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Assessment of the genetic and clinical determinants of fracture risk
Katerina Trajanoska, John A Morris, Ling Oei, Hou-Feng Zheng, David M Evans, Douglas P Kiel, Claes Ohlsson, J Brent Richards, Fernando Rivadeneira, GEFOS/GENOMOS consortium and the 23andMe research team
Jul 24, 2019
OBJECTIVES: To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. DESIGN: Meta-analysis of genome wide association studies (GWAS) and a two-sample...
Bridging Brain and Cognition
Ivan L. Simpson-Kent, Eiko I. Fried, Danyal Akarca, Silvana Mareva, Edward T. Bullmore, the CALM Team the CALM Team, Rogier A. Kievit
Jun 17, 2021
Network analytic methods that are ubiquitous in other areas, such as systems neuroscience, have recently been used to test network theories in psychology, including intelligence research. The network or mutualism theory of...
Replication and characterization of CADM2 and MSRA genes on human behavior.
Brian Boutwell, David Hinds, 23andMe Research Team, Jorim Tielbeek, Ken K Ong, Felix R Day, John RB Perry
Nov 29, 2017
Progress identifying the genetic determinants of personality has historically been slow, with candidate gene studies and small-scale genome-wide association studies yielding few reproducible results. In the UK Biobank study...
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Jue-Sheng Ong, Jiyuan An, Xikun Han, Matthew H Law, Priyanka Nandakumar, 23andMe Research Team, Esophageal Cancer Consortium, Johannes Schumacher, Ines Gockel, Anne Bohmer, Janusz Jankowski, Claire Palles, Catherine M Olsen, Rachel E Neale, Rebecca Fitzgerald, Aaron P Thrift, Thomas L Vaughan, Matthew F Buas, David A Hinds, Puya Gharahkhani, Bradley J Kendall, Stuart MacGregor
Jul 28, 2021
OBJECTIVE: Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based definitions. GERD genome-wide association studies (GWASs) have shown strong genetic overlaps with...
Current opportunities to catalyze research in nutrition and cancer prevention – an interdisciplinary perspective
The Cancer Research UK - Ludwig Cancer Research Nutrition and Cancer Prevention Collaborative Group
Jul 31, 2019
Cancer Research UK and Ludwig Cancer Research convened an inaugural international Cancer Prevention and Nutrition Conference in London on December 3–4, 2018. Much of the discussion focused on the need for systematic...
cancer prevention Developmental origins Diet EPIDEMIOLOGY epigenetics interdisciplinary metabolism Nutrition obesity physical activity Public Health Biomedical Research Body Weight Congresses as Topic Diet Exercise food Humans Interdisciplinary Communication Interdisciplinary Research Neoplasms Nutrition Therapy Nutritional Status obesity Risk Factors United Kingdom
The SPECTRUM Consortium
M Horton, PR Perman-Howe, C Angus, J Bishop, I Bogdanovica, A Brennan, J Britton, LS Brose, J Brown, J Collin, M Dockrell, N Fitzgerald, S Friel, D Gillespie, AB Gilmore, SE Hill, C Knai, T Langley, S Martin, A McNeill, G Moore, MR Munafò, RL Murray, M Opazo Breton, J Pearce, M Petticrew, G Reid, D Robson, H Rutter, L Shahab, N Shortt, K Smith, K Syrett, L Bauld
Dec 31, 2021
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures...
The SPECTRUM Consortium
M Horton, PR Perman-Howe, C Angus, J Bishop, I Bogdanovica, A Brennan, J Britton, LS Brose, J Brown, J Collin, M Dockrell, N Fitzgerald, S Friel, D Gillespie, AB Gilmore, SE Hill, C Knai, T Langley, S Martin, A McNeill, G Moore, MR Munafò, RL Murray, M Opazo Breton, J Pearce, M Petticrew, G Reid, D Robson, H Rutter, L Shahab, N Shortt, K Smith, K Syrett, L Bauld
Dec 31, 2021
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures...
The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
ENT audit and research in the era of trainee collaboratives.
Matthew E Smith, John Hardman, Matthew Ellis, Richard J Williams, The UK National ENT Trainee Research Network INTEGRATE
Sep 20, 2018
Large surgical audits and research projects are complex and costly to deliver, but increasingly surgical trainees are delivering these projects within formal collaboratives and research networks. Surgical trainee collaboratives...
Creating inclusive teams through perceptions of supplementary and complementary person-team fit
Using a multi-wave, multi-level design, this study unravels the impact of subjective (dis)similarities in teams on team effectiveness. Based on optimal distinctiveness theory and the social inclusion model, we assume combined...
Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe.
BACKGROUND: Rapid advances in scientific research have led to an increase in public awareness of genetic testing and pharmacogenetics. Direct-to-consumer (DTC) genetic testing companies, such as 23andMe, allow consumers to...
The Future of Biomedical Research and Education
The Rockefeller University
Jan 01, 0001
Four Talks on the Occasion of the Installation of Dr. Joshua Lederberg as President of The Rockefeller University, October 16, 1978
This publication has been aided by a grant from The Carl and Lily Pforzheimer Foundation, Inc.
Gerald M. Edelman Theodore Cooper Lewis Thomas James A. Linen III Joshual Lederberg Patrick E. Haggerty
Published by: The Rockefeller University
Gene Ontology Consortium
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe...
Creating inclusive teams through perceptions of supplementary and complementary person-team fit
Using a multi-wave, multi-level design, this study unravels the impact of subjective (dis)similarities in teams on team effectiveness. Based on optimal distinctiveness theory and the social inclusion model, we assume combined...
Multi-messenger Observations of a Binary Neutron Star Merger
LIGO Scientific Collaboration, Virgo Collaboration, GBM Fermi, INTEGRAL, IceCube Collaboration, AstroSat Cadmium Zinc Telluride Imager Team, IPN Collaboration, The Insight-Hxmt Collaboration, ANTARES Collaboration, The Swift Collaboration, AGILE Team, The 1M2H Team, The Dark Energy Camera GW-EM Collaboration, the DES Collaboration, The DLT40 Collaboration, GRAWITA, GRAvitational Wave Inaf TeAm, The Fermi Large Area Telescope Collaboration, ATCA, Australia Telescope Compact Array, ASKAP, Australian SKA Pathfinder, Las Cumbres Observatory Group, OzGrav, DWF, AST3, CAASTRO Collaborations, The VINROUGE Collaboration, MASTER Collaboration, J-GEM, GROWTH, JAGWAR, NRAO Caltech-, TTU-NRAO, NuSTAR Collaborations, Pan-STARRS, The MAXI Team, TZAC Consortium, KU Collaboration, Nordic Optical Telescope, ePESSTO, GROND, Texas Tech University, SALT Group, TOROS, Transient Robotic Observatory of the South Collaboration, The BOOTES Collaboration, MWA, Murchison Widefield Array, The CALET Collaboration, IKI-GW Follow-up Collaboration, H. E. S. S. Collaboration, LOFAR Collaboration, LWA, Long Wavelength Array, HAWC Collaboration, The Pierre Auger Collaboration, ALMA Collaboration, Euro VLBI Team, Pi of the Sky Collaboration, The Chandra Team at McGill University, DFN, Desert Fireball Network, ATLAS, High Time Resolution Universe Survey, RIMAS, RATIR, SKA South Africa/MeerKAT, Hendrik Van Eerten
Oct 16, 2017
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi...
Multi-messenger Observations of a Binary Neutron Star Merger
LIGO Scientific Collaboration, Virgo Collaboration, GBM Fermi, INTEGRAL, IceCube Collaboration, AstroSat Cadmium Zinc Telluride Imager Team, IPN Collaboration, The Insight-Hxmt Collaboration, ANTARES Collaboration, The Swift Collaboration, AGILE Team, The 1M2H Team, The Dark Energy Camera GW-EM Collaboration, the DES Collaboration, The DLT40 Collaboration, GRAWITA, GRAvitational Wave Inaf TeAm, The Fermi Large Area Telescope Collaboration, ATCA, Australia Telescope Compact Array, ASKAP, Australian SKA Pathfinder, Las Cumbres Observatory Group, OzGrav, DWF, AST3, CAASTRO Collaborations, The VINROUGE Collaboration, MASTER Collaboration, J-GEM, GROWTH, JAGWAR, NRAO Caltech-, TTU-NRAO, NuSTAR Collaborations, Pan-STARRS, The MAXI Team, TZAC Consortium, KU Collaboration, Nordic Optical Telescope, ePESSTO, GROND, Texas Tech University, SALT Group, TOROS, Transient Robotic Observatory of the South Collaboration, The BOOTES Collaboration, MWA, Murchison Widefield Array, The CALET Collaboration, IKI-GW Follow-up Collaboration, H. E. S. S. Collaboration, LOFAR Collaboration, LWA, Long Wavelength Array, HAWC Collaboration, The Pierre Auger Collaboration, ALMA Collaboration, Euro VLBI Team, Pi of the Sky Collaboration, The Chandra Team at McGill University, DFN, Desert Fireball Network, ATLAS, High Time Resolution Universe Survey, RIMAS, RATIR, SKA South Africa/MeerKAT, Hendrik Van Eerten
Oct 16, 2017
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi...
W404-010J-01 - Office of the Vice President for Academic Affairs: Office of Sponsored Programs and Research (SPAR): Correspondence and Memoranda
Office of Vice President for Academic Affairs, Sponsored Programs and Research, Office of, Grants and Sponsored Research Development, Office of
Jan 01, 0001
Published by: Winthrop University
Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC)
Keiji Fukuda, Direk Limmathurotsakul, Iruka N Okeke, Nandini Shetty, Rogier van Doorn, Nicholas A Feasey, Francesca Chiara, Ghada Zoubiane, Tim Jinks, Julian Parkhill, Jean Patel, Stuart WJ Reid, Alison H Holmes, Sharon J Peacock, Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC)
Nov 05, 2018
In recognition of the central importance of surveillance and epidemiology in the control of antimicrobial resistance and the need to strengthen surveillance at all levels, Wellcome has brought together a new international expert...
Stakeholder engagement in European brain research
Isabelle Budin-Ljøsne, Barbara B Friedman, William FC Baaré, David Bartrés-Faz, Rebecca B Carver, Christian A Drevon, Klaus P Ebmeier, Anders M Fjell, Paolo Ghisletta, Richard N Henson, Rogier Kievit, Kathrine S Madsen, Laura Nawijn, Sana Suri, Cristina Solé-Padullés, Kristine B Walhovd, Enikő Zsoldos
Mar 29, 2023
INTRODUCTION: Stakeholder engagement remains scarce in basic brain research. However, it can greatly improve the relevance of investigations and accelerate the translation of study findings to policy. The Lifebrain consortium...
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
Chris Eijsbouts, Tenghao Zheng, Nicholas A Kennedy, Ferdinando Bonfiglio, Carl A Anderson, Loukas Moutsianas, Joanne Holliday, Jingchunzi Shi, Suyash Shringarpure, 23andMe Research Team, Alexandru-Ioan Voda, Bellygenes Initiative, Gianrico Farrugia, Andre Franke, Matthias Hübenthal, Gonçalo Abecasis, Matthew Zawistowski, Anne Heidi Skogholt, Eivind Ness-Jensen, Kristian Hveem, Tõnu Esko, Maris Teder-Laving, Alexandra Zhernakova, Michael Camilleri, Guy Boeckxstaens, Peter J Whorwell, Robin Spiller, Gil McVean, Mauro D'Amato, Luke Jostins, Miles Parkes
Jan 05, 2022
Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK...
Aged Anxiety Disorders CD56 Antigen Cell Adhesion Molecules Cytoskeletal Proteins Female Genetic Predisposition to Disease Genome-Wide Association Study Guanine Nucleotide Exchange Factors Homeodomain Proteins Humans Irritable Bowel Syndrome Male Middle Aged Molecular Chaperones Mood Disorders Polymorphism Single Nucleotide United Kingdom
Genome-wide meta-analysis identifies 3 novel loci associated with stroke.
Rainer Malik, Kristiina Rannikmäe, Matthew Traylor, Marios K Georgakis, Muralidharan Sargurupremraj, Hugh S Markus, Jemma C Hopewell, Stephanie Debette, Cathie LM Sudlow, Martin Dichgans, MEGASTROKE consortium and the International Stroke Genetics Consortium
Dec 21, 2018
We conducted a European-only and transancestral genome-wide association meta-analysis in 72,147 stroke patients and 823,869 controls using data from UK Biobank (UKB) and the MEGASTROKE consortium. We identified an exonic...
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.
Ben Brumpton, Eleanor Sanderson, Karl Heilbron, Fernando Pires Hartwig, Sean Harrison, Gunnhild Åberge Vie, Yoonsu Cho, Laura D Howe, Amanda Hughes, Dorret I Boomsma, Alexandra Havdahl, John Hopper, Michael Neale, Michel G Nivard, Nancy L Pedersen, Chandra A Reynolds, Elliot M Tucker-Drob, Andrew Grotzinger, Laurence Howe, Tim Morris, Shuai Li, Within-family Consortium, 23andMe Research Team, Adam Auton, Frank Windmeijer, Wei-Min Chen, Johan Håkon Bjørngaard, Kristian Hveem, Cristen Willer, David M Evans, Jaakko Kaprio, George Davey Smith, Bjørn Olav Åsvold, Gibran Hemani, Neil M Davies
Jul 28, 2021
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and use...
'Be on the TEAM' Study (Teenagers Against Meningitis)
Jeremy Carr, Emma Plested, Parvinder Aley, Susana Camara, Kimberly Davis, Jenny M MacLennan, Steve Gray, Saul N Faust, Ray Borrow, Hannah Christensen, Caroline Trotter, Martin CJ Maiden, Adam Finn, Matthew D Snape, ‘Be on the TEAM’ investigators
Oct 27, 2020
INTRODUCTION: Capsular group B Neisseria meningitidis (MenB) is the most common cause of invasive meningococcal disease (IMD) in many parts of the world. A MenB vaccine directed against the polysaccharide capsule remains elusive...
Paediatric infectious disease and immunisation paediatric intensive and critical care Infectious Diseases Paediatrics Adolescent Adult Humans Meningitis Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Neisseria meningitidis Serogroup B Randomized Controlled Trials as Topic State Medicine Vaccination Young Adult
The National Institute for Health Research
V Goh, National Institute for Health Research Clinical Research Network Imaging Network Steering Group, Royal College of Radiologists' Academic Committee
Oct 01, 2019
Since the inception of the National Institute for Health Research (NIHR) in 2006, the landscape for the delivery of clinical research within the National Health Service (NHS) has been transformed. Clinical radiology has...
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