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Results: 37
Social Network User Profiling With Multilayer Semantic Modeling Using Ego Network
Jayapandian N., Godwin Tunze, Mounir Hamdi, Tamil Selvi P., Kishore Balasubramaniam, Vidhya S., Ramya K., Poongodi M.
Jan 01, 2022
Social and information networks undermine the real relationship between the individuals (ego) and the friends (alters) they are connected with on social media. The structure of individual network is highlighted by the ego...
Published by: IGI Global Scientific Publishing
Sheaf Representation of an Information System
Ever since Pawlak introduced the concepts of rough sets, it has attracted many researchers and scientists from various fields of science and technology. Particularly for algebraists as it presented a gold mine to explore the...
Published by: IGI Global Scientific Publishing
Human population as a key driver of biochemical burden in an inter-city system
Barbara Kasprzyk-Hordern, Kathryn Proctor, Kishore Jagadeesan, Felicity Edler, Richard Standerwick, Ruth Barden
May 05, 2022
This paper tests the hypothesis that human population and city function are key drivers of biochemical burden in an inter-city system, which can be used to inform One Health actions as it enables a holistic understanding of...
AMR exposure Illicit Drugs lifestyle Pesticides Pharmaceuticals Wastewater-based Epidemiology Water fingerprinting /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/subjectarea/asjc/2300/2307 name=Health, Toxicology and Mutagenesis /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours
L Harewood, K Kishore, MD Eldridge, S Wingett, D Pearson, S Schoenfelder, VP Collins, P Fraser
Aug 10, 2017
Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome...
Anaplastic astrocytoma Cancer chromosome conformation capture Chromosome rearrangement Copy number variation Glioblastoma Hi-C Tumour Chromosome Aberrations Chromosome Breakpoints Chromosome Inversion DNA Copy Number Variations Humans In Situ Hybridization Fluorescence Neoplasms Translocation Genetic
Human population as a key driver of biochemical burden in an inter-city system
Barbara Kasprzyk-Hordern, Kathryn Proctor, Kishore Jagadeesan, Felicity Edler, Richard Standerwick, Ruth Barden
May 05, 2022
This paper tests the hypothesis that human population and city function are key drivers of biochemical burden in an inter-city system, which can be used to inform One Health actions as it enables a holistic understanding of...
AMR exposure Illicit Drugs lifestyle Pesticides Pharmaceuticals Wastewater-based Epidemiology Water fingerprinting /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/subjectarea/asjc/2300/2307 name=Health, Toxicology and Mutagenesis /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours
Louise Harewood, Kamal Kishore, Matthew D Eldridge, Steven Wingett, Danita Pearson, Stefan Schoenfelder, V. P Collins, Peter Fraser
Jun 28, 2017
Abstract
Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and...
Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients
Sarah L Tansley, Zoe E Betteridge, Stefania Simou, Thomas S Jacques, Clarissa Pilkington, Mark Wood, Kishore Warrier, Lucy R Wedderburn, Neil J McHugh
Apr 01, 2017
OBJECTIVE: We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis.
METHODS: There were 381 patients investigated for anti-HMGCR...
Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients
Sarah L Tansley, Zoe E Betteridge, Stefania Simou, Thomas S Jacques, Clarissa Pilkington, Mark Wood, Kishore Warrier, Lucy R Wedderburn, Neil J McHugh
Apr 01, 2017
OBJECTIVE: We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis.
METHODS: There were 381 patients investigated for anti-HMGCR...
Publisher Correction
Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, Eddy Arnold, Tom L Blundell
Aug 05, 2020
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Published by: Sci Rep
C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling.
Alexander Jt Wood, Arlette M Vassallo, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Carmelo Zinnato, Carmen Gonzalez-Tejedo, Kamal Kishore, Clive S D'Santos, A John Simpson, David K Menon, Charlotte Summers, Edwin R Chilvers, Klaus Okkenhaug, Andrew Conway Morris
Jul 06, 2020
Order and information in the patterns of spinning magnetic micro-disks at the air-water interface.
Wendong Wang, Gaurav Gardi, Paolo Malgaretti, Vimal Kishore, Lyndon Koens, Donghoon Son, Hunter Gilbert, Zongyuan Wu, Palak Harwani, Eric Lauga, Christian Holm, Metin Sitti
Feb 14, 2022
The application of the Shannon entropy to study the relationship between information and structures has yielded insights into molecular and material systems. However, the difficulty in directly observing and manipulating atoms...
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription
Mami Oikawa, Angela Simeone, Eva Hormanseder, Marta Teperek, Vincent Gaggioli, Alan O’Doherty, Emma Falk, Matthieu Sporniak, Clive D’Santos, Valar Nila Roamio Franklin, Kamal Kishore, Charles R. Bradshaw, Declan Keane, Thomas Freour, Laurent David, Adrian T. Grzybowski, Alexander J. Ruthenburg, John Gurdon, Jerome Jullien
Jul 13, 2020
Abstract: Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, we investigated whether all...
CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death.
Sofia Pavlou, Stefanie Foskolou, Nikolaos Patikas, Sarah F Field, Evangelia K Papachristou, Clive D' Santos, Abigail R Edwards, Kamal Kishore, Rizwan Ansari, Sandeep S Rajan, Hugo JR Fernandes, Emmanouil Metzakopian
Mar 09, 2023
A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.
Evangelia K Papachristou, Kamal Kishore, Andrew N Holding, Kate Harvey, Theodoros I Roumeliotis, Chandra Sekhar Reddy Chilamakuri, Soleilmane Omarjee, Kee Ming Chia, Alex Swarbrick, Elgene Lim, Florian Markowetz, Matthew Eldridge, Rasmus Siersbaek, Clive S D'Santos, Jason S Carroll
Sep 26, 2018
Understanding the dynamics of endogenous protein-protein interactions in complex networks is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of protein interactions in chromatin-associated protein...
Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, Eddy Arnold, Tom L Blundell
Sep 27, 2018
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present...
Adolescent Adult Bacterial Proteins DNA Bacterial DNA-Directed RNA Polymerases Drug Resistance Bacterial Female Humans india Leprostatic Agents Leprosy Male Microbial Sensitivity Tests Middle Aged Mutation Mycobacterium leprae Protein Binding Protein Stability Recurrence Rifampin Sequence Analysis DNA Structure-Activity Relationship Treatment Outcome Young Adult
Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity
Joachim Hanna, Flavio Beke, Louise M O’Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B Kim, Kamal Kishore, Timon E Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Jul 14, 2022
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription
Mami Oikawa, Angela Simeone, Eva Hormanseder, Marta Teperek, Vincent Gaggioli, Alan O’Doherty, Emma Falk, Matthieu Sporniak, Clive D’Santos, Valar Nila Roamio Franklin, Kamal Kishore, Charles R. Bradshaw, Declan Keane, Thomas Freour, Laurent David, Adrian T. Grzybowski, Alexander J. Ruthenburg, John Gurdon, Jerome Jullien
Jul 28, 2021
Abstract: Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, we investigated whether all...
Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.
Amanda J Collier, Adam Bendall, Charlene Fabian, Andrew A Malcolm, Katarzyna Tilgner, Claudia I Semprich, Katarzyna Wojdyla, Paola Serena Nisi, Kamal Kishore, Valar Nila Roamio Franklin, Bahar Mirshekar-Syahkal, Clive D'Santos, Kathrin Plath, Kosuke Yusa, Peter J Rugg-Gunn
Apr 25, 2022
Uncovering the mechanisms that establish naïve pluripotency in humans is crucial for the future applications of pluripotent stem cells including the production of human blastoids. However, the regulatory pathways that control...
A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
Reductions in commuting mobility correlate with geographic differences in SARS-CoV-2 prevalence in New York City.
Stephen M Kissler, Nishant Kishore, Malavika Prabhu, Dena Goffman, Yaakov Beilin, Ruth Landau, Cynthia Gyamfi-Bannerman, Brian T Bateman, Jon Snyder, Armin S Razavi, Daniel Katz, Jonathan Gal, Angela Bianco, Joanne Stone, Daniel Larremore, Caroline O Buckee, Yonatan H Grad
Nov 02, 2020
SARS-CoV-2-related mortality and hospitalizations differ substantially between New York City neighborhoods. Mitigation efforts require knowing the extent to which these disparities reflect differences in prevalence and...
Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity
Joachim Hanna, Flavio Beke, Louise O'Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander Kim, Kamal Kishore, Timon Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Aug 14, 2022
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Madhav Kishore, Kenneth CP Cheung, Hongmei Fu, Fabrizia Bonacina, Guosu Wang, David Coe, Eleanor J Ward, Alessandra Colamatteo, Maryam Jangani, Andrea Baragetti, Giuseppe Matarese, David M Smith, Robert Haas, Claudio Mauro, David C Wraith, Klaus Okkenhaug, Alberico L Catapano, Veronica De Rosa, Giuseppe D Norata, Federica M Marelli-Berg
Jan 24, 2018
Migration of activated regulatory T (Treg) cells to inflamed tissue is crucial for their immune-modulatory function. While metabolic reprogramming during Treg cell differentiation has been extensively studied, the bioenergetics...
CD28 CTLA-4 Glycolysis mTOR metabolism Migration regulatory T cells Adaptor Proteins Signal Transducing Animals CD28 Antigens CTLA-4 Antigen Cells Cultured glucokinase Glycolysis Humans Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Mice Mice Inbred Strains Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt T-Lymphocytes Regulatory
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