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Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST)
Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Emmanuel Nsutebu, Robert Tilley, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Tim Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin J Llewelyn, Jonathan D Edgeworth, A Sarah Walker, United Kingdom Clinical Infection Research Group (UKCIRG)
Jun 27, 2018
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed...
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
Duration of exposure to multiple antibiotics is associated with increased risk of VRE bacteraemia
Theodore Gouliouris, Ben Warne, Edward JP Cartwright, Luke Bedford, Chathika K Weerasuriya, Kathy E Raven, Nick M Brown, M Estée Török, Direk Limmathurotsakul, Sharon J Peacock
Sep 29, 2018
BACKGROUND: VRE bacteraemia has a high mortality and continues to defy control. Antibiotic risk factors for VRE bacteraemia have not been adequately defined. We aimed to determine the risk factors for VRE bacteraemia focusing on...
Adult Aged Anti-Bacterial Agents Antimicrobial Stewardship Bacteremia Case-Control Studies Cross Infection Enterococcus Female Gram-Positive Bacterial Infections Humans Intensive Care Units Logistic Models Male Middle Aged Retrospective Studies Risk Factors Time Factors United Kingdom vancomycin Vancomycin Resistance
Urbanicity and Paediatric Bacteraemia in Ghana-A Case-Control Study within a Rural-Urban Transition Zone.
Peter Sothmann, Ralf Krumkamp, Benno Kreuels, Nimako Sarpong, Clemens Frank, Lutz Ehlkes, Julius Fobil, Kennedy Gyau, Anna Jaeger, Benedicta Bosu, Florian Marks, Ellis Owusu-Dabo, Bernd Salzberger, Jürgen May
Feb 20, 2019
BACKGROUND: Systemic bacterial infections are a major cause of paediatric febrile illness in sub-Saharan Africa. Aim of this study was to assess the effects of social and geographical determinants on the risk of bacteraemia in a...
A Modified Progressive Supranuclear Palsy Rating Scale.
Marie-Therese Grötsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea FM Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macías-García, Wassilios G Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B Rowe, Klaus Seppi, Maria Stamelou, John C van Swieten, Gregor Wenning, Teodoro del Ser, Lawrence I Golbe, Günter U Höglinger, the ProPSP Study Group, and the Movement Disorder Society-Endorsed PSP Study Group Describe PSP Study Group
Jan 26, 2021
BACKGROUND: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion...
Changing Antimicrobial Resistance Trends in Kathmandu, Nepal
Raphaël M Zellweger, Buddha Basnyat, Poojan Shrestha, Krishna G Prajapati, Sabina Dongol, Paban K Sharma, Samir Koirala, Thomas C Darton, Christine Boinett, Corinne N Thompson, Guy E Thwaites, Stephen Baker, Abhilasha Karkey
Apr 10, 2019
A comprehensive longitudinal understanding of the changing epidemiology of the agents causing bacteraemia and their AMR profiles in key locations is crucial for assessing the progression and magnitude of the global AMR crisis....
Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children.
Kenyan Bacteraemia Study Group, Wellcome Trust Case Control Consortium 2 (WTCCC2), Anna Rautanen, Matti Pirinen, Tara C Mills, Kirk A Rockett, Amy Strange, Anne W Ndungu, Vivek Naranbhai, James J Gilchrist, Céline Bellenguez, Colin Freeman, Gavin Band, Suzannah J Bumpstead, Sarah Edkins, Eleni Giannoulatou, Emma Gray, Serge Dronov, Sarah E Hunt, Cordelia Langford, Richard D Pearson, Zhan Su, Damjan Vukcevic, Alex W Macharia, Sophie Uyoga, Carolyne Ndila, Neema Mturi, Patricia Njuguna, Shebe Mohammed, James A Berkley, Isaiah Mwangi, Salim Mwarumba, Barnes S Kitsao, Brett S Lowe, Susan C Morpeth, Iqbal Khandwalla, Kilifi Bacteraemia Surveillance Group, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin NA Palmer, Robert Plomin, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Panos Deloukas, Leena Peltonen, Thomas N Williams, J Anthony G Scott, Stephen J Chapman, Peter Donnelly, Adrian VS Hill, Chris CA Spencer
Jun 10, 2016
The Role of Grit Among Kenyan Immigrants in the United States
Sharon Ndolo
Jun 18, 2021
This research study examines the role of grit in the success of Kenyan immigrants in the United States. It gives an illustration as to why grit is more relevant than IQ in the accomplishment of long-term goals. It will also...
Published by: IGI Global Scientific Publishing
Emergency surgery for splenic flexure cancer
Nicola de'Angelis, Eloy Espin, Frederic Ris, Filippo Landi, Bertrand Le Roy, Federico Coccolini, Valerio Celentano, Angela Gurrado, Denis Pezet, Giorgio Bianchi, Riccardo Memeo, Giulio C Vitali, Alejandro Solis, Christine Denet, Salomone Di Saverio, Gian Luigi de'Angelis, Miquel Kraft, Paula Gonzálvez-Guardiola, Aine Stakelum, Fausto Catena, David Fuks, Des C Winter, Mario Testini, Aleix Martínez-Pérez, SFC Study Group
Apr 30, 2021
BACKGROUND: The effectiveness of surgical treatment for splenic flexure carcinomas (SFCs) in emergency settings remains unexplored. This study aims to compare the perioperative and long-term outcomes of different alternatives...
An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment.
Marcus Jepson, Daisy Elliott, Carmel Conefrey, Julia Wade, Leila Rooshenas, Caroline Wilson, David Beard, Jane M Blazeby, Alison Birtle, Alison Halliday, Rob Stein, Jenny L Donovan, CSAW study group, Chemorad study group, POUT study group, ACST-2 study group, OPTIMA prelim study group
Aug 23, 2018
OBJECTIVES: To explore how the concept of randomization is described by clinicians and understood by patients in randomized controlled trials (RCTs) and how it contributes to patient understanding and recruitment. STUDY DESIGN...
Patient information qualitative research randomization Randomized controlled trials Recruitment Recruitment to RCTs Comprehension Decision Making Computer-Assisted Gambling Humans metaphor Patient Education as Topic Patient Selection qualitative research Random Allocation Randomized Controlled Trials as Topic United Kingdom
Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening.
SG Thompson, HA Ashton, L Gao, MJ Buxton, RAP Scott, Multicentre Aneurysm Screening Study (MASS) Group
Jan 27, 2020
BACKGROUND: The long-term effects of abdominal aortic aneurysm (AAA) screening were investigated in extended follow-up from the UK Multicentre Aneurysm Screening Study (MASS) randomized trial. METHODS: A population-based sample...
New perspectives in eosinophilic granulomatosis with polyangiitis (EGPA)
Chiara Marvisi, Renato Alberto Sinico, Carlo Salvarani, David Jayne, Domenico Prisco, Benjamin Terrier, Giacomo Emmi, Augusto Vaglio, European EGPA Study Group
May 27, 2020
The European Eosinophilic Granulomatosis with Polyangiitis (EGPA) study group first gathered in Firenze in December 2018. The discussion was centred around the clinical and therapeutic needs in EGPA which still remain unmet....
Protocol for the Pathways Study
Conrad Wanyama, Claire Blacklock, Juliet Jepkosgei, Mike English, Lisa Hinton, Jacob McKnight, Sassy Molyneux, Mwanamvua Boga, Peris Muoga Musitia, Geoff Wong
Apr 13, 2023
Introduction
The informal social ties that health workers form with their colleagues influence knowledge, skills and individual and group behaviours and norms in the workplace. However, improved understanding of these...
Neonatology Health Policy quality In health care Humans Focus Groups communication Child Preschool Infant Newborn Delivery of Health Care Kenya Quality Improvement
Published by: BMJ Open
Primary post-transplant lymphoproliferative disorder of the central nervous system
Mary M Taj, Britta Maecker-Kolhoff, Rebecca Ling, Simon Bomken, Birgit Burkhardt, Alan KS Chiang, Monika Csoka, Anna Füreder, Stéphanie Haouy, Jelena Lazic, Natalia Miakova, Veronique Minard-Colin, Suzanne D Turner, Anne Uyttebroeck, Andishe Attarbaschi, the international Berlin-Frankfurt-Münster (i-BFM) Study Group European Intergroup for Childhood Non-Hodgkin’s Lymphoma (EICNHL)
Feb 17, 2021
Primary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin's Lymphoma and/or...
Central Nervous System outcome post-transplant lymphoproliferative disorder transplant Treatment Adolescent Adult Allografts Brain Neoplasms Child Child Preschool Disease-Free Survival Female Hematopoietic Stem Cell Transplantation Humans Infant Injections Spinal Lymphoproliferative Disorders Male Organ Transplantation Rituximab Survival Rate
The Max-Min Group Contest
We investigate a group all-pay auction in which each group's effort is represented by the minimum among the effort levels exerted by the group members and the prize is a group-specific public good. We fully characterize the...
The Max-Min Group Contest
We investigate a group all-pay auction in which each group's effort is represented by the minimum among the effort levels exerted by the group members and the prize is a group-specific public good. We fully characterize the...
Antenatal iron supplementation, FGF23, and bone metabolism in Kenyan women and their offspring
Vickie S Braithwaite, Martin N Mwangi, Kerry S Jones, Ayşe Y Demir, Ann Prentice, Andrew M Prentice, Pauline EA Andang'o, Hans Verhoef
Mar 22, 2021
BACKGROUND: Fibroblast growth factor-23 (FGF23) regulates body phosphate homeostasis primarily by increasing phosphaturia. It also acts as a vitamin D-regulating hormone. Maternal iron deficiency is associated with perturbed...
Education quality and the Kenyan 8-4-4 curriculum
Lizzi O. Milligan
Jun 01, 2017
This article explores the implementation of Kenyan secondary education in rural Western Kenya, focusing on learners’ experiences. One of the key challenges to educational quality is shown to be the size and breadth of the...
New Therapeutics in Alzheimer's Disease Longitudinal Cohort study (NTAD)
Juliette Helene Lanskey, Ece Kocagoncu, Andrew J Quinn, Yun-Ju Cheng, Melek Karadag, Jemma Pitt, Stephen Lowe, Michael Perkinton, Vanessa Raymont, Krish D Singh, Mark Woolrich, Anna C Nobre, Richard N Henson, James B Rowe, NTAD study group
Dec 20, 2022
Impact of COVID-19 pandemic on surgical neuro-oncology multi-disciplinary team decision making
Stephen John Price, Alexis Joannides, Puneet Plaha, Fardad Taghizadeh Afshari, Erminia Albanese, Neil U Barua, Huan Wee Chan, Giles Critchley, Thomas Flannery, Daniel M Fountain, Ryan K Mathew, Rory J Piper, Michael TC Poon, Chittoor Rajaraman, Ola Rominiyi, Stuart Smith, Georgios Solomou, Anna Solth, Surash Surash, Victoria Wykes, Colin Watts, Helen Bulbeck, Peter Hutchinson, Michael D Jenkinson, COVID-CNSMDT study group
Aug 17, 2020
OBJECTIVES: Pressures on healthcare systems due to COVID-19 has impacted patients without COVID-19 with surgery disproportionally affected. This study aims to understand the impact on the initial management of patients with...
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia.
Thomas C Darton, Liqing Zhou, Christoph J Blohmke, Claire Jones, Claire S Waddington, Stephen Baker, Andrew J Pollard
Apr 10, 2019
BACKGROUND: Improved diagnostics for typhoid are needed; a typhoid controlled human infection model may accelerate their development and translation. Here, we evaluated a blood culture-PCR assay for detecting infection after...
controlled human infection model Diagnostics Febrile disease Polymerase Chain Reaction Salmonella typhi Typhoid Fever Adolescent Adult Asymptomatic Infections Bacteremia blood culture Culture Media DNA Bacterial Female Fever Healthy Volunteers Humans Male Middle Aged Polymerase Chain Reaction Salmonella typhi Sensitivity and Specificity Typhoid Fever Young Adult
An ontological foundation for ocular phenotypes and rare eye diseases.
Panagiotis I Sergouniotis, Emmanuel Maxime, Dorothée Leroux, Annie Olry, Rachel Thompson, Ana Rath, Peter N Robinson, Hélène Dollfus, ERN-EYE Ontology Study Group
Feb 15, 2019
BACKGROUND: The optical accessibility of the eye and technological advances in ophthalmic diagnostics have put ophthalmology at the forefront of data-driven medicine. The focus of this study is rare eye disorders, a group of...
Education quality and the Kenyan 8-4-4 curriculum
Lizzi O. Milligan
Jun 01, 2017
This article explores the implementation of Kenyan secondary education in rural Western Kenya, focusing on learners’ experiences. One of the key challenges to educational quality is shown to be the size and breadth of the...
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study
Rachel M Freathy, M Geoffrey Hayes, Margrit Urbanek, Lynn P Lowe, Hoon Lee, Christine Ackerman, Timothy M Frayling, Nancy J Cox, David B Dunger, Alan R Dyer, Andrew T Hattersley, Boyd E Metzger, William L Lowe, HAPO Study Cooperative Research Group
Feb 21, 2020
OBJECTIVE: Common genetic variants in GCK and TCF7L2 are associated with higher fasting glucose and type 2 diabetes in nonpregnant populations. However, their associations with glucose levels from oral glucose tolerance tests...
Birth Weight Female genetic variation Genotype Germinal Center Kinases Humans Hyperglycemia Infant Newborn Polymorphism Single Nucleotide Pregnancy Pregnancy Complications Pregnancy Outcome Pregnancy in Diabetics Protein Serine-Threonine Kinases TCF Transcription Factors Transcription Factor 7-Like 2 Protein White People
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