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Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions
Samantha C Salvage, Esther M Gallant, James A Fraser, Christopher L-H Huang, Angela F Dulhunty
Sep 27, 2021
Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide...
Atrial fibrillation Catecholaminergic polymorphic ventricular tachycardia RyR2 flecainide RyR2 activation RyR2 inhibition RyR2-P2328S
Published by: Cells
Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions
Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide...
Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions
Samantha C Salvage, Esther M Gallant, James A Fraser, Christopher L-H Huang, Angela F Dulhunty
Aug 16, 2021
Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide...
RyR2 RyR2 activation RyR2 inhibition RyR2-P2328S Atrial fibrillation Catecholaminergic polymorphic ventricular tachycardia flecainide Animals Anti-Arrhythmia Agents Arrhythmias Cardiac Calcium flecainide Ion Channel Gating Lipid Bilayers Membrane Potentials Mice Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Voltage-Gated Sodium Channel Blockers
Multiple targets for flecainide action
SC Salvage, KH Chandrasekharan, K Jeevaratnam, AF Dulhunty, AJ Thompson, AP Jackson, CL-H Huang
Jun 29, 2017
Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse.
Samantha C Salvage, Esther M Gallant, Nicole A Beard, Shiraz Ahmad, Haseeb Valli, James A Fraser, Christopher L-H Huang, Angela F Dulhunty
May 01, 2019
Mutations in the cardiac ryanodine receptor Ca2+ release channel (RyR2) can cause deadly ventricular arrhythmias and atrial fibrillation (AF). The RyR2-P2328S mutation produces catecholaminergic polymorphic ventricular...
Atrial fibrillation Catecholaminergic polymorphic ventricular tachycardia Cytoplasmic Ca2+ activation Cytoplasmic Ca2+ inactivation FKBP P2328S-RyR2 mouse RyR2 P2328S ion channel Animals Arrhythmias Cardiac Atrial fibrillation Calcium Cytoplasm Ion Channel Gating Mice Myocytes Cardiac Phosphorylation Ryanodine Receptor Calcium Release Channel