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Results: 6377
Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people
M Byford, C Brayne, I McKeith, M Chatfield, Pg Ince, FE Matthews, MRC CFAS Neuropathology group
Jun 16, 2011
BACKGROUND: Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in subcortical areas of...
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne, MRC Cognitive Function and Ageing Study
Jul 10, 2018
BACKGROUND: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate...
Microinfarcts in an older population-representative brain donor cohort (MRC CFAS)
Pg Ince, T Minett, G Forster, C Brayne, SB Wharton, Medical Research Council Cognitive Function and Ageing Neuropathology Study
Aug 13, 2018
INTRODUCTION: Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship with dementia, mobility and cerebrovascular disease in an older...
Epidemiological pathology of Aβ deposition in the ageing brain in CFAS
SB Wharton, D Wang, C Parikh, FE Matthews, C Brayne, Pg Ince, Cognitive Function and Ageing Neuropathology Study Group
Jan 10, 2020
Aβ-amyloid deposition is a key feature of Alzheimer's disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships to dementia. Thal...
Cohort differences in disease and disability in the young-old
Carol Jagger, Ruth J Matthews, Fiona E Matthews, Nicola A Spiers, Judith Nickson, Eugene S Paykel, Felicia A Huppert, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS)
Jun 14, 2011
BACKGROUND: Projections of health and social care need are highly sensitive to assumptions about cohort trends in health and disability. We use a repeated population-based cross-sectional study from the Cambridgeshire centre of...
Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection.
Mohammed D Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E Matthews, Li Su, Paul G Ince, Stephen B Wharton, Dennis Wang, Cognitive Function and Ageing Neuropathology Study Group
Mar 10, 2023
Although a variety of brain lesions may contribute to the pathological assessment of dementia, the relationship of these lesions to dementia, how they interact and how to quantify them remains uncertain. Systematically assessing...
An investigation of the population impact of variation in HbA1c levels in older people in England and Wales
BACKGROUND: Diabetes is common in the older population and is increasing. Glycated hemoglobin (HbA1c) is an indicator of average blood glucose concentration over the past three months. The HbA1c test is currently one of clinical...
Metaflammasome components in the human brain
Mariko Taga, Thais Minett, John Classey, Fiona E Matthews, Carol Brayne, Paul G Ince, James AR Nicoll, Jacques Hugon, Delphine Boche, MRC CFAS
Aug 09, 2018
Epidemiological and genetic studies have identified metabolic disorders and inflammation as risk factors for Alzheimer's disease (AD). Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome...
Alzheimer's Disease CFAS Dementia HUMAN BRAIN metaflammasome Aged Aged 80 and over Alzheimer Disease Apolipoproteins E Cohort Studies Diabetes mellitus Type 2 Female Humans I-kappa B Kinase Immunohistochemistry Insulin Receptor Substrate Proteins MAP Kinase Kinase 4 Male Mental Status Schedule Neocortex Phosphorylation Polymorphism Genetic Risk Factors eIF-2 Kinase
Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies
Rachel Waller, Ruth Narramore, Julie E. Simpson, Paul R. Heath, Nikita Verma, Megan Tinsley, Jordan R. Barnes, Hanna T. Haris, Frances E. Henderson, Fiona E. Matthews, Connor D. Richardson, Carol Brayne, Paul G. Ince, Raj N. Kalaria, Stephen B. Wharton, CFAS
May 27, 2021
Abstract: White matter lesions (WML) are common in the ageing brain, often arising in a field effect of diffuse white matter abnormality. Although WML are associated with cerebral small vessel disease (SVD) and Alzheimer’s...
RESEARCH ARTICLE RESEARCH ARTICLES Dementia epidemiological neuropathology Neuroinflammation Small vessel disease white matter lesions
Published by: Brain Pathology
Regional differences in multidimensional aspects of health
Fiona E Matthews, Laura L Miller, Carol Brayne, Carol Jagger, Medical Research Council Cognitive Function and Aging Study (MRC CFAS)
Jun 16, 2011
Activities of Daily Living Aged Aged 80 and over Attitude to Health Cognition Disorders Cohort Studies Female Geography Geriatric Assessment Health Surveys Humans Life Change Events Life Expectancy Male Prospective Studies Quality of life Rural Health Self Concept Socioeconomic Factors United Kingdom Urban Health
Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity.
Liam R Wilson, Deniz Vatansever, Tiina Annus, Guy B Williams, Young T Hong, Tim D Fryer, Peter J Nestor, Anthony J Holland, Shahid H Zaman
Jul 10, 2019
Down's syndrome is a chromosomal disorder that invariably results in both intellectual disability and Alzheimer's disease neuropathology. However, only a limited number of studies to date have investigated intrinsic brain...
Alzheimer's Disease Down's syndrome anti-correlation Default mode network functional connectivity Memory Adult Alzheimer Disease Amyloid Aniline Compounds Carbon Radioisotopes Cerebral Cortex Connectome Cross-Sectional Studies Down Syndrome Female Humans Magnetic Resonance Imaging Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals Thiazoles
What determines the self-rated health of older individuals with stroke compared to other older individuals? A cross-sectional analysis of the Medical Research Council Cognitive Function and Aging Study.
BACKGROUND: Poor self-rated health has been associated with poorer objective health outcomes across a range of conditions including stroke. Identification of factors associated with poor self-rated health in stroke survivors has...
Frailty and neuropathology in relation to dementia status
Lindsay Wallace, Sally Hunter, Olga Theou, Jane Fleming, Kenneth Rockwood, Carol Brayne
May 19, 2021
OBJECTIVE: To examine the relative contributions of frailty and neuropathology to dementia expression in a population-based cohort study. DESIGN: Cross-sectional analysis of observational data. SETTING: Population-representative...
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.
Julie E Simpson, Paul G Ince, Thais Minett, Fiona E Matthews, Paul R Heath, Pamela J Shaw, Emily Goodall, Claire J Garwood, Laura E Ratcliffe, Carol Brayne, Magnus Rattray, Stephen B Wharton, MRC Cognitive Function and Ageing Neuropathology Study Group
Aug 09, 2018
AIMS: Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for...
Ageing brain Alzheimer's DNA damage response Dementia microarray neurones Aged 80 and over aging Alzheimer Disease Blotting Western Brain Cholesterol DNA Damage Female Humans Immunohistochemistry Laser Capture Microdissection Male Neurons Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Signal Transduction Transcriptome
The Max-Min Group Contest
We investigate a group all-pay auction in which each group's effort is represented by the minimum among the effort levels exerted by the group members and the prize is a group-specific public good. We fully characterize the...
Microglial immunophenotype in dementia with Alzheimer's pathology.
Thais Minett, John Classey, Fiona E Matthews, Marie Fahrenhold, Mariko Taga, Carol Brayne, Paul G Ince, James AR Nicoll, Delphine Boche, MRC CFAS
Aug 14, 2017
BACKGROUND: Genetic risk factors for Alzheimer's disease imply that inflammation plays a causal role in development of the disease. Experimental studies suggest that microglia, as the brain macrophages, have diverse functions...
Alzheimer’s disease Apolipoprotein E Dementia Microglia neuropathology Aged Aged 80 and over Alzheimer Disease Antigens CD Antigens Differentiation Myelomonocytic Calcium-Binding Proteins Cohort Studies Cytokines DNA-Binding Proteins Dementia Diagnosis Female HLA-DR Antigens Humans Male Mental Status Schedule Methionine Sulfoxide Reductases Microfilament Proteins Microglia Neuropsychological Tests Receptors IgG
The Max-Min Group Contest
We investigate a group all-pay auction in which each group's effort is represented by the minimum among the effort levels exerted by the group members and the prize is a group-specific public good. We fully characterize the...
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
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