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Determinants of Influencer Credibility and Platform Credibility to Understand the Effectiveness of Indian Fashion Influencers
The concept of influencer marketing refers to the use of selected influencers to create and promote branded content to the influencer’s followers and the brand’s selected target market. Fashion Influencers on social media are...
Published by: IGI Global Scientific Publishing
Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density.
John R James
May 11, 2018
The T cell antigen receptor (TCR) recognizes peptides from pathogenic proteins bound in the major histocompatibility complex (MHC). To convert this binding event into downstream signaling, the TCR complex contains immunoreceptor...
Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
Jun Mori, Zoltan Nagy, Giada Di Nunzio, Christopher W Smith, Mitchell J Geer, Rashid Al Ghaithi, Johanna P van Geffen, Silke Heising, Luke Boothman, Bibian ME Tullemans, Joao N Correia, Louise Tee, Marijke JE Kuijpers, Paul Harrison, Johan WM Heemskerk, Gavin E Jarvis, Alexander Tarakhovsky, Arthur Weiss, Alexandra Mazharian, Yotis A Senis
Mar 16, 2018
Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like...
Amino Acid Motifs Animals Blood Platelets CSK Tyrosine-Protein Kinase Homeostasis Mice Mice Knockout Platelet Membrane Glycoproteins Protein Tyrosine Phosphatase Non-Receptor Type 11 Protein Tyrosine Phosphatase Non-Receptor Type 6 Receptor-Like Protein Tyrosine Phosphatases Class 3 Thrombosis src-Family Kinases
Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.
Mitchell J Geer, Johanna P van Geffen, Piraveen Gopalasingam, Timo Vögtle, Christopher W Smith, Silke Heising, Marijke JE Kuijpers, Bibian ME Tullemans, Gavin E Jarvis, Johannes A Eble, Mark Jeeves, Michael Overduin, Johan WM Heemskerk, Alexandra Mazharian, Yotis A Senis
Oct 10, 2018
The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of...
Animals Binding Sites Blood Platelets Homeostasis Mice Mice Inbred C57BL Mice Transgenic Models Molecular Phosphorylation Point Mutation Protein Interaction Maps Protein Tyrosine Phosphatase Non-Receptor Type 11 Protein Tyrosine Phosphatase Non-Receptor Type 6 Receptors Immunologic Signal Transduction Thrombocytopenia src Homology Domains
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Valeria Radjabova, Piero Mastroeni, Karsten Skjødt, Paola Zaccone, Bernard de Bono, Jane C Goodall, Edwin R Chilvers, Jatinder K Juss, Des C Jones, John Trowsdale, Alexander David Barrow
Jul 29, 2015
Amino Acid Sequence Animals Base Sequence CD4-Positive T-Lymphocytes Cell Line Cytokines Dendritic Cells Female Granulocytes HEK293 Cells HLA Antigens Humans Inflammation Ligands Lipopolysaccharides Lymphocyte Activation MACROPHAGES Mice Mice Inbred C57BL Mice Inbred NOD Molecular Sequence Data Neutrophils Protein Transport Receptors Immunologic Recombinant Fusion Proteins Signal Transduction