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Results: 5813
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Adi L Tarca, Bálint Ármin Pataki, Roberto Romero, Marina Sirota, Yuanfang Guan, Rintu Kutum, Nardhy Gomez-Lopez, Bogdan Done, Gaurav Bhatti, Thomas Yu, Gaia Andreoletti, Tinnakorn Chaiworapongsa, DREAM Preterm Birth Prediction Challenge Consortium, Sonia S Hassan, Chaur-Dong Hsu, Nima Aghaeepour, Gustavo Stolovitzky, Istvan Csabai, James C Costello
Jun 25, 2021
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM...
Aptamers collaborative competition human transcriptome arrays Machine Learning plasma proteomics predictive modeling preterm labor and delivery spontaneous preterm birth whole blood transcriptomics Adult Asymptomatic Diseases Biomarkers Blood Proteins Cell-Free Nucleic Acids Crowdsourcing Female Gestational Age Humans Infant Newborn Longitudinal Studies pre-eclampsia Pregnancy premature birth Proteomics ROC Curve Transcriptome
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
Jun 08, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications.
There is emergent literature on the relationship between the development of sleep-wake cycles, sleep architecture, and sleep duration during the neonatal period on neurodevelopmental outcomes among children born preterm. There...
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
May 23, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
Published by: Scientific reports
Fetal growth and spontaneous preterm birth in high‐altitude pregnancy
Abstract: Objective: To understand the relationship between birth weight and altitude to improve health outcomes in high‐altitude populations, to systematically assess the impact of altitude on the likelihood of low birth weight...
review article Review articles growth restriction high‐altitude pregnancy low birth weight Small for gestational age
Published by: International Journal of Gynecology & Obstetrics
Postal recruitment for genetic studies of preterm birth
Oonagh E Keag, Lee Murphy, Aoibheann Bradley, Naomi Deakin, Sonia Whyte, Jane E Norman, Sarah J Stock
Sep 24, 2020
Background: Preterm birth (PTB) represents the leading cause of neonatal death. Large-scale genetic studies are necessary to determine genetic influences on PTB risk, but prospective cohort studies are expensive and...
Postal recruitment for genetic studies of preterm birth
Oonagh E Keag, Lee Murphy, Aoibheann Bradley, Naomi Deakin, Sonia Whyte, Jane E Norman, Sarah J Stock
May 24, 2020
Background: Preterm birth (PTB) represents the leading cause of neonatal death. Large-scale genetic studies are necessary to determine genetic influences on PTB risk, but prospective cohort studies are expensive and...
DNA Phenotype Fetal Membranes premature birth Premature Premature Rupture Obstetric Labour Surveys and Questionnaires
Published by: Wellcome open research
The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications.
There is emergent literature on the relationship between the development of sleep-wake cycles, sleep architecture, and sleep duration during the neonatal period on neurodevelopmental outcomes among children born preterm. There...
The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
Melinda C Mills, Felix C Tropf, David M Brazel, Natalie van Zuydam, Ahmad Vaez, eQTLGen Consortium, BIOS Consortium, Human Reproductive Behaviour Consortium, Tune H Pers, Harold Snieder, John RB Perry, Ken K Ong, Marcel den Hoed, Nicola Barban, Felix R Day
Jul 19, 2021
Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901)...
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.
Michael P Menden, Dennis Wang, Mike J Mason, Bence Szalai, Krishna C Bulusu, Yuanfang Guan, Thomas Yu, Jaewoo Kang, Minji Jeon, Russ Wolfinger, Tin Nguyen, Mikhail Zaslavskiy, AstraZeneca-Sanger Drug Combination DREAM Consortium, In Sock Jang, Zara Ghazoui, Mehmet Eren Ahsen, Robert Vogel, Elias Chaibub Neto, Thea Norman, Eric KY Tang, Mathew J Garnett, Giovanni Y Di Veroli, Stephen Fawell, Gustavo Stolovitzky, Justin Guinney, Jonathan R Dry, Julio Saez-Rodriguez
Jul 08, 2019
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven...
ADAM17 Protein Antineoplastic Combined Chemotherapy Protocols Benchmarking Biomarkers Tumor Cell Line Tumor Computational Biology Datasets as Topic Drug Antagonism Drug Resistance Neoplasm Drug Synergism Genomics Humans Molecular Targeted Therapy Mutation Neoplasms Pharmacogenetics Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Treatment Outcome
Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years.
John R Hurst, Joanne Beckmann, Yanyan Ni, Charlotte E Bolton, Carmel M McEniery, John R Cockcroft, Neil Marlow
Apr 21, 2020
Rationale: Growth and development during adolescence may modify the respiratory and vascular differences seen among extremely preterm (EP) individuals in childhood and early adolescence.Objectives: To assess the trajectory of...
adult outcomes cardiovascular function extreme prematurity lung function Asthma blood pressure Breath Tests bronchopulmonary dysplasia C-Reactive Protein Cardiovascular Diseases Cohort Studies Creatinine Exercise Tolerance Female Forced Expiratory Volume Glomerular Filtration Rate Humans Infant Extremely Premature Infant Newborn Inflammation Ireland Longitudinal Studies Lung Male Manometry Maximal Midexpiratory Flow Rate Nitric oxide Pulse Wave Analysis Spirometry United Kingdom Vascular Resistance Vital Capacity Walk Test Young Adult
Problems associated with preterm births and its management
A child is the greatest treasure of mankind. His health, well-being, safety and future are in the hands of his parents from birth until he is on his own. A preterm infant is traditionally defined as a live-born infant born...
Published by: IJHS Medical Association
Gas flow in preterm infants treated with bubble CPAP
Cameron D Payne, Louise S Owen, Kate Alison Hodgson, Colin J Morley, Peter G Davis, Brett James Manley
Aug 28, 2020
OBJECTIVE: To measure the nasal gas flow in infants treated with bubble continuous positive airway pressure (CPAP) and compare it with commonly used flows during nasal high flow (nHF) treatment. DESIGN: This is a prospective...
Inferring causal molecular networks
Steven M Hill, Laura M Heiser, Thomas Cokelaer, Michael Unger, Nicole K Nesser, Daniel E Carlin, Yang Zhang, Artem Sokolov, Evan O Paull, Chris K Wong, Kiley Graim, Adrian Bivol, Haizhou Wang, Fan Zhu, Bahman Afsari, Ludmila V Danilova, Alexander V Favorov, Wai Shing Lee, Dane Taylor, Chenyue W Hu, Byron L Long, David P Noren, Alexander J Bisberg, HPN-DREAM Consortium, Gordon B Mills, Joe W Gray, Michael Kellen, Thea Norman, Stephen Friend, Amina A Qutub, Elana J Fertig, Yuanfang Guan, Mingzhou Song, Joshua M Stuart, Paul T Spellman, Heinz Koeppl, Gustavo Stolovitzky, Julio Saez-Rodriguez, Sach Mukherjee
Aug 10, 2018
It remains unclear whether causal, rather than merely correlational, relationships in molecular networks can be inferred in complex biological settings. Here we describe the HPN-DREAM network inference challenge, which focused...
Problems associated with preterm births and its management
A child is the greatest treasure of mankind. His health, well-being, safety and future are in the hands of his parents from birth until he is on his own. A preterm infant is traditionally defined as a live-born infant born...
Published by: IJHS Medical Association
Gene Ontology Consortium
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe...
BRCA Challenge
Melissa S Cline, Rachel G Liao, Michael T Parsons, Benedict Paten, Faisal Alquaddoomi, Antonis Antoniou, Samantha Baxter, Larry Brody, Robert Cook-Deegan, Amy Coffin, Fergus J Couch, Brian Craft, Robert Currie, Chloe C Dlott, Lena Dolman, Johan T den Dunnen, Stephanie OM Dyke, Susan M Domchek, Douglas Easton, Zachary Fischmann, William D Foulkes, Judy Garber, David Goldgar, Mary J Goldman, Peter Goodhand, Steven Harrison, David Haussler, Kazuto Kato, Bartha Knoppers, Charles Markello, Robert Nussbaum, Kenneth Offit, Sharon E Plon, Jem Rashbass, Heidi L Rehm, Mark Robson, Wendy S Rubinstein, Dominique Stoppa-Lyonnet, Sean Tavtigian, Adrian Thorogood, Can Zhang, Marc Zimmermann, BRCA Challenge Authors, John Burn, Stephen Chanock, Gunnar Rätsch, Amanda B Spurdle
Jan 08, 2019
The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to...
DREAM Educational Management and Leadership
Phil Quirke
Feb 19, 2024
This chapter describes the DREAM educational management and leadership approach, which the author has been implementing, researching, and developing for two decades. The DREAM acronym is based on ten principles inspired by...
Educational Technologies Education Educational Technologies Computer Science and Information Technology Library and Information Science
Published by: IGI Global Scientific Publishing
ImmUniverse Consortium
Stefania Vetrano, Gerben Bouma, Robert J Benschop, Thomas Birngruber, Antonio Costanzo, GRAM D'Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans JPM Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium
Jan 04, 2023
Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation. The immune...
Contribution of de novo and inherited rare CNVs to very preterm birth.
Hilary S Wong, Megan Wadon, Alexandra Evans, George Kirov, Neena Modi, Michael C O'Donovan, Anita Thapar
Feb 14, 2020
BACKGROUND: The genomic contribution to adverse health sequelae in babies born very preterm (<32 weeks' gestation) is unknown. We conducted an investigation of rare CNVs in infants born very preterm as part of a study to...
Pilot study to establish a prospective neonatal cohort
BACKGROUND: Genetic risk variants and preterm birth are early and potent risk factors for later neuropsychiatric disorders. To understand the interrelationships between these factors, a large-scale genetic study of very preterm...
Cell-to-cell and type-to-type heterogeneity of signaling networks
Attila Gabor, Marco Tognetti, Alice Driessen, Jovan Tanevski, Baosen Guo, Wencai Cao, He Shen, Thomas Yu, Verena Chung, Single Cell Signaling in Breast Cancer DREAM Consortium members, Bernd Bodenmiller, Julio Saez-Rodriguez
Nov 19, 2021
Recent technological developments allow us to measure the status of dozens of proteins in individual cells. This opens the way to understand the heterogeneity of complex multi-signaling networks across cells and cell types, with...
Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.
Charles Jonathan Peter Snart, Diane Erin Threapleton, Claire Keeble, Elizabeth Taylor, Dagmar Waiblinger, Stephen Reid, Nisreen A Alwan, Dan Mason, Rafaq Azad, Janet Elizabeth Cade, Nigel AB Simpson, Sarah Meadows, Amanda McKillion, Gillian Santorelli, Amanda H Waterman, Michael Zimmermann, Paul M Stewart, John Wright, Mark Mon-Williams, Darren Charles Greenwood, Laura J Hardie
Jun 11, 2021
BACKGROUND: Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on...
DREAM represses distinct targets by cooperating with different THAP domain proteins.
Csenge Gal, Francesco Nicola Carelli, Alex Appert, Chiara Cerrato, Ni Huang, Yan Dong, Jane Murphy, Andrea Frapporti, Julie Ahringer
Sep 27, 2021
The DREAM (dimerization partner [DP], retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell-cycle and other genes, but its mechanism of action is unclear. Here, we demonstrate that two...
dream H2A.Z H3K9me2 THAP lin-15B lin-35 lin-36 quiescence retinoblastoma TRANSCRIPTIONAL REPRESSION Animals Animals Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Cycle Proteins DNA Methylation E2F Transcription Factors Gene Expression Regulation Histones Promoter Regions Genetic Protein Binding Protein Interaction Domains and Motifs Retinoblastoma Protein Transcription Factors
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