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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC)
Keiji Fukuda, Direk Limmathurotsakul, Iruka N Okeke, Nandini Shetty, Rogier van Doorn, Nicholas A Feasey, Francesca Chiara, Ghada Zoubiane, Tim Jinks, Julian Parkhill, Jean Patel, Stuart WJ Reid, Alison H Holmes, Sharon J Peacock, Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC)
Nov 05, 2018
In recognition of the central importance of surveillance and epidemiology in the control of antimicrobial resistance and the need to strengthen surveillance at all levels, Wellcome has brought together a new international expert...
Circulating bilirubin levels and risk of colorectal cancer
Nazlisadat Seyed Khoei, Mazda Jenab, Neil Murphy, Barbara L. Banbury, Robert Carreras-Torres, Vivian Viallon, Tilman Kühn, Bas Bueno-de-Mesquita, Krasimira Aleksandrova, Amanda J. Cross, Elisabete Weiderpass, Magdalena Stepien, Andrew Bulmer, Anne Tjønneland, Marie-Christine Boutron-Ruault, Gianluca Severi, Franck Carbonnel, Verena Katzke, Heiner Boeing, Manuela M. Bergmann, Antonia Trichopoulou, Anna Karakatsani, Georgia Martimianaki, Domenico Palli, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Susana Merino, Catalina Bonet, Miguel Rodríguez-Barranco, Leire Gil, Maria-Dolores Chirlaque, Eva Ardanaz, Robin Myte, Johan Hultdin, Aurora Perez-Cornago, Dagfinn Aune, Konstantinos K. Tsilidis, Demetrius Albanes, John A. Baron, Sonja I. Berndt, Stéphane Bézieau, Hermann Brenner, Peter T. Campbell, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Michelle Cotterchio, Steven Gallinger, Stephen B. Gruber, Robert W. Haile, Jochen Hampe, Michael Hoffmeister, John L. Hopper, Li Hsu, Jeroen R. Huyghe, Mark A. Jenkins, Amit D. Joshi, Ellen Kampman, Susanna C. Larsson, Loic Le Marchand, Christopher I. Li, Li Li, Annika Lindblom, Noralane M. Lindor, Vicente Martín, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Shuji Ogino, Patrick S. Parfrey, Paul D. P. Pharoah, Gad Rennert, Lori C. Sakoda, Clemens Schafmayer, Stephanie L. Schmit, Robert E. Schoen, Martha L. Slattery, Stephen N. Thibodeau, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Korbinian Weigl, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Xuehong Zhang, Pietro Ferrari, Gabriele Anton, Annette Peters, Ulrike Peters, Marc J. Gunter, Karl-Heinz Wagner, Heinz Freisling
Sep 03, 2021
Abstract: Background: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate...
Circulating bilirubin levels and risk of colorectal cancer
Nazlisadat Seyed Khoei, Mazda Jenab, Neil Murphy, Barbara L. Banbury, Robert Carreras-Torres, Vivian Viallon, Tilman Kühn, Bas Bueno-de-Mesquita, Krasimira Aleksandrova, Amanda J. Cross, Elisabete Weiderpass, Magdalena Stepien, Andrew Bulmer, Anne Tjønneland, Marie-Christine Boutron-Ruault, Gianluca Severi, Franck Carbonnel, Verena Katzke, Heiner Boeing, Manuela M. Bergmann, Antonia Trichopoulou, Anna Karakatsani, Georgia Martimianaki, Domenico Palli, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Susana Merino, Catalina Bonet, Miguel Rodríguez-Barranco, Leire Gil, Maria-Dolores Chirlaque, Eva Ardanaz, Robin Myte, Johan Hultdin, Aurora Perez-Cornago, Dagfinn Aune, Konstantinos K. Tsilidis, Demetrius Albanes, John A. Baron, Sonja I. Berndt, Stéphane Bézieau, Hermann Brenner, Peter T. Campbell, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Michelle Cotterchio, Steven Gallinger, Stephen B. Gruber, Robert W. Haile, Jochen Hampe, Michael Hoffmeister, John L. Hopper, Li Hsu, Jeroen R. Huyghe, Mark A. Jenkins, Amit D. Joshi, Ellen Kampman, Susanna C. Larsson, Loic Le Marchand, Christopher I. Li, Li Li, Annika Lindblom, Noralane M. Lindor, Vicente Martín, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Shuji Ogino, Patrick S. Parfrey, Paul D. P. Pharoah, Gad Rennert, Lori C. Sakoda, Clemens Schafmayer, Stephanie L. Schmit, Robert E. Schoen, Martha L. Slattery, Stephen N. Thibodeau, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Korbinian Weigl, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Xuehong Zhang, Pietro Ferrari, Gabriele Anton, Annette Peters, Ulrike Peters, Marc J. Gunter, Karl-Heinz Wagner, Heinz Freisling
Sep 03, 2020
Abstract: Background: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate...
Circulating bilirubin levels and risk of colorectal cancer
Nazlisadat Seyed Khoei, Mazda Jenab, Neil Murphy, Barbara L Banbury, Robert Carreras-Torres, Vivian Viallon, Tilman Kühn, Bas Bueno-de-Mesquita, Krasimira Aleksandrova, Amanda J Cross, Elisabete Weiderpass, Magdalena Stepien, Andrew Bulmer, Anne Tjønneland, Marie-Christine Boutron-Ruault, Gianluca Severi, Franck Carbonnel, Verena Katzke, Heiner Boeing, Manuela M Bergmann, Antonia Trichopoulou, Anna Karakatsani, Georgia Martimianaki, Domenico Palli, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Susana Merino, Catalina Bonet, Miguel Rodríguez-Barranco, Leire Gil, Maria-Dolores Chirlaque, Eva Ardanaz, Robin Myte, Johan Hultdin, Aurora Perez-Cornago, Dagfinn Aune, Konstantinos K Tsilidis, Demetrius Albanes, John A Baron, Sonja I Berndt, Stéphane Bézieau, Hermann Brenner, Peter T Campbell, Graham Casey, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Michelle Cotterchio, Steven Gallinger, Stephen B Gruber, Robert W Haile, Jochen Hampe, Michael Hoffmeister, John L Hopper, Li Hsu, Jeroen R Huyghe, Mark A Jenkins, Amit D Joshi, Ellen Kampman, Susanna C Larsson, Loic Le Marchand, Christopher I Li, Li Li, Annika Lindblom, Noralane M Lindor, Vicente Martín, Victor Moreno, Polly A Newcomb, Kenneth Offit, Shuji Ogino, Patrick S Parfrey, Paul DP Pharoah, Gad Rennert, Lori C Sakoda, Clemens Schafmayer, Stephanie L Schmit, Robert E Schoen, Martha L Slattery, Stephen N Thibodeau, Cornelia M Ulrich, Franzel JB van Duijnhoven, Korbinian Weigl, Stephanie J Weinstein, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Xuehong Zhang, Pietro Ferrari, Gabriele Anton, Annette Peters, Ulrike Peters, Marc J Gunter, Karl-Heinz Wagner, Heinz Freisling
Oct 02, 2020
BACKGROUND: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether...
Pan-cancer analysis of whole genomes.
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of...
Cell Proliferation Cellular Senescence Chromothripsis Cloud Computing DNA Mutational Analysis evolution Molecular Female Genome Human Genomics Germ-Line Mutation High-Throughput Nucleotide Sequencing Humans Information Dissemination Male Mutagenesis Mutation Neoplasms Oncogenes Promoter Regions Genetic RNA Splicing Reproducibility of Results Telomerase Telomere
Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer
Nikhil K Khankari, Xiao-Ou Shu, Wanqing Wen, Peter Kraft, Sara Lindström, Ulrike Peters, Joellen Schildkraut, Fredrick Schumacher, Paolo Bofetta, Angela Risch, Heike Bickeböller, Christopher I Amos, Douglas Easton, Rosalind A Eeles, Stephen B Gruber, Christopher A Haiman, David J Hunter, Stephen J Chanock, Brandon L Pierce, Wei Zheng, Colorectal Transdisciplinary Study (CORECT), Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Discovery, Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE), Transdisciplinary Research in Cancer of the Lung (TRICL)
Oct 31, 2016
Alcohol intake and risk of colorectal cancer
JY Park, CC Dahm, RH Keogh, PN Mitrou, BJ Cairns, DC Greenwood, EA Spencer, IS Fentiman, MJ Shipley, EJ Brunner, JE Cade, VJ Burley, GD Mishra, D Kuh, AM Stephen, IR White, RN Luben, AA Mulligan, K-T Khaw, SA Rodwell
Nov 25, 2021
BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent. METHODS: We...
Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer
Susanna C Larsson, Amy M Mason, Siddhartha Kar, Mathew Vithayathil, Paul Carter, John A Baron, Karl Michaëlsson, Stephen Burgess
Nov 06, 2020
BACKGROUND: Observational studies have shown that milk consumption is inversely associated with colorectal, bladder, and breast cancer risk, but positively associated with prostate cancer. However, whether the associations...
The Colorectal cancer RISk Prediction (CRISP) trial
Jon D Emery, Mark A Jenkins, Sibel Saya, Patty Chondros, Jasmeen Oberoi, Shakira Milton, Kitty Novy, Emily Habgood, Napin Karnchanachari, Marie Pirotta, Lyndal Trevena, Adrian Bickerstaffe, Richard De Abreu Lourenço, Anna Crothers, Driss Ait Ouakrim, Louisa Flander, James G Dowty, Fiona M Walter, Malcolm Clark, Sally Doncovio, Dariush Etemadmoghadam, George Fishman, Finlay Macrae, Ingrid Winship, Jennifer G McIntosh
Apr 17, 2023
BACKGROUND: A risk-stratified approach to colorectal cancer (CRC) screening could result in a more acceptable balance of benefits and harms, and be more cost-effective. AIM: To determine the effect of a consultation in general...
Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer.
Alexi N Archambault, Yu-Ru Su, Jihyoun Jeon, Minta Thomas, Yi Lin, David V Conti, Aung Ko Win, Lori C Sakoda, Iris Lansdorp-Vogelaar, Elisabeth FP Peterse, Ann G Zauber, David Duggan, Andreana N Holowatyj, Jeroen R Huyghe, Hermann Brenner, Michelle Cotterchio, Stéphane Bézieau, Stephanie L Schmit, Christopher K Edlund, Melissa C Southey, Robert J Macinnis, Peter T Campbell, Jenny Chang-Claude, Martha L Slattery, Andrew T Chan, Amit D Joshi, Mingyang Song, Yin Cao, Michael O Woods, Emily White, Stephanie J Weinstein, Cornelia M Ulrich, Michael Hoffmeister, Stephanie A Bien, Tabitha A Harrison, Jochen Hampe, Christopher I Li, Clemens Schafmayer, Kenneth Offit, Paul D Pharoah, Victor Moreno, Annika Lindblom, Alicja Wolk, Anna H Wu, Li Li, Marc J Gunter, Andrea Gsur, Temitope O Keku, Rachel Pearlman, D Timothy Bishop, Sergi Castellví-Bel, Leticia Moreira, Pavel Vodicka, Ellen Kampman, Graham G Giles, Demetrius Albanes, John A Baron, Sonja I Berndt, Stefanie Brezina, Stephan Buch, Daniel D Buchanan, Antonia Trichopoulou, Gianluca Severi, María-Dolores Chirlaque, Maria-José Sánchez, Domenico Palli, Tilman Kühn, Neil Murphy, Amanda J Cross, Andrea N Burnett-Hartman, Stephen J Chanock, Albert de la Chapelle, Douglas F Easton, Faye Elliott, Dallas R English, Edith JM Feskens, Liesel M Fitzgerald, Phyllis J Goodman, John L Hopper, Thomas J Hudson, David J Hunter, Eric J Jacobs, Corinne E Joshu, Sébastien Küry, Sanford D Markowitz, Roger L Milne, Elizabeth A Platz, Gad Rennert, Hedy S Rennert, Fredrick R Schumacher, Robert S Sandler, Daniela Seminara, Catherine M Tangen, Stephen N Thibodeau, Amanda E Toland, Franzel JB van Duijnhoven, Kala Visvanathan, Ludmila Vodickova, John D Potter, Satu Männistö, Korbinian Weigl, Jane Figueiredo, Vicente Martín, Susanna C Larsson, Patrick S Parfrey, Wen-Yi Huang, Heinz-Josef Lenz, Jose E Castelao, Manuela Gago-Dominguez, Victor Muñoz-Garzón, Christoph Mancao, Christopher A Haiman, Lynne R Wilkens, Erin Siegel, Elizabeth Barry, Ban Younghusband, Bethany Van Guelpen, Sophia Harlid, Anne Zeleniuch-Jacquotte, Peter S Liang, Mengmeng Du, Graham Casey, Noralane M Lindor, Loic Le Marchand, Steven J Gallinger, Mark A Jenkins, Polly A Newcomb, Stephen B Gruber, Robert E Schoen, Heather Hampel, Douglas A Corley, Li Hsu, Ulrike Peters, Richard B Hayes
Dec 12, 2019
BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for...
colon cancer EOCRC Penetrance SNP Age of Onset Case-Control Studies Cohort Studies Colorectal Neoplasms DNA Mutational Analysis Datasets as Topic Female Genetic Predisposition to Disease Genome-Wide Association Study Genotyping Techniques Humans Life Style Male Medical History Taking Middle Aged Mutation Rate Polymorphism Single Nucleotide Risk Factors whole genome sequencing
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
Amit V Khera, Hong-Hee Won, Gina M Peloso, Colm O'Dushlaine, Dajiang Liu, Nathan O Stitziel, Pradeep Natarajan, Akihiro Nomura, Connor A Emdin, Namrata Gupta, Ingrid B Borecki, Rosanna Asselta, Stefano Duga, Piera Angelica Merlini, Adolfo Correa, Thorsten Kessler, James G Wilson, Matthew J Bown, Alistair S Hall, Peter S Braund, David J Carey, Michael F Murray, H Lester Kirchner, Joseph B Leader, Daniel R Lavage, J Neil Manus, Dustin N Hartzel, Nilesh J Samani, Heribert Schunkert, Jaume Marrugat, Roberto Elosua, Ruth McPherson, Martin Farrall, Hugh Watkins, Eric S Lander, Daniel J Rader, John Danesh, Diego Ardissino, Stacey Gabriel, Cristen Willer, Gonçalo R Abecasis, Danish Saleheen, Frederick E Dewey, Sekar Kathiresan, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium Myocardial Infarction Genetics Consortium
Jun 25, 2018
IMPORTANCE: The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene (LPL) lead to lifelong deficiency in enzymatic...
Physical activity and risks of breast and colorectal cancer
Nikos Papadimitriou, Niki Dimou, Konstantinos K. Tsilidis, Barbara Banbury, Richard M. Martin, Sarah J. Lewis, Nabila Kazmi, Timothy M. Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I. Berndt, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Bas Bueno-de-Mesquita, Peter T. Campbell, Sergi Castellví-Bel, Andrew T. Chan, Jenny Chang-Claude, Merete Ellingjord-Dale, Jane C. Figueiredo, Steven J. Gallinger, Graham G. Giles, Edward Giovannucci, Stephen B. Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Li Hsu, José María Huerta, Jeroen R. Huyghe, Mark A. Jenkins, Temitope O. Keku, Tilman Kühn, Carlo La Vecchia, Loic Le Marchand, Christopher I. Li, Li Li, Annika Lindblom, Noralane M. Lindor, Brigid Lynch, Sanford D. Markowitz, Giovanna Masala, Anne M. May, Roger Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Vittorio Perduca, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Elio Riboli, Maria-Jose Sánchez, Stephanie L. Schmit, Robert E. Schoen, Gianluca Severi, Sabina Sieri, Martha L. Slattery, Mingyang Song, Catherine M. Tangen, Stephen N. Thibodeau, Ruth C. Travis, Antonia Trichopoulou, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Marc J. Gunter, Neil Murphy
Jan 29, 2021
Abstract: Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian...
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma.
Thanos P Mourikis, Lorena Benedetti, Elizabeth Foxall, Damjan Temelkovski, Joel Nulsen, Juliane Perner, Matteo Cereda, Jesper Lagergren, Michael Howell, Christopher Yau, Rebecca C Fitzgerald, Paola Scaffidi, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Francesca D Ciccarelli
Sep 09, 2019
The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to...
Adenocarcinoma Antineoplastic Agents Biomarkers Tumor Computational Biology Datasets as Topic Disease Progression Esophageal Neoplasms Gene Dosage Gene Expression Profiling Gene Expression Regulation Neoplastic Genomic Instability Humans Machine Learning Models Genetic Multigene Family Mutation Rate Polymorphism Single Nucleotide Precision Medicine
Salicylic Acid and Risk of Colorectal Cancer
Aayah Nounu, Rebecca C Richmond, Isobel D Stewart, Praveen Surendran, Nicholas J Wareham, Adam Butterworth, Stephanie J Weinstein, Demetrius Albanes, John A Baron, John L Hopper, Jane C Figueiredo, Polly A Newcomb, Noralane M Lindor, Graham Casey, Elizabeth A Platz, Loïc Le Marchand, Cornelia M Ulrich, Christopher I Li, Fränzel JB van Dujinhoven, Andrea Gsur, Peter T Campbell, Víctor Moreno, Pavel Vodicka, Ludmila Vodickova, Efrat Amitay, Elizabeth Alwers, Jenny Chang-Claude, Lori C Sakoda, Martha L Slattery, Robert E Schoen, Marc J Gunter, Sergi Castellví-Bel, Hyeong-Rok Kim, Sun-Seog Kweon, Andrew T Chan, Li Li, Wei Zheng, D Timothy Bishop, Daniel D Buchanan, Graham G Giles, Stephen B Gruber, Gad Rennert, Zsofia K Stadler, Tabitha A Harrison, Yi Lin, Temitope O Keku, Michael O Woods, Clemens Schafmayer, Bethany Van Guelpen, Steven Gallinger, Heather Hampel, Sonja I Berndt, Paul DP Pharoah, Annika Lindblom, Alicja Wolk, Anna H Wu, Emily White, Ulrike Peters, David A Drew, Dominique Scherer, Justo Lorenzo Bermejo, Hermann Brenner, Michael Hoffmeister, Ann C Williams, Caroline L Relton
Nov 22, 2021
Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a...
Physical activity and risks of breast and colorectal cancer
Nikos Papadimitriou, Niki Dimou, Konstantinos K Tsilidis, Barbara Banbury, Richard M Martin, Sarah J Lewis, Nabila Kazmi, Timothy M Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I Berndt, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Bas Bueno-de-Mesquita, Peter T Campbell, Sergi Castellví-Bel, Andrew T Chan, Jenny Chang-Claude, Merete Ellingjord-Dale, Jane C Figueiredo, Steven J Gallinger, Graham G Giles, Edward Giovannucci, Stephen B Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A Harrison, Michael Hoffmeister, John L Hopper, Li Hsu, José María Huerta, Jeroen R Huyghe, Mark A Jenkins, Temitope O Keku, Tilman Kühn, Carlo La Vecchia, Loic Le Marchand, Christopher I Li, Li Li, Annika Lindblom, Noralane M Lindor, Brigid Lynch, Sanford D Markowitz, Giovanna Masala, Anne M May, Roger Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly A Newcomb, Kenneth Offit, Vittorio Perduca, Paul D P Pharoah, Elizabeth A Platz, John D Potter, Gad Rennert, Elio Riboli, Maria-Jose Sánchez, Stephanie L Schmit, Robert E Schoen, Gianluca Severi, Sabina Sieri, Martha L Slattery, Mingyang Song, Catherine M Tangen, Stephen N Thibodeau, Ruth C Travis, Antonia Trichopoulou, Cornelia M Ulrich, Franzel J B van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Ulrike Peters, Marc J Gunter, Neil Murphy
Mar 02, 2020
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation...
Published by: Nature Communications
Quantifying the Genetic Correlation between Multiple Cancer Types.
Sara Lindström, Hilary Finucane, Brendan Bulik-Sullivan, Fredrick R Schumacher, Christopher I Amos, Rayjean J Hung, Kristin Rand, Stephen B Gruber, David Conti, Jennifer B Permuth, Hui-Yi Lin, Ellen L Goode, Thomas A Sellers, Laufey T Amundadottir, Rachael Stolzenberg-Solomon, Alison Klein, Gloria Petersen, Harvey Risch, Brian Wolpin, Li Hsu, Jeroen R Huyghe, Jenny Chang-Claude, Andrew Chan, Sonja Berndt, Rosalind Eeles, Douglas Easton, Christopher A Haiman, David J Hunter, Benjamin Neale, Alkes L Price, Peter Kraft, GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL-ILCCO PanScan
Nov 28, 2017
Background: Many cancers share specific genetic risk factors, including both rare high-penetrance mutations and common SNPs identified through genome-wide association studies (GWAS). However, little is known about the overall...
Physical activity and risks of breast and colorectal cancer
Nikos Papadimitriou, Niki Dimou, Konstantinos K Tsilidis, Barbara Banbury, Richard M Martin, Sarah J Lewis, Nabila Kazmi, Timothy M Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I Berndt, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Bas Bueno-de-Mesquita, Peter T Campbell, Sergi Castellví-Bel, Andrew T Chan, Jenny Chang-Claude, Merete Ellingjord-Dale, Jane C Figueiredo, Steven J Gallinger, Graham G Giles, Edward Giovannucci, Stephen B Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A Harrison, Michael Hoffmeister, John L Hopper, Li Hsu, José María Huerta, Jeroen R Huyghe, Mark A Jenkins, Temitope O Keku, Tilman Kühn, Carlo La Vecchia, Loic Le Marchand, Christopher I Li, Li Li, Annika Lindblom, Noralane M Lindor, Brigid Lynch, Sanford D Markowitz, Giovanna Masala, Anne M May, Roger Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly A Newcomb, Kenneth Offit, Vittorio Perduca, Paul DP Pharoah, Elizabeth A Platz, John D Potter, Gad Rennert, Elio Riboli, Maria-Jose Sánchez, Stephanie L Schmit, Robert E Schoen, Gianluca Severi, Sabina Sieri, Martha L Slattery, Mingyang Song, Catherine M Tangen, Stephen N Thibodeau, Ruth C Travis, Antonia Trichopoulou, Cornelia M Ulrich, Franzel JB van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Ulrike Peters, Marc J Gunter, Neil Murphy
Feb 14, 2020
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation...
Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium.
Pooja Middha Kapoor, Sara Lindström, Sabine Behrens, Xiaoliang Wang, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Alison M Dunning, Paul DP Pharoah, Marjanka K Schmidt, Peter Kraft, Montserrat García-Closas, Douglas F Easton, Roger L Milne, Jenny Chang-Claude, Breast Cancer Association Consortium
Sep 04, 2019
BACKGROUND: Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest available dataset to date, we performed a comprehensive assessment of potential...
Europeans Gene-Environment Interaction Breast Cancer EPIDEMIOLOGY Risk Factors single nucleotide polymorphism Alleles Breast Neoplasms Case-Control Studies Europe Factor XIII Female Gene-Environment Interaction Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Polymorphism Single Nucleotide Receptors Estrogen Risk Factors White People
Overview of the oncogenic signaling pathways in colorectal cancer
Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from almost a quarter century of research, it is obvious that deregulation of spatio-temporally controlled signaling...
A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes.
Sally Mortlock, Rosario I Corona, Pik Fang Kho, Paul Pharoah, Ji-Heui Seo, Matthew L Freedman, Simon A Gayther, Matthew T Siedhoff, Peter AW Rogers, Ronald Leuchter, Christine S Walsh, Ilana Cass, Beth Y Karlan, BJ Rimel, International Endometriosis Genetics Consortium Ovarian Cancer Association Consortium, Grant W Montgomery, Kate Lawrenson, Siddhartha P Kar
Jun 07, 2022
Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using data from large endometriosis and EOC genome-wide association meta-analyses, we estimate the genetic correlation and evaluate the causal...
Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK biobank and genetic consortia participants
Susanna C Larsson, Paul Carter, Mathew Vithayathil, Amy M Mason, Karl Michaëlsson, John A Baron, Stephen Burgess
Nov 03, 2020
BACKGROUND & AIMS: Arachidonic acid (AA) is metabolized by cyclooxygenases and lipoxygenases to pro-inflammatory eicosanoids, which according to experimental research modulate tumor cell proliferation, differentiation, and...
Current opportunities to catalyze research in nutrition and cancer prevention – an interdisciplinary perspective
The Cancer Research UK - Ludwig Cancer Research Nutrition and Cancer Prevention Collaborative Group
Jul 31, 2019
Cancer Research UK and Ludwig Cancer Research convened an inaugural international Cancer Prevention and Nutrition Conference in London on December 3–4, 2018. Much of the discussion focused on the need for systematic...
cancer prevention Developmental origins Diet EPIDEMIOLOGY epigenetics interdisciplinary metabolism Nutrition obesity physical activity Public Health Biomedical Research Body Weight Congresses as Topic Diet Exercise food Humans Interdisciplinary Communication Interdisciplinary Research Neoplasms Nutrition Therapy Nutritional Status obesity Risk Factors United Kingdom
Sex differences in oncogenic mutational processes.
Constance H Li, Stephenie D Prokopec, Ren X Sun, Fouad Yousif, Nathaniel Schmitz, PCAWG Tumour Subtypes and Clinical Translation, Paul C Boutros, PCAWG Consortium
Sep 11, 2020
Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have...
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