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Assessment of Disease Activity in Large-vessel Vasculitis
Sibel Z Aydin, Haner Direskeneli, Peter A Merkel, International Delphi on Disease Activity Assessment in Large-vessel Vasculitis
Mar 06, 2020
OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials. METHODS: A Delphi survey including 99 items was circulated among international experts...
Isolated large vessel pulmonary vasculitis as a cause of chronic obstruction of the pulmonary arteries.
Guy Hagan, Deepa Gopalan, Colin Church, Doris Rassl, Chetan Mukhtyar, Trevor Wistow, Chim Lang, Pasupathy Sivasothy, Susan Stewart, David Jayne, Karen Sheares, Steven Tsui, David P Jenkins, Joanna Pepke-Zaba
Dec 15, 2020
Isolated pulmonary artery involvement by large vessel vasculitis is rare. This case report describes two patients with large vessel pulmonary vasculitis initially thought to have chronic thromboembolic pulmonary hypertension who...
Pituitary Society Delphi Survey
Nicholas A Tritos, Pouneh K Fazeli, Ann McCormack, Susana M Mallea-Gil, Maria M Pineyro, Mirjam Christ-Crain, Stefano Frara, Artak Labadzhyan, Adriana G Ioachimescu, Ilan Shimon, Yutaka Takahashi, Mark Gurnell, Maria Fleseriu, “Pituitary Society Delphi Collaborative Group”
Sep 24, 2021
PURPOSE: In adults and children, transsphenoidal surgery (TSS) represents the cornerstone of management for most large or functioning sellar lesions with the exception of prolactinomas. Endocrine evaluation and management are an...
Pituitary Society Delphi Survey
Nicholas A Tritos, Pouneh K Fazeli, Ann McCormack, Susana M Mallea-Gil, Maria M Pineyro, Mirjam Christ-Crain, Stefano Frara, Artak Labadzhyan, Adriana G Ioachimescu, Ilan Shimon, Yutaka Takahashi, Mark Gurnell, Maria Fleseriu, “Pituitary Society Delphi Collaborative Group”
Feb 07, 2022
PURPOSE: In adults and children, transsphenoidal surgery (TSS) represents the cornerstone of management for most large or functioning sellar lesions with the exception of prolactinomas. Endocrine evaluation and management are an...
Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis.
Andrej Ćorović, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R Jayne, Stephen P Hoole, Patrick A Calvert, Andrew F Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Fiona J Gilbert, Marc R Dweck, David E Newby, Zahi A Fayad, Gary Reynolds, Ann W Morgan, Eric O Aboagye, Anthony P Davenport, Helle F Jørgensen, Ziad Mallat, Martin R Bennett, James E Peters, James HF Rudd, Justin C Mason, Jason M Tarkin
Feb 25, 2023
BACKGROUND: Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures. OBJECTIVES: We aimed to investigate somatostatin receptor 2 (SST2) as a novel...
Takayasu arteritis Atherosclerosis Giant Cell Arteritis Inflammation Molecular Imaging somatostatin receptor Humans Receptors Somatostatin Prospective Studies Fluorodeoxyglucose F18 Inflammation Positron-Emission Tomography Magnetic Resonance Imaging Takayasu arteritis Coronary Vessels Atherosclerosis Myocardial Infarction Giant Cell Arteritis Radiopharmaceuticals
Pituitary Society Delphi Survey
Nicholas A Tritos, Pouneh K Fazeli, Ann McCormack, Susana M Mallea-Gil, Maria M Pineyro, Mirjam Christ-Crain, Stefano Frara, Artak Labadzhyan, Adriana G Ioachimescu, Ilan Shimon, Yutaka Takahashi, Mark Gurnell, Maria Fleseriu
Aug 26, 2021
Purpose
In adults and children, transsphenoidal surgery (TSS) represents the cornerstone of management for most large or functioning sellar lesions with the exception of prolactinomas. Endocrine evaluation and management...
pituitary adenoma hypopituitarism perioperative Delphi process Postoperative Assessment Transsphenoidal surgery
Published by: Pituitary
Risk Factors for Severe Outcomes in Patients With Systemic Vasculitis and COVID-19
Matthew A Rutherford, Jennifer Scott, Maira Karabayas, Marilina Antonelou, Seerapani Gopaluni, David Gray, Joe Barrett, Silke R Brix, Neeraj Dhaun, Stephen P McAdoo, Rona M Smith, Colin C Geddes, David Jayne, Raashid Luqmani, Alan D Salama, Mark A Little, Neil Basu, UK and Ireland Vasculitis Rare Disease Group (UKIVAS)
Nov 15, 2021
OBJECTIVE: COVID-19 is a novel infectious disease with a broad spectrum of clinical severity. Patients with systemic vasculitis have an increased risk of serious infections and may be at risk of severe outcomes following...
Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis covid-19 Comorbidity Female Glucocorticoids Hospitalization Humans Immunosuppressive Agents Intensive Care Units Male Middle Aged Odds Ratio Oxygen Inhalation Therapy Registries Respiration Artificial Respiratory Tract Diseases Risk Factors SARS-CoV-2 Severity of Illness Index Systemic Vasculitis
Patient perceptions of health-related quality of life in giant cell arteritis; international development of a disease-specific Patient-Reported Outcome Measure
Joanna C Robson, Celia Almeida, Jill Dawson, Alison Bromhead, Emma Dures, Catherine Guly, Elizabeth Hoon, Sarah Mackie, Mwidimi Ndosi, John Pauling, Catherine Hill
Oct 31, 2021
OBJECTIVES: Giant cell arteritis is a large vessel vasculitis presenting with headache, jaw claudication, musculoskeletal and visual involvement. Current treatment is glucocorticoids and anti-IL6 Tocilizumab in refractory...
Patient perceptions of health-related quality of life in giant cell arteritis; international development of a disease-specific Patient-Reported Outcome Measure
Joanna C Robson, Celia Almeida, Jill Dawson, Alison Bromhead, Emma Dures, Catherine Guly, Elizabeth Hoon, Sarah Mackie, Mwidimi Ndosi, John Pauling, Catherine Hill
Oct 31, 2021
OBJECTIVES: Giant cell arteritis is a large vessel vasculitis presenting with headache, jaw claudication, musculoskeletal and visual involvement. Current treatment is glucocorticoids and anti-IL6 Tocilizumab in refractory...
Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma. A Delphi Study.
Carey M Suehs, Andrew Menzies-Gow, David Price, Eugene R Bleecker, Giorgio Walter Canonica, Mark Gurnell, Arnaud Bourdin, Oral Corticosteroids Tapering Delphi Expert Panel
Oct 26, 2020
Rationale: There is a need to minimize oral corticosteroid (OCS) use in patients with asthma to prevent their costly and burdensome adverse effects. Current guidelines do not provide recommendations for OCS tapering in patients...
Effect of Disease Activity at Three and Six Months After Diagnosis on Long-Term Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Seerapani Gopaluni, Oliver Flossmann, Mark A Little, Paul O'Hara, Pirow Bekker, David Jayne, European Vasculitis Society
Dec 13, 2018
OBJECTIVE: The treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) aims to suppress disease activity and prevent subsequent disease flare. This study sought to explore the association of early...
Adult Age Factors Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Female Glomerular Filtration Rate Humans Immunosuppressive Agents Kidney Failure Chronic Male Middle Aged Mortality Plasma Exchange Prognosis Proportional Hazards Models Recurrence Remission Induction Severity of Illness Index
Improving National and International Surveillance of Movement Behaviours in Childhood and Adolescence
John J Reilly, Rachel Andrew, Chalchisa Abdeta, Liane B Azevedo, Nicolas Aguilar Farias, Sharon Barak, Farid Bardid, Bruno Bizzozero-Peroni, Javier Brazo-Sayavera, Jonathan Y Cagas, Mohamed-Souhaiel Chelly, Lars B. Christiansen, Visnja D Djordjic, Catherine E. Draper, Asmaa El-Hamdouchi, Elie-Jacques Fares, Aleš Gába, Kylie D Hesketh, Mohammad Sorowar Hossain, Wendy Huang, Alejandra Jáuregui, Sanjay K Juvekar, Nicholas Kuzik, Richard Larouche, Eun-Young Lee, Sharon Levi, Yang Liu, Marie Löf, Tom Loney, Jose Francisco Lopez Gil, Evelin Mäestu, Taru Manyanga, Clarice Martins, Maria Mendoza-Muñoz, Shawnda A Morrison, Nyaradzai Munambah, Tawonga W Mwase-Vuma, Rowena Naidoo, Reginald Ocansey, Anthony D Okely, Aoko Oluwayomi, Susan Paudel, Bee Koon Poh, Evelyn H Ribeiro, Diego Augusto Santos Silva, Mohd Razif Shahril, Melody Smith, Amanda E Staiano, Martyn Standage, Narayan Subedi, Chiaki Tanaka, Hong K Tang, David Thivel, Mark S Tremblay, Edin Uzicanin, Dimitris Vlachopoulos, E Kipling Webster, Dyah Anantalia Widyastari, Pawel Zembura, Salome Aubert
Oct 03, 2024
BACKGROUND: The actions required to achieve higher-quality and harmonised global surveillance of child and adolescent movement behaviours (physical activity, sedentary behaviour including screen time, sleep) are...
Modifiable pathways in Alzheimer's disease
Susanna C Larsson, Matthew Traylor, Rainer Malik, Martin Dichgans, Stephen Burgess, Hugh S Markus, on behalf of the International Genomics of Alzheimer’s Project CoSTREAM Consortium
Mar 07, 2018
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease. DESIGN: Mendelian randomisation...
Improving National and International Surveillance of Movement Behaviours in Childhood and Adolescence
John J Reilly, Rachel Andrew, Chalchisa Abdeta, Liane B Azevedo, Nicolas Aguilar Farias, Sharon Barak, Farid Bardid, Bruno Bizzozero-Peroni, Javier Brazo-Sayavera, Jonathan Y Cagas, Mohamed-Souhaiel Chelly, Lars B. Christiansen, Visnja D Djordjic, Catherine E. Draper, Asmaa El-Hamdouchi, Elie-Jacques Fares, Aleš Gába, Kylie D Hesketh, Mohammad Sorowar Hossain, Wendy Huang, Alejandra Jáuregui, Sanjay K Juvekar, Nicholas Kuzik, Richard Larouche, Eun-Young Lee, Sharon Levi, Yang Liu, Marie Löf, Tom Loney, Jose Francisco Lopez Gil, Evelin Mäestu, Taru Manyanga, Clarice Martins, Maria Mendoza-Muñoz, Shawnda A Morrison, Nyaradzai Munambah, Tawonga W Mwase-Vuma, Rowena Naidoo, Reginald Ocansey, Anthony D Okely, Aoko Oluwayomi, Susan Paudel, Bee Koon Poh, Evelyn H Ribeiro, Diego Augusto Santos Silva, Mohd Razif Shahril, Melody Smith, Amanda E Staiano, Martyn Standage, Narayan Subedi, Chiaki Tanaka, Hong K Tang, David Thivel, Mark S Tremblay, Edin Uzicanin, Dimitris Vlachopoulos, E Kipling Webster, Dyah Anantalia Widyastari, Pawel Zembura, Salome Aubert
Oct 03, 2024
BACKGROUND: The actions required to achieve higher-quality and harmonised global surveillance of child and adolescent movement behaviours (physical activity, sedentary behaviour including screen time, sleep) are...
Vessel wall magnetic resonance and arterial spin labelling imaging in the management of presumed inflammatory intracranial arterial vasculopathy.
LA Benjamin, E Lim, M Sokolska, J Markus, T Zaletel, V Aggarwal, R Luder, E Sanchez, K Brown, R Sofat, A Singh, C Houlihan, E Nastouli, N Losseff, DJ Werring, MM Brown, JC Mason, RJ Simister, HR Jäger
Aug 11, 2022
Optimal criteria for diagnosing and monitoring response to treatment for infectious and inflammatory medium-large vessel intracranial vasculitis presenting with stroke are lacking. We integrated intracranial vessel wall MRI with...
IgA vasculitis (Henoch-Schönlein purpura)
BACKGROUND: The disease course of adult immunoglobulin A (IgA) vasculitis (IgAV; Henoch-Schönlein purpura) has not been well defined. METHODS: In a retrospective survey, we studied 85 adult IgAV patients with extended follow-up...
Assessment of venous hemodynamics and volume homeostasis during pregnancy
Venous hemodynamics and volume homeostasis are important aspects of cardiovascular physiology. However, today their relevance is still very much underappreciated. Their most important role is maintenance and control of venous...
maternal hemodynamics plasma volume Pregnancy venous hemodynamics venous return volume homeostasis Blood Flow Velocity cardiac output Cardiovascular Physiological Phenomena Consensus Development Conferences as Topic Female Guidelines as Topic Hemodynamics Homeostasis Humans Maternal Health Pregnancy Pregnancy Complications Cardiovascular Prenatal Diagnosis Uterine Artery
Cognitive impact of cerebral microbleeds in patients with symptomatic small vessel disease.
Stefania Nannoni, Laura Ohlmeier, Robin B Brown, Robin G Morris, Andrew D MacKinnon, Hugh S Markus, DNA Lacunar 2 investigators
Mar 31, 2022
BACKGROUND AND AIM: Whether cerebral microbleeds cause cognitive impairment remains uncertain. We analyzed whether cerebral microbleeds are associated with cognitive dysfunction in patients with symptomatic cerebral small vessel...
The international universities walking project
W J Brown, G Faulkner, J McKenna, M Murphy, A Pringle, K Proper, A Puig-Ribera, Afroditi Stathi, M R Umstattd
Jul 01, 2010
Background: This paper aimed to use the Delphi technique to develop a consensus framework for a multinational, workplace walking intervention.
Methods: Ideas were gathered and ranked from eight recognized and emerging...
ANCA-associated vasculitis.
A Richard Kitching, Hans-Joachim Anders, Neil Basu, Elisabeth Brouwer, Jennifer Gordon, David R Jayne, Joyce Kullman, Paul A Lyons, Peter A Merkel, Caroline OS Savage, Ulrich Specks, Renate Kain
Sep 14, 2020
The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of disorders involving severe, systemic, small-vessel vasculitis and are characterized by the development of autoantibodies to the...
Position paper
Xavier Bossuyt, Jan-Willem Cohen Tervaert, Yoshihiro Arimura, Daniel Blockmans, Luis Felipe Flores-Suárez, Loïc Guillevin, Bernhard Hellmich, David Jayne, J Charles Jennette, Cees GM Kallenberg, Sergey Moiseev, Pavel Novikov, Antonella Radice, Judith Anne Savige, Renato Alberto Sinico, Ulrich Specks, Pieter van Paassen, Ming-Hui Zhao, Niels Rasmussen, Jan Damoiseaux, Elena Csernok
Feb 24, 2020
Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic...
The international universities walking project
W J Brown, G Faulkner, J McKenna, M Murphy, A Pringle, K Proper, A Puig-Ribera, Afroditi Stathi, M R Umstattd
Jul 01, 2010
Background: This paper aimed to use the Delphi technique to develop a consensus framework for a multinational, workplace walking intervention.
Methods: Ideas were gathered and ranked from eight recognized and emerging...
Estimating physical activity from self-reported behaviours in large-scale population studies using network harmonisation
Matthew Pearce, Tessa Strain, Youngwon Kim, Stephen J Sharp, Kate Westgate, Katrien Wijndaele, Tomas Gonzales, Nicholas J Wareham, Søren Brage
Apr 17, 2020
BACKGROUND:UK Biobank is a large prospective cohort study containing accelerometer-based physical activity data with strong validity collected from 100,000 participants approximately 5 years after baseline. In contrast, the main...
Estimating physical activity from self-reported behaviours in large-scale population studies using network harmonisation
Matthew Pearce, Tessa Strain, Youngwon Kim, Stephen J. Sharp, Kate Westgate, Katrien Wijndaele, Tomas Gonzales, Nicholas J. Wareham, Søren Brage
Mar 16, 2021
Abstract: Background: UK Biobank is a large prospective cohort study containing accelerometer-based physical activity data with strong validity collected from 100,000 participants approximately 5 years after baseline. In...
Natural history of Charcot-Marie-Tooth disease type 2A
Menelaos Pipis, Shawna ME Feely, James M Polke, Mariola Skorupinska, Laura Perez, Rosemary R Shy, Matilde Laura, Jasper M Morrow, Isabella Moroni, Chiara Pisciotta, Franco Taroni, Dragan Vujovic, Thomas E Lloyd, Gyula Acsadi, Sabrina W Yum, Richard A Lewis, Richard S Finkel, David N Herrmann, John W Day, Jun Li, Mario Saporta, Reza Sadjadi, David Walk, Joshua Burns, Francesco Muntoni, Sindhu Ramchandren, Rita Horvath, Nicholas E Johnson, Stephan Züchner, Davide Pareyson, Steven S Scherer, Alexander M Rossor, Michael E Shy, Mary M Reilly, Inherited Neuropathies Consortium - Rare Disease Clinical Research Network (INC-RDCRN)
Oct 15, 2020
Mitofusin-2 (MFN2) is one of two ubiquitously expressed homologous proteins in eukaryote cells, playing a critical role in mitochondrial fusion. Mutations in MFN2 (most commonly autosomal dominant) cause Charcot-Marie-Tooth...
Charcot-Marie-Tooth Examination Score v2.0 Charcot-Marie-Tooth disease type 2A genotype-phenotype correlations mitofusin-2 standardized response mean Adolescent Adult Age of Onset Charcot-Marie-Tooth disease Child Child Preschool Cohort Studies Disease Progression Female GTP Phosphohydrolases Genes Dominant Genes Recessive Genetic Association Studies Genetic Markers Humans Infant Longitudinal Studies Male Mitochondrial Proteins Neurologic Examination Orthotic Devices Prognosis Prospective Studies Wheelchairs Young Adult
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