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Results: 3448
Graduated compression stockings as adjuvant to pharmaco-thromboprophylaxis in elective surgical patients (GAPS study)
Joseph Shalhoub, Rebecca Lawton, Jemma Hudson, Christopher Baker, Andrew Bradbury, Karen Dhillon, Tamara Everington, Manjit S Gohel, Zaed Hamady, Beverley J Hunt, Gerrard Stansby, David Warwick, John Norrie, Alun H Davies, GAPS trial investigators
May 15, 2020
OBJECTIVES: To investigate whether the use of graduated compression stockings (GCS) offers any adjuvant benefit when pharmaco-thromboprophylaxis is used for venous thromboembolism prophylaxis in patients undergoing elective...
Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1)
Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair
Michael J Sweeting, Rajesh Patel, Janet T Powell, Roger M Greenhalgh, EVAR Trial Investigators
Dec 06, 2017
OBJECTIVE: The aim of the study was to compare long-term total and aneurysm-related mortality in physically frail patients with abdominal aortic aneurysm (AAA) randomized to either early endovascular aneurysm repair (EVAR) or...
Editor's Choice - Re-interventions After Repair of Ruptured Abdominal Aortic Aneurysm
Janet T Powell, Michael J Sweeting, Pinar Ulug, Matthew M Thompson, Robert J Hinchliffe, IMPROVE Trial Investigators
May 25, 2018
OBJECTIVE/BACKGROUND: The aim was to describe the re-interventions after endovascular and open repair of rupture, and investigate whether these were associated with aortic morphology. METHODS: In total, 502 patients from the...
Value of risk scores in the decision to palliate patients with ruptured abdominal aortic aneurysm.
MJ Sweeting, P Ulug, J Roy, R Hultgren, R Indrakusuma, R Balm, MM Thompson, RJ Hinchliffe, SG Thompson, JT Powell, Ruptured Aneurysm Collaborators: AJAX Trial investigators, ECAR Trial investigators, IMPROVE Trial investigators: management committee, STAR Cohort investigators
Mar 12, 2018
External data required timely response by the Trial Steering-Data Monitoring Committee for the NALoxone InVEstigation (N-ALIVE) pilot trial
The prison-based N-ALIVE pilot trial had undertaken to notify the Research Ethics Committee and participants if we had reason to believe that the N-ALIVE pilot trial would not proceed to the main trial. In this paper, we...
The Positive Choices trial
Ruth Ponsford, Rebecca Meiksin, Elizabeth Allen, GJ Melendez-Torres, Stephen Morris, Catherine Mercer, Rona Campbell, Honor Young, Maria Lohan, Karin Coyle, Chris Bonell
Nov 22, 2021
BACKGROUND: Positive Choices is a whole-school social marketing intervention to promote sexual health among secondary school students. Intervention comprises school health promotion council involving staff and students...
The Positive Choices trial
Ruth Ponsford, Rebecca Meiksin, Elizabeth Allen, GJ Melendez-Torres, Steve Morris, Catherine Mercer, Rona Campbell, Honor Young, Maria Lohan, Karin Coyle, Chris Bonell
Apr 11, 2022
BACKGROUND: Positive Choices is a whole-school social marketing intervention to promote sexual health among secondary school students. Intervention comprises school health promotion council involving staff and students...
ADOLESCENTS Cluster trials Pregnancy Public Health Schools Sexual competence Sexual health Sexually Transmitted Infections Whole-school Adolescent Child Female Health Status Disparities Humans Male Pregnancy Randomized Controlled Trials as Topic School Health Services Schools Sexual health Social Marketing
An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH)
Catherine M Sackley, Marion F Walker, Christopher R Burton, Caroline L Watkins, Jonathan Mant, Andrea K Roalfe, Keith Wheatley, Bart Sheehan, Leslie Sharp, Katie E Stant, Joanna Fletcher-Smith, Kerry Steel, Kate Wilde, Lisa Irvine, Guy Peryer, OTCH trial investigators
Mar 10, 2015
The Positive Choices trial
Ruth Ponsford, Rebecca Meiksin, Elizabeth Allen, GJ Melendez-Torres, Stephen Morris, Catherine Mercer, Rona Campbell, Honor Young, Maria Lohan, Karin Coyle, Chris Bonell
Jan 07, 2022
BACKGROUND: Positive Choices is a whole-school social marketing intervention to promote sexual health among secondary school students. Intervention comprises school health promotion council involving staff and students...
The COSI trial
Camilla Rosan, Kim Alyousefi-van Dijk, Zoe Darwin, Daphne Babalis, Victoria Cornelius, Rachel Phillips, Lani Richards, Hannah Wright, Steve Pilling, Pasco Fearon, Elena Pizzo, Peter Fonagy
Mar 14, 2023
BACKGROUND: Perinatal mental health difficulties affect up to 27% of birthing parents during pregnancy and the first postnatal year, and if untreated are associated with difficulties in bonding and long-term adverse outcomes to...
Child Attachment Child Development Circle Of Security-parenting Parent-infant Bonding Perinatal mental health randomised controlled trial Child Female Pregnancy Humans Parenting Cost-Benefit Analysis Quality of life Single-Blind Method England Community Mental Health Services Randomized Controlled Trials as Topic Multicenter Studies as Topic
Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial
Angelos G Kolias, Ellie Edlmann, Eric P Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner, Lynne Whitehead, Ian Wilkinson, Peter J Hutchinson, British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators
Feb 07, 2019
BACKGROUND: Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20%...
chronic subdural haematoma Dexamethasone Neurology Neurosurgery Randomised control trial Cost-Benefit Analysis Dexamethasone Double-Blind Method Drug Administration Schedule Drug Costs Glucocorticoids Hematoma Subdural Chronic Humans Multicenter Studies as Topic Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom
The COSI trial
Camilla Rosan, Kim Alyousefi-van Dijk, Zoe Darwin, Daphne Babalis, Victoria Cornelius, Rachel Phillips, Lani Richards, Hannah Wright, Steve Pilling, Pasco Fearon, Elena Pizzo, Peter Fonagy
Apr 13, 2023
Background
Perinatal mental health difficulties affect up to 27% of birthing parents during pregnancy and the first postnatal year, and if untreated are associated with difficulties in bonding and long-term adverse...
Child Development randomised controlled trial Perinatal mental health Child Attachment Circle Of Security-parenting Parent-infant Bonding Humans Single-Blind Method Parenting Community Mental Health Services Pregnancy Quality of life Child Cost-Benefit Analysis England Female Multicenter Studies as Topic Randomized Controlled Trials as Topic
Published by: Trials
Study within a trial (SWAT) protocol. Participants' perspectives and preferences on clinical trial result dissemination
Emmy Racine, Caroline Hurley, Aoife Cheung, Carol Sinnott, Karen Matvienko-Sikar, William H Smithson, Patricia M Kearney
Jan 18, 2018
INTRODUCTION: Dissemination of results of randomised controlled trials is traditionally limited to academic and professional groups rather than clinical trial participants. While there is increasing consensus that results should...
Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4)
Richard J McManus, Jonathan Mant, Marloes Franssen, Alecia Nickless, Claire Schwartz, James Hodgkinson, Peter Bradburn, Andrew Farmer, Sabrina Grant, Sheila M Greenfield, Carl Heneghan, Susan Jowett, Una Martin, Siobhan Milner, Mark Monahan, Sam Mort, Emma Ogburn, Rafael Perera-Salazar, Syed Ahmar Shah, Ly-Mee Yu, Lionel Tarassenko, FD Richard Hobbs, TASMINH4 investigators
May 18, 2018
BACKGROUND: Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place of telemonitoring over self-monitoring alone is unclear. The TASMINH4 trial aimed to...
Surveillance arterioveNous fistulAs using ultRasound (SONAR) trial in haemodialysis patients
James Richards, Mohammed Hossain, Dominic Summers, Matthew Slater, Matthew Bartlett, Vasilis Kosmoliaptsis, Edward Cf Wilson, Regin Lagaac, Anna Sidders, Claire Foley, Emma Laing, Valerie Hopkins, Chloe Fitzpatrick-Creamer, Cara Hudson, Helen Thomas, Sam Turner, Andrew Tambyraja, Subash Somalanka, James Hunter, Sam Dutta, Sarah Lawman, Tracey Salter, Mohammed Aslam, Atul Bagul, Rajesh Sivaprakasam, George Smith, Zia Moinuddin, Simon Knight, Paul Gibbs, Reza Motallebzadeh, Nicholas Barnett, Gavin Pettigrew, SONAR trial group
Oct 21, 2019
INTRODUCTION: Arteriovenous fistulas (AVFs) are considered the best and safest modality for providing haemodialysis in patients with end-stage renal disease. Only 20% of UK centres achieve the recommended 80% target for...
Group sequential crossover trial designs with strong control of the familywise error rate.
Crossover designs are an extremely useful tool to investigators, and group sequential methods have proven highly proficient at improving the efficiency of parallel group trials. Yet, group sequential methods and crossover...
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Mar 13, 2023
Background
While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service...
Vaccination Reminder Systems SMS mHealth Text Messaging Childhood immunisation Humans Bayes Theorem Child Australia Randomized Controlled Trials as Topic Vaccination Coverage Cell Phone
Published by: Trials
The HARMONIC trial
TI Dalgleish, Melissa Black, Caitlin Hitchcock, Anna Bevan, Cliodhna O'Leary, James Clarke, Rachel Elliot, Peter Watson, Louise Lafortune, Sarah Rae, Simon Gilbody, Willem Kuyken, David Johnston, Jill Newby, Timothy Dalgleish
Dec 14, 2018
Axiety, mood and trauma-related disorders are common, affecting up to 20% of adults. Many of these individuals will experience symptoms of more than one disorder as diagnostically defined. However, most psychological treatments...
Anxiety common mental health problems Depression Posttraumatic stress disorder transdiagnostic Adult Anxiety Disorders Feasibility Studies Humans Mood Disorders Obsessive-Compulsive Disorder Patient Acceptance of Health Care Patient Reported Outcome Measures Randomized Controlled Trials as Topic Research Design Stress Disorders Traumatic Symptom Assessment
Impact of solitary pulmonary nodule size on qualitative and quantitative assessment using 18F-fluorodeoxyglucose PET/CT
JR Weir-McCall, S Harris, KA Miles, NR Qureshi, RC Rintoul, S Dizdarevic, L Pike, Heok K Cheow, Fiona J Gilbert, Sputnik investigators
May 11, 2021
PURPOSE: To compare qualitative and semi-quantitative PET/CT criteria, and the impact of nodule size on the diagnosis of solitary pulmonary nodules in a prospective multicentre trial. METHODS: Patients with an SPN on CT ≥ 8 and...
cost-effectiveness DCE-CT Diagnostic accuracy trial Diagnostic Imaging Lung cancer PET/CT Solitary pulmonary nodule (SPN) Fluorodeoxyglucose F18 Humans Lung Neoplasms Positron Emission Tomography Computed Tomography Positron-Emission Tomography Prospective Studies Radiopharmaceuticals Retrospective Studies Solitary pulmonary nodule
Addressing ethical gaps in ‘Technology for Good’
This paper identifies and addresses persistent gaps in the consideration of ethical practice in ‘technology for good’ development contexts. Its main contribution is to model an integrative approach using multiple...
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment.
Henk-Jan van den Ham, Jason D Cooper, Jakub Tomasik, Sabine Bahn, Joeri L Aerts, Albert DME Osterhaus, Rob A Gruters, Arno C Andeweg, DC-TRN trial investigators
May 23, 2018
OBJECTIVES: To characterize the host response to dendritic cell-based immunotherapy and subsequent combined antiretroviral therapy (cART) interruption in HIV-1-infected individuals at the plasma protein level. DESIGN: An...
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Feb 09, 2023
BACKGROUND: While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service (SMS)...
Participants' perspectives and preferences on clinical trial result dissemination
Emmy Racine, Caroline Hurley, Aoife Cheung, Carol Sinnott, Karen Matvienko-Sikar, Christine Baumgartner, Nicolas Rodondi, William H Smithson, Patricia M Kearney
Mar 02, 2020
Background: While there is an increasing consensus that clinical trial results should be shared with trial participants, there is a lack of evidence on the most appropriate methods. The aim of this study is to use a patient and...
patient and public involvement Research Dissemination SWAT Study Results Study within a trial Clinical trial result dissemination Patient Involvement In Clinical Trials Trial Results.
Published by: HRB Open Research
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