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Results: 80
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne, MRC Cognitive Function and Ageing Study
Jul 10, 2018
BACKGROUND: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate...
Cohort differences in disease and disability in the young-old
Carol Jagger, Ruth J Matthews, Fiona E Matthews, Nicola A Spiers, Judith Nickson, Eugene S Paykel, Felicia A Huppert, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS)
Jun 14, 2011
BACKGROUND: Projections of health and social care need are highly sensitive to assumptions about cohort trends in health and disability. We use a repeated population-based cross-sectional study from the Cambridgeshire centre of...
Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people
M Byford, C Brayne, I McKeith, M Chatfield, Pg Ince, FE Matthews, MRC CFAS Neuropathology group
Jun 16, 2011
BACKGROUND: Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in subcortical areas of...
Metaflammasome components in the human brain
Mariko Taga, Thais Minett, John Classey, Fiona E Matthews, Carol Brayne, Paul G Ince, James AR Nicoll, Jacques Hugon, Delphine Boche, MRC CFAS
Aug 09, 2018
Epidemiological and genetic studies have identified metabolic disorders and inflammation as risk factors for Alzheimer's disease (AD). Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome...
Alzheimer's Disease CFAS Dementia HUMAN BRAIN metaflammasome Aged Aged 80 and over Alzheimer Disease Apolipoproteins E Cohort Studies Diabetes mellitus Type 2 Female Humans I-kappa B Kinase Immunohistochemistry Insulin Receptor Substrate Proteins MAP Kinase Kinase 4 Male Mental Status Schedule Neocortex Phosphorylation Polymorphism Genetic Risk Factors eIF-2 Kinase
Microinfarcts in an older population-representative brain donor cohort (MRC CFAS)
Pg Ince, T Minett, G Forster, C Brayne, SB Wharton, Medical Research Council Cognitive Function and Ageing Neuropathology Study
Aug 13, 2018
INTRODUCTION: Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship with dementia, mobility and cerebrovascular disease in an older...
Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.
BACKGROUND: To date, there are no effective disease-modifying treatments for Alzheimer's disease (AD). In order to develop new therapeutics for stages where they are most likely to be effective, it is important to identify the...
Regional differences in multidimensional aspects of health
Fiona E Matthews, Laura L Miller, Carol Brayne, Carol Jagger, Medical Research Council Cognitive Function and Aging Study (MRC CFAS)
Jun 16, 2011
Activities of Daily Living Aged Aged 80 and over Attitude to Health Cognition Disorders Cohort Studies Female Geography Geriatric Assessment Health Surveys Humans Life Change Events Life Expectancy Male Prospective Studies Quality of life Rural Health Self Concept Socioeconomic Factors United Kingdom Urban Health
Disseminated $\textit{Mycobacterium malmoense}$ and $\textit{Salmonella}$ Infections Associated with a Novel Variant in $\textit{NFKBIA}$
E Staples, B Morillo-Gutierrez, J Davies, D Petersheim, M Massaad, M Slatter, D Dimou, R Doffinger, S Hackett, D Kumararatne, J Hadfield, MD Eldridge, RS Geha, M Abinun, JED Thaventhiran
May 05, 2017
JEDT is supported by a MRC Clinician Scientist Fellowship (MR/L006197/1). This work has been funded by BRC III PPG funding and by grant number 1R21AI124101-01 “Mechanisms of disease in patients with IκBα mutations” in RG’s...
A new online tool for visualization of volumetric data
This work was sponsored by the Engineering and Physical Sciences Research Council (EPSRC) UK, the Medical Research Council (MRC) UK and the Wellcome Trust.
Older people, the natural environment and common mental disorders
An investigation of the population impact of variation in HbA1c levels in older people in England and Wales
BACKGROUND: Diabetes is common in the older population and is increasing. Glycated hemoglobin (HbA1c) is an indicator of average blood glucose concentration over the past three months. The HbA1c test is currently one of clinical...
Brief cognitive assessment in a UK population sample -- distributional properties and the relationship between the MMSE and an extended mental state examination.
Felicia A Huppert, Sara T Cabelli, Fiona E Matthews, MRC Cognitive Function and Ageing Study
Jun 16, 2011
What determines the self-rated health of older individuals with stroke compared to other older individuals? A cross-sectional analysis of the Medical Research Council Cognitive Function and Aging Study.
BACKGROUND: Poor self-rated health has been associated with poorer objective health outcomes across a range of conditions including stroke. Identification of factors associated with poor self-rated health in stroke survivors has...
Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa
DG Dillon
Apr 09, 2019
During the preparation of this article, owing to an administrative oversight between the collaborating institutions,
we omitted Dr Dermot Maher from the author list. Dr
Maher was involved in the early phases of the...
Land use mix and five-year mortality in later life
Yu-Tzu Wu, A Matthew Prina, Andy Jones, Linda E Barnes, Fiona E Matthews, Carol Brayne, MRC CFAS
Dec 08, 2015
Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor.
Simone Queiroz Pantaleão, Lívia de Moraes Bomediano Camillo, Tainan Cerqueira Neves, Isabela de Godoy Menezes, Lucas Matheus Stangherlin, Helena Beatriz de Carvalho Ruthner Batista, Emma Poole, Michael Nevels, Eric Alisson Philot, Ana Ligia Scott, Maria Cristina Carlan da Silva
Jan 04, 2023
The human cytomegalovirus (HCMV) UL111A gene encodes several homologs of the cellular interleukin 10 (cIL-10). Alternative splicing in the UL111A region produces two relatively well-characterized transcripts designated cmvIL-10...
Neuroanatomy of Individual Differences in Language in Adult Males with Autism.
Meng-Chuan Lai, Michael V Lombardo, Christine Ecker, Bhismadev Chakrabarti, John Suckling, Edward T Bullmore, Francesca Happé, MRC AIMS Consortium, Declan GM Murphy, Simon Baron-Cohen
Aug 22, 2014
Neurological and psychiatric presentations associated with human monkeypox virus infection
James B Badenoch, Isabella Conti, Emma R Rengasamy, Cameron J Watson, Matthew Butler, Zain Hussain, Ben Carter, Alasdair G Rooney, Michael S Zandi, Glyn Lewis, Anthony S David, Catherine F Houlihan, Ava Easton, Benedict D Michael, Krutika Kuppalli, Timothy R Nicholson, Thomas A Pollak, Jonathan P Rogers
Nov 17, 2022
BACKGROUND: Neuropsychiatric presentations of monkeypox (MPX) infection have not been well characterised, despite evidence of nervous system involvement associated with the related smallpox infection. METHODS: In this...
Prevalence and factors associated with poor performance in the 5-chair stand test
Richard Matthew Dodds, James C Murray, Antoneta Granic, Christopher Hurst, Germaine Uwimpuhwe, Sarah Richardson, Carol Brayne, Fiona E Matthews, Avan A Sayer, MRC CFAS
Dec 04, 2020
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