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Results: 569
Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase.
Sarah M Leiter, Victoria ER Parker, Alena Welters, Rachel Knox, Nuno Rocha, Graeme Clark, Felicity Payne, Luca Lotta, Julie Harris, Julio Guerrero-Fernández, Isabel González-Casado, Sixto García-Miñaur, Gema Gordo, Nick Wareham, Víctor Martínez-Glez, Michael Allison, Stephen O'Rahilly, Inês Barroso, Thomas Meissner, Susan Davies, Khalid Hussain, Karen Temple, Ana-Coral Barreda-Bonis, Sebastian Kummer, Robert K Semple
Aug 21, 2017
OBJECTIVE: Genetic activation of the insulin signal-transducing kinase AKT2 causes syndromic hypoketotic hypoglycaemia without elevated insulin. Mosaic activating mutations in class 1A phospatidylinositol-3-kinase (PI3K)...
Engineered mosaic protein polymers; a simple route to multifunctional biomaterials.
BACKGROUND: Engineered living materials (ELMs) are an exciting new frontier, where living organisms create highly functional materials. In particular, protein ELMs have the advantage that their properties can be manipulated via...
Engineered mosaic protein polymers; a simple route to multifunctional biomaterials
Abstract: Background: Engineered living materials (ELMs) are an exciting new frontier, where living organisms create highly functional materials. In particular, protein ELMs have the advantage that their properties can be...
First Report of Cucumber mosaic virus Infecting Pimpinella brachycarpa in Korea
Pimpinella brachycarpa (family Apiaceae) is an edible green, leafy vegetable frequently consumed in Korea. The plant species is commonly used to prepare Namul, a seasoned raw vegetable dish. Recently, we reported an isolate of...
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza.
Akhilesh Jha, Jake Dunning, Tanushree Tunstall, Ryan S Thwaites, Long T Hoang, MOSAIC Investigators, Onn Min Kon, Maria C Zambon, Trevor T Hansel, Peter J Openshaw
Aug 22, 2019
Adolescent Adrenal Cortex Hormones Adult Antiviral Agents Asthma Cytokines Female Hospitalization Humans Immunity mucosal Inflammation Influenza Vaccines Influenza Human Interferon-alpha Length of Stay Male Middle Aged Mortality Nasal Mucosa Oxygen Inhalation Therapy Respiration Artificial Transcriptome United Kingdom Young Adult
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Extensive recombination challenges the utility of Sugarcane mosaic virus phylogeny and strain typing
Abstract: Sugarcane mosaic virus (SCMV) is distributed worldwide and infects three major crops: sugarcane, maize, and sorghum. The impact of SCMV is increased by its interaction with Maize chlorotic mottle virus which causes the...
Transcriptome Analyses of Mosaic (MSC) Mitochondrial Mutants of Cucumber in a Highly Inbred Nuclear Background.
Tomasz L Mróz, Sebastian Eves-van den Akker, Agata Bernat, Agnieszka Skarzyńska, Leszek Pryszcz, Madeline Olberg, Michael J Havey, Grzegorz Bartoszewski
Aug 31, 2018
Cucumber (Cucumis sativus L.) has a large, paternally transmitted mitochondrial genome. Cucumber plants regenerated from cell cultures occasionally show paternally transmitted mosaic (MSC) phenotypes, characterized by slower...
Maize phenylalanine ammonia-lyases contribute to resistance to Sugarcane mosaic virus infection, most likely through positive regulation of salicylic acid accumulation.
Wen Yuan, Tong Jiang, Kaitong Du, Hui Chen, Yanyong Cao, Jipeng Xie, Mengfei Li, John P Carr, Boming Wu, Zaifeng Fan, Tao Zhou
May 13, 2019
Sugarcane mosaic virus (SCMV) is a pathogen of worldwide importance that causes dwarf mosaic disease on maize (Zea mays). Until now, few maize genes/proteins have been shown to be involved in resistance to SCMV. In this study...
Mosaic autosomal aneuploidies are detectable from single-cell RNAseq data.
BACKGROUND: Aneuploidies are copy number variants that affect entire chromosomes. They are seen commonly in cancer, embryonic stem cells, human embryos, and in various trisomic diseases. Aneuploidies frequently affect only a...
Extensive recombination challenges the utility of Sugarcane mosaic virus phylogeny and strain typing.
Sugarcane mosaic virus (SCMV) is distributed worldwide and infects three major crops: sugarcane, maize, and sorghum. The impact of SCMV is increased by its interaction with Maize chlorotic mottle virus which causes the...
Effects of the cucumber mosaic virus 2a protein on aphid-plant interactions in Arabidopsis thaliana.
The cucumber mosaic virus (CMV) 2a RNA-dependent RNA polymerase protein has an additional function in Arabidopsis thaliana, which is to stimulate feeding deterrence (antixenosis) against aphids. Antixenosis is thought to...
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Oct 16, 2020
Abstract: Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and biological mechanisms underlying mLOY are not fully understood. In a cohort of 95,380...
Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.
Claire Chewapreecha, Pekka Marttinen, Nicholas J Croucher, Susannah J Salter, Simon R Harris, Alison E Mather, William P Hanage, David Goldblatt, Francois H Nosten, Claudia Turner, Paul Turner, Stephen D Bentley, Julian Parkhill
Jun 25, 2019
Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks, confounding the identification of causative variants. Beta-lactam antibiotic...
Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes
Shu-Hong Lin, Derek W Brown, Brandon Rose, Felix Day, Olivia W Lee, Sairah M Khan, Jada Hislop, Stephen J Chanock, John RB Perry, Mitchell J Machiela
Aug 02, 2021
BACKGROUND: Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many individuals with detectable mCAs have no notable adverse...
Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes
Shu-Hong Lin, Derek W Brown, Brandon Rose, Felix Day, Olivia W Lee, Sairah M Khan, Jada Hislop, Stephen J Chanock, John R B Perry, Mitchell J Machiela
Aug 26, 2021
Background
Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many individuals with detectable mCAs have no notable...
Published by: Cell & bioscience
Analysis of mosaic mortars from the Roman, Byzantine and Early Islamic periods sourced from Gerasa’s Northwest Quarter
Richard Ball, M. P. Ansell, Tugce Busra Su, Vahiddin Alperen Baki, Philip J. Fletcher, Achim Lichtenberger, Rubina Raja, Will Wootton
Dec 31, 2024
This study analyses and compares around 650 years of mosaic mortar production spanning the Roman, late Roman and Umayyad periods, at Gerasa/Jerash in Jordan, offering a better understanding of composition, structural features...
Wendell M. Stanley, 1938
The Rockefeller University
Jan 01, 0001
Dr. Wendell M. Stanley. The Isolation and Properties of Tobacco Mosaic and Other Virus Proteins
Lecture delivered March, 17th, 1938
Posted with permission
Published by: The William & Wilkins Company
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Clinically-relevant postzygotic mosaicism in parents and children with developmental disorders in trio exome sequencing data.
CF Wright, E Prigmore, D Rajan, J Handsaker, J McRae, J Kaplanis, TW Fitzgerald, DR FitzPatrick, HV Firth, ME Hurles
Jul 04, 2020
Mosaic genetic variants can have major clinical impact. We systematically analyse trio exome sequence data from 4,293 probands from the DDD Study with severe developmental disorders for pathogenic postzygotic mosaicism (PZM) in...
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.
Jorge de la Rosa, José MP Freije, Rubén Cabanillas, Fernando G Osorio, Mario F Fraga, M Soledad Fernández-García, Roland Rad, Víctor Fanjul, Alejandro P Ugalde, Qi Liang, Haydn M Prosser, Allan Bradley, Juan Cadiñanos, Carlos López-Otín
Oct 14, 2020
Defining the relationship between ageing and cancer is a crucial but challenging task. Mice deficient in Zmpste24, a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation, recapitulate...
Analysis of mosaic mortars from the Roman, Byzantine and Early Islamic periods sourced from Gerasa’s Northwest Quarter
Richard Ball, M. P. Ansell, Tugce Busra Su, Vahiddin Alperen Baki, Philip J. Fletcher, Achim Lichtenberger, Rubina Raja, Will Wootton
Dec 31, 2024
This study analyses and compares around 650 years of mosaic mortar production spanning the Roman, late Roman and Umayyad periods, at Gerasa/Jerash in Jordan, offering a better understanding of composition, structural features...
Brain death and postmortem organ donation
Ernest van Veen, Mathieu van der Jagt, Maryse C Cnossen, Andrew IR Maas, Inez D de Beaufort, David K Menon, Giuseppe Citerio, Nino Stocchetti, Wim JR Rietdijk, Jeroen TJM van Dijck, Erwin JO Kompanje, CENTER-TBI Investigators and Participants
Apr 14, 2020
BACKGROUND: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. METHODS: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic...
Three Aphid-Transmitted Viruses Encourage Vector Migration From Infected Common Bean ( Phaseolus vulgaris ) Plants Through a Combination of Volatile and Surface Cues
Francis O. Wamonje, Trisna D. Tungadi, Alex M. Murphy, Adrienne E. Pate, Christine Woodcock, John C. Caulfield, J. Musembi Mutuku, Nik J. Cunniffe, Toby J. A. Bruce, Christopher A. Gilligan, John A. Pickett, John P. Carr
Dec 28, 2020
Bean common mosaic virus (BCMV), bean common mosaic necrosis virus (BCMNV), and cucumber mosaic virus (CMV) are important pathogens of common bean (Phaseolus vulgaris), a crop vital for food security in sub-Saharan Africa. These...
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