Search
Results: 25138
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population
Alexia Cardona, Felix R Day, John RB Perry, Marie Loh, Audrey Y Chu, Benjamin Lehne, Dirk S Paul, Luca A Lotta, Isobel D Stewart, Nicola D Kerrison, Robert A Scott, Kay-Tee Khaw, Nita G Forouhi, Claudia Langenberg, Chunyu Liu, Michael M Mendelson, Daniel Levy, Stephan Beck, R David Leslie, Josée Dupuis, James B Meigs, Jaspal S Kooner, Jussi Pihlajamäki, Allan Vaag, Alexander Perfilyev, Charlotte Ling, Marie-France Hivert, John C Chambers, Nicholas J Wareham, Ken K Ong
Sep 20, 2019
Epigenetic changes may contribute substantially to risks of diseases of aging. Previous studies reported seven methylation variable positions (MVPs) robustly associated with incident type 2 diabetes mellitus (T2DM). However...
Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study
Michelle PY Chan, David C Broadway, Anthony P Khawaja, Jennifer LY Yip, David F Garway-Heath, Jennifer M Burr, Robert Luben, Shabina Hayat, Nichola Dalzell, Kay-Tee Khaw, Paul J Foster
Jul 31, 2018
Objectives To report the distribution of intraocular pressure (IOP) by age and sex and the prevalence of glaucoma.Design Community based cross sectional observational study.Setting EPIC-Norfolk cohort in Norwich and the...
A new tool for converting food frequency questionnaire data into nutrient and food group values
Angela A Mulligan, Robert N Luben, Amit Bhaniani, David J Parry-Smith, Laura O'Connor, Anthony P Khawaja, Nita G Forouhi, Kay-Tee Khaw, EPIC-Norfolk FFQ Study
Sep 08, 2018
Opposites don't attract
OBJECTIVE: Dietary supplements are commonly consumed but may not be beneficial for everyone. It is known that supplement users have healthy behaviour characteristics but until now concordance between spouses living in the same...
Validation of the Systematic COronary Risk Evaluation - Older Persons (SCORE-OP) in the EPIC-Norfolk prospective population study.
Lotte Verweij, Ron Jg Peters, Wilma JM Scholte Op Reimer, S Matthijs Boekholdt, Robert M Luben, Nicholas J Wareham, Kay-Tee Khaw, Corine HM Latour, Harald T Jorstad
Aug 29, 2019
BACKGROUND: The Systematic COronary Risk Evaluation - Older Persons (SCORE-OP) algorithm is developed to assess 10-year risk of death due to cardiovascular disease (CVD) in individuals aged ≥65 years. We studied the performance...
Residential area deprivation and risk of subsequent hospital admission in a British population
Robert Luben, Shabina Hayat, Anthony Khawaja, Nicholas Wareham, Paul P Pharoah, Kay-Tee Khaw
Jan 27, 2020
OBJECTIVES:To investigate whether residential area deprivation index predicts subsequent admissions to hospital and time spent in hospital independently of individual social class and lifestyle factors. DESIGN:Prospective...
Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study.
Tiberiu A Pana, Robert N Luben, Mamas A Mamas, John F Potter, Nicholas J Wareham, Kay-Tee Khaw, Phyo K Myint
Jul 12, 2021
AIMS: We aimed to determine the sex differences in longitudinal systolic and diastolic blood pressure (SBP and DBP) trajectories in mid-life and delineate the associations between these and mortality (all-cause, cardiovascular...
Residential area deprivation and risk of subsequent hospital admission in a British population
Robert Luben, Shabina Hayat, Anthony Khawaja, Nicholas Wareham, Paul P Pharoah, Kay-Tee Khaw
Dec 26, 2019
Objectives: To investigate whether residential area deprivation index predicts subsequent admissions to hospital and time spent in hospital independently of individual social class and lifestyle factors. Design: Prospective...
The relationship between alcohol intake and falls hospitalization
Guo Jeng Tan, Maw Pin Tan, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw, Phyo Kyaw Myint
Aug 19, 2021
AIM: To evaluate the relationship between habitual alcohol consumption and the risk of falls hospitalization. METHODS: The EPIC-Norfolk is a prospective population-based cohort study in Norfolk, UK. In total, 25 637 community...
Bidirectional associations of accelerometer-assessed physical activity and sedentary time with physical function among older English adults
Dharani Yerrakalva, Samantha Hajna, Katrien Wijndaele, Paddy C Dempsey, Kate Westgate, Nick Wareham, Simon J Griffin, Soren Brage
Dec 08, 2022
UNLABELLED: To develop healthy ageing interventions, longitudinal associations between objectively assessed physical behaviours and physical function need to be better understood. We assessed associations between...
Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population
Abstract
Background
Despite convincing evidence in the Mediterranean region, the cardiovascular benefit of the Mediterranean diet is not well established in non-Mediterranean...
Plasma trimethylamine N-oxide (TMAO) levels predict future risk of coronary artery disease in apparently healthy individuals in the EPIC-Norfolk prospective population study.
WH Wilson Tang, Xinmin S Li, Yuping Wu, Zeneng Wang, Kay-Tee Khaw, Nicholas J Wareham, Max Nieuwdorp, S Matthijs Boekholdt, Stanley L Hazen
Mar 01, 2021
BACKGROUND: Recent studies show a mechanistic link between gut microbiota-dependent formation of the atherosclerosis- and thrombosis-promoting metabolite trimethylamine N-oxide (TMAO) and cardiovascular disease (CVD). The...
Impact of physical activity on the risk of cardiovascular disease in middle-aged and older adults
Sangeeta Lachman, S Matthijs Boekholdt, Robert N Luben, Stephen J Sharp, Soren Brage, Kay-Tee Khaw, Ron Jg Peters, Nicholas J Wareham
Feb 12, 2018
Background There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether physical activity...
physical activity cardiovascular disease elderly people middle-aged adults Adult Age Factors Aged Cardiovascular Diseases England Exercise Female health status healthy aging Healthy lifestyle Humans Male Middle Aged Prognosis Prospective Studies Protective factors Risk Factors Risk Reduction Behavior Time Factors
Residential area deprivation and risk of subsequent hospital admission in a British population
Robert Luben, Shabina Hayat, Anthony Khawaja, Nicholas Wareham, Paul P Pharoah, Kay-Tee Khaw
Nov 25, 2019
OBJECTIVES: To investigate whether residential area deprivation index predicts subsequent admissions to hospital and time spent in hospital independently of individual social class and lifestyle factors. DESIGN: Prospective...
EPIDEMIOLOGY Health Policy Public Health social medicine Aged Body Mass Index Cross-Sectional Studies Educational Status England Female Hospitalization Humans Logistic Models Male Middle Aged Multivariate Analysis Neoplasms occupations Poverty Poverty Areas Prospective Studies Risk Factors Smoking Social Class
Weight change and 15 year mortality
Angela A Mulligan, Marleen AH Lentjes, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw
Feb 23, 2018
Studies have reported a higher mortality risk associated with weight loss, particularly in middle-aged and older adults, although some of these studies did find that gaining weight was also associated with an increased mortality...
Alcohol consumption and future hospital usage
Robert Luben, Shabina Hayat, Angela Mulligan, Marleen Lentjes, Nicholas Wareham, Paul Pharoah, Kay-Tee Khaw
Sep 05, 2018
BACKGROUND: Heavy drinkers of alcohol are reported to use hospitals more than non-drinkers, but it is unclear whether light-to-moderate drinkers use hospitals more than non-drinkers. OBJECTIVE: We examined the relationship...
apoB/apoA-I Ratio and Lp(a) Associations With Aortic Valve Stenosis Incidence
Kang H Zheng, Benoit J Arsenault, Yannick Kaiser, Kay-Tee Khaw, Nicholas J Wareham, Erik SG Stroes, S Matthijs Boekholdt
Aug 21, 2019
Background Apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio and lipoprotein(a) (Lp[a]) are associated with aortic valve stenosis (AVS) disease progression. Clinical characteristics such as age, sex, and presence of...
aortic valve stenosis apoB/apoA‐I ratio lipids and lipoproteins lipoprotein(a) low‐density lipoprotein cholesterol Adult Aged aortic valve stenosis Apolipoprotein A-I Apolipoproteins B Cholesterol LDL Comorbidity Coronary Artery Disease Female Humans Incidence lipoprotein(a) Longitudinal Studies Male Middle Aged Prospective Studies United Kingdom
Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population
Tiberiu A Pana, Mohsen Dehghani, Hamid Reza Baradaran, Samuel R Neal, Adrian D Wood, Chun Shing Kwok, Yoon K Loke, Robert N Luben, Mamas A Mamas, Kay-Tee Khaw, Phyo Kyaw Myint
Aug 29, 2021
The role of dietary calcium in cardiovascular disease prevention is unclear. We aimed to determine the association between calcium intake and incident cardiovascular disease and mortality. Data were extracted from the European...
Calcium supplements cardiovascular disease Dietary calcium Meta-Analysis Mortality Systematic review Adult Aged Aged 80 and over Calcium Calcium Dietary Cardiovascular Diseases Cause of Death Diet Surveys Dietary Supplements Female Follow-Up Studies Humans Male Middle Aged Proportional Hazards Models Prospective Studies Protective factors United Kingdom
Risk factors for herpes simplex virus type-1 infection and reactivation
Harriet Forbes, Ben Warne, Lars Doelken, Nicole Brenner, Tim Waterboer, Robert Luben, Nicholas J Wareham, Charlotte Warren-Gash, Effrossyni Gkrania-Klotsas
May 15, 2019
BACKGROUND: The prevalence of, and risk factors for, herpes simplex virus type-1 (HSV-1) infection and reactivation in older individuals are poorly understood. METHODS: This is a prospective population-based study among...
Risk factors for previously undiagnosed primary open-angle glaucoma
Michelle PY Chan, Anthony P Khawaja, David C Broadway, Jennifer Yip, Robert Luben, Shabina Hayat, Tunde Peto, Kay-Tee Khaw, Paul J Foster
Jun 29, 2021
BACKGROUND AND AIM: Undiagnosed glaucoma is an invisible but important public health issue. At least half of glaucoma cases are estimated to be undiagnosed in western populations. The aim of this study is to examine risk factors...
Long-term mortality of hospitalized pneumonia in the EPIC-Norfolk cohort.
Little is known about cause-specific long-term mortality beyond 30 days in pneumonia. We aimed to compare the mortality of patients with hospitalized pneumonia compared to age- and sex-matched controls beyond 30 days....
All-cause mortality cardiovascular mortality long-term mortality Pneumonia respiratory mortality Adult Aged Cardiovascular Diseases Case-Control Studies Cause of Death England Female Hospitalization Humans Incidence Male Middle Aged Pneumonia Proportional Hazards Models Prospective Studies Respiratory Tract Diseases Time Factors
Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk.
Javier I Ottaviani, Abigail Britten, Debora Lucarelli, Robert Luben, Angela A Mulligan, Marleen A Lentjes, Reedmond Fong, Nicola Gray, Philip B Grace, Deborah H Mawson, Amy Tym, Antonia Wierzbicki, Nita G Forouhi, Kay-Tee Khaw, Hagen Schroeter, Gunter GC Kuhnle
Nov 12, 2020
Flavan-3-ols are a group of bioactive compounds that have been shown to improve vascular function in intervention studies. They are therefore of great interest for the development of dietary recommendation for the prevention of...
Cross-sectional associations of dietary and circulating magnesium with skeletal muscle mass in the EPIC-Norfolk cohort.
Richard PG Hayhoe, Marleen AH Lentjes, Angela A Mulligan, Robert N Luben, Kay-Tee Khaw, Ailsa A Welch
Mar 16, 2018
BACKGROUND: Maintenance of skeletal muscle in older age is critical to reducing frailty and the risk of falls and fractures. Nutrition has established importance for muscle health in general, but less research has looked at...
Hypertensive Disorders of Pregnancy (HDP) and the Risk of Common Cancers in Women
Zahra Pasdar, David T Gamble, Phyo K Myint, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw, Sohinee Bhattacharya
Nov 16, 2020
PURPOSE: The purpose was to determine the association between HDP and cancer in a UK cohort. METHODS: Between 1993 and 1997, participants from the EPIC-Norfolk cohort attended baseline health-checks and completed questionnaires...
|
|< |
< |
1 |