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An E-Collaboration Application for Final-Year Project Management
The advent of digital technologies has contributed to collaboration in many areas of life, including academia. This paper examines student final year projects (FYPs) and proposes a collaborative system that provides tools in...
Published by: IGI Global Scientific Publishing
Design of a Functional H Filter for Linear Singular Systems With an Additional Unknown Input, Bounded Disturbance, and Variable Time Delay
This paper deals with a new method for the design of a functional filter for linear singular systems with bounded disturbance and variable time delay in the state and the known input vectors. Moreover, a disturbance unknown...
Published by: IGI Global Scientific Publishing
A New Design of a Functional H Filter for Linear Singular Systems With an Additional Unknown Input and Bounded Disturbances
This paper proposes a design of a H_¥ filter for a functional of the system state that the authors call functional H_¥ filter in time domain for linear singular systems with additional unknown inputs and bounded disturbances....
Published by: IGI Global Scientific Publishing
Resistance mechanisms and population structure of highly drug resistant Klebsiella in Pakistan during the introduction of the carbapenemase NDM-1.
Eva Heinz, Hasan Ejaz, Josefin Bartholdson Scott, Nancy Wang, Shruti Gujaran, Derek Pickard, Jonathan Wilksch, Hanwei Cao, Ikram-Ul Haq, Gordon Dougan, Richard A Strugnell
Mar 11, 2019
Klebsiella pneumoniae is a major threat to public health with the emergence of isolates resistant to most, if not all, useful antibiotics. We present an in-depth analysis of 178 extended-spectrum beta-lactamase (ESBL)-producing...
Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan.
Hasan Ejaz, Nancy Wang, Jonathan J Wilksch, Andrew J Page, Hanwei Cao, Shruti Gujaran, Jacqueline A Keane, Trevor Lithgow, Ikram Ul-Haq, Gordon Dougan, Richard A Strugnell, Eva Heinz
Aug 09, 2019
Australia ESBL Klebsiella Klebsiella pneumonia Pakistan United Kingdom Antimicrobial resistance Bacteria children Extended-spectrum β-lactamase multidrug resistance neonatal infection Adolescent Anti-Bacterial Agents Child Child Hospitalized Child Preschool Drug Resistance Multiple Bacterial Genome Bacterial Humans Infant Infant Newborn Klebsiella Infections Klebsiella pneumoniae Pakistan Phylogeny Sequence Analysis DNA
A Hybrid Hierarchical Heuristic-ACO With Local Search Applied to Travelling Salesman Problem, AS-FA-Ls
The combinatorial optimization problem is attracting research because they have a wide variety of applications ranging from route planning and supply chain optimization to industrial scheduling and the IoT. Solving such problems...
Published by: IGI Global Scientific Publishing
The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases
Ke-Xin Wen, Jelena Miliç, Bassem El-Khodor, Klodian Dhana, Jana Nano, Tammy Pulido, Bledar Kraja, Asija Zaciragic, Wichor M Bramer, John Troup, Rajiv Chowdhury, M Arfam Ikram, Abbas Dehghan, Taulant Muka, Oscar H Franco
Nov 20, 2017
IMPORTANCE: Epigenetic modifications of the genome, such as DNA methylation and histone modifications, have been reported to play a role in neurodegenerative diseases (ND) such as Alzheimer's disease (AD) and Parkinson's disease...
Trends in the incidence of dementia
Lori B Chibnik, Frank J Wolters, Kristoffer Bäckman, Alexa Beiser, Claudine Berr, Joshua C Bis, Eric Boerwinkle, Daniel Bos, Carol Brayne, Jean-Francois Dartigues, Sirwan KL Darweesh, Stephanie Debette, Kendra L Davis-Plourde, Carole Dufouil, Myriam Fornage, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M Arfan Ikram, M Kamran Ikram, Silke Kern, Lewis H Kuller, Lenore Launer, Oscar L Lopez, Fiona Matthews, Osorio Meirelles, Thomas Mosley, Alison Ower, Bruce M Psaty, Claudia L Satizabal, Sudha Seshadri, Ingmar Skoog, Blossom CM Stephan, Christophe Tzourio, Reem Waziry, Mei Mei Wong, Anna Zettergren, Albert Hofman
May 01, 2018
Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or...
The changing prevalence and incidence of dementia over time — current evidence
Y-T Wu, AS Beiser, MMB Breteler, L Fratiglioni, C Helmer, HC Hendrie, H Honda, MA Ikram, KM Langa, A Lobo, FE Matthews, T Ohara, K Pérès, C Qiu, S Seshadri, B-M Sjölund, I Skoog, C Brayne
Aug 03, 2017
Dementia is an increasing focus for policymakers, civil organizations and multidisciplinary researchers. The most recent descriptive epidemiological research into dementia is enabling investigation into how the prevalence and...
Dementia Research Fit for the Planet
Carol E Brayne, Linda E Barnes, Monique MB Breteler, Rachael L Brooks, Carole Dufouil, Chris Fox, Laura Fratiglioni, M Arfan Ikram, Rose A Kenny, Miia Kivipelto, Antonio Lobo, Massimo Musicco, Chengxuan Qiu, Edo Richard, Steffi G Riedel-Heller, Craig Ritchie, Ingmar Skoog, Blossom CM Stephan, Annalena Venneri, Fiona E Matthews
Feb 14, 2020
In recent years, a rapidly increasing collection of investigative methods in addition to changes in diagnostic criteria for dementia have followed "high-tech" trends in medicine, with the aim to better define the dementia...
Metabolomic profiles predict individual multidisease outcomes.
Thore Buergel, Jakob Steinfeldt, Greg Ruyoga, Maik Pietzner, Daniele Bizzarri, Dina Vojinovic, Julius Upmeier Zu Belzen, Lukas Loock, Paul Kittner, Lara Christmann, Noah Hollmann, Henrik Strangalies, Jana M Braunger, Benjamin Wild, Scott T Chiesa, Joachim Spranger, Fabian Klostermann, Erik B van den Akker, Stella Trompet, Simon P Mooijaart, Naveed Sattar, J Wouter Jukema, Birgit Lavrijssen, Maryam Kavousi, Mohsen Ghanbari, Mohammad A Ikram, Eline Slagboom, Mika Kivimaki, Claudia Langenberg, John Deanfield, Roland Eils, Ulf Landmesser
Nov 18, 2022
Risk stratification is critical for the early identification of high-risk individuals and disease prevention. Here we explored the potential of nuclear magnetic resonance (NMR) spectroscopy-derived metabolomic profiles to inform...
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations.
Danielle E Haslam, Gina M Peloso, Melanie Guirette, Fumiaki Imamura, Traci M Bartz, Achilleas N Pitsillides, Carol A Wang, Ruifang Li-Gao, Jason M Westra, Niina Pitkänen, Kristin L Young, Mariaelisa Graff, Alexis C Wood, Kim VE Braun, Jian'an Luan, Mika Kähönen, Jessica C Kiefte-de Jong, Mohsen Ghanbari, Nathan Tintle, Rozenn N Lemaitre, Dennis O Mook-Kanamori, Kari North, Mika Helminen, Yasmin Mossavar-Rahmani, Linda Snetselaar, Lisa W Martin, Jorma S Viikari, Wendy H Oddy, Craig E Pennell, Frits R Rosendall, M Arfan Ikram, Andre G Uitterlinden, Bruce M Psaty, Dariush Mozaffarian, Jerome I Rotter, Kent D Taylor, Terho Lehtimäki, Olli T Raitakari, Kara A Livingston, Trudy Voortman, Nita G Forouhi, Nick J Wareham, Renée de Mutsert, Steven S Rich, JoAnn E Manson, Samia Mora, Paul M Ridker, Jordi Merino, James B Meigs, Hassan S Dashti, Daniel I Chasman, Alice H Lichtenstein, Caren E Smith, Josée Dupuis, Mark A Herman, Nicola M McKeown
Jul 20, 2021
BACKGROUND: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have...
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Eliana Portilla-Fernández, Shih-Jen Hwang, Rory Wilson, Jane Maddock, W David Hill, Alexander Teumer, Pashupati P Mishra, Jennifer A Brody, Roby Joehanes, Symen Ligthart, Mohsen Ghanbari, Maryam Kavousi, Anton JM Roks, AH Jan Danser, Daniel Levy, Annette Peters, Sahar Ghasemi, Ulf Schminke, Marcus Dörr, Hans J Grabe, Terho Lehtimäki, Mika Kähönen, Mikko A Hurme, Traci M Bartz, Nona Sotoodehnia, Joshua C Bis, Joachim Thiery, Wolfgang Koenig, Kenneth Ong, Jordana T Bell, Christine Meisinger, Joanna M Wardlaw, John M Starr, Jochen Seissler, Cornelia Then, Wolfgang Rathmann, M Arfan Ikram, Bruce M Psaty, Olli T Raitakari, Henry Völzke, Ian J Deary, Andrew Wong, Melanie Waldenberger, Christopher J O'Donnell, Abbas Dehghan
Jun 14, 2021
Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study...
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
S. Fleur W. Meddens, Ronald de Vlaming, Peter Bowers, Casper A. P. Burik, Richard Karlsson Linnér, Chanwook Lee, Aysu Okbay, Patrick Turley, Cornelius A. Rietveld, Mark Alan Fontana, Mohsen Ghanbari, Fumiaki Imamura, George McMahon, Peter J. van der Most, Trudy Voortman, Kaitlin H. Wade, Emma L. Anderson, Kim V. E. Braun, Pauline M. Emmett, Tonũ Esko, Juan R. Gonzalez, Jessica C. Kiefte-de Jong, Claudia Langenberg, Jian’an Luan, Taulant Muka, Susan Ring, Fernando Rivadeneira, Harold Snieder, Frank J. A. van Rooij, Bruce H. R. Wolffenbuttel, George Davey Smith, Oscar H. Franco, Nita G. Forouhi, M. Arfan Ikram, Andre G. Uitterlinden, Jana V. van Vliet-Ostaptchouk, Nick J. Wareham, David Cesarini, K. Paige Harden, James J. Lee, Daniel J. Benjamin, Carson C. Chow, Philipp D. Koellinger
Sep 15, 2021
Abstract: We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique...
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle.
S Fleur W Meddens, Ronald de Vlaming, Peter Bowers, Casper AP Burik, Richard Karlsson Linnér, Chanwook Lee, Aysu Okbay, Patrick Turley, Cornelius A Rietveld, Mark Alan Fontana, Mohsen Ghanbari, Fumiaki Imamura, George McMahon, Peter J van der Most, Trudy Voortman, Kaitlin H Wade, Emma L Anderson, Kim VE Braun, Pauline M Emmett, Tonũ Esko, Juan R Gonzalez, Jessica C Kiefte-de Jong, Claudia Langenberg, Jian'an Luan, Taulant Muka, Susan Ring, Fernando Rivadeneira, Harold Snieder, Frank JA van Rooij, Bruce Hr Wolffenbuttel, 23andMe Research Team, EPIC- InterAct Consortium, Lifelines Cohort Study, George Davey Smith, Oscar H Franco, Nita G Forouhi, M Arfan Ikram, Andre G Uitterlinden, Jana V van Vliet-Ostaptchouk, Nick J Wareham, David Cesarini, K Paige Harden, James J Lee, Daniel J Benjamin, Carson C Chow, Philipp D Koellinger
Sep 06, 2019
Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.
Anna L Eriksson, John RB Perry, Andrea D Coviello, Graciela E Delgado, Luigi Ferrucci, Andrew R Hoffman, Ilpo T Huhtaniemi, M Arfan Ikram, Magnus K Karlsson, Marcus E Kleber, Gail A Laughlin, Yongmei Liu, Mattias Lorentzon, Kathryn L Lunetta, Dan Mellström, Joanne M Murabito, Anna Murray, Maria Nethander, Carrie M Nielson, Inga Prokopenko, Stephen R Pye, Leslie J Raffel, Fernando Rivadeneira, Priya Srikanth, Lisette Stolk, Alexander Teumer, Thomas G Travison, André G Uitterlinden, Dhananjay Vaidya, Dirk Vanderschueren, Joseph M Zmuda, Winfried März, Eric S Orwoll, Pamela Ouyang, Liesbeth Vandenput, Frederick CW Wu, Frank H de Jong, Shalender Bhasin, Douglas P Kiel, Claes Ohlsson
Jun 26, 2018
CONTEXT: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. OBJECTIVE: To investigate the genetic regulation of serum E2 and E1 in men. DESIGN, SETTING, AND PARTICIPANTS: Genome-wide association study...
Carotid intima-media thickness progression and risk of vascular events in people with diabetes
Matthias W Lorenz, Jackie F Price, Christine Robertson, Michiel L Bots, Joseph F Polak, Holger Poppert, Maryam Kavousi, Marcus Dörr, Eva Stensland, Pierre Ducimetiere, Kimmo Ronkainen, Stefan Kiechl, Matthias Sitzer, Tatjana Rundek, Lars Lind, Jing Liu, Göran Bergström, Liliana Grigore, Lena Bokemark, Alfonsa Friera, David Yanez, Horst Bickel, M Arfan Ikram, Henry Völzke, Stein Harald Johnsen, Jean Philippe Empana, Tomi-Pekka Tuomainen, Peter Willeit, Helmuth Steinmetz, Moise Desvarieux, Wuxiang Xie, Caroline Schmidt, Giuseppe D Norata, Carmen Suarez, Dirk Sander, Albert Hofman, Ulf Schminke, Ellisiv Mathiesen, Matthieu Plichart, Jussi Kauhanen, Johann Willeit, Ralph L Sacco, Stela McLachlan, Dong Zhao, Björn Fagerberg, Alberico L Catapano, Rafael Gabriel, Oscar H Franco, Alpaslan Bülbül, Frank Scheckenbach, Anja Pflug, Lu Gao, Simon G Thompson
Jun 05, 2019
OBJECTIVE: Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with...
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
David L Duffy, Gu Zhu, Xin Li, Marianna Sanna, Mark M Iles, Leonie C Jacobs, David M Evans, Seyhan Yazar, Jonathan Beesley, Matthew H Law, Peter Kraft, Alessia Visconti, John C Taylor, Fan Lui, Margaret J Wright, Anjali K Henders, Lisa Bowdler, Dan Glass, Arfan M Ikram, André G Uitterlinden, Pamela A Madden, Andrew C Heath, Elliot C Nelson, Adele C Green, Stephen Chanock, Jennifer H Barrett, Matthew A Brown, Nicholas K Hayward, Stuart MacGregor, Richard A Sturm, Alex W Hewitt, Melanoma GWAS Consortium, Manfred Kayser, David J Hunter, Julia A Newton Bishop, Timothy D Spector, Grant W Montgomery, David A Mackey, George Davey Smith, Tamar E Nijsten, D Timothy Bishop, Veronique Bataille, Mario Falchi, Jiali Han, Nicholas G Martin
Jan 31, 2019
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We...
Carrier Proteins Cytochrome P-450 CYP1B1 Genetic Pleiotropy Genetic Predisposition to Disease Genome-Wide Association Study Group VI Phospholipases A2 Guanine Nucleotide Exchange Factors Histone Deacetylases Humans Interferon Regulatory Factors Melanoma MicroRNAs Microfilament Proteins Nerve Tissue Proteins Nevus Pigmented Nuclear Proteins Polymorphism Single Nucleotide RNA RNA-Binding Proteins Receptors G-Protein-Coupled Repressor Proteins Skin Neoplasms Stem Cell Factor Telomerase Telomere-Binding Proteins White People
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Eliana Portilla-Fernández, Shih-Jen Hwang, Rory Wilson, Jane Maddock, W David Hill, Alexander Teumer, Pashupati P Mishra, Jennifer A Brody, Roby Joehanes, Symen Ligthart, Mohsen Ghanbari, Maryam Kavousi, Anton JM Roks, AH Jan Danser, Daniel Levy, Annette Peters, Sahar Ghasemi, Ulf Schminke, Marcus Dörr, Hans J Grabe, Terho Lehtimäki, Mika Kähönen, Mikko A Hurme, Traci M Bartz, Nona Sotoodehnia, Joshua C Bis, Joachim Thiery, Wolfgang Koenig, Ken K Ong, Jordana T Bell, Christine Meisinger, Joanna M Wardlaw, John M Starr, Jochen Seissler, Cornelia Then, Wolfgang Rathmann, M Arfan Ikram, Bruce M Psaty, Olli T Raitakari, Henry Völzke, Ian J Deary, Andrew Wong, Melanie Waldenberger, Christopher J O'Donnell, Abbas Dehghan
Dec 15, 2021
cardiovascular risk factors Common carotid intima-media thickness DNA Methylation Differentially methylated regions Epigenome-wide association studies Mendelian randomization Vascular outcomes Carotid Intima-Media Thickness Coronary Artery Disease Cross-Sectional Studies epigenome Humans Risk Factors
Genetic variation at 16q24.2 is associated with small vessel stroke.
Matthew Traylor, Rainer Malik, Mike A Nalls, Ioana Cotlarciuc, Farid Radmanesh, Gudmar Thorleifsson, Ken B Hanscombe, Carl Langefeld, Danish Saleheen, Natalia S Rost, Idil Yet, Tim D Spector, Jordana T Bell, Eilis Hannon, Jonathan Mill, Ganesh Chauhan, Stephanie Debette, Joshua C Bis, WT Longstreth, M Arfan Ikram, Lenore J Launer, Sudha Seshadri, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium METASTROKE, Monica Anne Hamilton-Bruce, Jordi Jimenez-Conde, John W Cole, Reinhold Schmidt, Agnieszka Słowik, Robin Lemmens, Arne Lindgren, Olle Melander, Raji P Grewal, Ralph L Sacco, Tatjana Rundek, Kathryn Rexrode, Donna K Arnett, Julie A Johnson, Oscar R Benavente, Sylvia Wasssertheil-Smoller, Jin-Moo Lee, Sara L Pulit, Quenna Wong, Stephen S Rich, Paul IW de Bakker, Patrick F McArdle, Daniel Woo, Christopher D Anderson, Huichun Xu, Laura Heitsch, Myriam Fornage, Christina Jern, Kari Stefansson, Unnur Thorsteinsdottir, Solveig Gretarsdottir, Cathryn M Lewis, Pankaj Sharma, Cathie LM Sudlow, Peter M Rothwell, Giorgio B Boncoraglio, Vincent Thijs, Chris Levi, James F Meschia, Jonathan Rosand, Steven J Kittner, Braxton D Mitchell, Martin Dichgans, Bradford B Worrall, Hugh S Markus, International Stroke Genetics Consortium
Feb 24, 2017
Genetic loci for retinal arteriolar microcirculation.
Xueling Sim, Richard A Jensen, M Kamran Ikram, Mary Frances Cotch, Xiaohui Li, Stuart MacGregor, Jing Xie, Albert Vernon Smith, Eric Boerwinkle, Paul Mitchell, Ronald Klein, Barbara EK Klein, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Paulus TVM de Jong, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, Cornelia M van Duijn, Thor Aspelund, Gudny Eiriksdottir, Tamara B Harris, Fridbert Jonasson, Lenore J Launer, Wellcome Trust Case Control Consortium 2, John Attia, Paul N Baird, Stephen Harrap, Elizabeth G Holliday, Michael Inouye, Elena Rochtchina, Rodney J Scott, Ananth Viswanathan, Global BPGen Consortium, Guo Li, Nicholas L Smith, Kerri L Wiggins, Jane Z Kuo, Kent D Taylor, Alex W Hewitt, Nicholas G Martin, Grant W Montgomery, Cong Sun, Terri L Young, David A Mackey, Natalie R Van Zuydam, Alex SF Doney, Colin NA Palmer, Andrew D Morris, Jerome I Rotter, E Shyong Tai, Vilmundur Gudnason, Johannes R Vingerling, David S Siscovick, Jie Jin Wang, Tien Y Wong
Jan 23, 2018
Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a...
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
Carolina Medina-Gomez, John P Kemp, Katerina Trajanoska, Jian'an Luan, Alessandra Chesi, Tarunveer S Ahluwalia, Dennis O Mook-Kanamori, Annelies Ham, Fernando P Hartwig, Daniel S Evans, Raimo Joro, Ivana Nedeljkovic, Hou-Feng Zheng, Kun Zhu, Mustafa Atalay, Ching-Ti Liu, Maria Nethander, Linda Broer, Gudmar Porleifsson, Benjamin H Mullin, Samuel K Handelman, Mike A Nalls, Leon E Jessen, Denise HM Heppe, J Brent Richards, Carol Wang, Bo Chawes, Katharina E Schraut, Najaf Amin, Nick Wareham, David Karasik, Nathalie van der Velde, M Arfan Ikram, Babette S Zemel, Yanhua Zhou, Christian J Carlsson, Yongmei Liu, Fiona E McGuigan, Cindy G Boer, Klaus Bønnelykke, Stuart H Ralston, John A Robbins, John P Walsh, M Carola Zillikens, Claudia Langenberg, Ruifang Li-Gao, Frances MK Williams, Tamara B Harris, Kristina Akesson, Rebecca D Jackson, Gunnar Sigurdsson, Martin den Heijer, Bram CJ van der Eerden, Jeroen van de Peppel, Timothy D Spector, Craig Pennell, Bernardo L Horta, Janine F Felix, Jing Hua Zhao, Scott G Wilson, Renée de Mutsert, Hans Bisgaard, Unnur Styrkársdóttir, Vincent W Jaddoe, Eric Orwoll, Timo A Lakka, Robert Scott, Struan FA Grant, Mattias Lorentzon, Cornelia M van Duijn, James F Wilson, Kari Stefansson, Bruce M Psaty, Douglas P Kiel, Claes Ohlsson, Evangelia Ntzani, Andre J van Wijnen, Vincenzo Forgetta, Mohsen Ghanbari, John G Logan, Graham R Williams, JH Duncan Bassett, Peter I Croucher, Evangelos Evangelou, Andre G Uitterlinden, Cheryl L Ackert-Bicknell, Jonathan H Tobias, David M Evans, Fernando Rivadeneira
Mar 14, 2018
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to...
BMD CREB3L1 ESR1 GWASs RANKL age-dependent effects Bone mineral density Fracture genetic correlation genome-wide association studies meta-regression total-body DXA Adolescent Age Factors Animals Bone Density Child Child Preschool Genetic Loci Genome-Wide Association Study Humans Infant Infant Newborn Mice Knockout Polymorphism Single Nucleotide Quantitative Trait Heritable Regression Analysis
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
Gail Davies, Max Lam, Sarah E Harris, Joey W Trampush, Michelle Luciano, W David Hill, Saskia P Hagenaars, Stuart J Ritchie, Riccardo E Marioni, Chloe Fawns-Ritchie, David Cm Liewald, Judith A Okely, Ari V Ahola-Olli, Catriona LK Barnes, Lars Bertram, Joshua C Bis, Katherine E Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E Gustavson, Caroline Hayward, Edith Hofer, M Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A Smith, Albert V Smith, Natalie Terzikhan, Anbupalam Thalamuthu, Stella Trompet, Sven J van der Lee, Erin B Ware, B Gwen Windham, Margaret J Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A Andreassen, Nicola J Armstrong, Amelia A Assareh, John R Attia, Deborah Attix, Dimitrios Avramopoulos, David A Bennett, Anne C Böhmer, Patricia A Boyle, Henry Brodaty, Harry Campbell, Tyrone D Cannon, Elizabeth T Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R Cox, Anders M Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G Eriksson, Evangelos Evangelou, Jessica D Faul, Ian Ford, Nelson A Freimer, He Gao, Ina Giegling, Nathan A Gillespie, Scott D Gordon, Rebecca F Gottesman, Michael E Griswold, Vilmundur Gudnason, Tamara B Harris, Annette M Hartmann, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G Holliday, Peter K Joshi, Mika Kähönen, Sharon LR Kardia, Ida Karlsson, Luca Kleineidam, David S Knopman, Nicole A Kochan, Bettina Konte, John B Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T Longstreth, Oscar L Lopez, Anu Loukola, Tobias Luck, Astri J Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G Martin, Grant W Montgomery, Alison D Murray, Anna C Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A Poldrack, Bruce M Psaty, Simone Reppermund, Steffi G Riedel-Heller, Richard J Rose, Jerome I Rotter, Panos Roussos, Suvi P Rovio, Yasaman Saba, Fred W Sabb, Perminder S Sachdev, Claudia L Satizabal, Matthias Schmid, Rodney J Scott, Matthew A Scult, Jeannette Simino, P Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C Stefanis, David J Stott, Richard E Straub, Kjetil Sundet, Adele M Taylor, Kent D Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N Voineskos, Jaakko Kaprio, Michael Wagner, Holger Wagner, Leonie Weinhold, K Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab HH Adams, Dan E Arking, Robert M Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L Fitzpatrick, Michael Gill, David C Glahn, Sara Hägg, Narelle K Hansell, Ahmad R Hariri, M Kamran Ikram, J Wouter Jukema, Eero Vuoksimaa, Matthew C Keller, William S Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L Pedersen, Neil Pendleton, David J Porteous, Katri Räikkönen, Olli T Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W Schofield, Peter R Schofield, John M Starr, Vidar M Steen, Julian N Trollor, Steven T Turner, Cornelia M van Duijn, Arno Villringer, Daniel R Weinberger, David R Weir, James F Wilson, Anil Malhotra, Andrew M McIntosh, Catharine R Gale, Sudha Seshadri, Thomas H Mosley, Jan Bressler, Todd Lencz, Ian J Deary
Sep 24, 2018
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total...
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Xia Jiang, Paul F O'Reilly, Hugues Aschard, Yi-Hsiang Hsu, J Brent Richards, Josée Dupuis, Erik Ingelsson, David Karasik, Stefan Pilz, Diane Berry, Bryan Kestenbaum, Jusheng Zheng, Jianan Luan, Eleni Sofianopoulou, Elizabeth A Streeten, Demetrius Albanes, Pamela L Lutsey, Lu Yao, Weihong Tang, Michael J Econs, Henri Wallaschofski, Henry Völzke, Ang Zhou, Chris Power, Mark I McCarthy, Erin D Michos, Eric Boerwinkle, Stephanie J Weinstein, Neal D Freedman, Wen-Yi Huang, Natasja M van Schoor, Nathalie van der Velde, Lisette CPGM de Groot, Anke Enneman, L Adrienne Cupples, Sarah L Booth, Ramachandran S Vasan, Ching-Ti Liu, Yanhua Zhou, Samuli Ripatti, Claes Ohlsson, Liesbeth Vandenput, Mattias Lorentzon, Johan G Eriksson, M Kyla Shea, Denise K Houston, Stephen B Kritchevsky, Yongmei Liu, Kurt K Lohman, Luigi Ferrucci, Munro Peacock, Christian Gieger, Marian Beekman, Eline Slagboom, Joris Deelen, Diana van Heemst, Marcus E Kleber, Winfried März, Ian H de Boer, Alexis C Wood, Jerome I Rotter, Stephen S Rich, Cassianne Robinson-Cohen, Martin den Heijer, Marjo-Riitta Jarvelin, Alana Cavadino, Peter K Joshi, James F Wilson, Caroline Hayward, Lars Lind, Karl Michaëlsson, Stella Trompet, M Carola Zillikens, Andre G Uitterlinden, Fernando Rivadeneira, Linda Broer, Lina Zgaga, Harry Campbell, Evropi Theodoratou, Susan M Farrington, Maria Timofeeva, Malcolm G Dunlop, Ana M Valdes, Emmi Tikkanen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Mika Kähönen, Olli T Raitakari, Vera Mikkilä, M Arfan Ikram, Naveed Sattar, J Wouter Jukema, Nicholas J Wareham, Claudia Langenberg, Nita G Forouhi, Thomas E Gundersen, Kay-Tee Khaw, Adam S Butterworth, John Danesh, Timothy Spector, Thomas J Wang, Elina Hyppönen, Peter Kraft, Douglas P Kiel
Mar 02, 2018
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC...
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