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The Adaptive designs CONSORT Extension (ACE) statement
Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, Douglas G Altman, ACE Consensus Group
Jul 01, 2020
Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of...
The adaptive designs CONSORT extension (ACE) statement
Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, Douglas G Altman, ACE Consensus Group
Jun 17, 2021
Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of...
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
JT Powell, MJ Sweeting, P Ulug, JD Blankensteijn, FA Lederle, J-P Becquemin, RM Greenhalgh, DREAM, OVER and ACE Trialists EVAR-1
Nov 13, 2017
BACKGROUND: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. METHODS: An...
Comprehensive review on some food-derived bioactive peptides with anti-hypertension therapeutic potential for angiotensin-converting enzyme (ACE) inhibition
Angiotensin-converting enzyme (ACE) inhibitory peptides have lately attracted interest since functional foods that help maintain homeostatic regulations have been developed. Rarely discussed are the intrinsic ACE-peptide...
The adaptive designs CONSORT extension (ACE) statement
Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A. Julious, Adrian P. Mander, Christopher J. Weir, Franz Koenig, Marc K. Walton, Jon P. Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A. Proschan, John A. Scott, Yuki Ando, Daniel Hind, Douglas G. Altman, Munyaradzi Dimairo, Jon Nicholl, William J. Meurer, Christopher Cates, Matthew Sydes, Yannis Jemiai, Deborah Ashby, Christina Yap, Frank Waldron-Lynch, James Roger, Joan Marsh, Olivier Collignon, David J. Lawrence, Catey Bunce, Tom Parke, Gus Gazzard, Sally Hopewell
Jun 17, 2020
Abstract: Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The...
ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes.
M Loredana Marcovecchio, Scott T Chiesa, Simon Bond, Denis Daneman, Sarah Dawson, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, R Neil Dalton, John Deanfield, David B Dunger, AdDIT Study Group
Jul 10, 2017
BACKGROUND: Among adolescents with type 1 diabetes, rapid increases in albumin excretion during puberty precede the development of microalbuminuria and macroalbuminuria, long-term risk factors for renal and cardiovascular...
Comprehensive review on some food-derived bioactive peptides with anti-hypertension therapeutic potential for angiotensin-converting enzyme (ACE) inhibition
Angiotensin-converting enzyme (ACE) inhibitory peptides have lately attracted interest since functional foods that help maintain homeostatic regulations have been developed. Rarely discussed are the intrinsic ACE-peptide...
ACE-domain selectivity extends beyond direct interacting residues at the active site
Angiotensin-converting enzyme (ACE) is best known for its formation of the vasopressor angiotensin II that controls blood pressure but is also involved in other physiological functions through the hydrolysis of a variety of...
Participant and public involvement in refining a peer-volunteering active aging intervention
Janet Withall, Janice L Thompson, Kenneth R Fox, Mark Davis, Selena Gray, Jolanthe De Koning, Liz Lloyd, Graham Parkhurst, Afroditi Stathi
Dec 06, 2016
Background: Evidence for the health benefits of a physically active lifestyle among older adults is strong, yet only a small proportion of older people meet physical activity recommendations. A synthesis of evidence identified...
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne, MRC Cognitive Function and Ageing Study
Jul 10, 2018
BACKGROUND: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate...
Participant and public involvement in refining a peer-volunteering active aging intervention
Janet Withall, Janice L Thompson, Kenneth R Fox, Mark Davis, Selena Gray, Jolanthe De Koning, Liz Lloyd, Graham Parkhurst, Afroditi Stathi
Dec 06, 2016
Background: Evidence for the health benefits of a physically active lifestyle among older adults is strong, yet only a small proportion of older people meet physical activity recommendations. A synthesis of evidence identified...
ACE-domain selectivity extends beyond direct interacting residues at the active site
Angiotensin-converting enzyme (ACE) is best known for its formation of the vasopressor angiotensin II that controls blood pressure but is also involved in other physiological functions through the hydrolysis of a variety of...
Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.
Elżbieta Niechciał, Carlo L Acerini, Scott T Chiesa, Tracey Stevens, R Neil Dalton, Denis Daneman, John E Deanfield, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, M Loredana Marcovecchio, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group, Adolescent Type 1 Diabetes Cardio-renal Intervention Trial AdDIT Study Group
Jan 31, 2020
OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim...
Adolescent Angiotensin-Converting Enzyme Inhibitors Australia Canada Cardiovascular Diseases Chemotherapy Adjuvant Child Diabetes mellitus Type 1 Diabetic Angiopathies Double-Blind Method Drug Therapy Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Male Medication Adherence United Kingdom
Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes.
Scott T Chiesa, M Loredana Marcovecchio, Paul Benitez-Aguirre, Fergus J Cameron, Maria E Craig, Jennifer J Couper, Elizabeth A Davis, R Neil Dalton, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, John E Deanfield, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Nov 03, 2020
An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial...
Adolescent arteries Diabetes Type 1 Puberty Vascular diseases Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors C-Reactive Protein Creatinine Diabetes mellitus Type 1 Double-Blind Method Drug Therapy Combination Endothelium Vascular Female Glycated Hemoglobin Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipids Male Pulse Wave Analysis Vascular Stiffness
The Origins and Manifestations of the Modern Queer Look
Ace Melendez
Jan 01, 0001
Queerness should be inclusive. It should be an identity with a group that is accessible, unifying, and welcoming. In Sarah Ahmed's "Queer Feelings," she makes the assertion that queer people gather together through their own...
queer androgyny fashion coding look modern Arts and Humanities Feminist, Gender, and Sexuality Studies
Published by: Ursinus College
General Relativity, Mental Causation, and Energy Conservation.
J Brian Pitts
Jul 20, 2022
The conservation of energy and momentum have been viewed as undermining Cartesian mental causation since the 1690s. Modern discussions of the topic tend to use mid-nineteenth century physics, neglecting both locality and...
The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.
Timothy Rittman, Boyd C Ghosh, Peter McColgan, David P Breen, Jonathan Evans, Caroline H Williams-Gray, Roger A Barker, James B Rowe
May 16, 2018
OBJECTIVE: Differentiating idiopathic Parkinson's disease from atypical parkinsonian syndromes is challenging, especially in the early stages. We assessed whether the Revised Addenbrooke's Cognitive Examination (ACE-R) could...
Identifying a large number of high-yield genes in rice by pedigree analysis, whole genome sequencing and CRISPR-Cas9 gene knockout
Ju Huang, Jing Li, Jun Zhou, Long Wang, Sihai Yang, Laurence Hurst, Wen-Hsiung Li, Dacheng Tian
Aug 07, 2018
Repeated artificial selection of a complex trait facilitates the identification of genes underlying the trait, especially if multiple selected descendant lines are available. Here we developed a pedigree-based approach to...
Adverse childhood experiences (ACEs) and later-life depression
OBJECTIVE: To investigate associations between adverse childhood experiences (ACEs) and later-life depressive symptoms; and to explore whether perceived social support (PSS) moderates these. METHOD: We analysed baseline data...
adverse childhood experience depression and mood disorders Mental Health Adolescent Adult Survivors of Child Abuse Aged Child Child Abuse Child Preschool Cohort Studies Depression Depressive Disorder Family Characteristics Family Relations Humans Ireland Life Change Events Logistic Models Middle Aged Perception Protective factors Self Report social support Surveys and Questionnaires
Genetic Evidence for Protective Effects of Angiotensin-Converting Enzyme Against Alzheimer Disease But Not Other Neurodegenerative Diseases in European Populations.
David K Ryan, Ville Karhunen, Bowen Su, Matthew Traylor, Tom G Richardson, Stephen Burgess, Ioanna Tzoulaki, Dipender Gill
Oct 01, 2022
BACKGROUND AND OBJECTIVES: Angiotensin-converting enzyme (ACE) inhibitors are a commonly prescribed class of medication used to treat heart failure, hypertension, and chronic kidney disease. However, previous observational...
Structure based drug design of angiotensin-i converting enzyme inhibitors
Cardiovascular disease (CVD) is responsible for ̃27% of deaths worldwide, with 80% of these occuring in developing countries. Hypertension is one of the most important treatable factors in the prevention of CVD. Angiotensin-I...
Low defect and high electrical conductivity of graphene through plasma graphene healing treatment monitored with in situ optical emission spectroscopy.
Mohammad Salehi, Parnia Bastani, Loghman Jamilpanah, Abbas Madani, Seyed Majid Mohseni, Babak Shokri
Oct 13, 2021
Fundamental studies on graphene (Gr) and its real device applications have been affected by unavoidable defects and impurities which are usually present in synthesized Gr. Therefore, post treatment methods on Gr have been an...
Structure based drug design of angiotensin-i converting enzyme inhibitors
Cardiovascular disease (CVD) is responsible for ̃27% of deaths worldwide, with 80% of these occuring in developing countries. Hypertension is one of the most important treatable factors in the prevention of CVD. Angiotensin-I...
Adverse Childhood Experiences (ACE) Among Prolific Young Robbery Offenders in London
Abstract
Research Question
How prevalent are various types of adverse childhood experiences among prolific young robbery...
Pre-injury Comorbidities Are Associated With Functional Impairment and Post-concussive Symptoms at 3- and 6-Months After Mild Traumatic Brain Injury
John K Yue, Maryse C Cnossen, Ethan A Winkler, Hansen Deng, Ryan RL Phelps, Nathan A Coss, Sourabh Sharma, Caitlin K Robinson, Catherine G Suen, Mary J Vassar, David M Schnyer, Ava M Puccio, Raquel C Gardner, Esther L Yuh, Pratik Mukherjee, Alex B Valadka, David O Okonkwo, Hester F Lingsma, Geoffrey T Manley, TRACK-TBI Investigators
Jun 20, 2019
Introduction: Over 70% of traumatic brain injuries (TBI) are classified as mild (mTBI), which present heterogeneously. Associations between pre-injury comorbidities and outcomes are not well-understood, and understanding their...
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