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Results: 524
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease
Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators, Tim Raine, Miles Parkes, UK IBD Bioresource Investigators
Jul 20, 2020
OBJECTIVE: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date...
NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.
T Schwerd, RV Bryant, S Pandey, M Capitani, L Meran, J-B Cazier, J Jung, K Mondal, M Parkes, CG Mathew, K Fiedler, DJ McCarthy, WGS500 Consortium, Oxford IBD cohort study investigators, COLORS in IBD group investigators, UK IBD Genetics Consortium, PB Sullivan, A Rodrigues, SPL Travis, C Moore, J Sambrook, WH Ouwehand, DJ Roberts, J Danesh, INTERVAL Study, RK Russell, DC Wilson, JR Kelsen, R Cornall, LA Denson, S Kugathasan, UG Knaus, EG Serra, CA Anderson, RH Duerr, D Pb McGovern, J Cho, F Powrie, V Sw Li, AM Muise, HH Uhlig
Feb 05, 2018
Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel hemizygous defect in NOX1 encoding NAPDH oxidase 1...
Animals Child Child Preschool Colon Genes Modifier Genetic Association Studies Genetic Predisposition to Disease Genome Genotype High-Throughput Nucleotide Sequencing Host-Pathogen Interactions Humans Inflammatory Bowel Diseases Male Mice Mice Inbred C57BL Mutation Missense NADPH Oxidase 1 Polymorphism Single Nucleotide Reactive Oxygen Species
Somatic Evolution in Non-neoplastic IBD-Affected Colon.
Sigurgeir Olafsson, Rebecca E McIntyre, Tim Coorens, Timothy Butler, Hyunchul Jung, Philip S Robinson, Henry Lee-Six, Mathijs A Sanders, Kenneth Arestang, Claire Dawson, Monika Tripathi, Konstantina Strongili, Yvette Hooks, Michael R Stratton, Miles Parkes, Inigo Martincorena, Tim Raine, Peter J Campbell, Carl A Anderson
Jan 18, 2021
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts...
Crohn's Disease IL17 PIGR ZC3H12A inflammatory bowel disease intestinal epithelia Mutation Rate mutational signatures somatic mutations Ulcerative colitis Adult Aged Aged 80 and over aging Clonal Evolution Colitis Colitis Ulcerative Crohn Disease DNA-Binding Proteins Epithelial Cells F-Box-WD Repeat-Containing Protein 7 Female Humans INDEL Mutation Inflammatory Bowel Diseases Interleukin-17 Intestinal Mucosa Male Middle Aged Mutation Rate Phylogeny Point Mutation Receptors Cell Surface Ribonucleases Toll-Like Receptors Transcription Factors whole genome sequencing
IBD considerations in spondyloarthritis.
Spondyloarthritis (SpA) may be regarded a family of auto-inflammatory conditions with inflammation focused on the joints. These form part of a wider family of immune-mediated inflammatory diseases, which include inflammatory...
Moving towards more patient-centred clinical trials in IBD.
Declining recruitment rates in inflammatory bowel disease (IBD) trials have resulted in calls to modify the conduct of trials in IBD in order to make them more efficient and patient centred. Here, we propose a number of...
covid-19 Clinical Trials as Topic Humans Inflammatory Bowel Diseases Informed Consent Patient Acceptance of Health Care Patient Outcome Assessment Patient Reported Outcome Measures patient satisfaction Patient Selection Patient-Centered Care SARS-CoV-2 Self-testing Telemedicine Therapeutic Equipoise
Highlights in IBD Epidemiology and Its Natural History in the Paediatric Age.
Background. The number of patients of all age brackets diagnosed with Inflammatory Bowel Disease (IBD) has risen dramatically worldwide over the past 50 years. IBD's changing epidemiology suggests that environmental factors play...
Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.
Maria Laura Santoru, Cristina Piras, Antonio Murgia, Vanessa Palmas, Tania Camboni, Sonia Liggi, Ivan Ibba, Maria Antonia Lai, Sandro Orrù, Sylvain Blois, Anna Lisa Loizedda, Julian Leether Griffin, Paolo Usai, Pierluigi Caboni, Luigi Atzori, Aldo Manzin
Jun 15, 2018
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change...
Sources of excess steroid prescriptions and clinical adverse outcomes associated with steroid excess in patients with inflammatory bowel disease
Konstantina Rosiou, Jenelyn Carbonell, Vivien Dolby, Niloufar Monfared, Tim Raine, Christian P Selinger
May 25, 2022
BACKGROUND: Corticosteroids remain important for managing inflammatory bowel disease (IBD) flares. Steroid excess, however, may be a marker of poor care. Patients access steroid prescriptions from primary (General Practitioners...
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.
Yukihide Momozawa, Julia Dmitrieva, Emilie Théâtre, Valérie Deffontaine, Souad Rahmouni, Benoît Charloteaux, François Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cécile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd Bouma, Frank Hoentjen, Mark Löwenberg, Bas Oldenburg, Marieke J Pierik, Andrea E Vander Meulen-de Jong, C Janneke van der Woude, Marijn C Visschedijk, International IBD Genetics Consortium, Mark Lathrop, Jean-Pierre Hugot, Rinse K Weersma, Martine De Vos, Denis Franchimont, Severine Vermeire, Michiaki Kubo, Edouard Louis, Michel Georges
Mar 28, 2019
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these...
Adult Aged Aged 80 and over Cohort Studies Crohn Disease Female Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Inflammatory Bowel Diseases Male Middle Aged Multifactorial Inheritance Polymorphism Single Nucleotide Quantitative Trait Loci Sequence Analysis DNA
BSG 2024 IBD guidelines protocol (standard operating procedures).
Ana-Maria Darie, Vasiliki Sinopoulou, Verma Ajay, Klaartje Bel Kok, Kamal V Patel, Jimmy Limdi, Naila Arebi, Philip Smith, Shahida Din, Said Din, Matthew Shale, Sreedhar Subramanian, Polychronis Pavlidis, Rachel Cooney, Dennis McGonagle, Newton A C S Wong, Gordon W Moran, Morris Gordon
Mar 14, 2023
Introduction
In the past 5 years, there have been several advances in the management of inflammatory bowel disease (IBD). We aim for a new guideline to update the most recent guideline published in 2019. We present the...
inflammatory bowel disease health service research IBD clinical IBD BASIC RESEARCH SURGERY FOR IBD Humans Inflammatory Bowel Diseases Prospective Studies Delivery of Health Care Randomized Controlled Trials as Topic
Published by: BMJ open gastroenterology
Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab.
Nicholas A Kennedy, James R Goodhand, Claire Bewshea, Rachel Nice, Desmond Chee, Simeng Lin, Neil Chanchlani, Jeffrey Butterworth, Rachel Cooney, Nicholas M Croft, Ailsa L Hart, Peter M Irving, Klaartje B Kok, Christopher A Lamb, Jimmy K Limdi, Jonathan Macdonald, Dermot PB McGovern, Shameer J Mehta, Charles D Murray, Kamal V Patel, Richard Cg Pollok, Timothy Raine, Richard K Russell, Christian P Selinger, Philip J Smith, Jack Bowden, Timothy J McDonald, Charlie W Lees, Shaji Sebastian, Nicholas Powell, Tariq Ahmad, Contributors to the CLARITY IBD study
Mar 23, 2021
OBJECTIVE: Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following pneumococcal, influenza and viral hepatitis vaccination and increase the risk of serious respiratory infections. We sought to determine...
covid-19 Autoimmune Disease CLARITY inflammatory bowel disease inflammatory diseases Infliximab vedoluzimab Adult Antibodies Monoclonal Humanized Antibodies Viral Antibody Formation covid-19 Female Gastrointestinal Agents Humans Inflammatory Bowel Diseases Infliximab Male Middle Aged Prospective Studies SARS-CoV-2 Serologic Tests United Kingdom
Clinical trials (and tribulations)
There have been immediate and profound impacts of SARS-CoV-2 and COVID-19 on healthcare services worldwide with major consequences for non-COVID-19 related healthcare. Alongside efforts to reconfigure services and enable...
COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP)
James L Alexander, Zhigang Liu, Diana Muñoz Sandoval, Catherine Reynolds, Hajir Ibraheim, Sulak Anandabaskaran, Aamir Saifuddin, Rocio Castro Seoane, Nikhil Anand, Rachel Nice, Claire Bewshea, Andrea D'Mello, Laura Constable, Gareth R Jones, Sharmili Balarajah, Francesca Fiorentino, Shaji Sebastian, Peter M Irving, Lucy C Hicks, Horace RT Williams, Alexandra J Kent, Rachel Linger, Miles Parkes, Klaartje Kok, Kamal V Patel, Julian P Teare, Daniel M Altmann, James R Goodhand, Ailsa L Hart, Charlie W Lees, Rosemary J Boyton, Nicholas A Kennedy, Tariq Ahmad, Nick Powell, VIP study investigators
Oct 12, 2022
BACKGROUND: COVID-19 vaccine-induced antibody responses are reduced in patients with inflammatory bowel disease (IBD) taking anti-TNF or tofacitinib after two vaccine doses. We sought to assess whether immunosuppressive...
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M Croft, Carsten Posovszky, Astor Rodrigues, Richard K Russell, Farah Barakat, Marcus KH Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C Matte, Kimberly C Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A Baeumler, Tudor A Fulga, Eli M Carrami, Ahmed Ahmed, Rachel Wilson, Jeffrey C Barrett, Abdul Elkadri, Anne M Griffiths, COLORS in IBD group investigators, Oxford IBD cohort study investigators, INTERVAL Study, Swiss IBD cohort investigators, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Scott B Snapper, Neil Shah, Aleixo M Muise, David C Wilson, Holm H Uhlig, Carl A Anderson
Jan 31, 2020
Adult Age of Onset Case-Control Studies Child Child Preschool Cohort Studies Female Genes Recessive Genetic Predisposition to Disease genetic variation Humans Infant Infant Newborn Inflammatory Bowel Diseases Loss of Function Mutation Male Mosaicism Multifactorial Inheritance Mutation NADPH Oxidase 2 Pedigree Primary Immunodeficiency Diseases Risk Factors Exome Sequencing
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Prevalence of axial spondyloarthritis in patients with inflammatory bowel disease using cross-sectional imaging
BACKGROUND: Patients with inflammatory bowel disease (IBD) have an excess burden of axial spondyloarthritis (axSpA), which, if left untreated, may significantly impact on clinical outcomes. We aimed to estimate the prevalence of...
Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.
Arianne C Richard, James E Peters, Natalia Savinykh, James C Lee, Eric T Hawley, Françoise Meylan, Richard M Siegel, Paul A Lyons, Kenneth GC Smith
Sep 05, 2018
Chronic inflammation in inflammatory bowel disease (IBD) results from a breakdown of intestinal immune homeostasis and compromise of the intestinal barrier. Genome-wide association studies have identified over 200 genetic loci...
International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.
Pablo A Olivera, Stephane Zuily, Paulo G Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C Ng, Alfredo Papa, Tim Raine, Fabio V Teixeira, David T Rubin, Silvio Danese, Laurent Peyrin-Biroulet
Sep 28, 2021
Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events. Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based Guideline were to summarize available...
Published by: Nature reviews. Gastroenterology & hepatology
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease
Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators, Tim Raine, Miles Parkes, UK IBD BioResource Investigators, Tariq Ahmad, Nick Kennedy, Peter Irving, Natalie Prescott, Charlie Lees, John Mansfield, Chris Lamb, Jack Satsangi, Alison Simmons, Alisa Hart, Sreedhar Subramanian, Chris Probert, Richard Shenderey, Anton Gunasekera, Klaartje Bel Kok, Babur Javaid, Leena Sinha, Salil Singh, Cathryn Preston, Mark Jarvis, Ruth Penn, Anjan Dhar, Achuth Shenoy, Kath Phillis, Arabis Oglesby, Jude Tilbury, Glyn Scott, Joseph Collum, Martyn Carter, Jamie Barbour, John Gordon, John Ramage, Ganesh Sivagi, Phil Roberts, Monica Bose, Shaji Sebastian, Joy Wilkins, Paul Banim, Alexana Kent, Ajay Verma, Dawn Warren, Alan Wiles, Matthew Johnson, Konrad Koss, Chirag Oza, Khalid Elamin, Annette Woods, Bijay Baburajan, Chris MacDonald, Byron Theron, Mark Tremelling, Udi Shmueli, Roisin Bevan, Jimmy Limdi, Prakash Nair, Deven Vani, Stephen Lewis, Michelle Baker-Moffat, Gordon Moran, Simon McLaughlin, Aminda de Silva, John Beckly, Anew Cole, Charles Murray, Alan Lobo, Melissa Smith, Sanju Mathew, John Saunders, Helen Steed, Matthew Brookes, Juliette Loehry, Monira Rahman, Jeff Butterworth, Ajay Muddu, Katie Clark, Christian Selinger, Arvind Ramadas, John McLaughlin, Richard Pollok, Colin Rees, Simon Panter, David Hobday, Stephen Foley, Vinod Patel, Emma Wesley, Daniel Gavin, Cathryn Edwards, Stuart Bloom, Chuka Nwokolo, John deCaestecker, Mina Hanna, Albert Davies, Laura Hancock, Fraser Cummings, Subramaniam Ramakrishnan, Theresa Tindall, Jonathan Landy, Richard Appleby, Dan Sharpstone, Andy Li, Richard Keld, Lin Mear, Anne Philips, Horace Willia, Laura Hancock Ben Warner, Dharmaraj Durai, Elaine Brinkworth, Zahid Mahmood, Rachel Cooney
Oct 06, 2020
Objective: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date...
Guidance on the interpretation of faecal calprotectin levels in children
Martina Orfei, Marco Gasparetto, Kai O. Hensel, Florian Zellweger, Robert B. Heuschkel, Matthias Zilbauer
Feb 11, 2021
Background: Faecal calprotectin (FCP) is a powerful tool to predict inflammatory bowel disease (IBD) in patients with gastrointestinal symptoms. In the paediatric patient population, the reference value of < 50 μg/g and the...
Prevalence of axial spondyloarthritis in patients with inflammatory bowel disease using cross-sectional imaging
Background:: Patients with inflammatory bowel disease (IBD) have an excess burden of axial spondyloarthritis (axSpA), which, if left untreated, may significantly impact on clinical outcomes. We aimed to estimate the prevalence...
Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis
Simon SM Chan, Ye Chen, Kevin Casey, Ola Olen, Jonas F Ludvigsson, Franck Carbonnel, Bas Oldenburg, Marc J Gunter, Anne Tjønneland, Olof Grip, DEFINe-IBD Investigators, Paul Lochhead, Andrew T Chan, Alicia Wolk, Hamed Khalili
Aug 18, 2021
BACKGROUND AND AIMS: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and...
International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.
Pablo A Olivera, Stephane Zuily, Paulo G Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C Ng, Alfredo Papa, Tim Raine, Fabio V Teixeira, David T Rubin, Silvio Danese, Laurent Peyrin-Biroulet
Nov 24, 2021
Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events. Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based Guideline were to summarize available...
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