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Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Liquid jet leaping from a free surface
We investigate the characteristics of a liquid jet ejected from an inclined tube, which is submerged immediately under a free surface. Jets are classified into three regimes: the curtain regime, transition regime, and column...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Liquid jet leaping from a free surface
We investigate the characteristics of a liquid jet ejected from an inclined tube, which is submerged immediately under a free surface. Jets are classified into three regimes: the curtain regime, transition regime, and column...
Droplets passing through a soap film
Here, we report an experimental study of droplets colliding with a soap film. The behavior of the droplet is found to be dependent on the impact velocity. The threshold for a droplet to pass through the soap film is influenced...
Droplets passing through a soap film
Here, we report an experimental study of droplets colliding with a soap film. The behavior of the droplet is found to be dependent on the impact velocity. The threshold for a droplet to pass through the soap film is influenced...
Learning Sparrow Algorithm With Non-Uniform Search for Global Optimization
Sparrow Algorithm as a New Swarm Intelligence Search Algorithm, the sparrow algorithm has good optimization ability, but in complex environments, it still has certain limitations, such as weak learning ability. Therefore, this...
Published by: IGI Global Scientific Publishing
Vortex coupling in trailing vortex-wing interactions
The interaction of trailing vortices of an upstream wing with rigid and flexible downstream wings has been investigated experimentally in a wind tunnel, using particle image velocimetry, hot-wire, force and deformation...
On hydrodynamic characteristics of gap resonance between two fixed bodies in close proximity
The resonant water motion inside a narrow gap between two identical fixed boxes that are in side-by-side configuration is investigated using a two-dimensional (2D) numerical wave tank based on OpenFOAM®, an open...
Vortex coupling in trailing vortex-wing interactions
The interaction of trailing vortices of an upstream wing with rigid and flexible downstream wings has been investigated experimentally in a wind tunnel, using particle image velocimetry, hot-wire, force and deformation...
Ultrafast Field-Emission Electron Sources Based on Nanomaterials
The search for electron sources with simultaneous optimal spatial and temporal resolution has become an area of intense activity for a wide variety of applications in the emerging fields of lightwave electronics and...
The search for electron sources with simultaneous optimal spatial and temporal resolution has become an area of intense activity for a wide variety of applications in the emerging fields of lightwave electronics and...
Study on Influences of Fringing Reef on Harbor Oscillations Triggered by N-Waves
Influences of topographic variations of the offshore fringing reef on the harbor oscillations excited by incident N-waves with different amplitudes and waveform types are studied for the first time. Both the propagation of...
A 3D parallel Particle-In-Cell solver for extreme wave interaction with floating bodies
Floating structures are widely used for vessels, offshore platforms, and recently considered for deep water floating offshore wind system and wave energy devices. However, modelling complex wave interactions with floating...
On the relaxation approach for wave absorption in numerical wave tanks
In CFD modelling, relaxation methods are widely used in numerical wave tanks (NWTs) for wave absorption; however, this method can be very expensive as part of the NWT must be dedicated to a relaxation zone. In this short...
Secondary Metabolites of Osmanthus fragrans
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Aug 01, 2022
Osmanthus fragrans (scientific name: Osmanthus fragrans (Thunb.) Lour.) is a species of the Osmanthus genus in the family Oleaceae, and it has a long history of cultivation in China. O. fragrans is edible and is well known for...
A 3D numerical study of solitary wave interaction with vertical cylinders using a parallelised Particle-In-Cell solver
This paper aims to provide a better understanding of the interaction between solitary waves and vertical circular cylinders. This is achieved via process based numerical modelling using the parallel Particle-In-Cell based...
Metabolically Specific In Situ Fluorescent Visualization of Bacterial Infection on Wound Tissues
Chen Jian Zhong, Xi Le Hu, Xiao Lan Yang, Hui Qi Gan, Kai Cheng Yan, Fu Ting Shu, Pei Wei, Teng Gong, Peng Fei Luo, Tony D. James, Zhao Hong Chen, Yong Jun Zheng, Xiao Peng He, Zhao Fan Xia
Sep 07, 2022
The ability to effectively detect bacterial infection in human tissues is important for the timely treatment of the infection. However, traditional techniques fail to visualize bacterial species adhered to host cells in situ...
A 3D parallel Particle-In-Cell solver for wave interaction with vertical cylinders
In this paper, the Particle-In-Cell (PIC) based PICIN solver is extended to three spatial dimensions and parallelised using the Message Passing Interface (MPI) approach. The PICIN solver employs both Eulerian grid and Lagrangian...
A 3D numerical study of solitary wave interaction with vertical cylinders using a parallelised Particle-In-Cell solver
This paper aims to provide a better understanding of the interaction between solitary waves and vertical circular cylinders. This is achieved via process based numerical modelling using the parallel Particle-In-Cell based...
PICIN
Please note there is a typo in the paper on page B419 for the CPU time used for the second case, the correct CPU time for 12s of simulation time should be 1200s with Δx = Δz =...
On the relaxation approach for wave absorption in numerical wave tanks
In CFD modelling, relaxation methods are widely used in numerical wave tanks (NWTs) for wave absorption; however, this method can be very expensive as part of the NWT must be dedicated to a relaxation zone. In this short...
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