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Detecting Community Structures Within Complex Networks Using a Discrete Unconscious Search Algorithm
Detecting the communities that exist within complex social networks has a wide range of application in business, engineering, and sociopolitical settings. As a result, many community detection methods are being developed by...
Published by: IGI Global Scientific Publishing
A Scheduling and Rescheduling Decision Support System for Apparel Manufacturing
The manufacturing environment for apparel is subject to a variety of constraints, stochasticity, and unforeseen events. In order to create an accurate scheduling-system for this environment, these complexities must be...
Published by: IGI Global Scientific Publishing
A GIS-based Spatiotemporal Study of the Variability of Water Quality Parameters in the Dubai Creek
High concentrations of nutrients canincrease algal growth in coastal marine systems. The growth of harmful algal blooms (HAB’s) has become common in UAE, especially in late 2008 and early 2009 when a huge HAB event devastated...
Logistics planning of cash transfer to Syrian refugees in Turkey
Ramez Kian, Güneş Erdoğan, Sander de Leeuw, Sibel Salman, Bahar Kara, Ehsan Sabet, Muhittin Demir
Feb 01, 2022
This paper addresses a humanitarian logistics problem connected with the Syrian refugee crisis. The ongoing conflict in Syria has caused displacement of millions of people. Cash-based interventions play an important role in...
Logistics planning of cash transfer to Syrian refugees in Turkey
Ramez Kian, Güneş Erdoğan, Sander de Leeuw, Sibel Salman, Bahar Kara, Ehsan Sabet, Muhittin Demir
Feb 01, 2022
This paper addresses a humanitarian logistics problem connected with the Syrian refugee crisis. The ongoing conflict in Syria has caused displacement of millions of people. Cash-based interventions play an important role in...
Digital Transformation and Corporate Risk-Taking
Researchers are studying whether digital transformation can increase corporate risk-taking. A study using data from Chinese companies between 2010 and 2019 shows that digital transformation does enhance risk-taking. This is...
Published by: IGI Global Scientific Publishing
A GIS-based Spatiotemporal Study of the Variability of Water Quality Parameters in the Dubai Creek
High concentrations of nutrients canincrease algal growth in coastal marine systems. The growth of harmful algal blooms (HAB’s) has become common in UAE, especially in late 2008 and early 2009 when a huge HAB event devastated...
Implementation of birth plans integrated into childbirth preparation classes for vaginal birth
Zaynab Mohaghegh, Mojgan Javadnoori, Mahin Najafian, Simin Montazeri, Parvin Abedi, Ehsan Kazemnejad Leyli, Shahla Bakhtiari
Jan 04, 2023
BACKGROUND: Understanding women's experience of birth planning is necessary for introducing and implementing this process in the Iranian maternity services. This study aims to explore perceptions of birth plan implementation in...
Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells.
Tumours have developed strategies to interfere with most steps required for anti-tumour immune responses. Although many populations contribute to anti-tumour responses, tumour-infiltrating cytotoxic T cells dominate, hence, many...
Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge.
Sonia Baig, Ehsan Parvaresh Rizi, Chelsea Chia, Muhammad Shabeer, Nweni Aung, Tze Ping Loh, Faidon Magkos, Antonio Vidal-Puig, Raymond CS Seet, Chin Meng Khoo, Sue-Anne Toh
Oct 09, 2020
Background: Oxidative stress induced by nutritional overload has been linked to the pathogenesis of insulin resistance, which is associated with metabolic syndrome, obesity, type 2 diabetes and diabetic vascular complications....
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion.
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond CS Seet, Sue-Anne Toh
Oct 08, 2020
INTRODUCTION AND OBJECTIVE: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond C S Seet, Sue-Anne Toh
Mar 14, 2020
INTRODUCTION AND OBJECTIVE:Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Oxidative Stress Adipocytes Inflammation mononuclear cells myotubes family history of type 2 diabetes
Published by: BMJ open diabetes research & care
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.
Ferdinand von Meyenn, Mario Iurlaro, Ehsan Habibi, Ning Qing Liu, Ali Salehzadeh-Yazdi, Fátima Santos, Edoardo Petrini, Inês Milagre, Miao Yu, Zhenqing Xie, Leonie I Kroeze, Tatyana B Nesterova, Joop H Jansen, Hehuang Xie, Chuan He, Wolf Reik, Hendrik G Stunnenberg
Jun 24, 2019
Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hypomethylated ones (serum-to-2i) is a...
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond C S Seet, Sue-Anne Toh
Feb 10, 2020
Introduction and objective: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew JS Furness, Kevin Litchfield, Kroopa Joshi, Rachel Rosenthal, Ehsan Ghorani, Isabelle Solomon, Marta H Lesko, Nora Ruef, Claire Roddie, Jake Y Henry, Lavinia Spain, Assma Ben Aissa, Andrew Georgiou, Yien Ning Sophia Wong, Myles Smith, Dirk Strauss, Andrew Hayes, David Nicol, Tim O'Brien, Linda Mårtensson, Anne Ljungars, Ingrid Teige, Björn Frendéus, TRACERx Melanoma, TRACERx Renal, TRACERx Lung consortia, Martin Pule, Teresa Marafioti, Martin Gore, James Larkin, Samra Turajlic, Charles Swanton, Karl S Peggs, Sergio A Quezada
Jun 29, 2018
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo...
CTLA-4 Fc-gamma receptors IgG subclass antibody-dependent cell-mediated cytotoxicity immune checkpoints immune regulatory antibodies ipilimumab regulatory T cell depletion tremelimumab tumor immunotherapy Animals Antibodies Monoclonal Antibodies Monoclonal Humanized Antineoplastic Agents Immunological CTLA-4 Antigen Cell Line Tumor Female Humans Ipilimumab Melanoma Mice Polymorphism Single Nucleotide Receptors IgG T-Lymphocytes Regulatory Treatment Outcome Xenograft Model Antitumor Assays
Cell-type specialization is encoded by specific chromatin topologies.
Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, Luna Zea-Redondo, Dominik Szabó, Mandy Meijer, Leonid Serebreni, Yingnan Zhang, Simona Bianco, Andrea M Chiariello, Ibai Irastorza-Azcarate, Christoph J Thieme, Thomas M Sparks, Sílvia Carvalho, Luca Fiorillo, Francesco Musella, Ehsan Irani, Elena Torlai Triglia, Aleksandra A Kolodziejczyk, Andreas Abentung, Galina Apostolova, Eleanor J Paul, Vedran Franke, Rieke Kempfer, Altuna Akalin, Sarah A Teichmann, Georg Dechant, Mark A Ungless, Mario Nicodemi, Lonnie Welch, Gonçalo Castelo-Branco, Ana Pombo
Jan 07, 2022
The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems such...
Cell-type specialization is encoded by specific chromatin topologies.
Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, Luna Zea-Redondo, Dominik Szabó, Mandy Meijer, Leonid Serebreni, Yingnan Zhang, Simona Bianco, Andrea M Chiariello, Ibai Irastorza-Azcarate, Christoph J Thieme, Thomas M Sparks, Sílvia Carvalho, Luca Fiorillo, Francesco Musella, Ehsan Irani, Elena Torlai Triglia, Aleksandra A Kolodziejczyk, Andreas Abentung, Galina Apostolova, Eleanor J Paul, Vedran Franke, Rieke Kempfer, Altuna Akalin, Sarah Teichmann, Georg Dechant, Mark A Ungless, Mario Nicodemi, Lonnie Welch, Gonçalo Castelo-Branco, Ana Pombo
Nov 24, 2021
The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems such...
Battle of the Attack Detection Algorithms
Riccardo Taormina, Stefano Galelli, Nils Ole Tippenhauer, Elad Salomons, Avi Ostfeld, Demetrios G. Eliades, Mohsen Aghashahi, Raanju Sundararajan, Mohsen Pourahmadi, M. Katherine Banks, B. M. Brentan, Enrique Campbell, G. Lima, D. Manzi, D. Ayala-Cabrera, M. Herrera, I. Montalvo, J. Izquierdo, E. Luvizotto, Sarin E. Chandy, Amin Rasekh, Zachary A. Barker, Bruce Campbell, M. Ehsan Shafiee, Marcio Giacomoni, Nikolaos Gatsis, Ahmad Taha, Ahmed A. Abokifa, Kelsey Haddad, Cynthia S. Lo, Pratim Biswas, M. Fayzul, Bijay Kc, Saravanakumar Lakshmanan Somasundaram, Mashor Housh, Ziv Ohar
Aug 01, 2018
The BATtle of the Attack Detection ALgorithms (BATADAL) is the most recent competition on planning and management of water networks undertaken within the Water Distribution Systems Analysis Symposium. The goal of the battle...
Battle of the Attack Detection Algorithms
Riccardo Taormina, Stefano Galelli, Nils Ole Tippenhauer, Elad Salomons, Avi Ostfeld, Demetrios G. Eliades, Mohsen Aghashahi, Raanju Sundararajan, Mohsen Pourahmadi, M. Katherine Banks, B. M. Brentan, Enrique Campbell, G. Lima, D. Manzi, D. Ayala-Cabrera, M. Herrera, I. Montalvo, J. Izquierdo, E. Luvizotto, Sarin E. Chandy, Amin Rasekh, Zachary A. Barker, Bruce Campbell, M. Ehsan Shafiee, Marcio Giacomoni, Nikolaos Gatsis, Ahmad Taha, Ahmed A. Abokifa, Kelsey Haddad, Cynthia S. Lo, Pratim Biswas, M. Fayzul, Bijay Kc, Saravanakumar Lakshmanan Somasundaram, Mashor Housh, Ziv Ohar
Aug 01, 2018
The BATtle of the Attack Detection ALgorithms (BATADAL) is the most recent competition on planning and management of water networks undertaken within the Water Distribution Systems Analysis Symposium. The goal of the battle...
Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils.
Luigi Grassi, Farzin Pourfarzad, Sebastian Ullrich, Angelika Merkel, Felipe Were, Enrique Carrillo-de-Santa-Pau, Guoqiang Yi, Ida H Hiemstra, Anton TJ Tool, Erik Mul, Juliane Perner, Eva Janssen-Megens, Kim Berentsen, Hinri Kerstens, Ehsan Habibi, Marta Gut, Marie Laure Yaspo, Matthias Linser, Ernesto Lowy, Avik Datta, Laura Clarke, Paul Flicek, Martin Vingron, Dirk Roos, Timo K van den Berg, Simon Heath, Daniel Rico, Mattia Frontini, Myrto Kostadima, Ivo Gut, Alfonso Valencia, Willem H Ouwehand, Hendrik G Stunnenberg, Joost HA Martens, Taco W Kuijpers
Nov 22, 2018
Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important...
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.
Qiao Fan, Alfred Pozarickij, Nicholas YQ Tan, Xiaobo Guo, Virginie JM Verhoeven, Veronique Vitart, Jeremy A Guggenheim, Masahiro Miyake, J Willem L Tideman, Anthony P Khawaja, Liang Zhang, Stuart MacGregor, René Höhn, Peng Chen, Ginevra Biino, Juho Wedenoja, Seyed Ehsan Saffari, Milly S Tedja, Jing Xie, Carla Lanca, Ya Xing Wang, Srujana Sahebjada, Johanna Mazur, Alireza Mirshahi, Nicholas G Martin, Seyhan Yazar, Craig E Pennell, Maurice Yap, Annechien EG Haarman, Clair A Enthoven, JanRoelof Polling, Consortium for Refractive Error and Myopia (CREAM), UK Biobank Eye and Vision Consortium, Alex W Hewitt, Vincent WV Jaddoe, Cornelia M van Duijn, Caroline Hayward, Ozren Polasek, E-Shyong Tai, Hosoda Yoshikatsu, Pirro G Hysi, Terri L Young, Akitaka Tsujikawa, Jie Jing Wang, Paul Mitchell, Norbert Pfeiffer, Olavi Pärssinen, Paul J Foster, Maurizio Fossarello, Shea Ping Yip, Cathy Williams, Christopher J Hammond, Jost B Jonas, Mingguang He, David A Mackey, Tien-Yin Wong, Caroline CW Klaver, Seang-Mei Saw, Paul N Baird, Ching-Yu Cheng
Mar 19, 2021
Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in...
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.
Lewis Au, Emine Hatipoglu, Marc Robert de Massy, Kevin Litchfield, Gordon Beattie, Andrew Rowan, Desiree Schnidrig, Rachael Thompson, Fiona Byrne, Stuart Horswell, Nicos Fotiadis, Steve Hazell, David Nicol, Scott TC Shepherd, Annika Fendler, Robert Mason, Lyra Del Rosario, Kim Edmonds, Karla Lingard, Sarah Sarker, Mary Mangwende, Eleanor Carlyle, Jan Attig, Kroopa Joshi, Imran Uddin, Pablo D Becker, Mariana Werner Sunderland, Ayse Akarca, Ignazio Puccio, William W Yang, Tom Lund, Kim Dhillon, Marcos Duran Vasquez, Ehsan Ghorani, Hang Xu, Charlotte Spencer, José I López, Anna Green, Ula Mahadeva, Elaine Borg, Miriam Mitchison, David A Moore, Ian Proctor, Mary Falzon, Lisa Pickering, Andrew JS Furness, James L Reading, Roberto Salgado, Teresa Marafioti, Mariam Jamal-Hanjani, PEACE consortium, George Kassiotis, Benny Chain, James Larkin, Charles Swanton, Sergio A Quezada, Samra Turajlic, TRACERx Renal Consortium
Nov 02, 2021
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism...
T cell receptor TCR clonal maintenance TCR clonal replacement Anti-PD-1 Autopsy clear cell renal cell carcinoma human endogenous retrovirus multiregion Nivolumab CD8-Positive T-Lymphocytes Carcinoma Renal Cell Clinical Trials Phase II as Topic Drug Resistance Neoplasm endogenous retroviruses Gene Expression Profiling Genomics Humans Immune Checkpoint Inhibitors Kidney Neoplasms Nivolumab Prospective Studies Receptors Antigen T-Cell Sequence Analysis RNA Single-Cell Analysis Tumor Escape Tumor Microenvironment Exome Sequencing
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