clinical...
Neuropathological correlates of falling in the CC75C population-based sample of the older old.
Kathryn Richardson, Sally Hunter, Tom Dening, John H Xuereb, Fiona E Matthews, Carol Brayne, Jane Fleming, Cambridge City over-75s Cohort (CC75C) Study Neuropathology Collaboration
Jan 27, 2020
BACKGROUND: Previous imaging studies have suggested links between brain pathologies and factors that are associated with falls such as gait, balance and daily function. Possible neuropathological correlates of older people's...
Epidemiology of back pain in older adults
Rachael E Docking, Jane Fleming, Carol Brayne, Jun Zhao, Gary J Macfarlane, Gareth T Jones, Cambridge City over-75s Cohort Study collaboration
Jun 14, 2019
OBJECTIVES: To determine the prevalence of disabling and non-disabling back pain across age in older adults, and identify risk factors for back pain onset in this age group. METHODS: Participants aged ≥ 75 years answered...
Health-related quality of life in the Cambridge City over-75s Cohort (CC75C)
Jaime Perales, Theodore D Cosco, Blossom CM Stephan, Jane Fleming, Steven Martin, Josep Maria Haro, Carol Brayne, CC75C Study
Jan 09, 2018
BACKGROUND: The assessment of Health Related Quality of Life (HRQL) is important in people with dementia as it could influence their care and support plan. Many studies on dementia do not specifically set out to measure...
Pain reporting in older adults
Rachael E Docking, Jane Fleming, Carol Brayne, Jun Zhao, Gary J Macfarlane, Gareth T Jones, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 14, 2019
OBJECTIVES: Evidence suggests that while disabling back pain (BP), and rheumatic diseases associated with pain, continues to increase with age, the prevalence of non-disabling BP reaches a plateau, or even decreases, in the...
TDP-43 Related Neuropathologies and Phosphorylation State
Sally Hunter, Suvi RK Hokkanen, Hannah AD Keage, Jane Fleming, Thais Minett, Tuomo Polvikoski, Kieren Allinson, Carol Brayne, Cambridge City over 75s Cohort collaboration
Apr 16, 2020
Frailty and neuropathology in relation to dementia status
Lindsay Wallace, Sally Hunter, Olga Theou, Jane Fleming, Kenneth Rockwood, Carol Brayne
May 19, 2021
OBJECTIVE: To examine the relative contributions of frailty and neuropathology to dementia expression in a population-based cohort study. DESIGN: Cross-sectional analysis of observational data. SETTING: Population-representative...
Dying comfortably in very old age with or without dementia in different care settings – a representative "older old" population study
Jane Fleming, Carol Brayne, R Calloway, A Perrels, M Farquhar, Stephen Barclay, CC75C Cambridge City over-75s Cohort
Sep 12, 2017
Is loneliness associated with increased health and social care utilisation in the oldest old? Findings from a population-based longitudinal study.
Hanyuying Wang, Emily Zhao, Jane Fleming, Tom Dening, Kay-Tee Khaw, Carol Brayne, CC75C Study Collaboration
Apr 17, 2019
OBJECTIVES: The present study aimed to examine the impact of loneliness on health and social care service use in the oldest old over a 7-year follow-up. DESIGN: Prospective study. SETTING: UK population-based cohort....
Re-examining tau-immunoreactive pathology in the population
Sally Hunter, Thais Minett, Tuomo Polvikoski, Elizabeta Mukaetova-Ladinska, Carol Brayne, Cambridge City over-75s Cohort Collaboration
Aug 27, 2015
Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts.
Suvi RK Hokkanen, Mia Kero, Karri Kaivola, Sally Hunter, Hannah AD Keage, Anna Kiviharju, Anna Raunio, Pentti J Tienari, Anders Paetau, Fiona E Matthews, Jane Fleming, Caroline Graff, Tuomo M Polvikoski, Liisa Myllykangas, Carol Brayne, EClipSE Collaboration
Oct 22, 2019
Limbic-predominant age-related TAR-DNA-binding protein-43 (TDP-43) encephalopathy with hippocampal sclerosis pathology (LATE-NC + HS) is a neurodegenerative disorder characterized by severe hippocampal CA1 neuron loss and...
ABCC9 GRN LATE-NC TDP-43 TMEM106b hippocampal sclerosis population study Aged Aged 80 and over Alleles Autopsy Brain Diseases CA1 Region Hippocampal Cohort Studies Female Genetic Predisposition to Disease Humans Male Membrane Proteins Nerve Tissue Proteins Neurodegenerative Diseases Polymorphism Single Nucleotide Progranulins Pyramidal Cells Risk Factors Sclerosis
A Novel Examination of Successful Aging Trajectories at the End of Life.
Theodore D Cosco, Blossom CM Stephan, Graciela Muniz, Carol Brayne, CC75C Study Collaboration
Sep 27, 2018
A successful aging (SA) index was captured in a longitudinal population-based cohort study of individuals aged 75 and older and examined longitudinally using growth mixture modelling (GMM) to identify groups with similar...
Mortality risk of loneliness in the oldest old over a 10-year follow-up.
Hanyuying Wang, Yue Leng, Emily Zhao, Jane Fleming, Carol Brayne, CC75C Study Collaboration
Sep 11, 2018
When Frail Older People Relocate in Very Old Age, Who Makes the Decision?
Fiona Scheibl, Morag Farquhar, Jackie Buck, Stephen Barclay, Carol Brayne, Jane Fleming
May 11, 2020
Older people are likely to transition to a new home closer to family who can provide assistance or to long-term residential care as their health declines and their care needs increase. A minority choose to move to "age-friendly"...
Published by: Innovation in aging
Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection.
Mohammed D Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E Matthews, Li Su, Paul G Ince, Stephen B Wharton, Dennis Wang, Cognitive Function and Ageing Neuropathology Study Group
Mar 10, 2023
Although a variety of brain lesions may contribute to the pathological assessment of dementia, the relationship of these lesions to dementia, how they interact and how to quantify them remains uncertain. Systematically assessing...
The experience of transitions in care in very old age
Fiona Scheibl, Jane Fleming, Jackie Buck, Stephen Barclay, Carol Brayne, Morag Farquhar
Apr 05, 2019
BACKGROUND: It can be challenging for general practitioners to support their oldest old patients through the complex process of relocation. OBJECTIVE: To provide a typology of the experiences of moving in very old age that is...
Temporal trends without seasonal effects on gestational diabetes incidence relate to reductions in indices of insulin secretion
Clive J. Petry, Benjamin G. Fisher, Ken K. Ong, Ieuan A. Hughes, Carlo L. Acerini, David B. Dunger
Jun 06, 2020
Abstract: Aims: The incidence of gestational diabetes has been reported to have risen over the first decade of this century. Some studies have also found it to vary with seasons of the year. We investigated temporal and seasonal...
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