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The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs
Typhoid fever is estimated to cause between 11.9-26.9 million infections globally each year with 129,000-216,510 deaths. Access to improved water sources have reduced disease incidence in parts of the world but the use of...
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
International Typhoid Consortium, Vanessa K Wong, Kathryn E Holt, Chinyere Okoro, Stephen Baker, Derek J Pickard, Florian Marks, Andrew J Page, Grace Olanipekun, Huda Munir, Roxanne Alter, Paul D Fey, Nicholas A Feasey, Francois-Xavier Weill, Simon Le Hello, Peter J Hart, Samuel Kariuki, Robert F Breiman, Melita A Gordon, Robert S Heyderman, Jan Jacobs, Octavie Lunguya, Chisomo Msefula, Calman A MacLennan, Karen H Keddy, Anthony M Smith, Robert S Onsare, Elizabeth de Pinna, Satheesh Nair, Ben Amos, Gordon Dougan, Stephen Obaro
Feb 19, 2019
BACKGROUND: The burden of typhoid in sub-Saharan African (SSA) countries has been difficult to estimate, in part, due to suboptimal laboratory diagnostics. However, surveillance blood cultures at two sites in Nigeria have...
An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid.
Vanessa K Wong, Stephen Baker, Thomas R Connor, Derek Pickard, Andrew J Page, Jayshree Dave, Niamh Murphy, Richard Holliman, Armine Sefton, Michael Millar, Zoe A Dyson, Gordon Dougan, Kathryn E Holt, International Typhoid Consortium
Feb 19, 2019
The population of Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationally discriminate individual isolates. Here we...
The global burden of typhoid and paratyphoid fevers
GBD 2017 Typhoid and Paratyphoid Collaborators
Apr 18, 2019
BACKGROUND: Efforts to quantify the global burden of enteric fever are valuable for understanding the health lost and the large-scale spatial distribution of the disease. We present the estimates of typhoid and paratyphoid fever...
Adolescent Adult Aged Aged 80 and over Cause of Death Child Child Preschool Disabled Persons Female Global Burden of Disease Humans Incidence Infant Life Expectancy Male Mass Vaccination Middle Aged Paratyphoid Fever Quality-Adjusted Life Years Risk Factors Salmonella enterica Sanitation Typhoid Fever Typhoid-Paratyphoid Vaccines Young Adult
ICC-dementia (International Centenarian Consortium - dementia)
Henry Brodaty, Claudia Woolf, Stacy Andersen, Nir Barzilai, Carol Brayne, Karen Siu-Lan Cheung, Maria M Corrada, John D Crawford, Catriona Daly, Yasuyuki Gondo, Bo Hagberg, Nobuyoshi Hirose, Henne Holstege, Claudia Kawas, Jeffrey Kaye, Nicole A Kochan, Bobo Hi-Po Lau, Ugo Lucca, Gabriella Marcon, Peter Martin, Leonard W Poon, Robyn Richmond, Jean-Marie Robine, Ingmar Skoog, Melissa J Slavin, Jan Szewieczek, Mauro Tettamanti, José Viña, Thomas Perls, Perminder S Sachdev
Sep 29, 2016
BACKGROUND: Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence...
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
Terrence F Meehan, Nathalie Conte, David B West, Julius O Jacobsen, Jeremy Mason, Jonathan Warren, Chao-Kung Chen, Ilinca Tudose, Mike Relac, Peter Matthews, Natasha Karp, Luis Santos, Tanja Fiegel, Natalie Ring, Henrik Westerberg, Simon Greenaway, Duncan Sneddon, Hugh Morgan, Gemma F Codner, Michelle E Stewart, James Brown, Neil Horner, International Mouse Phenotyping Consortium, Melissa Haendel, Nicole Washington, Christopher J Mungall, Corey L Reynolds, Juan Gallegos, Valerie Gailus-Durner, Tania Sorg, Guillaume Pavlovic, Lynette R Bower, Mark Moore, Iva Morse, Xiang Gao, Glauco P Tocchini-Valentini, Yuichi Obata, Soo Young Cho, Je Kyung Seong, John Seavitt, Arthur L Beaudet, Mary E Dickinson, Yann Herault, Wolfgang Wurst, Martin Hrabe de Angelis, KC Kent Lloyd, Ann M Flenniken, Lauryl MJ Nutter, Susan Newbigging, Colin McKerlie, Monica J Justice, Stephen A Murray, Karen L Svenson, Robert E Braun, Jacqueline K White, Allan Bradley, Paul Flicek, Sara Wells, William C Skarnes, David J Adams, Helen Parkinson, Ann-Marie Mallon, Steve DM Brown, Damian Smedley
Oct 22, 2020
Although next-generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge of the functions and...
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
Raffaele Ferrari, Yunpeng Wang, Jana Vandrovcova, Sebastian Guelfi, Aree Witeolar, Celeste M Karch, Andrew J Schork, Chun C Fan, James B Brewer, International FTD-Genomics Consortium (IFGC), International Parkinson's Disease Genomics Consortium (IPDGC), International Genomics of Alzheimer's Project (IGAP), Parastoo Momeni, Gerard D Schellenberg, William P Dillon, Leo P Sugrue, Christopher P Hess, Jennifer S Yokoyama, Luke W Bonham, Gil D Rabinovici, Bruce L Miller, Ole A Andreassen, Anders M Dale, John Hardy, Rahul S Desikan
Feb 06, 2018
BACKGROUND: Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders...
Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
Justin Im, Md. Taufiqul Islam, Deok Ryun Kim, Faisal Ahmmed, Yun Chon, K. Zaman, Ashraful Islam Khan, Mohammad Ali, Dipika Sur, Suman Kanungo, Shanta Dutta, Sujit K. Bhattacharya, Gordon Dougan, Kathryn E. Holt, Florian Marks, Jerome H. Kim, Firdausi Qadri, John D. Clemens
Aug 17, 2020
We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with...
Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata.
Justin Im, Md Taufiqul Islam, Deok Ryun Kim, Faisal Ahmmed, Yun Chon, K Zaman, Ashraful Islam Khan, Mohammad Ali, Dipika Sur, Suman Kanungo, Shanta Dutta, Sujit K Bhattacharya, Gordon Dougan, Kathryn E Holt, Florian Marks, Jerome H Kim, Firdausi Qadri, John D Clemens
Aug 21, 2020
We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with...
Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.
Malick M Gibani, Elizabeth Jones, Amber Barton, Celina Jin, Juliette Meek, Susana Camara, Ushma Galal, Eva Heinz, Yael Rosenberg-Hasson, Gerlinde Obermoser, Claire Jones, Danielle Campbell, Charlotte Black, Helena Thomaides-Brears, Christopher Darlow, Christina Dold, Laura Silva-Reyes, Luke Blackwell, Maria Lara-Tejero, Xuyao Jiao, Gabrielle Stack, Christoph J Blohmke, Jennifer Hill, Brian Angus, Gordon Dougan, Jorge Galán, Andrew J Pollard
Jul 02, 2020
Salmonella Typhi is a human host-restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annually1. The typhoid toxin is postulated to have a central role in disease pathogenesis, the...
Gene Ontology Consortium
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe...
Typhoid conjugate vaccines
Jason R Andrews, Stephen Baker, Florian Marks, Marcella Alsan, Denise Garrett, Bruce G Gellin, Samir K Saha, Farah Naz Qamar, Mohammad Tahir Yousafzai, Isaac I Bogoch, Marina Antillon, Virginia E Pitzer, Jong-Hoon Kim, Jacob John, Jillian Gauld, Vittal Mogasale, Edward T Ryan, Stephen P Luby, Nathan C Lo
Aug 01, 2019
Typhoid fever is an acute systemic infectious disease responsible for an estimated 12-20 million illnesses and over 150 000 deaths annually. In March, 2018, a new recommendation was issued by WHO for the programmatic use of...
ImmUniverse Consortium
Stefania Vetrano, Gerben Bouma, Robert J Benschop, Thomas Birngruber, Antonio Costanzo, GRAM D'Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans JPM Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium
Jan 04, 2023
Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation. The immune...
The mammalian gene function resource
Allan Bradley, Konstantinos Anastassiadis, Abdelkader Ayadi, James F Battey, Cindy Bell, Marie-Christine Birling, Joanna Bottomley, Steve D Brown, Antje Bürger, Carol J Bult, Wendy Bushell, Francis S Collins, Christian Desaintes, Brendan Doe, Aris Economides, Janan T Eppig, Richard H Finnell, Colin Fletcher, Martin Fray, David Frendewey, Roland H Friedel, Frank G Grosveld, Jens Hansen, Yann Hérault, Geoffrey Hicks, Andreas Hörlein, Richard Houghton, Martin Hrabé de Angelis, Danny Huylebroeck, Vivek Iyer, Pieter J de Jong, James A Kadin, Cornelia Kaloff, Karen Kennedy, Manousos Koutsourakis, KC Kent Lloyd, Susan Marschall, Jeremy Mason, Colin McKerlie, Michael P McLeod, Harald von Melchner, Mark Moore, Alejandro O Mujica, Andras Nagy, Mikhail Nefedov, Lauryl M Nutter, Guillaume Pavlovic, Jane L Peterson, Jonathan Pollock, Ramiro Ramirez-Solis, Derrick E Rancourt, Marcello Raspa, Jacques E Remacle, Martin Ringwald, Barry Rosen, Nadia Rosenthal, Janet Rossant, Patricia Ruiz Noppinger, Ed Ryder, Joel Zupicich Schick, Frank Schnütgen, Paul Schofield, Claudia Seisenberger, Mohammed Selloum, Elizabeth M Simpson, William C Skarnes, Damian Smedley, William L Stanford, A Francis Stewart, Kevin Stone, Kate Swan, Hamsa Tadepally, Lydia Teboul, Glauco P Tocchini-Valentini, David Valenzuela, Anthony P West, Ken-ichi Yamamura, Yuko Yoshinaga, Wolfgang Wurst
Oct 14, 2020
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the...
Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa.
Elin Näsström, Christopher M Parry, Nga Tran Vu Thieu, Rapeephan R Maude, Hanna K de Jong, Masako Fukushima, Olena Rzhepishevska, Florian Marks, Ursula Panzner, Justin Im, Hyonjin Jeon, Seeun Park, Zabeen Chaudhury, Aniruddha Ghose, Rasheda Samad, Tan Trinh Van, Anders Johansson, Arjen M Dondorp, Guy E Thwaites, Abul Faiz, Henrik Antti, Stephen Baker
Feb 19, 2019
Salmonella Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in...
The Control of Typhoid Fever in Vietnam.
Tran Vu Thieu Nga, Pham Thanh Duy, Nguyen Phu Huong Lan, Nguyen Van Vinh Chau, Stephen Baker
Apr 10, 2019
Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a diminishing public health problem in Vietnam, and this process may represent a prototype for typhoid elimination in Asia. Here, we review typhoid...
The IPASC data format
Janek Gröhl, Lina Hacker, Ben T Cox, Kris K Dreher, Stefan Morscher, Avotra Rakotondrainibe, François Varray, Lawrence CM Yip, William C Vogt, Sarah E Bohndiek, Members of the International Photoacoustic Standardisation Consortium (IPASC)
Apr 19, 2022
Photoacoustic imaging (PAI) is an emerging modality that has shown promise for improving patient management in a range of applications. Unfortunately, the current lack of uniformity in PAI data formats compromises inter-user...
The Burden of Typhoid Fever in Sub-Saharan Africa
Cara Lynn Kim, Ligia Maria Cruz Espinoza, Kirsten S Vannice, Birkneh Tilahun Tadesse, Ellis Owusu-Dabo, Raphaël Rakotozandrindrainy, Ilesh V Jani, Mekonnen Teferi, Abdramane Bassiahi Soura, Octavie Lunguya, A Duncan Steele, Florian Marks
Apr 20, 2022
While typhoid fever has largely been eliminated in high-income regions which have developed modern water, sanitation, and hygiene facilities, it remains a significant public health burden resulting in morbidity and mortality...
The SPECTRUM Consortium
M Horton, PR Perman-Howe, C Angus, J Bishop, I Bogdanovica, A Brennan, J Britton, LS Brose, J Brown, J Collin, M Dockrell, N Fitzgerald, S Friel, D Gillespie, AB Gilmore, SE Hill, C Knai, T Langley, S Martin, A McNeill, G Moore, MR Munafò, RL Murray, M Opazo Breton, J Pearce, M Petticrew, G Reid, D Robson, H Rutter, L Shahab, N Shortt, K Smith, K Syrett, L Bauld
Dec 31, 2021
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures...
The SPECTRUM Consortium
M Horton, PR Perman-Howe, C Angus, J Bishop, I Bogdanovica, A Brennan, J Britton, LS Brose, J Brown, J Collin, M Dockrell, N Fitzgerald, S Friel, D Gillespie, AB Gilmore, SE Hill, C Knai, T Langley, S Martin, A McNeill, G Moore, MR Munafò, RL Murray, M Opazo Breton, J Pearce, M Petticrew, G Reid, D Robson, H Rutter, L Shahab, N Shortt, K Smith, K Syrett, L Bauld
Dec 31, 2021
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures...
The burden of typhoid fever in low- and middle-income countries
Marina Antillón, Joshua L Warren, Forrest W Crawford, Daniel M Weinberger, Esra Kürüm, Gi Deok Pak, Florian Marks, Virginia E Pitzer
Feb 19, 2019
BACKGROUND: Upcoming vaccination efforts against typhoid fever require an assessment of the baseline burden of disease in countries at risk. There are no typhoid incidence data from most low- and middle-income countries (LMICs)...
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.
Alberto Romagnoni, Simon Jégou, Kristel Van Steen, Gilles Wainrib, Jean-Pierre Hugot, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
Oct 29, 2019
Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent...
Alleles Area Under Curve Crohn Disease Decision Trees Deep learning Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Genotyping Techniques Humans INDEL Mutation Logistic Models Male Models Genetic Neural Networks Computer Nonlinear dynamics Polymorphism Single Nucleotide ROC Curve
Antibiotic Resistance and Typhoid.
Multiple drug (antibiotic) resistance (MDR) has become a major threat to the treatment of typhoid and other infectious diseases. Since the 1970s, this threat has increased in Salmonella enterica serovar Typhi, driven in part by...
Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC)
Keiji Fukuda, Direk Limmathurotsakul, Iruka N Okeke, Nandini Shetty, Rogier van Doorn, Nicholas A Feasey, Francesca Chiara, Ghada Zoubiane, Tim Jinks, Julian Parkhill, Jean Patel, Stuart WJ Reid, Alison H Holmes, Sharon J Peacock, Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC)
Nov 05, 2018
In recognition of the central importance of surveillance and epidemiology in the control of antimicrobial resistance and the need to strengthen surveillance at all levels, Wellcome has brought together a new international expert...
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