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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.
Heather J Cordell, Younghun Han, George F Mells, Yafang Li, Gideon M Hirschfield, Casey S Greene, Gang Xie, Brian D Juran, Dakai Zhu, David C Qian, James AB Floyd, Katherine I Morley, Daniele Prati, Ana Lleo, Daniele Cusi, Canadian-US PBC Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, M Eric Gershwin, Carl A Anderson, Konstantinos N Lazaridis, Pietro Invernizzi, Michael F Seldin, Richard N Sandford, Christopher I Amos, Katherine A Siminovitch
Dec 02, 2020
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of...
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
George F Mells, James AB Floyd, Katherine I Morley, Heather J Cordell, Christopher S Franklin, So-Youn Shin, Michael A Heneghan, James M Neuberger, Peter T Donaldson, Darren B Day, Samantha J Ducker, Agnes W Muriithi, Elizabeth F Wheater, Christopher J Hammond, Muhammad F Dawwas, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, David E Jones, Leena Peltonen, Graeme J Alexander, Richard N Sandford, Carl A Anderson
Dec 15, 2020
In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have been identified in recent genome-wide association studies (GWAS). To identify additional loci, we carried out a GWAS using 1,840...
Adaptive Immunity B7-1 Antigen Case-Control Studies Cohort Studies Databases Genetic Death Domain Receptor Signaling Adaptor Proteins Female Genetic Predisposition to Disease Genome-Wide Association Study Guanine Nucleotide Exchange Factors Humans Immunity Innate Lectins C-Type Linkage Disequilibrium Liver Cirrhosis Biliary Male Monosaccharide Transport Proteins NF-kappa B p50 Subunit Polymorphism Single Nucleotide Receptors CXCR5 Receptors Interleukin-7 Receptors Tumor Necrosis Factor Type I Risk Factors STAT4 Transcription Factor
The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis.
JK Dyson, N Wilkinson, L Jopson, G Mells, A Bathgate, MA Heneghan, J Neuberger, GM Hirschfield, SJ Ducker, UK-PBC Consortium, R Sandford, G Alexander, D Stocken, DEJ Jones
Nov 20, 2017
BACKGROUND: Age at presentation with primary biliary cholangitis (PBC) is associated with differential response to ursodeoxycholic acid (UDCA) therapy. Younger-presenting patients are less likely to respond to treatment and more...
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
Jimmy Z Liu, Mohamed A Almarri, Daniel J Gaffney, George F Mells, Luke Jostins, Heather J Cordell, Samantha J Ducker, Darren B Day, Michael A Heneghan, James M Neuberger, Peter T Donaldson, Andrew J Bathgate, Andrew Burroughs, Mervyn H Davies, David E Jones, Graeme J Alexander, Jeffrey C Barrett, Richard N Sandford, Carl A Anderson, UK Primary Biliary Cirrhosis (PBC) Consortium, Wellcome Trust Case Control Consortium 3
Feb 05, 2021
We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium and 8,514 UK population controls across 196,524 variants within 186 known autoimmune risk loci. We identified 3 loci newly associated with...
Adaptor Proteins Signal Transducing Case-Control Studies Chromosome Mapping Chromosomes Human Pair 19 Gene Frequency Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genotype HLA Antigens Humans Intracellular Signaling Peptides and Proteins Linkage Disequilibrium Liver Cirrhosis Biliary Polymorphism Single Nucleotide Proteins Regression Analysis Sequence Analysis DNA TYK2 Kinase
Gene Ontology Consortium
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe...
The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
ImmUniverse Consortium
Stefania Vetrano, Gerben Bouma, Robert J Benschop, Thomas Birngruber, Antonio Costanzo, GRAM D'Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans JPM Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium
Jan 04, 2023
Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation. The immune...
CANADIAN RAISING
The objective of this study was to find out how language is spoken in a particular region; in particular, it was to investigate aspects of Canadian Raising in Fredericton, New Brunswick. The study was limited to instances of...
Published by: Atlantic Provinces Linguistic Association
CANADIAN RAISING
The objective of this study was to find out how language is spoken in a particular region; in particular, it was to investigate aspects of Canadian Raising in Fredericton, New Brunswick. The study was limited to instances of...
Published by: Atlantic Provinces Linguistic Association
The SPECTRUM Consortium
M Horton, PR Perman-Howe, C Angus, J Bishop, I Bogdanovica, A Brennan, J Britton, LS Brose, J Brown, J Collin, M Dockrell, N Fitzgerald, S Friel, D Gillespie, AB Gilmore, SE Hill, C Knai, T Langley, S Martin, A McNeill, G Moore, MR Munafò, RL Murray, M Opazo Breton, J Pearce, M Petticrew, G Reid, D Robson, H Rutter, L Shahab, N Shortt, K Smith, K Syrett, L Bauld
Dec 31, 2021
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures...
Alcohol Commercial determinants Inequalities Non-communicable disease Policy Prevention Public Health Tobacco Unhealthy commodities /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The SPECTRUM Consortium
M Horton, PR Perman-Howe, C Angus, J Bishop, I Bogdanovica, A Brennan, J Britton, LS Brose, J Brown, J Collin, M Dockrell, N Fitzgerald, S Friel, D Gillespie, AB Gilmore, SE Hill, C Knai, T Langley, S Martin, A McNeill, G Moore, MR Munafò, RL Murray, M Opazo Breton, J Pearce, M Petticrew, G Reid, D Robson, H Rutter, L Shahab, N Shortt, K Smith, K Syrett, L Bauld
Dec 31, 2021
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures...
Alcohol Commercial determinants Inequalities Non-communicable disease Policy Prevention Public Health Tobacco Unhealthy commodities /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
“About Nothing Without Us”
Christopher B. R. Smith
Dec 29, 2016
Background: A growing body of literature demonstrates the value of autonomous organizations of people who use drugs (PUD) in education, mutual support, and policy debates. Simultaneously, over the past 10 years, Canada has...
Harm reduction addiction treatment consumer participation structural barriers capacity building health promotion
Published by: Memorial University of Newfoundland
Stability Analysis of EPC Consortium Cooperation Based on Evolutionary Game
Consortium contracting is a contracting model that China encourages and advocates. Due to the interest drive, members within the consortium are very prone to negative cooperation and midway withdrawal, which hinders the healthy...
Published by: IGI Global Scientific Publishing
The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs
Typhoid fever is estimated to cause between 11.9-26.9 million infections globally each year with 129,000-216,510 deaths. Access to improved water sources have reduced disease incidence in parts of the world but the use of...
“About Nothing Without Us”
Christopher B. R. Smith
Dec 29, 2016
Background: A growing body of literature demonstrates the value of autonomous organizations of people who use drugs (PUD) in education, mutual support, and policy debates. Simultaneously, over the past 10 years, Canada has...
Published by: Memorial University of Newfoundland
Proposing a Library Consortium Model for National Development in Zimbabwe
Collence Chisita
Jul 01, 2021
Globally library cooperation and collaboration is transforming the scholarship landscape as academic libraries battle to survive amidst escalating costs of subscriptions. Zimbabwe is no exception to this phenomenon as evidenced...
Published by: IGI Global Scientific Publishing
Has Simeon's vision prevailed among Canadian policy scholars?
Concerned by the proliferation of idiosyncratic prescriptive case studies in the nascent subfield of policy studies, Richard Simeon, in his seminal 1976 article, asked scholars to produce more comparative policy research that...
Canadian Wraparound
For youth in the care of child welfare, the need for a greater emphasis on service integration and youth-centered approaches is widely agreed. This case study examined an implementation of the Wraparound approach, which focuses...
Published by: Memorial University of Newfoundland
Canadian Wraparound
For youth in the care of child welfare, the need for a greater emphasis on service integration and youth-centered approaches is widely agreed. This case study examined an implementation of the Wraparound approach, which focuses...
Published by: Memorial University of Newfoundland
Rescue US energy innovation
President Trump has proposed severe cuts to US government spending on energy research, development and demonstration, but Congress has the ‘power of the purse’ and can rescue US energy innovation. If serious cuts are enacted...
US Bilateral Relations With China and Their Effects on US-Japan and US-India Relations
Mackenzie Owens
Jan 01, 0001
How do US-China relations impact US relations with other Asian nations, specifically with India and Japan? US-China relations can be seen as the main driver in US relations with Japan and India following rapprochement with the...
United States China Japan india USSR 1969 Sino-Soviet Border Conflict International Relations Political Science Social and Behavioral Sciences
Published by: Ursinus College
Meningococcal carriage in the African meningitis belt.
MenAfriCar consortium
Jan 23, 2018
A meningococcal serogroup A polysaccharide/tetanus toxoid conjugate vaccine (PsA-TT) (MenAfriVac(™) ) is being deployed in countries of the African meningitis belt. Experience with other polysaccharide/protein conjugate vaccines...
Africa MenAfriCar Neisseria meningitidis meningococcal carriage Meningococcal Vaccines meningococcus Adolescent Adult Africa Carrier State Child Child Preschool Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Epidemics Humans Immunization Programs Infant International Cooperation Meningitis Meningococcal Meningococcal Vaccines Neisseria meningitidis Serogroup A Pharynx Pilot Projects Polymerase Chain Reaction Program Evaluation Specimen Handling vaccines Conjugate Young Adult
A data-driven model of brain volume changes in progressive supranuclear palsy.
WJ Scotton, M Bocchetta, E Todd, DM Cash, N Oxtoby, L VandeVrede, H Heuer, 4RTNI Consortium PROSPECT Consortium, DC Alexander, JB Rowe, HR Morris, A Boxer, JD Rohrer, PA Wijeratne
Jun 29, 2022
The most common clinical phenotype of progressive supranuclear palsy is Richardson syndrome, characterized by levodopa unresponsive symmetric parkinsonism, with a vertical supranuclear gaze palsy, early falls and cognitive...
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