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Toward a New Multi-Dimensional Classification of Traumatic Brain Injury
Benjamin Y Gravesteijn, Charlie A Sewalt, Ari Ercole, Cecilia Akerlund, David Nelson, Andrew IR Maas, David Menon, Hester F Lingsma, Ewout W Steyerberg, Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Collaborators
Oct 28, 2019
Traumatic brain injury (TBI) is currently classified as mild, moderate, or severe TBI by trichotomizing the Glasgow Coma Scale (GCS). We aimed to explore directions for a more refined multidimensional classification system. For...
Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury
Frederick A Zeiler, Erta Beqiri, Manuel Cabeleira, Peter J Hutchinson, Nino Stocchetti, David K Menon, Marek Czosnyka, Peter Smielewski, Ari Ercole, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Mar 31, 2020
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO2) are associated with outcome in traumatic brain injury (TBI). This study explores the relationship between PRx and PbtO2 in adult moderate/severe TBI. Using the...
ICP autoregulation brain tissue oxygen physiological burden Adult Aged Biomedical Research Brain Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Cost of Illness Europe Female Glasgow Outcome Scale Humans Intersectoral Collaboration Male Middle Aged Oxygen Consumption Prospective Studies Treatment Outcome
Systemic Markers of Injury and Injury Response Are Not Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Sep 15, 2020
The role of extra-cranial injury burden and systemic injury response on cerebrovascular response in traumatic brain injury (TBI) is poorly documented. This study preliminarily assesses the association between admission features...
TBI autoregulation cerebrovascular reactivity extra-cranial injury injury burden Adult Biomarkers Biomedical Research Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Europe Female Humans Intersectoral Collaboration Male Middle Aged Patient Admission Prospective Studies Treatment Outcome
Variation in Blood Transfusion and Coagulation Management in Traumatic Brain Injury at the Intensive Care Unit
Jilske A Huijben, Mathieu van der Jagt, Maryse C Cnossen, Marieke JHA Kruip, Iain K Haitsma, Nino Stocchetti, Andrew IR Maas, David K Menon, Ari Ercole, Marc Maegele, Simon J Stanworth, Giuseppe Citerio, Suzanne Polinder, Ewout W Steyerberg, Hester F Lingsma, CENTER-TBI Investigators and Participants
Mar 07, 2018
Our aim was to describe current approaches and to quantify variability between European intensive care units (ICUs) in patients with traumatic brain injury (TBI). Therefore, we conducted a provider profiling survey as part of...
Variation in general supportive and preventive intensive care management of traumatic brain injury
Jilske A Huijben, Victor Volovici, Maryse C Cnossen, Iain K Haitsma, Nino Stocchetti, Andrew IR Maas, David K Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W Steyerberg, Hester F Lingsma, Mathieu van der Jagt, CENTER-TBI Investigators and Participants
May 02, 2018
BACKGROUND: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess...
blood pressure Europe Fever Glucose intensive care unit Nutrition Seizure Survey Traumatic brain injury ventilation Adult Brain Injuries Traumatic Comparative Effectiveness Research Europe Female Humans Intensive Care Units Male Program Evaluation Quality of Health Care Surveys and Questionnaires Trauma Centers
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury
MC Cnossen, JA Huijben, M van der Jagt, V Volovici, T van Essen, S Polinder, D Nelson, A Ercole, N Stocchetti, G Citerio, WC Peul, AIR Maas, D Menon, EW Steyerberg, HF Ligsma
Dec 07, 2017
Background: No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potential...
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury
Maryse C Cnossen, Jilske A Huijben, Mathieu van der Jagt, Victor Volovici, Thomas van Essen, Suzanne Polinder, David Nelson, Ari Ercole, Nino Stocchetti, Giuseppe Citerio, Wilco C Peul, Andrew I R Maas, David Menon, Ewout W Steyerberg, Hester F Lingsma
Sep 06, 2017
Abstract
Background
No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that...
Rehabilitation after traumatic brain injury
Maryse C Cnossen, Hester F Lingsma, Olli Tenovuo, Andrew IR Maas, David Menon, Ewout W Steyerberg, Gerard M Ribbers, Suzanne Polinder
Jun 25, 2018
OBJECTIVE: To describe variation in structural and process characteristics of acute in-hospital rehabilitation and referral to post-acute care for patients with traumatic brain injury across Europe. DESIGN: Survey study, of...
Variation in Structure and Process of Care in Traumatic Brain Injury
Maryse C Cnossen, Suzanne Polinder, Hester F Lingsma, Andrew IR Maas, David Menon, Ewout W Steyerberg, CENTER-TBI Investigators and Participants
Jun 19, 2018
INTRODUCTION: The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for...
Tracheal intubation in traumatic brain injury
Benjamin Yael Gravesteijn, Charlie Aletta Sewalt, Daan Nieboer, David Krishna Menon, Andrew Maas, Fiona Lecky, Markus Klimek, Hester Floor Lingsma, CENTER-TBI collaborators
Oct 07, 2021
BACKGROUND: We aimed to study the associations between pre- and in-hospital tracheal intubation and outcomes in traumatic brain injury (TBI), and whether the association varied according to injury severity. METHODS: Data from...
Variation in the practice of tracheal intubation in Europe after traumatic brain injury
BY Gravesteijn, CA Sewalt, A Ercole, F Lecky, D Menon, EW Steyerberg, AIR Maas, HF Lingsma, M Klimek, CENTER-TBI collaborators
Aug 20, 2019
Traumatic brain injury patients frequently undergo tracheal intubation. We aimed to assess current intubation practice in Europe and identify variation in practice. We analysed data from patients with traumatic brain injury...
Translation and Linguistic Validation of Outcome Instruments for Traumatic Brain Injury Research and Clinical Practice
Nicole von Steinbuechel, Katrin Rauen, Ugne Krenz, Yi-Jhen Wu, Amra Covic, Anne Marie Plass, Katrin Cunitz, Isabelle Mueller, Fabian Bockhop, Suzanne Polinder, Lindsay Wilson, Ewout W Steyerberg, Andrew IR Maas, David Menon, Marina Zeldovich, The Linguistic Validation Group Of Center-Tbi
Jul 01, 2021
Assessing outcomes in multinational studies on traumatic brain injury (TBI) poses major challenges and requires relevant instruments in languages other than English. Of the 19 outcome instruments selected for use in the...
Serum metabolome associated with severity of acute traumatic brain injury.
Ilias Thomas, Alex M Dickens, Jussi P Posti, Endre Czeiter, Daniel Duberg, Tim Sinioja, Matilda Kråkström, Isabel RA Retel Helmrich, Kevin KW Wang, Andrew IR Maas, Ewout W Steyerberg, David Menon, Olli Tenovuo, Tuulia Hyötyläinen, András Büki, Matej Orešič, CENTER-TBI Participants and Investigators
May 10, 2022
Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we...
A New Approach to Evidence Synthesis in Traumatic Brain Injury
Anneliese Synnot, Russell L Gruen, David Menon, Ewout W Steyerberg, Andras Buki, Wilco C Peul, Julian H Elliott, Andrew Maas
Jun 21, 2018
Living systematic reviews (LSRs) are online summaries of health care research that are updated as new research becomes available. This new development in evidence synthesis is being trialled as part of the Collaborative European...
Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI)
Julia K Böhm, Helge Güting, Sophie Thorn, Nadine Schäfer, Victoria Rambach, Herbert Schöchl, Oliver Grottke, Rolf Rossaint, Simon Stanworth, Nicola Curry, Rolf Lefering, Marc Maegele, CENTER-TBI Participants and Investigators
Sep 10, 2021
BACKGROUND: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated...
Serum metabolome associated with severity of acute traumatic brain injury.
Ilias Thomas, Alex M Dickens, Jussi P Posti, Endre Czeiter, Daniel Duberg, Tim Sinioja, Matilda Kråkström, Isabel RA Retel Helmrich, Kevin KW Wang, Andrew IR Maas, Ewout W Steyerberg, David K Menon, Olli Tenovuo, Tuulia Hyötyläinen, András Büki, Matej Orešič, CENTER-TBI Participants and Investigators
Jun 11, 2022
Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we...
How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study.
Marjolein Timmers, Jeroen TJM van Dijck, Roel PJ van Wijk, Valerie Legrand, Ernest van Veen, Andrew IR Maas, David K Menon, Giuseppe Citerio, Nino Stocchetti, Erwin JO Kompanje, CENTER-TBI Investigators and Participants
Jun 08, 2020
BACKGROUND: The European Union (EU) aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase...
How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study
Marjolein Timmers, Jeroen T. J. M. van Dijck, Roel P. J. van Wijk, Valerie Legrand, Ernest van Veen, Andrew I. R. Maas, David K. Menon, Giuseppe Citerio, Nino Stocchetti, Erwin J. O. Kompanje, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Anna Antoni, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Pál Barzó, Romuald Beauvais, Ronny Beer, Bo-Michael Bellander, Antonio Belli, Habib Benali, Maurizio Berardino, Luigi Beretta, Morten Blaabjerg, Peter Bragge, Alexandra Brazinova, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Andras Buki, Monika Bullinger, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Iris Ceyisakar, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Amra Čović, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Helen Dawes, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Đula Đilvesi, Abhishek Dixit, Emma Donoghue, Jens Dreier, Guy-Loup Dulière, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Kelly Foks, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Pradeep George, Alexandre Ghuysen, Lelde Giga, Ben Glocker, Jagoš Golubovic, Pedro A. Gomez, Johannes Gratz, Benjamin Gravesteijn, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Iain Haitsma, Raimund Helbok, Eirik Helseth, Lindsay Horton, Jilske Huijben, Peter J. Hutchinson, Bram Jacobs, Stefan Jankowski, Mike Jarrett, Ji-Yao Jiang, Faye Johnson, Kelly Jones, Mladen Karan, Angelos G. Kolias, Erwin Kompanje, Daniel Kondziella, Evgenios Koraropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Linda Lanyon, Steven Laureys, Fiona Lecky, Didier Ledoux, Rolf Lefering, Aurelie Lejeune, Leon Levi, Roger Lightfoot, Hester Lingsma, Ana M. Castaño-León, Marc Maegele, Marek Majdan, Alex Manara, Geoffrey Manley, Costanza Martino, Hugues Maréchal, Julia Mattern, Catherine McMahon, Béla Melegh, David Menon, Tomas Menovsky, Benoit Misset, Davide Mulazzi, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Daan Nieboer, József Nyirádi, Otesile Olubukola, Matej Oresic, Fabrizio Ortolano, Aarno Palotie, Paul M. Parizel, Jean-François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Matti Pirinen, Horia Ples, Suzanne Polinder, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Jonathan Rhodes, Sylvia Richardson, Sophie Richter, Samuli Ripatti, Saulius Rocka, Cecilie Roe, Olav Roise, Jonathan Rosand, Jeffrey V. Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Daniel Rueckert, Martin Rusnák, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Janos Sandor, Nadine Schäfer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Charlie Sewalt, Toril Skandsen, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Robert Stevens, William Stewart, Ewout W. Steyerberg, Nina Sundström, Anneliese Synnot, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Alice Theadom, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Gregory Van der Steen, Joukje van der Naalt, Thomas A. van Essen, Wim Van Hecke, Caroline van Heugten, Dominique Van Praag, Thijs Vande Vyvere, Alessia Vargiolu, Emmanuel Vega, Kimberley Velt, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Victor Volovici, Nicole von Steinbüchel, Daphne Voormolen, Petar Vulekovic, Kevin K. W. Wang, Eveline Wiegers, Guy Williams, Lindsay Wilson, Stefan Winzeck, Stefan Wolf, Zhihui Yang, Peter Ylén, Alexander Younsi, Frederick A. Zeiler, Veronika Zelinkova, Agate Ziverte, Tommaso Zoerle
Jun 06, 2020
Abstract: Background: The European Union (EU) aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase...
How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study
Marjolein Timmers, Jeroen T. J. M. van Dijck, Roel P. J. van Wijk, Valerie Legrand, Ernest van Veen, Andrew I. R. Maas, David K. Menon, Giuseppe Citerio, Nino Stocchetti, Erwin J. O. Kompanje, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Anna Antoni, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Pál Barzó, Romuald Beauvais, Ronny Beer, Bo-Michael Bellander, Antonio Belli, Habib Benali, Maurizio Berardino, Luigi Beretta, Morten Blaabjerg, Peter Bragge, Alexandra Brazinova, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Andras Buki, Monika Bullinger, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Iris Ceyisakar, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Amra Čović, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Helen Dawes, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Đula Đilvesi, Abhishek Dixit, Emma Donoghue, Jens Dreier, Guy-Loup Dulière, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Kelly Foks, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Pradeep George, Alexandre Ghuysen, Lelde Giga, Ben Glocker, Jagoš Golubovic, Pedro A. Gomez, Johannes Gratz, Benjamin Gravesteijn, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Iain Haitsma, Raimund Helbok, Eirik Helseth, Lindsay Horton, Jilske Huijben, Peter J. Hutchinson, Bram Jacobs, Stefan Jankowski, Mike Jarrett, Ji-Yao Jiang, Faye Johnson, Kelly Jones, Mladen Karan, Angelos G. Kolias, Erwin Kompanje, Daniel Kondziella, Evgenios Koraropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Linda Lanyon, Steven Laureys, Fiona Lecky, Didier Ledoux, Rolf Lefering, Aurelie Lejeune, Leon Levi, Roger Lightfoot, Hester Lingsma, Ana M. Castaño-León, Marc Maegele, Marek Majdan, Alex Manara, Geoffrey Manley, Costanza Martino, Hugues Maréchal, Julia Mattern, Catherine McMahon, Béla Melegh, David Menon, Tomas Menovsky, Benoit Misset, Davide Mulazzi, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Daan Nieboer, József Nyirádi, Otesile Olubukola, Matej Oresic, Fabrizio Ortolano, Aarno Palotie, Paul M. Parizel, Jean-François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Matti Pirinen, Horia Ples, Suzanne Polinder, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Jonathan Rhodes, Sylvia Richardson, Sophie Richter, Samuli Ripatti, Saulius Rocka, Cecilie Roe, Olav Roise, Jonathan Rosand, Jeffrey V. Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Daniel Rueckert, Martin Rusnák, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Janos Sandor, Nadine Schäfer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Charlie Sewalt, Toril Skandsen, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Robert Stevens, William Stewart, Ewout W. Steyerberg, Nina Sundström, Anneliese Synnot, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Alice Theadom, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Gregory Van der Steen, Joukje van der Naalt, Thomas A. van Essen, Wim Van Hecke, Caroline van Heugten, Dominique Van Praag, Thijs Vande Vyvere, Alessia Vargiolu, Emmanuel Vega, Kimberley Velt, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Victor Volovici, Nicole von Steinbüchel, Daphne Voormolen, Petar Vulekovic, Kevin K. W. Wang, Eveline Wiegers, Guy Williams, Lindsay Wilson, Stefan Winzeck, Stefan Wolf, Zhihui Yang, Peter Ylén, Alexander Younsi, Frederick A. Zeiler, Veronika Zelinkova, Agate Ziverte, Tommaso Zoerle
May 12, 2021
Abstract: Background: The European Union (EU) aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase...
Management of Mild Traumatic Brain Injury at the Emergency Department and Hospital Admission in Europe
Kelly A Foks, Maryse C Cnossen, Diederik WJ Dippel, Andrew IR Maas, David Menon, Joukje van der Naalt, Ewout W Steyerberg, Hester F Lingsma, Suzanne Polinder
Nov 19, 2018
Previous studies have indicated that there is no consensus about management of mild traumatic brain injury (mTBI) at the emergency department (ED) and during hospital admission. We aim to study variability between management...
Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury
François Mathieu, Helge Güting, Benjamin Gravesteijn, Miguel Monteiro, Ben Glocker, Evgenios N Kornaropoulos, Konstantinos Kamnistas, Claudia S Robertson, Harvey Levin, Daniel P Whitehouse, Tilak Das, Hester F Lingsma, Marc Maegele, Virginia FJ Newcombe, David K Menon, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants
Apr 09, 2020
anticoagulant antiplatelet Intracranial hemorrhage Traumatic brain injury Aged Aged 80 and over Anticoagulants Brain Injuries Traumatic Case-Control Studies Cohort Studies Disease Progression Female Glasgow Outcome Scale Humans Intracranial hemorrhage Traumatic Male Middle Aged Platelet Aggregation Inhibitors Propensity Score Tomography X-Ray Computed
Variation in neurosurgical management of traumatic brain injury
Thomas A van Essen, Hugo F den Boogert, Maryse C Cnossen, Godard CW de Ruiter, Iain Haitsma, Suzanne Polinder, Ewout W Steyerberg, David Menon, Andrew IR Maas, Hester F Lingsma, Wilco C Peul, CENTER-TBI Investigators and Participants
Apr 09, 2020
BACKGROUND: Neurosurgical management of traumatic brain injury (TBI) is challenging, with only low-quality evidence. We aimed to explore differences in neurosurgical strategies for TBI across Europe. METHODS: A survey was sent...
Imputation of Ordinal Outcomes
Kevin Kunzmann, Lorenz Wernisch, Sylvia Richardson, Ewout W Steyerberg, Hester Lingsma, Ari Ercole, Andrew IR Maas, David Menon, Lindsay Wilson
Oct 15, 2020
Loss to follow-up and missing outcomes data are important issues for longitudinal observational studies and clinical trials in traumatic brain injury. One popular solution to missing 6-month outcomes has been to use the last...
GOSe imputation missing data Traumatic brain injury Adolescent Adult Aged Aged 80 and over Brain Injuries Traumatic Child Child Preschool Data Interpretation Statistical Female Glasgow Outcome Scale Humans Infant Infant Newborn Male Middle Aged Models Neurological Prognosis Recovery of Function Research Design Young Adult
Modeling Brain-Heart Crosstalk Information in Patients with Traumatic Brain Injury.
Giovanna Maria Dimitri, Erta Beqiri, Michal M Placek, Marek Czosnyka, Nino Stocchetti, Ari Ercole, Peter Smielewski, Pietro Lio, CENTER-TBI collaborators
Sep 13, 2021
BACKGROUND: Traumatic brain injury (TBI) is an extremely heterogeneous and complex pathology that requires the integration of different physiological measurements for the optimal understanding and clinical management of...
Imputation strategies for missing baseline neurological assessment covariates after traumatic brain injury
Ari Ercole, Abhishek Dixit, David W Nelson, Shubhayu Bhattacharyay, Frederick A Zeiler, Daan Nieboer, Omar Bouamra, David K Menon, Andrew I R Maas, Simone A Dijkland, Hester F Lingsma, Lindsay Wilson, Fiona Lecky, Ewout W Steyerberg
Sep 08, 2021
Statistical models for outcome prediction are central to traumatic brain injury research and critical to baseline risk adjustment. Glasgow coma score (GCS) and pupil reactivity are crucial covariates in all such models but may...
Published by: PLOS ONE
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