A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.
Matthew Traylor,
Kari-Matti Mäkelä,
Laura L Kilarski,
Elizabeth G Holliday,
William J Devan,
Mike A Nalls,
Kerri L Wiggins,
Wei Zhao,
Yu-Ching Cheng,
Sefanja Achterberg,
Rainer Malik,
Cathie Sudlow,
Steve Bevan,
Emma Raitoharju,
International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2) METASTROKE,
Niku Oksala,
Vincent Thijs,
Robin Lemmens,
Arne Lindgren,
Agnieszka Slowik,
Jane M Maguire,
Matthew Walters,
Ale Algra,
Pankaj Sharma,
John R Attia,
Giorgio B Boncoraglio,
Peter M Rothwell,
Paul IW de Bakker,
Joshua C Bis,
Danish Saleheen,
Steven J Kittner,
Braxton D Mitchell,
Jonathan Rosand,
James F Meschia,
Christopher Levi,
Martin Dichgans,
Terho Lehtimäki,
Cathryn M Lewis,
Hugh S Markus
Nov 08, 2018
Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of...