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The tale of TILs in breast cancer
Khalid El Bairi, Harry R Haynes, Elizabeth Blackley, Susan Fineberg, Jeffrey Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel Sur, Luis Claudio Amendola, Masoumeh Gharib, Amine Kallala, Indu Arun, Farid Azmoudeh-Ardalan, Luciana Fujimoto, Luz F Sua, Shi-Wei Liu, Huang-Chun Lien, Pawan Kirtani, Marcelo Balancin, Hicham El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I-Chun Chen, Veronica Bautista, Jose Fernando Do Prado Moura, Bernardo L Rapoport, Carlos Castaneda, Eunice Spengler, Gabriela Acosta-Haab, Isabel Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, Reena R Md Zin, Ruohong Shui, Timothy Onyuma, Wentao Yang, Zaheed Husain, Karen Willard-Gallo, An Coosemans, Edith A Perez, Elena Provenzano, Paula Gonzalez Ericsson, Eduardo Richardet, Ravi Mehrotra, Sandra Sarancone, Anna Ehinger, David L Rimm, John MS Bartlett, Giuseppe Viale, Carsten Denkert, Akira I Hida, Christos Sotiriou, Sibylle Loibl, Stephen M Hewitt, Sunil Badve, William Fraser Symmans, Rim S Kim, Giancarlo Pruneri, Shom Goel, Prudence A Francis, Gloria Inurrigarro, Rin Yamaguchi, Hernan Garcia-Rivello, Hugo Horlings, Said Afqir, Roberto Salgado, Sylvia Adams, Marleen Kok, Maria Vittoria Dieci, Stefan Michiels, Sandra Demaria, Sherene Loi, International Immuno-Oncology Biomarker Working Group
Dec 15, 2021
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with...
The tale of TILs in breast cancer
Khalid El Bairi, Harry R Haynes, Elizabeth Blackley, Susan Fineberg, Jeffrey Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel Sur, Luis Claudio Amendola, Masoumeh Gharib, Amine Kallala, Indu Arun, Farid Azmoudeh-Ardalan, Luciana Fujimoto, Luz F Sua, Shi-Wei Liu, Huang-Chun Lien, Pawan Kirtani, Marcelo Balancin, Hicham El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I-Chun Chen, Veronica Bautista, Jose Fernando Do Prado Moura, Bernardo L Rapoport, Carlos Castaneda, Eunice Spengler, Gabriela Acosta-Haab, Isabel Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, Reena R Md Zin, Ruohong Shui, Timothy Onyuma, Wentao Yang, Zaheed Husain, Karen Willard-Gallo, An Coosemans, Edith A Perez, Elena Provenzano, Paula Gonzalez Ericsson, Eduardo Richardet, Ravi Mehrotra, Sandra Sarancone, Anna Ehinger, David L Rimm, John MS Bartlett, Giuseppe Viale, Carsten Denkert, Akira I Hida, Christos Sotiriou, Sibylle Loibl, Stephen M Hewitt, Sunil Badve, William Fraser Symmans, Rim S Kim, Giancarlo Pruneri, Shom Goel, Prudence A Francis, Gloria Inurrigarro, Rin Yamaguchi, Hernan Garcia-Rivello, Hugo Horlings, Said Afqir, Roberto Salgado, Sylvia Adams, Marleen Kok, Maria Vittoria Dieci, Stefan Michiels, Sandra Demaria, Sherene Loi, International Immuno-Oncology Biomarker Working Group
Jan 28, 2022
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with...
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group.
Mohamed Amgad, Elisabeth Specht Stovgaard, Eva Balslev, Jeppe Thagaard, Weijie Chen, Sarah Dudgeon, Ashish Sharma, Jennifer K Kerner, Carsten Denkert, Yinyin Yuan, Khalid AbdulJabbar, Stephan Wienert, Peter Savas, Leonie Voorwerk, Andrew H Beck, Anant Madabhushi, Johan Hartman, Manu M Sebastian, Hugo M Horlings, Jan Hudeček, Francesco Ciompi, David A Moore, Rajendra Singh, Elvire Roblin, Marcelo Luiz Balancin, Marie-Christine Mathieu, Jochen K Lennerz, Pawan Kirtani, I-Chun Chen, Jeremy P Braybrooke, Giancarlo Pruneri, Sandra Demaria, Sylvia Adams, Stuart J Schnitt, Sunil R Lakhani, Federico Rojo, Laura Comerma, Sunil S Badve, Mehrnoush Khojasteh, W Fraser Symmans, Christos Sotiriou, Paula Gonzalez-Ericsson, Katherine L Pogue-Geile, Rim S Kim, David L Rimm, Giuseppe Viale, Stephen M Hewitt, John MS Bartlett, Frédérique Penault-Llorca, Shom Goel, Huang-Chun Lien, Sibylle Loibl, Zuzana Kos, Sherene Loi, Matthew G Hanna, Stefan Michiels, Marleen Kok, Torsten O Nielsen, Alexander J Lazar, Zsuzsanna Bago-Horvath, Loes FS Kooreman, Jeroen AWM van der Laak, Joel Saltz, Brandon D Gallas, Uday Kurkure, Michael Barnes, Roberto Salgado, Lee AD Cooper, International Immuno-Oncology Biomarker Working Group
May 12, 2021
Surveillance recommendations for DICER1 pathogenic variant carriers
Jette J Bakhuizen, Helen Hanson, Karin van der Tuin, Fiona Lalloo, Marc Tischkowitz, Karin Wadt, Marjolijn CJ Jongmans, SIOPE Host Genome Working Group, CanGene-CanVar Clinical Guideline Working Group, Expert Network Members
Oct 01, 2021
DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging because uncertainty exists about the clinical efficacy of surveillance...
Assessment of venous hemodynamics and volume homeostasis during pregnancy
Venous hemodynamics and volume homeostasis are important aspects of cardiovascular physiology. However, today their relevance is still very much underappreciated. Their most important role is maintenance and control of venous...
maternal hemodynamics plasma volume Pregnancy venous hemodynamics venous return volume homeostasis Blood Flow Velocity cardiac output Cardiovascular Physiological Phenomena Consensus Development Conferences as Topic Female Guidelines as Topic Hemodynamics Homeostasis Humans Maternal Health Pregnancy Pregnancy Complications Cardiovascular Prenatal Diagnosis Uterine Artery
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
Mohamed Amgad, Elisabeth Specht Stovgaard, Eva Balslev, Jeppe Thagaard, Weijie Chen, Sarah Dudgeon, Ashish Sharma, Jennifer K. Kerner, Carsten Denkert, Yinyin Yuan, Khalid AbdulJabbar, Stephan Wienert, Peter Savas, Leonie Voorwerk, Andrew H. Beck, Anant Madabhushi, Johan Hartman, Manu M. Sebastian, Hugo M. Horlings, Jan Hudeček, Francesco Ciompi, David A. Moore, Rajendra Singh, Elvire Roblin, Marcelo Luiz Balancin, Marie-Christine Mathieu, Jochen K. Lennerz, Pawan Kirtani, I-Chun Chen, Jeremy P. Braybrooke, Giancarlo Pruneri, Sandra Demaria, Sylvia Adams, Stuart J. Schnitt, Sunil R. Lakhani, Federico Rojo, Laura Comerma, Sunil S. Badve, Mehrnoush Khojasteh, W. Fraser Symmans, Christos Sotiriou, Paula Gonzalez-Ericsson, Katherine L. Pogue-Geile, Rim S. Kim, David L. Rimm, Giuseppe Viale, Stephen M. Hewitt, John M. S. Bartlett, Frédérique Penault-Llorca, Shom Goel, Huang-Chun Lien, Sibylle Loibl, Zuzana Kos, Sherene Loi, Matthew G. Hanna, Stefan Michiels, Marleen Kok, Torsten O. Nielsen, Alexander J. Lazar, Zsuzsanna Bago-Horvath, Loes F. S. Kooreman, Jeroen A. W. M. van der Laak, Joel Saltz, Brandon D. Gallas, Uday Kurkure, Michael Barnes, Roberto Salgado, Lee A. D. Cooper, Aini Hyytiäinen, Akira I. Hida, Alastair Thompson, Alex Lefevre, Allen Gown, Amy Lo, Anna Sapino, Andre Moreira, Andrea Richardson, Andrea Vingiani, Andrew M. Bellizzi, Andrew Tutt, Angel Guerrero-Zotano, Anita Grigoriadis, Anna Ehinger, Anna C. Garrido-Castro, Anne Vincent-Salomon, Anne-Vibeke Laenkholm, Ashley Cimino-Mathews, Ashok Srinivasan, Balazs Acs, Baljit Singh, Benjamin Calhoun, Benjamin Haibe-Kans, Benjamin Solomon, Bibhusal Thapa, Brad H. Nelson, Carlos Castaneda, Carmen Ballesteroes-Merino, Carmen Criscitiello, Carolien Boeckx, Cecile Colpaert, Cecily Quinn, Chakra S. Chennubhotla, Charles Swanton, Cinzia Solinas, Crispin Hiley, Damien Drubay, Daniel Bethmann, Deborah A. Dillon, Denis Larsimont, Dhanusha Sabanathan, Dieter Peeters, Dimitrios Zardavas, Doris Höflmayer, Douglas B. Johnson, E. Aubrey Thompson, Edi Brogi, Edith Perez, Ehab A. ElGabry, Elizabeth F. Blackley, Emily Reisenbichler, Enrique Bellolio, Ewa Chmielik, Fabien Gaire, Fabrice Andre, Fang-I Lu, Farid Azmoudeh-Ardalan, Forbius Tina Gruosso, Franklin Peale, Fred R. Hirsch, Frederick Klaushen, Gabriela Acosta-Haab, Gelareh Farshid, Gert van den Eynden, Giuseppe Curigliano, Giuseppe Floris, Glenn Broeckx, Harmut Koeppen, Harry R. Haynes, Heather McArthur, Heikki Joensuu, Helena Olofsson, Ian Cree, Iris Nederlof, Isabel Frahm, Iva Brcic, Jack Chan, Jacqueline A. Hall, James Ziai, Jane Brock, Jelle Wesseling, Jennifer Giltnane, Jerome Lemonnier, Jiping Zha, Joana M. Ribeiro, Jodi M. Carter, Johannes Hainfellner, John Le Quesne, Jonathan W. Juco, Jorge Reis-Filho, Jose van den Berg, Joselyn Sanchez, Joseph Sparano, Joël Cucherousset, Juan Carlos Araya, Julien Adam, Justin M. Balko, Kai Saeger, Kalliopi Siziopikou, Karen Willard-Gallo, Karolina Sikorska, Karsten Weber, Keith E. Steele, Kenneth Emancipator, Khalid El Bairi, Kim R. M. Blenman, Kimberly H. Allison, Koen K. van de Vijver, Konstanty Korski, Lajos Pusztai, Laurence Buisseret, Leming Shi, Liu Shi-wei, Luciana Molinero, M. Valeria Estrada, Maartje van Seijen, Magali Lacroix-Triki, Maggie C. U. Cheang, Maise al Bakir, Marc van de Vijver, Maria Vittoria Dieci, Marlon C. Rebelatto, Martine Piccart, Matthew P. Goetz, Matthias Preusser, Melinda E. Sanders, Meredith M. Regan, Michael Christie, Michael Misialek, Michail Ignatiadis, Michiel de Maaker, Mieke van Bockstal, Miluska Castillo, Nadia Harbeck, Nadine Tung, Nele Laudus, Nicolas Sirtaine, Nicole Burchardi, Nils Ternes, Nina Radosevic-Robin, Oleg Gluz, Oliver Grimm, Paolo Nuciforo, Paul Jank, Petar Jelinic, Peter H. Watson, Prudence A. Francis, Prudence A. Russell, Robert H. Pierce, Robert Hills, Roberto Leon-Ferre, Roland de Wind, Ruohong Shui, Sabine Declercq, Sam Leung, Sami Tabbarah, Sandra C. Souza, Sandra O’Toole, Sandra Swain, Scooter Willis, Scott Ely, Seong- Rim Kim, Shahinaz Bedri, Sheeba Irshad, Shi-Wei Liu, Shona Hendry, Simonetta Bianchi, Sofia Bragança, Soonmyung Paik, Stephen B. Fox, Stephen J. Luen, Stephen Naber, Sua Luz, Susan Fineberg, Teresa Soler, Thomas Gevaert, Timothy d’Alfons, Tom John, Tomohagu Sugie, Veerle Bossuyt, Venkata Manem, Vincente Peg Cámaea, Weida Tong, Wentao Yang, William T. Tran, Yihong Wang, Yves Allory, Zaheed Husain
Feb 12, 2021
Changing the name of diabetes insipidus
Working Group for Renaming Diabetes Insipidus, Hiroshi Arima, Timothy Cheetham, Mirjam Christ-Crain, Deborah Cooper, Mark Gurnell, Juliana B Drummond, Miles Levy, Ann I McCormack, Joseph Verbalis, John Newell-Price, John AH Wass
Nov 16, 2022
'What's in a name? That which we call a rose/By any other name would smell as sweet' (Juliet, from Romeo and Juliet by William Shakespeare). Shakespeare's implication is that a name is nothing but a word, and it therefore...
Patient centered guidelines for the laboratory diagnosis of Gaucher disease type 1.
A Dardis, H Michelakakis, P Rozenfeld, K Fumic, J Wagner, E Pavan, M Fuller, S Revel-Vilk, D Hughes, T Cox, J Aerts, International Working Group of Gaucher Disease (IWGGD)
Dec 21, 2022
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder due to the deficient activity of the acid beta-glucosidase (GCase) enzyme, resulting in the progressive lysosomal accumulation of glucosylceramide...
The GRAPPA-OMERACT Working Group
Ying Ying Leung, William Tillett, Ana-Maria Orbai, Alexis Ogdie, Lihi Eder, Laura C Coates, Richard Holland, Anna Antony, Niti Goel, Philip J Mease
Jun 30, 2020
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis (PsA) working group provided updates at the 2019 GRAPPA annual meeting on its...
The GRAPPA-OMERACT Working Group
Ying Ying Leung, William Tillett, Ana-Maria Orbai, Alexis Ogdie, Lihi Eder, Laura C Coates, Richard Holland, Anna Antony, Niti Goel, Philip J Mease
Jun 30, 2020
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis (PsA) working group provided updates at the 2019 GRAPPA annual meeting on its...
Patient centered guidelines for the laboratory diagnosis of Gaucher disease type 1.
A Dardis, H Michelakakis, P Rozenfeld, K Fumic, J Wagner, E Pavan, M Fuller, S Revel-Vilk, D Hughes, T Cox, J Aerts, International Working Group of Gaucher Disease (IWGGD)
Jan 22, 2023
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder due to the deficient activity of the acid beta-glucosidase (GCase) enzyme, resulting in the progressive lysosomal accumulation of glucosylceramide...
Recent Advancements and Applications of Human Immune System Mice in Preclinical Immuno-Oncology.
Michelle Curran, Maelle Mairesse, Alba Matas-Céspedes, Bethany Bareham, Giovanni Pellegrini, Ardi Liaunardy, Edward Powell, Rebecca Sargeant, Emanuela Cuomo, Richard Stebbings, Catherine J Betts, Kourosh Saeb-Parsy
Jan 20, 2020
Significant advances in immunotherapies have resulted in the increasing need of predictive preclinical models to improve immunotherapeutic drug development, treatment combination, and to prevent or minimize toxicity in clinical...
Working for the future
Tochukwu Nweze, Mary Basil Nwoke, Juliet Ifeoma Nwufo, Richard Ikechukwu Aniekwu, Florian Lange
Jun 12, 2020
BACKGROUND: The dominant view based on the deficit model of developmental psychopathology is that early adverse rearing impairs cognition. In contrast, an emerging evolutionary-developmental model argues that individuals exposed...
Report of the GRAPPA-OMERACT Psoriatic Arthritis Working Group from the GRAPPA 2015 Annual Meeting
Ana-Maria Orbai, Philip J Mease, Maarten de Wit, Umut Kalyoncu, Willemina Campbell, William Tillett, Lihi Eder, Musaab Elmamoun, Oliver FitzGerald, Dafna D Gladman, Niti Goel, Laure Gossec, Chris A Lindsay, Ingrid Steinkoenig, Philip S Helliwell, Neil J McHugh, Vibeke Strand, Alexis Ogdie
May 01, 2016
The GRAPPA-OMERACT psoriatic arthritis (PsA) working group is in the process of updating the PsA core domain set to improve and standardize the measurement of PsA outcomes. Work streams comprise literature reviews of domains...
Report of the GRAPPA-OMERACT Psoriatic Arthritis Working Group from the GRAPPA 2015 Annual Meeting
Ana-Maria Orbai, Philip J Mease, Maarten de Wit, Umut Kalyoncu, Willemina Campbell, William Tillett, Lihi Eder, Musaab Elmamoun, Oliver FitzGerald, Dafna D Gladman, Niti Goel, Laure Gossec, Chris A Lindsay, Ingrid Steinkoenig, Philip S Helliwell, Neil J McHugh, Vibeke Strand, Alexis Ogdie
May 01, 2016
The GRAPPA-OMERACT psoriatic arthritis (PsA) working group is in the process of updating the PsA core domain set to improve and standardize the measurement of PsA outcomes. Work streams comprise literature reviews of domains...
Comparing oncology clinical programs by use of innovative designs and expected net present value optimization
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Jan 01, 0001
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3...
Comparing oncology clinical programs by use of innovative designs and expected net present value optimization
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Jan 01, 0001
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3...
Robust group sequential designs for trials with survival endpoints and delayed response
Pranab Ghosh, Robin Ristl, Franz König, Martin Posch, Christopher Jennison, Heiko Götte, Armin Schüler, Cyrus Mehta
Feb 28, 2022
Randomized clinical trials in oncology typically utilize time-to-event endpoints such as progression-free survival or overall survival as their primary efficacy endpoints, and the most commonly used statistical test to...
A survey by the European Society of Breast Imaging on the implementation of breast diffusion-weighted imaging in clinical practice.
Roberto Lo Gullo, Varadan Sevilimedu, Pascal Baltzer, Denis Le Bihan, Julia Camps-Herrero, Paola Clauser, Fiona J Gilbert, Mami Iima, Ritse M Mann, Savannah C Partridge, Andrew Patterson, Eric E Sigmund, Sunitha Thakur, Fabienne E Thibault, Laura Martincich, Katja Pinker, EUSOBI International Breast Diffusion-Weighted Imaging working group
Jun 07, 2022
OBJECTIVES: To perform a survey among all European Society of Breast Imaging (EUSOBI) radiologist members to gather representative data regarding the clinical use of breast DWI. METHODS: An online questionnaire was developed by...
The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.
Emma J Crosbie, Neil AJ Ryan, Mark J Arends, Tjalling Bosse, John Burn, Joanna M Cornes, Robin Crawford, Diana Eccles, Ian M Frayling, Sadaf Ghaem-Maghami, Heather Hampel, Noah D Kauff, Henry C Kitchener, Sarah J Kitson, Ranjit Manchanda, Raymond FT McMahon, Kevin J Monahan, Usha Menon, Pål Møller, Gabriela Möslein, Adam Rosenthal, Peter Sasieni, Mourad W Seif, Naveena Singh, Pauline Skarrott, Tristan M Snowsill, Robert Steele, Marc Tischkowitz, Manchester International Consensus Group, D Gareth Evans
Feb 07, 2020
PURPOSE: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with...
Review of the psoriatic arthritis working group at OMERACT 12
William Tillett, Lihi Eder, Niti Goel, Maarten de Wit, Alexis Ogdie, Ana Maria Orbai, Willemina Campbell, Oliver FitzGerald, Neil J. McHugh, Dafna D. Gladman, Vibeke Strand, Philip J. Mease
Jun 01, 2015
At the 2014 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), the psoriatic arthritis (PsA) working group of OMERACT (Outcome Measures in Rheumatology) presented a review...
Biomarker-guided trials
M Antoniou, R Kolamunnage-Dona, J Wason, R Bathia, C Billingham, JM Bliss, LC Brown, A Gillman, J Paul, AL Jorgensen
Dec 09, 2019
Biomarker-guided trials have drawn considerable attention as they promise to lead to improvements in the benefit-risk ratio of treatments and enhanced opportunities for drug development. A variety of such designs have been...
Robust group sequential designs for trials with survival endpoints and delayed response
Pranab Ghosh, Robin Ristl, Franz König, Martin Posch, Christopher Jennison, Heiko Götte, Armin Schüler, Cyrus Mehta
Feb 28, 2022
Randomized clinical trials in oncology typically utilize time-to-event endpoints such as progression-free survival or overall survival as their primary efficacy endpoints, and the most commonly used statistical test to...
Review of the psoriatic arthritis working group at OMERACT 12
William Tillett, Lihi Eder, Niti Goel, Maarten de Wit, Alexis Ogdie, Ana Maria Orbai, Willemina Campbell, Oliver FitzGerald, Neil J. McHugh, Dafna D. Gladman, Vibeke Strand, Philip J. Mease
Jun 01, 2015
At the 2014 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), the psoriatic arthritis (PsA) working group of OMERACT (Outcome Measures in Rheumatology) presented a review...
Major milestones in translational oncology.
Tommaso A Dragani, Antoni Castells, Vathany Kulasingam, Eleftherios P Diamandis, Helena Earl, Wade T Iams, Christine M Lovly, JP Michiel Sedelaar, Jack A Schalken
Sep 29, 2016
Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. Today, translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies...
Biomarkers Breast Cancer vaccines Colorectal Early Diagnosis Genetic profile Immunotherapy Individual risk Liquid biopsy Lung Mutational landscape Next generation sequencing Ovarian Prostate Tumorigenesis Biomarkers Tumor Humans Medical Oncology Molecular Targeted Therapy Translational Research Biomedical
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