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Results: 1177
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Supersymmetry in the Standard Sachdev-Ye-Kitaev Model.
Supersymmetry is a powerful concept in quantum many-body physics. It helps to illuminate ground-state properties of complex quantum systems and gives relations between correlation functions. In this Letter, we show that the...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Generalized Ordered Weighted Simplified Neutrosophic Cosine Similarity Measure for Multiple Attribute Group Decision Making
Jun Ye
Jan 01, 2020
The paper proposes a generalized ordered weighted simplified neutrosophic cosine similarity (GOWSNCS) measure by combining the cosine similarity measure of simplified neutrosophic sets (SNSs) with the generalized ordered...
Published by: IGI Global Scientific Publishing
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Chaotic-Integrable Transition in the Sachdev-Ye-Kitaev Model.
Quantum chaos is one of the distinctive features of the Sachdev-Ye-Kitaev (SYK) model, N Majorana fermions in 0+1 dimensions with infinite-range two-body interactions, which is attracting a lot of interest as a toy model for...
A Benchmark for Performance Evaluation of a Multi-Model Database vs. Polyglot Persistence
As the need for handling data from various sources becomes crucial for making optimal decisions, managing multi-model data has become a key area of research. Currently, it is challenging to strike a balance between two methods...
Published by: IGI Global Scientific Publishing
Development of optimum cold-formed steel sections for maximum energy dissipation in uniaxial bending
Cold-formed steel (CFS) elements are increasingly used as load-bearing members in construction, including in seismic regions. More conventional hot-rolled steel and concrete building structures are typically allowed by the...
Computational grid generation for the design of free-form shells with complex boundary conditions
Free-form grid structures have been widely used in various public buildings, and many are bounded by complex curves including internal voids. Modern computational design software enables the rapid creation and exploration of...
A triangular grid generation and optimization framework for the design of free-form gridshells
Gridshells have been widely used in various public buildings, and many of them are defined over complex free-form surfaces with complex boundaries. This emphasizes the importance of general grid generation and optimization...
Dynamic relaxation Free-form surface Grid generation Grid quality Gridshell /dk/atira/pure/subjectarea/asjc/1700/1706 name=Computer Science Applications /dk/atira/pure/subjectarea/asjc/1700/1704 name=Computer Graphics and Computer-Aided Design /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Computational grid generation for the design of free-form shells with complex boundary conditions
Free-form grid structures have been widely used in various public buildings, and many are bounded by complex curves including internal voids. Modern computational design software enables the rapid creation and exploration of...
Strength and Deflection Behaviour of Cold-Formed Steel Back-to-Back Channels
Cold-formed steel (CFS) construction can lead to more efficient designs compared to hot-rolled steel members as a consequence of its high strength, light weight, ease of fabrication, and flexibility in their cross-section...
Strength and Deflection Behaviour of Cold-Formed Steel Back-to-Back Channels
Cold-formed steel (CFS) construction can lead to more efficient designs compared to hot-rolled steel members as a consequence of its high strength, light weight, ease of fabrication, and flexibility in their cross-section...
Development of optimum cold-formed steel sections for maximum energy dissipation in uniaxial bending
Cold-formed steel (CFS) elements are increasingly used as load-bearing members in construction, including in seismic regions. More conventional hot-rolled steel and concrete building structures are typically allowed by the...
A practical grid generation procedure for the design of free-form structures
Computer aided design software enables the rapid conceptual creation of a curved surface geometry, whereas it is neither a convenient nor an obvious task for engineers to create a discrete grid structure on a complex surface...
A practical grid generation procedure for the design of free-form structures
Computer aided design software enables the rapid conceptual creation of a curved surface geometry, whereas it is neither a convenient nor an obvious task for engineers to create a discrete grid structure on a complex surface...
Experimental Investigation of the Cross-Sectional Bending Capacity of Cold-Formed Steel Channels Subject to Local-Distortional Buckling Interaction
Jun Ye, Francisco Meza, Iman Hajirasouliha, Jurgen Becque, Paul Shepherd, Kypros Pilakoutas
Jul 01, 2019
This paper describes an experimental program carried out at the University of Sheffield to investigate the interaction of local and distortional buckling in cold-formed steel lipped channel beams. The channels were arranged...
buckling channel Cold-formed steel Experiment Local-distortional interaction Stability /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Digital and automatic design of free-form single-layer grid structures
Grid shells have been widely used in various long-span public buildings, and many of them are defined over free-form surfaces with complex boundaries. This emphasizes the importance of general and digitalised grid generation...
Dynamic relaxation Free-form surface Grid quality Grid structure parametric design /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction
A triangular grid generation and optimization framework for the design of free-form gridshells
Gridshells have been widely used in various public buildings, and many of them are defined over complex free-form surfaces with complex boundaries. This emphasizes the importance of general grid generation and optimization...
Dynamic relaxation Free-form surface Grid generation Grid quality Gridshell /dk/atira/pure/subjectarea/asjc/1700/1706 name=Computer Science Applications /dk/atira/pure/subjectarea/asjc/1700/1704 name=Computer Graphics and Computer-Aided Design /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Digital and automatic design of free-form single-layer grid structures
Grid shells have been widely used in various long-span public buildings, and many of them are defined over free-form surfaces with complex boundaries. This emphasizes the importance of general and digitalised grid generation...
Dynamic relaxation Free-form surface Grid quality Grid structure parametric design /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction
Experimental Investigation of the Cross-Sectional Bending Capacity of Cold-Formed Steel Channels Subject to Local-Distortional Buckling Interaction
Jun Ye, Francisco Meza, Iman Hajirasouliha, Jurgen Becque, Paul Shepherd, Kypros Pilakoutas
Jul 01, 2019
This paper describes an experimental program carried out at the University of Sheffield to investigate the interaction of local and distortional buckling in cold-formed steel lipped channel beams. The channels were arranged...
buckling channel Cold-formed steel Experiment Local-distortional interaction Stability /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Synthetic Spin-Orbit Coupling in an Optical Lattice Clock.
Michael L Wall, Andrew P Koller, Shuming Li, Xibo Zhang, Nigel R Cooper, Jun Ye, Ana Maria Rey
Mar 27, 2018
We propose the use of optical lattice clocks operated with fermionic alkaline-earth atoms to study spin-orbit coupling (SOC) in interacting many-body systems. The SOC emerges naturally during the clock interrogation, when atoms...
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