Search
Results: 76418
Cell-based therapeutic strategies for multiple sclerosis.
Neil J Scolding, Marcelo Pasquini, Stephen C Reingold, Jeffrey A Cohen, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis
Jan 15, 2018
The availability of multiple disease-modifying medications with regulatory approval to treat multiple sclerosis illustrates the substantial progress made in therapy of the disease. However, all are only partially effective in...
Clinical Trials medical ethics multiple sclerosis and neuroinflammation remyelination Stem Cells Hematopoietic Stem Cell Transplantation Humans Induced Pluripotent Stem Cells Mesenchymal Stem Cell Transplantation Multiple Sclerosis Myelin Sheath Oligodendroglia Regeneration Stem Cell Transplantation Stem Cells Transplantation Autologous
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis.
International Multiple Sclerosis Genetics Consortium
Jun 21, 2019
Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations has...
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk.
International Multiple Sclerosis Genetics Consortium. Electronic address: chris.cotsapas@yale.edu, International Multiple Sclerosis Genetics Consortium
Sep 21, 2018
Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable to common genetic variants, including >230 identified by genome-wide association studies. Multiple strands of evidence suggest...
Stem Cell Therapies for Progressive Multiple Sclerosis.
Jayden A Smith, Alexandra M Nicaise, Rosana-Bristena Ionescu, Regan Hamel, Luca Peruzzotti-Jametti, Stefano Pluchino
Jul 28, 2021
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients typically present with a relapsing-remitting (RR) disease course...
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.
International Multiple Sclerosis Genetics Consortium
Aug 13, 2019
Case-Control Studies Cell Cycle Proteins Chromosome Mapping Chromosomes Human X GTPase-Activating Proteins Gene Frequency Genetic Loci Genome-Wide Association Study Genomics Humans Inheritance Patterns Major Histocompatibility Complex Microglia Multiple Sclerosis Polymorphism Single Nucleotide Quantitative Trait Loci RNA-seq Transcriptome
Targeting Mitochondrial Metabolism in Neuroinflammation
The lack of effective treatment options for chronic neurological conditions, such as multiple sclerosis (MS), highlights the need to re-evaluate disease pathophysiology in the process of identifying novel therapeutic targets....
immune metabolism MACROPHAGES Microglia Mitochondria Neuroinflammation progressive multiple sclerosis Central Nervous System Crotonates Dimethyl Fumarate Electron Transport Glymphatic System Humans Hydroxybutyrates Immunity Innate Metabolic Networks and Pathways Microglia Mitochondria Molecular Targeted Therapy Mononuclear Phagocyte System Multiple Sclerosis Chronic Progressive Neurodegenerative Diseases Nitriles Signal Transduction Stem Cell Transplantation Toluidines
Enhanced axonal response of mitochondria to demyelination offers neuroprotection
Simon Licht-Mayer, Graham R Campbell, Marco Canizares, Arpan R Mehta, Angus B Gane, Katie McGill, Aniket Ghosh, Alexander Fullerton, Niels Menezes, Jasmine Dean, Jordon Dunham, Sarah Al-Azki, Gareth Pryce, Stephanie Zandee, Chao Zhao, Markus Kipp, Kenneth J Smith, David Baker, Daniel Altmann, Stephen M Anderton, Yolanda S Kap, Jon D Laman, Bert A 't Hart, Moses Rodriguez, Ralf Watzlawick, Jan M Schwab, Roderick Carter, Nicholas Morton, Michele Zagnoni, Robin Jm Franklin, Rory Mitchell, Sue Fleetwood-Walker, David A Lyons, Siddharthan Chandran, Hans Lassmann, Bruce D Trapp, Don J Mahad
Jun 26, 2020
Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly...
Multiple Sclerosis
Multiple sclerosis is an emerging neurological condition. It is a neurodegenerative disease. In both the central and the peripheral nervous systems, large-diameter axons are myelinated. Within the CNS, myelin is formed and...
Published by: IJHS Medical Association
Multiple Sclerosis
Multiple sclerosis is an emerging neurological condition. It is a neurodegenerative disease. In both the central and the peripheral nervous systems, large-diameter axons are myelinated. Within the CNS, myelin is formed and...
Published by: IJHS Medical Association
Delay from treatment start to full effect of immunotherapies for multiple sclerosis.
Izanne Roos, Emmanuelle Leray, Federico Frascoli, Romain Casey, J William L Brown, Dana Horakova, Eva K Havrdova, Maria Trojano, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Marco Onofrj, Alessandra Lugaresi, Alexandre Prat, Marc Girard, Pierre Grammond, Patrizia Sola, Diana Ferraro, Serkan Ozakbas, Roberto Bergamaschi, Maria José Sá, Elisabetta Cartechini, Cavit Boz, Franco Granella, Raymond Hupperts, Murat Terzi, Jeannette Lechner-Scott, Daniele Spitaleri, Vincent Van Pesch, Aysun Soysal, Javier Olascoaga, Julie Prevost, Eduardo Aguera-Morales, Mark Slee, Tunde Csepany, Recai Turkoglu, Youssef Sidhom, Riadh Gouider, Bart Van Wijmeersch, Pamela McCombe, Richard Macdonell, Alasdair Coles, Charles B Malpas, Helmut Butzkueven, Sandra Vukusic, Tomas Kalincik, MSBase, OFSEP investigators
Sep 24, 2020
In multiple sclerosis, treatment start or switch is prompted by evidence of disease activity. Whilst immunomodulatory therapies reduce disease activity, the time required to attain maximal effect is unclear. In this study we...
Impact of Covid-19 on clinical care and lived experience of systemic sclerosis
Introduction: Outcomes related to Covid-19 in systemic sclerosis patients could be influenced by internal organ involvement and/or immunosuppressive treatment, leading to efforts to shield patients from Covid-19 transmission....
Impact of Covid-19 on clinical care and lived experience of systemic sclerosis
Introduction: Outcomes related to Covid-19 in systemic sclerosis patients could be influenced by internal organ involvement and/or immunosuppressive treatment, leading to efforts to shield patients from Covid-19 transmission....
Gene and Cell-Based Therapies for Parkinson’s Disease
Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder that carries large health and socioeconomic burdens. Current therapies for PD are ultimately inadequate, both in terms of symptom control and in modification of...
Current Status of Cell-Based Therapies for Vitiligo.
Anna Domaszewska-Szostek, Agnieszka Polak, Monika Słupecka-Ziemilska, Marta Krzyżanowska, Monika Puzianowska-Kuźnicka
Mar 28, 2023
Vitiligo is a chronic pigmentary disease with complex etiology, the signs of which are caused by the destruction of melanocytes in the epidermis, leading to the lack of melanin pigment responsible for skin coloration. The...
Keratinocytes Melanocytes Cell transplantation vitiligo melanogenesis cell-based therapies epidermis Humans Hypopigmentation Treatment Outcome
Published by: International journal of molecular sciences
Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease.
Peter A Barbuti, Roger A Barker, Patrik Brundin, Serge Przedborski, Stella M Papa, Lorraine V Kalia, Hideki Mochizuki, MDS Scientific Issues Committee
Mar 17, 2021
The last decade has seen exciting advances in the development of potential stem cell-based therapies for Parkinson's disease (PD), which have used different types of stem cells as starting material. These cells have been...
Assessment of Disease Activity in Large-vessel Vasculitis
Sibel Z Aydin, Haner Direskeneli, Peter A Merkel, International Delphi on Disease Activity Assessment in Large-vessel Vasculitis
Mar 06, 2020
OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials. METHODS: A Delphi survey including 99 items was circulated among international experts...
The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
Lesions Detection of Multiple Sclerosis in 3D Brian MR Images by Using Artificial Immune Systems and Support Vector Machines
This paper presents a segmentation method to detect multiple sclerosis (MS) lesions in brain MRI based on the artificial immune systems (AIS) and a support vector machines (SVM). In the first step, AIS is used to segment the...
Published by: IGI Global Scientific Publishing
Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells.
Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, Bénédicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer
May 25, 2018
The increasing evidence supporting a role for B cells in the pathogenesis of multiple sclerosis prompted us to investigate the influence of known susceptibility variants on the surface expression of co-stimulatory molecules in...
Diffusion tensor imaging of the normal-appearing deep gray matter in primary and secondary progressive multiple sclerosis.
Background Despite strongly overlapping patterns of clinical and histopathologic findings in primary and secondary progressive multiple sclerosis, differences concerning motor symptoms...
Ramona Woitek, Fritz Leutmezer, Assunta Dal-Bianco, Julia Furtner, Gregor Kasprian, Daniela Prayer, Veronika Schöpf
Sep 10, 2019
International cancer seminars
G Murphy, V McCormack, B Abedi-Ardekani, M Arnold, MC Camargo, NA Dar, SM Dawsey, A Etemadi, RC Fitzgerald, DE Fleischer, ND Freedman, AM Goldstein, S Gopal, M Hashemian, N Hu, PL Hyland, B Kaimila, F Kamangar, R Malekzadeh, CG Mathew, D Menya, G Mulima, MM Mwachiro, A Mwasamwaja, N Pritchett, Y-L Qiao, LF Ribeiro-Pinto, M Ricciardone, J Schüz, F Sitas, PR Taylor, K Van Loon, S-M Wang, W-Q Wei, CP Wild, C Wu, CC Abnet, SJ Chanock, P Brennan
Nov 12, 2018
The International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI) have initiated a series of cancer-focused seminars [Scelo G, Hofmann JN, Banks RE et al. International cancer seminars: a focus on...
Lesions Detection of Multiple Sclerosis in 3D Brian MR Images by Using Artificial Immune Systems and Support Vector Machines
This paper presents a segmentation method to detect multiple sclerosis (MS) lesions in brain MRI based on the artificial immune systems (AIS) and a support vector machines (SVM). In the first step, AIS is used to segment the...
Medicine and Healthcare Medical Diagnosis and Practice Medical Imaging Computer Science and Information Technology Media and Communications
Published by: IGI Global Scientific Publishing
Promises and challenges of adoptive T-cell therapies for solid tumours.
Matteo Morotti, Ashwag Albukhari, Abdulkhaliq Alsaadi, Mara Artibani, James D Brenton, Stuart M Curbishley, Tao Dong, Michael L Dustin, Zhiyuan Hu, Nicholas McGranahan, Martin L Miller, Laura Santana-Gonzalez, Leonard W Seymour, Tingyan Shi, Peter Van Loo, Christopher Yau, Helen White, Nina Wietek, David N Church, David C Wedge, Ahmed A Ahmed
May 25, 2021
Cancer is a leading cause of death worldwide and, despite new targeted therapies and immunotherapies, many patients with advanced-stage- or high-risk cancers still die, owing to metastatic disease. Adoptive T-cell therapy...
Use of Disease-Modifying Therapies in Pediatric Relapsing-Remitting Multiple Sclerosis in the United Kingdom.
Omar A Abdel-Mannan, Celeste Manchoon, Thomas Rossor, Justine-Clair Southin, Carmen Tur, Wallace Brownlee, Susan Byrne, Manali Chitre, Alasdair Coles, Rob Forsyth, Rachel Kneen, Kshitij Mankad, Dipak Ram, Siobhan West, Sukhvir Wright, Evangeline Wassmer, Ming Lim, Olga Ciccarelli, Cheryl Hemingway, Yael Hacohen, UK-Childhood Inflammatory Disease Network
Jun 14, 2021
OBJECTIVES: To compare the real-world effectiveness of newer disease-modifying therapies (DMTs) vs injectables in children with relapsing-remitting multiple sclerosis (RRMS). METHODS: In this retrospective, multicenter study...
|
|< |
< |
1 |