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Effects of Maternal Obesity On Placental Phenotype.
obesity development Gestational diabetes Placenta Pregnancy programming Animals Blood Glucose Diabetes Gestational Energy Metabolism Female Humans Maternal Nutritional Physiological Phenomena Maternal-Fetal Exchange Nutritional Support obesity Maternal Phenotype Placenta Placentation Pregnancy Pregnancy Outcome Risk Factors
Near to One's Heart
The development of the fetal heart is exquisitely controlled by a multitude of factors, ranging from humoral to mechanical forces. The gatekeeper regulating many of these factors is the placenta, an external fetal organ. As...
Glucocorticoid maturation of mitochondrial respiratory capacity in skeletal muscle before birth.
In adults, glucocorticoids act to match the supply and demand for energy during physiological challenges, partly through actions on tissue mitochondrial oxidative phosphorylation (OXPHOS) capacity. However, little is known about...
'People like me don't get support'
Autistic people are at high risk of mental health problems, self-injury and suicidality. However, no studies have explored autistic peoples' experiences of treatment and support for these difficulties. In partnership with a...
Maternal antioxidant treatment protects adult offspring against memory loss and hippocampal atrophy in a rodent model of developmental hypoxia
Emily J. Camm, Christine M. Cross, Andrew D. Kane, Jane L. Tarry‐Adkins, Susan E. Ozanne, Dino A. Giussani
Apr 23, 2021
Abstract: Chronic fetal hypoxia is one of the most common outcomes in complicated pregnancy in humans. Despite this, its effects on the long‐term health of the brain in offspring are largely unknown. Here, we investigated in...
Published by: The FASEB Journal
Thyroid Hormone Deficiency Suppresses Fetal Pituitary-Adrenal Function Near Term
Emily J Camm, Isabella Inzani, Miles J De Blasio, Katie L Davies, India R Lloyd, FB Peter Wooding, Dominique Blache, Abigail L Fowden, Alison J Forhead
Oct 22, 2020
ACTH adrenal gland corticotrophs Cortisol Fetus Pituitary Gland Thyroid Hormones Adrenal Cortex Hormones Adrenal Glands Adrenal Medulla Adrenocorticotropic Hormone Animals Cell Count Cell Proliferation congenital hypothyroidism Corticotrophs Fetal Development Fetal Diseases Fetal Organ Maturity Hydrocortisone Hypothalamo-Hypophyseal System Insulin-Like Growth Factor I Pituitary-Adrenal System RNA Messenger Receptor IGF Type 1 Sheep Thyroidectomy Thyroxine Triiodothyronine Zona Fasciculata
Oxidative stress in the developing brain
Emily J Camm, Deodata Tijsseling, Hans G Richter, Alexandra Adler, Jeremy A Hansell, Jan B Derks, Christine M Cross, Dino A Giussani
Sep 08, 2020
In premature infants, glucocorticoids ameliorate chronic lung disease, but have adverse effects on long-term neurological function. Glucocorticoid excess promotes free radical overproduction. We hypothesised that the adverse...
Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat.
Andrew D Kane, Emily J Camm, Hans G Richter, Ciara Lusby, Deodata Tijsseling, Joepe J Kaandorp, Jan B Derks, Susan E Ozanne, Dino A Giussani
Aug 12, 2020
Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an inhibitor of the prooxidant...
Cortisol Regulates Cerebral Mitochondrial Oxidative Phosphorylation and Morphology of the Brain in a Region-Specific Manner in the Ovine Fetus
In adults, glucocorticoids are stress hormones that act, partly, through actions on mitochondrial oxidative phosphorylation (OXPHOS) to increase energy availability. Before birth, glucocorticoids are primarily maturational...
Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia.
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Catherine E Aiken, Jane L Tarry-Adkins, Ana-Mishel Spiroski, Anna M Nuzzo, Thomas J Ashmore, Alessandro Rolfo, Megan J Sutherland, Emily J Camm, Dino A Giussani, Susan E Ozanne
Feb 21, 2019
KEY POINTS: Exposure to chronic hypoxia during gestation influences long-term health and development, including reproductive capacity, across generations. If the peri-conceptual environment in the developing oviduct is affected...
Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.
Development of cerebral mitochondrial respiratory function is impaired by thyroid hormone deficiency before birth in a region-specific manner.
Katie L Davies, Danielle J Smith, Tatiana El-Bacha, Max E Stewart, Akshay Easwaran, Peter FP Wooding, Alison J Forhead, Andrew J Murray, Abigail L Fowden, Emily J Camm
Apr 23, 2021
Thyroid hormones regulate adult metabolism partly through actions on mitochondrial oxidative phosphorylation (OXPHOS). They also affect neurological development of the brain, but their role in cerebral OXPHOS before birth...
Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice.
Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress.
Dino A Giussani, Emily J Camm, Youguo Niu, Hans G Richter, Carlos E Blanco, Rachel Gottschalk, E Zachary Blake, Katy A Horder, Avnesh S Thakor, Jeremy A Hansell, Andrew D Kane, FB Peter Wooding, Christine M Cross, Emilio A Herrera
Sep 08, 2020
Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs remain elusive, precluding the...
Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease.
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India
Jitendra PS Sawhney, Veerappa A Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S Pieper, A John Camm, Ajay K Kakkar, GARFIELD-AF Investigators
Mar 18, 2020
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics...
Impact of gender on event rates at 1 year in patients with newly diagnosed non-valvular atrial fibrillation
A John Camm, Gabriele Accetta, Wael Al Mahmeed, Giuseppe Ambrosio, Samuel Z Goldhaber, Sylvia Haas, Petr Jansky, Gloria Kayani, Frank Misselwitz, Seil Oh, Ali Oto, Pekka Raatikainen, Jan Steffel, Martin van Eickels, Ajay K Kakkar, GARFIELD-AF Investigators
Mar 18, 2020
OBJECTIVES: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) explored the impact of gender, risk factors and anticoagulant (AC) treatment on 1-year outcomes in patients with non-valvular atrial...
Dispositional Mindfulness and its Relationship to Distress and Functioning in Adolescents with Chronic Pain and Low-Level Pain
Objective: Dispositional mindfulness is the general tendency to pay attention to present-moment awareness without judgment. The main aim of this cross-sectional study was to determine: a) whether dispositional mindfulness is...
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