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Results: 25265
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults.
Differences in access to Emergency Paediatric Intensive Care and care during Transport (DEPICT)
Padmanabhan Ramnarayan, Ruth Evans, Elizabeth S Draper, Sarah E Seaton, Jo Wray, Stephen Morris, Christina Pagel, DEPICT Study Investigators
Nov 17, 2020
INTRODUCTION: Following centralisation of UK paediatric intensive care, specialist retrieval teams were established who travel to general hospitals to stabilise and transport sick children to regional paediatric intensive care...
Toward a global and reproducible science for brain imaging in neurotrauma
Alexander Olsen, Talin Babikian, Erin D. Bigler, Karen Caeyenberghs, Virginia Conde, Kristen Dams-O’Connor, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta K. Håberg, Ingrid Heggland, Torgeir Hellstrøm, Cooper B. Hodges, Andrei Irimia, Ruchira M. Jha, Paula K. Johnson, Vassilis E. Koliatsos, Harvey Levin, Lucia M. Li, Hannah M. Lindsey, Abigail Livny, Marianne Løvstad, John Medaglia, David K. Menon, Stefania Mondello, Martin M. Monti, Virginia F.J. Newcombe, Agustin Petroni, Jennie Ponsford, David Sharp, Gershon Spitz, Lars T. Westlye, Paul M. Thompson, Emily L. Dennis, David F. Tate, Elisabeth A. Wilde, Frank G. Hillary
Aug 14, 2021
Abstract: The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a...
Toward a global and reproducible science for brain imaging in neurotrauma
Alexander Olsen, Talin Babikian, Erin D. Bigler, Karen Caeyenberghs, Virginia Conde, Kristen Dams-O’Connor, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta K. Håberg, Ingrid Heggland, Torgeir Hellstrøm, Cooper B. Hodges, Andrei Irimia, Ruchira M. Jha, Paula K. Johnson, Vassilis E. Koliatsos, Harvey Levin, Lucia M. Li, Hannah M. Lindsey, Abigail Livny, Marianne Løvstad, John Medaglia, David K. Menon, Stefania Mondello, Martin M. Monti, Virginia F.J. Newcombe, Agustin Petroni, Jennie Ponsford, David Sharp, Gershon Spitz, Lars T. Westlye, Paul M. Thompson, Emily L. Dennis, David F. Tate, Elisabeth A. Wilde, Frank G. Hillary
Apr 08, 2021
Abstract: The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a...
Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals
Sean R McWhinney, Katharina Brosch, Vince D Calhoun, Benedicto Crespo-Facorro, Nicolas A Crossley, Udo Dannlowski, Erin Dickie, Lorielle M F Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T J Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadić, Nils Opel, Julia-Katharina Pfarr, Amanda L Rodrigue, Kelly Rootes-Murdy, Alex J Ross, Kang Sim, Antonín Škoch, Filip Spaniel, Frederike Stein, Patrik Švancer, Diana Tordesillas-Gutiérrez, Juan Undurraga, Javier Váquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W Weickert, Cynthia Shannon Weickert, Paul M Thompson, Theo G M van Erp, Jessica A Turner, Tomas Hajek
Sep 30, 2022
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained...
Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.
Matthias Kirschner, Benazir Hodzic-Santor, Mathilde Antoniades, Igor Nenadic, Tilo Kircher, Axel Krug, Tina Meller, Dominik Grotegerd, Alex Fornito, Aurina Arnatkeviciute, Mark A Bellgrove, Jeggan Tiego, Udo Dannlowski, Katharina Koch, Carina Hülsmann, Harald Kugel, Verena Enneking, Melissa Klug, Elisabeth J Leehr, Joscha Böhnlein, Marius Gruber, David Mehler, Pamela DeRosse, Ashley Moyett, Bernhard T Baune, Melissa Green, Yann Quidé, Christos Pantelis, Raymond Chan, Yi Wang, Ulrich Ettinger, Martin Debbané, Melodie Derome, Christian Gaser, Bianca Besteher, Kelly Diederen, Tom J Spencer, Paul Fletcher, Wulf Rössler, Lukasz Smigielski, Veena Kumari, Preethi Premkumar, Haeme RP Park, Kristina Wiebels, Imke Lemmers-Jansen, James Gilleen, Paul Allen, Petya Kozhuharova, Jan-Bernard Marsman, Irina Lebedeva, Alexander Tomyshev, Anna Mukhorina, Stefan Kaiser, Anne-Kathrin Fett, Iris Sommer, Sanne Schuite-Koops, Casey Paquola, Sara Larivière, Boris Bernhardt, Alain Dagher, Phillip Grant, Theo GM van Erp, Jessica A Turner, Paul M Thompson, André Aleman, Gemma Modinos
Apr 29, 2022
Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be...
Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals
Sean R McWhinney, Katharina Brosch, Vince D Calhoun, Benedicto Crespo-Facorro, Nicolas A Crossley, Udo Dannlowski, Erin Dickie, Lorielle M F Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T J Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadić, Nils Opel, Julia-Katharina Pfarr, Amanda L Rodrigue, Kelly Rootes-Murdy, Alex J Ross, Kang Sim, Antonín Škoch, Filip Spaniel, Frederike Stein, Patrik Švancer, Diana Tordesillas-Gutiérrez, Juan Undurraga, Javier Váquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W Weickert, Cynthia Shannon Weickert, Paul M Thompson, Theo G M van Erp, Jessica A Turner, Tomas Hajek
Sep 30, 2022
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained...
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study.
David H Miller, Robert J Fox, J Theodore Phillips, Michael Hutchinson, Eva Havrdova, Mariko Kita, Claudia AM Wheeler-Kingshott, Daniel J Tozer, David G MacManus, Tarek A Yousry, Mary Goodsell, Minhua Yang, Ray Zhang, Vissia Viglietta, Katherine T Dawson, CONFIRM study investigators
Jun 22, 2018
OBJECTIVE: To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator...
Towards controlled terminology for reporting germline cancer susceptibility variants
Amanda B Spurdle, Stephanie Greville-Heygate, Antonis C Antoniou, Melissa Brown, Leslie Burke, Miguel de la Hoya, Susan Domchek, Thilo Dörk, Helen V Firth, Alvaro N Monteiro, Arjen Mensenkamp, Michael T Parsons, Paolo Radice, Mark Robson, Marc Tischkowitz, Emma Tudini, Clare Turnbull, Maaike PG Vreeswijk, Logan C Walker, Sean Tavtigian, Diana M Eccles
Feb 21, 2019
The vocabulary currently used to describe genetic variants and their consequences reflects many years of studying and discovering monogenic disease with high penetrance. With the recent rapid expansion of genetic testing brought...
cancer susceptibility genetic variant interpretation Reporting Vocabulary Biomarkers Tumor Computational Biology Gene Expression Profiling Genes BRCA1 Genes BRCA2 Genetic Predisposition to Disease genetic variation Germ-Line Mutation High-Throughput Nucleotide Sequencing Humans International Classification of Diseases Neoplasms Germ Cell and Embryonal Terminology as Topic Vocabulary Controlled
Accuracy of four lateral flow immunoassays for anti SARS-CoV-2 antibodies
Hayley Jones, Ranya Mulchandani, Sian Taylor-Phillips, AE Ades, Justin Shute, Keith Perry, Nastassya Chandra, Tim Brooks, Andre Charlett, Matthew Hickman, Isabel Oliver, Stephen Kaptoge, John Danesh, Emanuele Di Angelantonio, David Wyllie, COMPARE study investigators, EDSAB-HOME investigators
Jul 02, 2021
Background
SARS-CoV-2 antibody tests are used for population surveillance and might have a future role in individual risk assessment. Lateral flow immunoassays (LFIAs) can deliver results rapidly and at scale, but have...
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
External validation and recalibration of an incidental meningioma prognostic model - IMPACT
Abdurrahman I Islim, Christopher P Millward, Rory J Piper, Daniel M Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J Mills, Andrew R Brodbelt, Ryan K Mathew, Thomas Santarius, Michael D Jenkinson, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC) IMPACT Study Investigators
Feb 19, 2022
INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an...
External validation and recalibration of an incidental meningioma prognostic model - IMPACT
Abdurrahman I Islim, Christopher P Millward, Rory J Piper, Daniel M Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J Mills, Andrew R Brodbelt, Ryan K Mathew, Thomas Santarius, Michael D Jenkinson, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC) IMPACT Study Investigators
Jan 28, 2022
INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an...
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection
Hugh S Markus, Christopher Levi, Alice King, Jeremy Madigan, John Norris, Cervical Artery Dissection in Stroke Study (CADISS) Investigators
Mar 19, 2019
IMPORTANCE: Extracranial carotid and vertebral artery dissection is an important cause of stroke, particularly in younger individuals. In some but not all observational studies, it has been associated with a high risk of...
Adolescent Adult Aged Aged 80 and over Anticoagulants Aspirin Carotid Artery Internal Dissection Clopidogrel Dipyridamole Female Hemorrhage Heparin Humans Male Middle Aged Mortality Platelet Aggregation Inhibitors Recurrence Secondary Prevention stroke Treatment Outcome Vertebral Artery Dissection Warfarin Young Adult
Brain death and postmortem organ donation
Ernest van Veen, Mathieu van der Jagt, Maryse C Cnossen, Andrew IR Maas, Inez D de Beaufort, David K Menon, Giuseppe Citerio, Nino Stocchetti, Wim JR Rietdijk, Jeroen TJM van Dijck, Erwin JO Kompanje, CENTER-TBI Investigators and Participants
Apr 14, 2020
BACKGROUND: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. METHODS: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic...
Univariate comparison of performance of different cerebrovascular reactivity indices for outcome association in adult TBI
Dementia before death in ageing societies--the promise of prevention and the reality.
Carol Brayne, Lu Gao, Michael Dewey, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Study Investigators
Jul 10, 2018
BACKGROUND: Dementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions. Given population increases in longevity it is important to...
Relationship between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute Traumatic Brain Injury Patients
François Mathieu, Frederick A Zeiler, Ari Ercole, Miguel Monteiro, Konstantinos Kamnitsas, Ben Glocker, Daniel P Whitehouse, Tilak Das, Peter Smielewski, Marek Czosnyka, Peter J Hutchinson, Virginia FJ Newcombe, David K Menon, CENTER-TBI High Resolution Sub-Study Participants and Investigators
May 05, 2020
Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may...
cerebral autoregulation Intracranial hemorrhage Traumatic brain injury Adult Brain Injuries Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Disease Progression Europe Female Humans Intensive Care Units Intersectoral Collaboration Male Middle Aged Tomography X-Ray Computed Treatment Outcome
Descriptive analysis of low versus elevated intracranial pressure on cerebral physiology in adult traumatic brain injury
Frederick A Zeiler, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter J Hutchinson, Peter Smielewski, Marek Czosnyka, CENTER-TBI High Resolution (HR ICU) Sub-Study Participants and Investigators
Nov 11, 2020
BACKGROUND: To date, the cerebral physiologic consequences of persistently elevated intracranial pressure (ICP) have been based on either low-resolution physiologic data or retrospective high-frequency data from single centers....
Evaluation of inert gas rebreathing for determination of cardiac output
Jessica E Middlemiss, Alex Cocks, Kaido Paapstel, Kaisa M Maki-Petaja, Sunita, Ian B Wilkinson, Carmel M McEniery, ACCT Study Investigators
Dec 21, 2018
The aim of this study was to evaluate an inert gas rebreathing method (Innocor) for measurement of cardiac output and related haemodynamic variables and to provide robust normative data describing the influence of age, gender...
Body Size cardiac output Inert gas rebreathing Normative data Adult aging Bicycling Body Size Body Surface Area cardiac output Female Heart Rate Humans Male Middle Aged Noble Gases Posture Reference Values Reproducibility of Results Sex Characteristics Sitting Position Standing Position Stroke Volume Supine Position Young Adult
Association between Cerebrovascular Reactivity Monitoring and Mortality Is Preserved When Adjusting for Baseline Admission Characteristics in Adult Traumatic Brain Injury
Frederick A Zeiler, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Eric P Thelin, Nino Stocchetti, Ewout W Steyerberg, Andrew IR Maas, David K Menon, Marek Czosnyka, Peter Smielewski, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Nov 25, 2019
Cerebral autoregulation, as measured using the pressure reactivity index (PRx), has been related to global patient outcome in adult patients with traumatic brain injury (TBI). To date, this has been documented without accounting...
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