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Results: 8126
Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.
Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L Auer, Matthias W Beckmann, Amanda Black, Louise Brinton, Daniel D Buchanan, Stephen J Chanock, Chu Chen, Maxine M Chen, Timothy Ht Cheng, Linda S Cook, Marta Crous-Bous, Kamila Czene, Immaculata De Vivo, Joe Dennis, Thilo Dörk, Sean C Dowdy, Alison M Dunning, Matthias Dürst, Douglas F Easton, Arif B Ekici, Peter A Fasching, Brooke L Fridley, Christine M Friedenreich, Montserrat García-Closas, Mia M Gaudet, Graham G Giles, Ellen L Goode, Maggie Gorman, Christopher A Haiman, Per Hall, Susan E Hankinson, Alexander Hein, Peter Hillemanns, Shirley Hodgson, Erling A Hoivik, Elizabeth G Holliday, David J Hunter, Angela Jones, Peter Kraft, Camilla Krakstad, Diether Lambrechts, Loic Le Marchand, Xiaolin Liang, Annika Lindblom, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M Magliocco, Lynn Martin, Mark McEvoy, Roger L Milne, Miriam Mints, Rami Nassir, Geoffrey Otton, Claire Palles, Loreall Pooler, Tony Proietto, Timothy R Rebbeck, Stefan P Renner, Harvey A Risch, Matthias Rübner, Ingo Runnebaum, Carlotta Sacerdote, Gloria E Sarto, Fredrick Schumacher, Rodney J Scott, V Wendy Setiawan, Mitul Shah, Xin Sheng, Xiao-Ou Shu, Melissa C Southey, Emma Tham, Ian Tomlinson, Jone Trovik, Constance Turman, Jonathan P Tyrer, David Van Den Berg, Zhaoming Wang, Nicolas Wentzensen, Lucy Xia, Yong-Bing Xiang, Hannah P Yang, Herbert Yu, Wei Zheng, Penelope M Webb, Deborah J Thompson, Amanda B Spurdle, Dylan M Glubb, Tracy A O'Mara
Sep 23, 2020
Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood...
Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium.
Pooja Middha Kapoor, Sara Lindström, Sabine Behrens, Xiaoliang Wang, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Alison M Dunning, Paul DP Pharoah, Marjanka K Schmidt, Peter Kraft, Montserrat García-Closas, Douglas F Easton, Roger L Milne, Jenny Chang-Claude, Breast Cancer Association Consortium
Sep 04, 2019
BACKGROUND: Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest available dataset to date, we performed a comprehensive assessment of potential...
Europeans Gene-Environment Interaction Breast Cancer EPIDEMIOLOGY Risk Factors single nucleotide polymorphism Alleles Breast Neoplasms Case-Control Studies Europe Factor XIII Female Gene-Environment Interaction Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Polymorphism Single Nucleotide Receptors Estrogen Risk Factors White People
Genetically predicted circulating protein biomarkers and ovarian cancer risk.
Daniel PC Considine, Guochong Jia, Xiang Shu, Joellen M Schildkraut, Paul DP Pharoah, Wei Zheng, Siddhartha P Kar, Ovarian Cancer Association Consortium
Dec 10, 2020
OBJECTIVE: Most women with epithelial ovarian cancer (EOC) are diagnosed after the disease has metastasized and survival in this group remains poor. Circulating proteins associated with the risk of developing EOC have the...
circulating biomarkers Circulating proteins epithelial ovarian cancer Genome-Wide Association Study risk Biomarkers Tumor Carcinoma Ovarian Epithelial Case-Control Studies England Female Genetic Predisposition to Disease Genome-Wide Association Study Germ-Line Mutation Healthy Volunteers Humans Neoplasm Invasiveness Ovarian Neoplasms Polymorphism Single Nucleotide Risk Assessment
Genetic overlap between endometriosis and endometrial cancer
Jodie N Painter, Tracy A O'Mara, Andrew P Morris, Timothy Ht Cheng, Maggie Gorman, Lynn Martin, Shirley Hodson, Angela Jones, Nicholas G Martin, Scott Gordon, Anjali K Henders, John Attia, Mark McEvoy, Elizabeth G Holliday, Rodney J Scott, Penelope M Webb, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein, Matthias Rübner, Per Hall, Kamila Czene, Thilo Dörk, Matthias Dürst, Peter Hillemanns, Ingo Runnebaum, Diether Lambrechts, Frederic Amant, Daniela Annibali, Jeroen Depreeuw, Adriaan Vanderstichele, Ellen L Goode, Julie M Cunningham, Sean C Dowdy, Stacey J Winham, Jone Trovik, Erling Hoivik, Henrica MJ Werner, Camilla Krakstad, Katie Ashton, Geoffrey Otton, Tony Proietto, Emma Tham, Miriam Mints, Shahana Ahmed, Catherine S Healey, Mitul Shah, Paul DP Pharoah, Alison M Dunning, Joe Dennis, Manjeet K Bolla, Kyriaki Michailidou, Qin Wang, Jonathan P Tyrer, John L Hopper, Julian Peto, Anthony J Swerdlow, Barbara Burwinkel, Hermann Brenner, Alfons Meindl, Hiltrud Brauch, Annika Lindblom, Jenny Chang-Claude, Fergus J Couch, Graham G Giles, Vessela N Kristensen, Angela Cox, Krina T Zondervan, Dale R Nyholt, Stuart MacGregor, Grant W Montgomery, Ian Tomlinson, Douglas F Easton, Deborah J Thompson, Amanda B Spurdle
May 30, 2018
Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis...
Cross-disease analysis endometrial cancer endometriosis genetic correlation Genome-Wide Association Study Australia Endometrial Neoplasms endometriosis Endometrium Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Polymorphism Single Nucleotide Receptor-Like Protein Tyrosine Phosphatases Class 2 STAT3 Transcription Factor
Associations of obesity and circulating insulin and glucose with breast cancer risk
Xiang Shu, Lang Wu, Nikhil K Khankari, Xiao-Ou Shu, Thomas J Wang, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Roger L Milne, Marjanka K Schmidt, Paul DP Pharoah, Irene L Andrulis, David J Hunter, Jacques Simard, Douglas F Easton, Wei Zheng, Breast Cancer Association Consortium
Jul 29, 2019
BACKGROUND: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy....
Pan-cancer analysis of whole genomes.
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of...
Cell Proliferation Cellular Senescence Chromothripsis Cloud Computing DNA Mutational Analysis evolution Molecular Female Genome Human Genomics Germ-Line Mutation High-Throughput Nucleotide Sequencing Humans Information Dissemination Male Mutagenesis Mutation Neoplasms Oncogenes Promoter Regions Genetic RNA Splicing Reproducibility of Results Telomerase Telomere
Assessing the role of cortisol in cancer
BACKGROUND: Cortisol's immunosuppressive, obesogenic, and hyperglycaemic effects suggest that it may play a role in cancer development. However, whether cortisol increases cancer risk is not known. We investigated the potential...
A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes.
Sally Mortlock, Rosario I Corona, Pik Fang Kho, Paul Pharoah, Ji-Heui Seo, Matthew L Freedman, Simon A Gayther, Matthew T Siedhoff, Peter AW Rogers, Ronald Leuchter, Christine S Walsh, Ilana Cass, Beth Y Karlan, BJ Rimel, International Endometriosis Genetics Consortium Ovarian Cancer Association Consortium, Grant W Montgomery, Kate Lawrenson, Siddhartha P Kar
Jun 07, 2022
Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using data from large endometriosis and EOC genome-wide association meta-analyses, we estimate the genetic correlation and evaluate the causal...
Breast Cancer Risk Factors and Survival by Tumor Subtype
Anna Morra, Audrey Y Jung, Sabine Behrens, Renske Keeman, Thomas U Ahearn, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Päivi K Auvinen, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Hermann Brenner, Ignacio Briceno, Sara Y Brucker, Nicola J Camp, Daniele Campa, Federico Canzian, Jose E Castelao, Stephen J Chanock, Ji-Yeob Choi, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Thilo Dörk, Alison M Dunning, Miriam Dwek, Douglas F Easton, Diana M Eccles, Kathleen M Egan, D Gareth Evans, Peter A Fasching, Henrik Flyger, Manuela Gago-Dominguez, Susan M Gapstur, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Mervi Grip, Pascal Guénel, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny N Han, Steven N Hart, Mikael Hartman, Jane S Heyworth, Reiner Hoppe, John L Hopper, David J Hunter, Hidemi Ito, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Rudolf Kaaks, Daehee Kang, Pooja Middha Kapoor, Cari M Kitahara, Stella Koutros, Peter Kraft, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Jan Lubiński, Michael Lush, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Shivaani Mariapun, Keitaro Matsuo, Dimitrios Mavroudis, Roger L Milne, Taru A Muranen, William G Newman, Dong-Young Noh, Børge G Nordestgaard, Nadia Obi, Andrew F Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Christos Petridis, Paul DP Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Muhammad U Rashid, Gad Rennert, Hedy S Rennert, Valerie Rhenius, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Andreas Schneeweiss, Lukas Schwentner, Christopher Scott, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Melissa C Southey, Daniel O Stram, Rulla M Tamimi, William Tapper, Rob AEM Tollenaar, Ian Tomlinson, Diana Torres, Melissa A Troester, Thérèse Truong, Celine M Vachon, Qin Wang, Sophia S Wang, Justin A Williams, Robert Winqvist, Alicja Wolk, Anna H Wu, Keun-Young Yoo, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Xiaohong R Yang, A Heather Eliassen, Michelle D Holmes, Montserrat García-Closas, Soo Hwang Teo, Marjanka K Schmidt, Jenny Chang-Claude, ABCTB Investigators, NBCS Collaborators
Feb 16, 2021
BACKGROUND: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in...
Height, selected genetic markers and prostate cancer risk
Artitaya Lophatananon, Sarah Stewart-Brown, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Liesel M Fitzgerald, Melissa C Southey, Paul Pharoah, Nora Pashayan, Henrik Gronberg, Fredrik Wiklund, Markus Aly, Janet L Stanford, Hermann Brenner, Aida K Dieffenbach, Volker Arndt, Jong Y Park, Hui-Yi Lin, Thomas Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Amanda Spurdle, Judith A Clements, APCB BioResource, PRACTICAL Consortium, Douglas Easton, Rosalind A Eeles, Kenneth Muir
Dec 08, 2017
BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed data...
Evidence of a Causal Association Between Insulinemia and Endometrial Cancer
Kevin T Nead, Stephen J Sharp, Deborah J Thompson, Jodie N Painter, David B Savage, Robert K Semple, Adam Barker, Australian National Endometrial Cancer Study Group (ANECS), John RB Perry, John Attia, Alison M Dunning, Douglas F Easton, Elizabeth Holliday, Luca A Lotta, Tracy O'Mara, Mark McEvoy, Paul DP Pharoah, Rodney J Scott, Amanda B Spurdle, Claudia Langenberg, Nicholas J Wareham, Robert A Scott
Jun 19, 2015
chromMAGMA
Robbin Nameki, Anamay Shetty, Eileen Dareng, Jonathan Tyrer, Xianzhi Lin, Ovarian Cancer Association Consortium, Paul Pharoah, Rosario I Corona, Siddhartha Kar, Kate Lawrenson
Aug 01, 2022
Candidate causal risk variants from genome-wide association studies reside almost exclusively in noncoding regions of the genome and innovative approaches are necessary to understand their biological function. Multi-marker...
Patient survival and tumor characteristics associated with CHEK2
Taru A Muranen, Carl Blomqvist, Thilo Dörk, Anna Jakubowska, Päivi Heikkilä, Rainer Fagerholm, Dario Greco, Kristiina Aittomäki, Stig E Bojesen, Mitul Shah, Alison M Dunning, Valerie Rhenius, Per Hall, Kamila Czene, Judith S Brand, Hatef Darabi, Jenny Chang-Claude, Anja Rudolph, Børge G Nordestgaard, Fergus J Couch, Steven N Hart, Jonine Figueroa, Montserrat García-Closas, Peter A Fasching, Matthias W Beckmann, Jingmei Li, Jianjun Liu, Irene L Andrulis, Robert Winqvist, Katri Pylkäs, Arto Mannermaa, Vesa Kataja, Annika Lindblom, Sara Margolin, Jan Lubinski, Natalia Dubrowinskaja, Manjeet K Bolla, Joe Dennis, Kyriaki Michailidou, Qin Wang, Douglas F Easton, Paul D P Pharoah, Marjanka K Schmidt, Heli Nevanlinna
Dec 16, 2016
Abstract
Background
P.I157T is a CHEK2 missense mutation associated with a modest increase in breast cancer risk. Previously, another CHEK2 mutation, the protein truncating...
Fine-mapping the HOXB region detects common variants tagging a rare coding allele
Edward J Saunders, Tokhir Dadaev, Daniel A Leongamornlert, Sarah Jugurnauth-Little, Malgorzata Tymrakiewicz, Fredrik Wiklund, Ali Amin Al Olama, Sara Benlloch, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Gianluca Severi, Henrik Gronberg, Markus Aly, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Børge G Nordestgaard, Federico Canzian, Daniele Campa, Elio Riboli, Tim J Key, Ruth C Travis, Sue A Ingles, Esther M John, Richard B Hayes, Paul Pharoah, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Daniel Schaid, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Judith A Clements, Manuel R Teixeira, Jianfeng Xu, Christos Mikropoulos, Chee Goh, Koveela Govindasami, Michelle Guy, Rosemary A Wilkinson, Emma J Sawyer, Angela Morgan, COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative, UK Genetic Prostate Cancer Study Collaborators, UK ProtecT Study Collaborators, PRACTICAL Consortium, Douglas F Easton, Ken Muir, Rosalind A Eeles, Zsofia Kote-Jarai
Sep 10, 2018
The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the HOXB...
Endometrial Cancer Arising in Adenomyosis (EC-AIA)
Antonio Raffone, Diego Raimondo, Manuela Maletta, Antonio Travaglino, Federica Renzulli, Daniele Neola, Umberto De Laurentiis, Francesco De Laurentiis, Mohamed Mabrouk, Manuel Maria Ianieri, Renato Seracchioli, Paolo Casadio, Antonio Mollo
Mar 28, 2023
Endometrial cancer arising in adenomyosis (EC-AIA) is a rare uterine disease characterized by the malignant transformation of the ectopic endometrium within the adenomyotic foci. Clinicopathological and survival data are mostly...
Published by: Cancers
Polyunsaturated fatty acids and prostate cancer risk
Nikhil K Khankari, Harvey J Murff, Chenjie Zeng, Wanqing Wen, Rosalind A Eeles, Douglas F Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Jenny L Donovan, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Wei Zheng, PRACTICAL Consortium
Dec 01, 2017
BACKGROUND: Prostate cancer is a common cancer worldwide with no established modifiable lifestyle factors to guide prevention. The associations between polyunsaturated fatty acids (PUFAs) and prostate cancer risk have been...
Genetic predisposition to mosaic Y chromosome loss in blood.
Deborah J Thompson, Giulio Genovese, Jonatan Halvardson, Jacob C Ulirsch, Daniel J Wright, Chikashi Terao, Olafur B Davidsson, Felix R Day, Patrick Sulem, Yunxuan Jiang, Marcus Danielsson, Hanna Davies, Joe Dennis, Malcolm G Dunlop, Douglas F Easton, Victoria A Fisher, Florian Zink, Richard S Houlston, Martin Ingelsson, Siddhartha Kar, Nicola D Kerrison, Ben Kinnersley, Ragnar P Kristjansson, Philip J Law, Rong Li, Chey Loveday, Jonas Mattisson, Steven A McCarroll, Yoshinori Murakami, Anna Murray, Pawel Olszewski, Edyta Rychlicka-Buniowska, Robert A Scott, Unnur Thorsteinsdottir, Ian Tomlinson, Behrooz Torabi Moghadam, Clare Turnbull, Nicholas J Wareham, Daniel F Gudbjartsson, International Lung Cancer Consortium (INTEGRAL-ILCCO), Breast Cancer Association Consortium, Consortium of Investigators of Modifiers of BRCA1/2, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium, Kidney Cancer GWAS Meta-Analysis Project, eQTLGen Consortium, Biobank-based Integrative Omics Study (BIOS) Consortium, 23andMe Research Team, Yoichiro Kamatani, Eva R Hoffmann, Steve P Jackson, Kari Stefansson, Adam Auton, Ken K Ong, Mitchell J Machiela, Po-Ru Loh, Jan P Dumanski, Stephen J Chanock, Lars A Forsberg, John RB Perry
Aug 06, 2019
Identification of novel epithelial ovarian cancer loci in women of African ancestry.
Ani Manichaikul, Lauren C Peres, Xin-Qun Wang, Mollie E Barnard, Deanna Chyn, Xin Sheng, Zhaohui Du, Jonathan Tyrer, Joseph Dennis, Ann G Schwartz, Michele L Cote, Edward Peters, Patricia G Moorman, Melissa Bondy, Jill S Barnholtz-Sloan, Paul Terry, Anthony J Alberg, Elisa V Bandera, Ellen Funkhouser, Anna H Wu, Celeste Leigh Pearce, Malcom Pike, Veronica Wendy Setiawan, Christopher A Haiman, African American Breast Cancer Consortium (AABC), African Ancestry Prostate Cancer Consortium (AAPC), Julie R Palmer, Loic Lemarchand, Lynne R Wilkens, Andrew Berchuck, Jennifer A Doherty, Francesmary Modugno, Roberta Ness, Kirsten Moysich, Beth Y Karlan, Alice S Whittemore, Valerie McGuire, Weiva Sieh, Kate Lawrenson, Simon Gayther, Thomas A Sellers, Paul Pharoah, Joellen M Schildkraut, African American Cancer Epidemiology Study (AACES) and the Ovarian Cancer Association Consortium (OCAC)
Aug 20, 2019
Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC...
African ancestry eQTLs Gene Expression Genome wide association study ovarian cancer Black or African American Aldo-Keto Reductase Family 1 Member C3 Antigens Neoplasm Black People Breast Neoplasms Carcinoma Ovarian Epithelial Female Follistatin Genetic Predisposition to Disease Genome-Wide Association Study Humans Neoplasm Proteins Polymorphism Single Nucleotide United States White People
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma.
Thanos P Mourikis, Lorena Benedetti, Elizabeth Foxall, Damjan Temelkovski, Joel Nulsen, Juliane Perner, Matteo Cereda, Jesper Lagergren, Michael Howell, Christopher Yau, Rebecca C Fitzgerald, Paola Scaffidi, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Francesca D Ciccarelli
Sep 09, 2019
The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to...
Adenocarcinoma Antineoplastic Agents Biomarkers Tumor Computational Biology Datasets as Topic Disease Progression Esophageal Neoplasms Gene Dosage Gene Expression Profiling Gene Expression Regulation Neoplastic Genomic Instability Humans Machine Learning Models Genetic Multigene Family Mutation Rate Polymorphism Single Nucleotide Precision Medicine
In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer.
UNLABELLED: Fenofibrate, an agonist of PPAR-alpha, in doses above 25 microM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are potentiated by retinoic acid, an...
Animals Antineoplastic Agents Apoptosis Cell Line Tumor Cell Proliferation Cyclin D1 Dose-Response Relationship Drug Endometrial Neoplasms Female Fenofibrate Gene Expression Profiling Gene Expression Regulation Humans Methionine Adenosyltransferase Mice Mice Nude Neoplasm Transplantation Oligonucleotide Array Sequence Analysis PPAR alpha RNA Interference RNA Messenger Tretinoin
Annexin A1 expression in a pooled breast cancer series
Marcelo Sobral-Leite, Jelle Wesseling, Vincent T H B M Smit, Heli Nevanlinna, Martine H van Miltenburg, Joyce Sanders, Ingrid Hofland, Fiona M Blows, Penny Coulson, Gazinska Patrycja, Jan H M Schellens, Rainer Fagerholm, Päivi Heikkilä, Kristiina Aittomäki, Carl Blomqvist, Elena Provenzano, Hamid R Ali, Jonine Figueroa, Mark Sherman, Jolanta Lissowska, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Kelly-Anne Phillips, Fergus J Couch, Janet E Olson, Celine Vachon, Daniel Visscher, Hermann Brenner, Katja Butterbach, Volker Arndt, Bernd Holleczek, Maartje J Hooning, Antoinette Hollestelle, John W. M. Martens, Carolien H M van Deurzen, Bob van de Water, Annegien Broeks, Jenny Chang-Claude, Georgia Chenevix-Trench, Douglas F Easton, Paul D P Pharoah, Montserrat García-Closas, Marjo de Graauw, Marjanka K Schmidt
Sep 29, 2016
Abstract
Background
Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic...
Adult height is associated with increased risk of ovarian cancer
Suzanne C Dixon-Suen, Christina M Nagle, Aaron P Thrift, Paul DP Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Australian Ovarian Cancer Study Group, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Sandrina Lambrechts, Els Van Nieuwenhuysen, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Jenny Chang-Claude, Audrey Y Jung, Kirsten B Moysich, Kunle Odunsi, Marc T Goodman, Lynne R Wilkens, Pamela J Thompson, Yurii B Shvetsov, Thilo Dörk, Tjoung-Won Park-Simon, Peter Hillemanns, Natalia Bogdanova, Ralf Butzow, Heli Nevanlinna, Liisa M Pelttari, Arto Leminen, Francesmary Modugno, Roberta B Ness, Robert P Edwards, Joseph L Kelley, Florian Heitz, Andreas du Bois, Philipp Harter, Ira Schwaab, Beth Y Karlan, Jenny Lester, Sandra Orsulic, Bobbie J Rimel, Susanne K Kjaer, Estrid Høgdall, Allan Jensen, Ellen L Goode, Brooke L Fridley, Julie M Cunningham, Stacey J Winham, Graham G Giles, Fiona Bruinsma, Roger L Milne, Melissa C Southey, Michelle AT Hildebrandt, Xifeng Wu, Karen H Lu, Dong Liang, Douglas A Levine, Maria Bisogna, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Elisa V Bandera, Sara H Olson, Helga B Salvesen, Liv Cecilie Vestrheim Thomsen, Reidun K Kopperud, Line Bjorge, Lambertus A Kiemeney, Leon FAG Massuger, Tanja Pejovic, Amanda Bruegl, Linda S Cook, Nhu D Le, Kenneth D Swenerton, Angela Brooks-Wilson, Linda E Kelemen, Jan Lubiński, Tomasz Huzarski, Jacek Gronwald, Janusz Menkiszak, Nicolas Wentzensen, Louise Brinton, Hannah Yang, Jolanta Lissowska, Claus K Høgdall, Lene Lundvall, Honglin Song, Jonathan P Tyrer, Ian Campbell, Diana Eccles, James Paul, Rosalind Glasspool, Nadeem Siddiqui, Alice S Whittemore, Weiva Sieh, Valerie McGuire, Joseph H Rothstein, Steven A Narod, Catherine Phelan, Harvey A Risch, John R McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Anna H Wu, Malcolm C Pike, Chiu-Chen Tseng, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Agnieszka Budzilowska, Iwona K Rzepecka, Penelope M Webb, Ovarian Cancer Association Consortium
May 23, 2018
BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence...
The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.
Melissa A Buckley, Nicholas T Woods, Jonathan P Tyrer, Gustavo Mendoza-Fandiño, Kate Lawrenson, Dennis J Hazelett, Hamed S Najafabadi, Anxhela Gjyshi, Renato S Carvalho, Paulo C Lyra, Simon G Coetzee, Howard C Shen, Ally W Yang, Madalene A Earp, Sean J Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J Ramus, Catherine M Phelan, Gerhard A Coetzee, Houtan Noushmehr, Timothy R Hughes, Thomas A Sellers, Ellen L Goode, Paul D Pharoah, Simon A Gayther, Alvaro NA Monteiro, Ovarian Cancer Association Consortium
Dec 18, 2018
Genome-wide association studies have identified 40 ovarian cancer risk loci. However, the mechanisms underlying these associations remain elusive. In this study, we conducted a two-pronged approach to identify candidate causal...
Base Sequence Carcinoma Ovarian Epithelial Cell Cycle Proteins Cell Line Tumor Chromosome Mapping Chromosomes Human Pair 9 Cystadenocarcinoma Serous DNA Neoplasm DNA-Binding Proteins Female Genetic Predisposition to Disease Genome-Wide Association Study HEK293 Cells Humans Linkage Disequilibrium Ovarian Neoplasms Polymorphism Single Nucleotide
Circulating Selenium and Prostate Cancer Risk
James Yarmolinsky, Carolina Bonilla, Philip C Haycock, Ryan JQ Langdon, Luca A Lotta, Claudia Langenberg, Caroline L Relton, Sarah J Lewis, David M Evans, PRACTICAL Consortium, George Davey Smith, Richard M Martin
Sep 18, 2018
In the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not lower overall prostate cancer risk, but increased risk of high-grade...
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