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Results: 27257
Educational attainment does not influence brain aging.
Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baaré, David Bartrés-Faz, Lars Bertram, CJ Boraxbekk, Andreas M Brandmaier, Christian A Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N Henson, Carme Junqué, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kühn, Ulman Lindenberger, Brenda WJH Penninx, Sara Pudas, Øystein Sørensen, Lídia Vaqué-Alcázar, Kristine B Walhovd, Anders M Fjell
Jul 23, 2021
Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of...
Aging research using the common marmoset
Traditional animal models have been used to make seminal discoveries in biomedical research including a better understanding of the biology of the aging process. However, translation of these findings from laboratory to clinical...
Published by: Digital Commons @ Texas A&M University-San Antonio
Aging research using the common marmoset
Traditional animal models have been used to make seminal discoveries in biomedical research including a better understanding of the biology of the aging process. However, translation of these findings from laboratory to clinical...
Published by: Digital Commons @ Texas A&M University-San Antonio
Stem Cells of the Aging Brain
The adult central nervous system (CNS) contains resident stem cells within specific niches that maintain a self-renewal and proliferative capacity to generate new neurons, astrocytes, and oligodendrocytes throughout adulthood....
Aging research using the common marmoset
Traditional animal models have been used to make seminal discoveries in biomedical research including a better understanding of the biology of the aging process. However, translation of these findings from laboratory to clinical...
Published by: Digital Commons @ Texas A&M University-San Antonio
Stem Cells of the Aging Brain.
The adult central nervous system (CNS) contains resident stem cells within specific niches that maintain a self-renewal and proliferative capacity to generate new neurons, astrocytes, and oligodendrocytes throughout adulthood....
Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury
Frederick A Zeiler, Erta Beqiri, Manuel Cabeleira, Peter J Hutchinson, Nino Stocchetti, David K Menon, Marek Czosnyka, Peter Smielewski, Ari Ercole, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Mar 31, 2020
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO2) are associated with outcome in traumatic brain injury (TBI). This study explores the relationship between PRx and PbtO2 in adult moderate/severe TBI. Using the...
ICP autoregulation brain tissue oxygen physiological burden Adult Aged Biomedical Research Brain Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Cost of Illness Europe Female Glasgow Outcome Scale Humans Intersectoral Collaboration Male Middle Aged Oxygen Consumption Prospective Studies Treatment Outcome
A Novel Examination of Successful Aging Trajectories at the End of Life.
Theodore D Cosco, Blossom CM Stephan, Graciela Muniz, Carol Brayne, CC75C Study Collaboration
Sep 27, 2018
A successful aging (SA) index was captured in a longitudinal population-based cohort study of individuals aged 75 and older and examined longitudinally using growth mixture modelling (GMM) to identify groups with similar...
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Michele Vendruscolo, Alessandro Cellerino, Alessandro Ori
Jun 22, 2020
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived...
Developing EasySci, a High-Throughput and Low-Cost Single-Cell Genomic Technique, to Study Aging and Alzheimer's Disease in Human and Mouse Brain
Andras Sziraki
Jan 01, 0001
Previous single-cell methods are limited by their relatively low throughput and high costs. This prevents most laboratories from performing large-scale cell profiling, complicating the understanding of rare cell type...
Published by: Rockefeller University
Microglia and the aging brain
The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's disease is increased age. Therefore, understanding the changes that occur as a result of aging is central to any possible prevention...
Microglia and the aging brain
The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's disease is increased age. Therefore, understanding the changes that occur as a result of aging is central to any possible prevention...
The "Neural Shift" of Sleep Quality and Cognitive Aging
Sleep quality changes dramatically from young to old age, but its effects on brain dynamics and cognitive functions are not yet fully understood. We tested the hypothesis that a shift in brain networks dynamics relates to sleep...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Brain charts for the human lifespan
RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, R Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, DP Linares, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, BTT Yeo, HJ Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, AF Alexander-Bloch, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, ASRB, CALM team, Cam-CAN, 3R-BRAIN CCNP, COBRE, ENIGMA Developmental Brain Age Working Group, FinnBrain, Harvard Aging Brain Study, KNE96 IMAGEN, NSPN, OASIS-3, OpenPain Project, POND, VETSA, Bullmore, E.T The PREVENT-AD Research Group
Sep 24, 2022
Over the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in...
AIBL Alzheimer’s Disease Neuroimaging Initiative Alzheimer’s Disease Repository Without Borders Investigators ASRB CALM Team Cam-CAN CCNP 3R-BRAIN COBRE ENIGMA Developmental Brain Age working group FinnBrain Harvard Aging Brain Study IMAGEN KNE96 NSPN OASIS-3 OpenPain Project POND The PREVENT-AD Research Group VETSA Bullmore E.T
Systemic Markers of Injury and Injury Response Are Not Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Sep 15, 2020
The role of extra-cranial injury burden and systemic injury response on cerebrovascular response in traumatic brain injury (TBI) is poorly documented. This study preliminarily assesses the association between admission features...
TBI autoregulation cerebrovascular reactivity extra-cranial injury injury burden Adult Biomarkers Biomedical Research Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Europe Female Humans Intersectoral Collaboration Male Middle Aged Patient Admission Prospective Studies Treatment Outcome
Toward a New Multi-Dimensional Classification of Traumatic Brain Injury
Benjamin Y Gravesteijn, Charlie A Sewalt, Ari Ercole, Cecilia Akerlund, David Nelson, Andrew IR Maas, David Menon, Hester F Lingsma, Ewout W Steyerberg, Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Collaborators
Oct 28, 2019
Traumatic brain injury (TBI) is currently classified as mild, moderate, or severe TBI by trichotomizing the Glasgow Coma Scale (GCS). We aimed to explore directions for a more refined multidimensional classification system. For...
Brain Health Services
Daniele Altomare, José Luis Molinuevo, Craig Ritchie, Federica Ribaldi, Emmanuel Carrera, Bruno Dubois, Frank Jessen, Laura McWhirter, Philip Scheltens, Wiesje M van der Flier, Bruno Vellas, Jean-François Démonet, Giovanni B Frisoni, European Task Force for Brain Health Services
Nov 18, 2021
Dementia has a devastating impact on the quality of life of patients and families and comes with a huge cost to society. Dementia prevention is considered a public health priority by the World Health Organization. Delaying the...
Education and Successful Aging Trajectories
As the population ages, interest is increasing in studying aging well. However, more refined means of examining predictors of biopsychosocial conceptualizations of successful aging (SA) are required. Existing evidence of the...
Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue.
Oneil G Bhalala, Artika P Nath, UK Brain Expression Consortium, Michael Inouye, Christopher R Sibley
Sep 10, 2018
Schizophrenia and the affective disorders, here comprising bipolar disorder and major depressive disorder, are psychiatric illnesses that lead to significant morbidity and mortality worldwide. Whilst understanding of their...
Association between midlife dementia risk factors and longitudinal brain atrophy
John T O'Brien, Michael J Firbank, Karen Ritchie, Katie Wells, Guy B Williams, Craig W Ritchie, Li Su
Dec 11, 2019
Background: Increased rates of brain atrophy on serial MRI are frequently used as a surrogate marker of disease progression in Alzheimer’s disease and other dementias. However, the extent to which they are associated with future...
Asymmetry of Hemispheric Network Topology Reveals Dissociable Processes between Functional and Structural Brain Connectome in Community-Living Elders.
Human brain is structurally and functionally asymmetrical and the asymmetries of brain phenotypes have been shown to change in normal aging. Recent advances in graph theoretical analysis have showed topological lateralization...
Societal and equity challenges for Brain Health Services. A user manual for Brain Health Services-part 6 of 6.
Richard Milne, Daniele Altomare, Federica Ribaldi, José Luis Molinuevo, Giovanni B Frisoni, Carol Brayne, European Task Force for Brain Health Services
Nov 01, 2021
Brain Health Services are a novel approach to the personalized prevention of dementia. In this paper, we consider how such services can best reflect their social, cultural, and economic context and, in doing so, deliver fair and...
Dissociable circuits for visual shape learning in the young and aging human brain.
Recognizing objects in cluttered scenes is vital for successful interactions in our complex environments. Learning is known to play a key role in facilitating performance in a wide range of perceptual skills not only in young...
Habitual tea drinking modulates brain efficiency
The majority of tea studies have relied on neuropsychological measures, and much fewer on neuroimaging measures, especially for interregional connections. To date, there has been no exploration of the effect of tea on...
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