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Pancreas deficiency modifies bone development in the ovine fetus near term.
Stuart A Lanham, Dominique Blache, Richard OC Oreffo, Abigail L Fowden, Alison J Forhead
Jan 06, 2022
Hormones have an important role in the regulation of fetal growth and development, especially in response to nutrient availability in utero. Using micro-CT and an electromagnetic three-point bend test, this study examined the...
Metabolic Consequences of Glucocorticoid Exposure before Birth.
Glucocorticoids have an important role in development of the metabolic phenotype in utero. They act as environmental and maturational signals in adapting feto-placental metabolism to maximize the chances of survival both before...
Metabolic Consequences of Glucocorticoid Exposure before Birth.
Glucocorticoids have an important role in development of the metabolic phenotype in utero. They act as environmental and maturational signals in adapting feto-placental metabolism to maximize the chances of survival both before...
Pancreas deficiency modifies bone development in the ovine fetus near term.
Hormones have an important role in the regulation of fetal growth and development, especially in response to nutrient availability in utero. Using micro-CT and an electromagnetic three-point bend test, this study examined the...
Neonatal glucocorticoid overexposure alters cardiovascular function in young adult horses in a sex-linked manner.
Orlando A Valenzuela, Juanita K Jellyman, Vanessa L Allen, Youguo Niu, Nicola B Holdstock, Alison J Forhead, Dino A Giussani, Abigail L Fowden, Emilio A Herrera
Apr 30, 2020
Glucocorticoid maturation of mitochondrial respiratory capacity in skeletal muscle before birth.
In adults, glucocorticoids act to match the supply and demand for energy during physiological challenges, partly through actions on tissue mitochondrial oxidative phosphorylation (OXPHOS) capacity. However, little is known about...
Sex- and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus.
Miles J De Blasio, Stuart A Lanham, Dominique Blache, Richard OC Oreffo, Abigail L Fowden, Alison J Forhead
Apr 27, 2018
Widespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using microcomputed tomography, this study investigated the effects of...
Cortisol Regulates Cerebral Mitochondrial Oxidative Phosphorylation and Morphology of the Brain in a Region-Specific Manner in the Ovine Fetus
In adults, glucocorticoids are stress hormones that act, partly, through actions on mitochondrial oxidative phosphorylation (OXPHOS) to increase energy availability. Before birth, glucocorticoids are primarily maturational...
Effects of cortisol and dexamethasone on insulin signalling pathways in skeletal muscle of the ovine fetus during late gestation.
Juanita K Jellyman, Malgorzata S Martin-Gronert, Roselle L Cripps, Dino A Giussani, Susan E Ozanne, Qingwu W Shen, Min Du, Abigail L Fowden, Alison J Forhead
Feb 19, 2020
Before birth, glucocorticoids retard growth, although the extent to which this is mediated by changes in insulin signalling pathways in the skeletal muscle of the fetus is unknown. The current study determined the effects of...
Development and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth.
Effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose-insulin dynamics in young adult horses.
Cortisol Regulates Cerebral Mitochondrial Oxidative Phosphorylation and Morphology of the Brain in a Region-Specific Manner in the Ovine Fetus.
Katie L Davies, Danielle J Smith, Tatiana El-Bacha, Peter FP Wooding, Alison J Forhead, Andrew J Murray, Abigail L Fowden, Emily J Camm
Jul 24, 2022
Thyroid Hormone Deficiency Suppresses Fetal Pituitary-Adrenal Function Near Term
Emily J Camm, Isabella Inzani, Miles J De Blasio, Katie L Davies, India R Lloyd, FB Peter Wooding, Dominique Blache, Abigail L Fowden, Alison J Forhead
Oct 22, 2020
ACTH adrenal gland corticotrophs Cortisol Fetus Pituitary Gland Thyroid Hormones Adrenal Cortex Hormones Adrenal Glands Adrenal Medulla Adrenocorticotropic Hormone Animals Cell Count Cell Proliferation congenital hypothyroidism Corticotrophs Fetal Development Fetal Diseases Fetal Organ Maturity Hydrocortisone Hypothalamo-Hypophyseal System Insulin-Like Growth Factor I Pituitary-Adrenal System RNA Messenger Receptor IGF Type 1 Sheep Thyroidectomy Thyroxine Triiodothyronine Zona Fasciculata
Maternal Dexamethasone Treatment Alters Tissue and Circulating Components of the Renin-Angiotensin System in the Pregnant Ewe and Fetus.
Alison J Forhead, Juanita K Jellyman, Miles J De Blasio, Emma Johnson, Dino A Giussani, Fiona Broughton Pipkin, Abigail L Fowden
Jun 18, 2015
Developmental Expression and Glucocorticoid Control of the Leptin Receptor in Fetal Ovine Lung.
Miles J De Blasio, Maria Boije, Owen R Vaughan, Brett S Bernstein, Katie L Davies, Alice Plein, Sarah L Kempster, Gordon CS Smith, D Stephen Charnock-Jones, Dominique Blache, FB Peter Wooding, Dino A Giussani, Abigail L Fowden, Alison J Forhead
Aug 11, 2015
Development of cerebral mitochondrial respiratory function is impaired by thyroid hormone deficiency before birth in a region-specific manner.
Katie L Davies, Danielle J Smith, Tatiana El-Bacha, Max E Stewart, Akshay Easwaran, Peter FP Wooding, Alison J Forhead, Andrew J Murray, Abigail L Fowden, Emily J Camm
Apr 23, 2021
Thyroid hormones regulate adult metabolism partly through actions on mitochondrial oxidative phosphorylation (OXPHOS). They also affect neurological development of the brain, but their role in cerebral OXPHOS before birth...
Thyroid Deficiency Before Birth Alters the Adipose Transcriptome to Promote Overgrowth of White Adipose Tissue and Impair Thermogenic Capacity.
Shelley E Harris, Miles J De Blasio, Xiaohui Zhao, Marcella Ma, Katie Davies, FB Peter Wooding, Russell S Hamilton, Dominique Blache, David Meredith, Andrew J Murray, Abigail L Fowden, Alison J Forhead
Feb 19, 2020
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