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What are the important morbidities associated with paediatric cardiac surgery? A mixed methods study.
Katherine L Brown, Christina Pagel, Deborah Ridout, Jo Wray, David Anderson, David J Barron, Jane Cassidy, Peter Davis, Emma Hudson, Alison Jones, Andrew McLean, Stephen Morris, Warren Rodrigues, Karen Sheehan, Serban Stoica, Shane M Tibby, Thomas Witter, Victor T Tsang, Cardiac Impact Study Group
Sep 11, 2020
OBJECTIVES: Given the current excellent early mortality rates for paediatric cardiac surgery, stakeholders believe that this important safety outcome should be supplemented by a wider range of measures. Our objectives were to...
cardiac surgery complications Morbidity outcome Paediatrics Quality of life Adolescent Age Factors Cardiac Surgical Procedures Child Child Preschool Female Heart Diseases Humans Incidence Infant Infant Newborn Logistic Models Male Medical Audit multimorbidity Postoperative Complications Prospective Studies Quality Indicators Health Care Retreatment Risk Assessment Risk Factors Time Factors Treatment Outcome United Kingdom
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
External validation and recalibration of an incidental meningioma prognostic model - IMPACT
Abdurrahman I Islim, Christopher P Millward, Rory J Piper, Daniel M Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J Mills, Andrew R Brodbelt, Ryan K Mathew, Thomas Santarius, Michael D Jenkinson, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC) IMPACT Study Investigators
Feb 19, 2022
INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an...
External validation and recalibration of an incidental meningioma prognostic model - IMPACT
Abdurrahman I Islim, Christopher P Millward, Rory J Piper, Daniel M Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J Mills, Andrew R Brodbelt, Ryan K Mathew, Thomas Santarius, Michael D Jenkinson, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC) IMPACT Study Investigators
Jan 28, 2022
INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an...
Impact of COVID-19 pandemic on surgical neuro-oncology multi-disciplinary team decision making
Stephen John Price, Alexis Joannides, Puneet Plaha, Fardad Taghizadeh Afshari, Erminia Albanese, Neil U Barua, Huan Wee Chan, Giles Critchley, Thomas Flannery, Daniel M Fountain, Ryan K Mathew, Rory J Piper, Michael TC Poon, Chittoor Rajaraman, Ola Rominiyi, Stuart Smith, Georgios Solomou, Anna Solth, Surash Surash, Victoria Wykes, Colin Watts, Helen Bulbeck, Peter Hutchinson, Michael D Jenkinson, COVID-CNSMDT study group
Aug 17, 2020
OBJECTIVES: Pressures on healthcare systems due to COVID-19 has impacted patients without COVID-19 with surgery disproportionally affected. This study aims to understand the impact on the initial management of patients with...
A Modified Progressive Supranuclear Palsy Rating Scale.
Marie-Therese Grötsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea FM Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macías-García, Wassilios G Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B Rowe, Klaus Seppi, Maria Stamelou, John C van Swieten, Gregor Wenning, Teodoro del Ser, Lawrence I Golbe, Günter U Höglinger, the ProPSP Study Group, and the Movement Disorder Society-Endorsed PSP Study Group Describe PSP Study Group
Jan 26, 2021
BACKGROUND: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion...
The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study)
Lewis A Hall, Siobhan C McKay, James Halle-Smith, Joshua Soane, Daniel-Clement Osei-Bordom, Lesley Goodburn, Laura Magill, Thomas Pinkney, Ganesh Radhakrishna, Juan W Valle, Pippa Corrie, Keith J Roberts, CONTACT Study Group
Apr 17, 2023
INTRODUCTION: CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: The treatment...
Evaluation of inert gas rebreathing for determination of cardiac output
Jessica E Middlemiss, Alex Cocks, Kaido Paapstel, Kaisa M Maki-Petaja, Sunita, Ian B Wilkinson, Carmel M McEniery, ACCT Study Investigators
Dec 21, 2018
The aim of this study was to evaluate an inert gas rebreathing method (Innocor) for measurement of cardiac output and related haemodynamic variables and to provide robust normative data describing the influence of age, gender...
Body Size cardiac output Inert gas rebreathing Normative data Adult aging Bicycling Body Size Body Surface Area cardiac output Female Heart Rate Humans Male Middle Aged Noble Gases Posture Reference Values Reproducibility of Results Sex Characteristics Sitting Position Standing Position Stroke Volume Supine Position Young Adult
Costs of postoperative morbidity following paediatric cardiac surgery
Emma Hudson, Katherine Brown, Christina Pagel, Jo Wray, David Barron, Warren Rodrigues, Serban Stoica, Shane M Tibby, Victor Tsang, Deborah Ridout, Stephen Morris
Aug 26, 2020
OBJECTIVE: Early mortality rates for paediatric cardiac surgery have fallen due to advancements in care. Alternative indicators of care quality are needed. Postoperative morbidities are of particular interest. However, while...
cardiac surgery costing health economics health service paediatric surgery Adolescent Cardiac Surgical Procedures Child Child Preschool Cost of Illness Female Heart Defects Congenital Hospital Costs Humans Incidence Infant Infant Newborn Male Postoperative Complications Prospective Studies Regression Analysis United Kingdom
Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or...
Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development.
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or...
Costs of postoperative morbidity following paediatric cardiac surgery
Emma Hudson, Katherine Brown, Christina Pagel, Jo Wray, David Barron, Warren Rodrigues, Serban Stoica, Shane M Tibby, Victor Tsang, Deborah Ridout, Stephen Morris
May 16, 2020
Objective: Early mortality rates for paediatric cardiac surgery have fallen due to advancements in care. Alternative indicators of care quality are needed. Postoperative morbidities are of particular interest. However, while...
Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development.
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or...
Published by: Cells
Prediction of Patient Length of Stay on the Intensive Care Unit Following Cardiac Surgery
OBJECTIVE: The aim of this study was to develop a statistical model based on patient parameters to predict the length of stay (LOS) in the intensive care unit (ICU) following cardiac surgery in a single center. DESIGN: Data were...
EuroSCORE cardiac surgery intensive care unit Length of Stay Adolescent Adult Aged Aged 80 and over Cardiac Surgical Procedures Europe Female Hospital Mortality Humans Intensive Care Units Length of Stay Logistic Models Male Middle Aged Postoperative Complications Predictive Value of Tests Risk Factors Young Adult
Emergency surgery for splenic flexure cancer
Nicola de'Angelis, Eloy Espin, Frederic Ris, Filippo Landi, Bertrand Le Roy, Federico Coccolini, Valerio Celentano, Angela Gurrado, Denis Pezet, Giorgio Bianchi, Riccardo Memeo, Giulio C Vitali, Alejandro Solis, Christine Denet, Salomone Di Saverio, Gian Luigi de'Angelis, Miquel Kraft, Paula Gonzálvez-Guardiola, Aine Stakelum, Fausto Catena, David Fuks, Des C Winter, Mario Testini, Aleix Martínez-Pérez, SFC Study Group
Apr 30, 2021
BACKGROUND: The effectiveness of surgical treatment for splenic flexure carcinomas (SFCs) in emergency settings remains unexplored. This study aims to compare the perioperative and long-term outcomes of different alternatives...
IMPaCT Back study protocol. Implementation of subgrouping for targeted treatment systems for low back pain patients in primary care
Nadine E Foster, Ricky Mullis, Julie Young, Carol Doyle, Martyn Lewis, David Whitehurst, Elaine M Hay, IMPaCT Back Study team
Jun 14, 2011
Adolescent Adult Aged Clinical Protocols Clinical Trials as Topic Cohort Studies Cost-Benefit Analysis Critical Pathways England Female Humans Low Back Pain Male Middle Aged Outcome Assessment Health Care Pain Measurement Primary Health Care Prognosis Prospective Studies Quality Assurance Health Care Quality Improvement Young Adult
An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment.
Marcus Jepson, Daisy Elliott, Carmel Conefrey, Julia Wade, Leila Rooshenas, Caroline Wilson, David Beard, Jane M Blazeby, Alison Birtle, Alison Halliday, Rob Stein, Jenny L Donovan, CSAW study group, Chemorad study group, POUT study group, ACST-2 study group, OPTIMA prelim study group
Aug 23, 2018
OBJECTIVES: To explore how the concept of randomization is described by clinicians and understood by patients in randomized controlled trials (RCTs) and how it contributes to patient understanding and recruitment. STUDY DESIGN...
Patient information qualitative research randomization Randomized controlled trials Recruitment Recruitment to RCTs Comprehension Decision Making Computer-Assisted Gambling Humans metaphor Patient Education as Topic Patient Selection qualitative research Random Allocation Randomized Controlled Trials as Topic United Kingdom
Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening.
SG Thompson, HA Ashton, L Gao, MJ Buxton, RAP Scott, Multicentre Aneurysm Screening Study (MASS) Group
Jan 27, 2020
BACKGROUND: The long-term effects of abdominal aortic aneurysm (AAA) screening were investigated in extended follow-up from the UK Multicentre Aneurysm Screening Study (MASS) randomized trial. METHODS: A population-based sample...
Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.
Elizabeth K Bancroft, Sibel Saya, Elizabeth C Page, Kathryn Myhill, Sarah Thomas, Jennifer Pope, Anthony Chamberlain, Rachel Hart, Wayne Glover, Jackie Cook, Derek J Rosario, Brian T Helfand, Christina Hutten Selkirk, Rosemarie Davidson, Mark Longmuir, Diana M Eccles, Neus Gadea, Carole Brewer, Julian Barwell, Monica Salinas, Lynn Greenhalgh, Marc Tischkowitz, Alex Henderson, David Gareth Evans, Saundra S Buys, IMPACT Study Steering Committee, IMPACT Collaborators, Rosalind A Eeles, Neil K Aaronson
Feb 07, 2020
OBJECTIVES: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic...
BRCA1 BRCA2 #ProstateCancer #PCSM Psychosocial Quality of life Adult Anxiety Case-Control Studies Depression Early Detection of Cancer Genes BRCA1 Genes BRCA2 Health Knowledge Attitudes practice Humans Longitudinal Studies Male Middle Aged Mutation Perception Prostatic Neoplasms Psychiatric Status Rating Scales Quality of life Risk Factors Surveys and Questionnaires
New perspectives in eosinophilic granulomatosis with polyangiitis (EGPA)
Chiara Marvisi, Renato Alberto Sinico, Carlo Salvarani, David Jayne, Domenico Prisco, Benjamin Terrier, Giacomo Emmi, Augusto Vaglio, European EGPA Study Group
May 27, 2020
The European Eosinophilic Granulomatosis with Polyangiitis (EGPA) study group first gathered in Firenze in December 2018. The discussion was centred around the clinical and therapeutic needs in EGPA which still remain unmet....
CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis
Juan Carlos Quijano-Campos, Lynne Williams, Sharad Agarwal, Katharine Tweed, Robert Parker, Ajit Lalvani, Yi-da Chiu, Kane Dorey, Thomas Devine, Victoria Stoneman, Mark Toshner, Muhunthan Thillai
Nov 30, 2020
INTRODUCTION: Sarcoidosis is a multisystem disease, predominantly affecting the lungs but can involve the heart, resulting in cardiac sarcoidosis (CS). Patients require MRI/Positron Emission Tomography (PET) scans for diagnosis....
Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients
Barbara Mühlemann, Charlotte Thibeault, David Hillus, Elisa T Helbig, Lena J Lippert, Pinkus Tober-Lau, Tatjana Schwarz, Marcel A Müller, Pa-COVID-19 collaborative study group, Martin Witzenrath, Norbert Suttorp, Leif E Sander, Christian Drosten, Terry C Jones, Victor M Corman, Florian Kurth
Jul 28, 2021
OBJECTIVES: Dexamethasone has become the standard of care for severe coronavirus disease 2019 (COVID-19), but its virological impact is poorly understood. The objectives of this work were to characterize the kinetics of severe...
Antibody COVID-19 Nucleic Acid Testing Coronavirus disease 2019 (COVID-19) Dexamethasone Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Viral concentration Anti-Inflammatory Agents Antibodies Viral covid-19 Dexamethasone Hospitalization Humans Immunoglobulin A Immunoglobulin G Kinetics Prospective Studies RNA Viral Respiratory System SARS-CoV-2 Seroconversion Viral Load COVID-19 Drug Treatment
Cognitive impairment in Parkinson's disease
RA Lawson, AJ Yarnall, F Johnston, GW Duncan, TK Khoo, D Collerton, JP Taylor, DJ Burn, ICICLE-PD study group
Apr 12, 2018
BACKGROUND: The quality of life (QoL) of informal caregivers of people with Parkinson's disease (PD) (PwP) can be affected by the caring role. Because of cognitive symptoms and diminished activities of daily living, in addition...
The social network structure of a dynamic group of dairy cows
Natasha K. Boyland, David T. Mlynski, Richard James, Lauren J. N. Brent, Darren P. Croft
Jan 01, 2016
Social relationships have been shown to significantly impact individual and group success in wild animal populations, but are largely ignored in farm animal management. There are substantial gaps in our knowledge of how farm...
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