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Results: 107
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne, MRC Cognitive Function and Ageing Study
Jul 10, 2018
BACKGROUND: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate...
Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people
M Byford, C Brayne, I McKeith, M Chatfield, Pg Ince, FE Matthews, MRC CFAS Neuropathology group
Jun 16, 2011
BACKGROUND: Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in subcortical areas of...
Cohort differences in disease and disability in the young-old
Carol Jagger, Ruth J Matthews, Fiona E Matthews, Nicola A Spiers, Judith Nickson, Eugene S Paykel, Felicia A Huppert, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS)
Jun 14, 2011
BACKGROUND: Projections of health and social care need are highly sensitive to assumptions about cohort trends in health and disability. We use a repeated population-based cross-sectional study from the Cambridgeshire centre of...
Metaflammasome components in the human brain
Mariko Taga, Thais Minett, John Classey, Fiona E Matthews, Carol Brayne, Paul G Ince, James AR Nicoll, Jacques Hugon, Delphine Boche, MRC CFAS
Aug 09, 2018
Epidemiological and genetic studies have identified metabolic disorders and inflammation as risk factors for Alzheimer's disease (AD). Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome...
Alzheimer's Disease CFAS Dementia HUMAN BRAIN metaflammasome Aged Aged 80 and over Alzheimer Disease Apolipoproteins E Cohort Studies Diabetes mellitus Type 2 Female Humans I-kappa B Kinase Immunohistochemistry Insulin Receptor Substrate Proteins MAP Kinase Kinase 4 Male Mental Status Schedule Neocortex Phosphorylation Polymorphism Genetic Risk Factors eIF-2 Kinase
Regional differences in multidimensional aspects of health
Fiona E Matthews, Laura L Miller, Carol Brayne, Carol Jagger, Medical Research Council Cognitive Function and Aging Study (MRC CFAS)
Jun 16, 2011
Activities of Daily Living Aged Aged 80 and over Attitude to Health Cognition Disorders Cohort Studies Female Geography Geriatric Assessment Health Surveys Humans Life Change Events Life Expectancy Male Prospective Studies Quality of life Rural Health Self Concept Socioeconomic Factors United Kingdom Urban Health
An investigation of the population impact of variation in HbA1c levels in older people in England and Wales
BACKGROUND: Diabetes is common in the older population and is increasing. Glycated hemoglobin (HbA1c) is an indicator of average blood glucose concentration over the past three months. The HbA1c test is currently one of clinical...
Microinfarcts in an older population-representative brain donor cohort (MRC CFAS)
Pg Ince, T Minett, G Forster, C Brayne, SB Wharton, Medical Research Council Cognitive Function and Ageing Neuropathology Study
Aug 13, 2018
INTRODUCTION: Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship with dementia, mobility and cerebrovascular disease in an older...
Microglial immunophenotype in dementia with Alzheimer's pathology.
Thais Minett, John Classey, Fiona E Matthews, Marie Fahrenhold, Mariko Taga, Carol Brayne, Paul G Ince, James AR Nicoll, Delphine Boche, MRC CFAS
Aug 14, 2017
BACKGROUND: Genetic risk factors for Alzheimer's disease imply that inflammation plays a causal role in development of the disease. Experimental studies suggest that microglia, as the brain macrophages, have diverse functions...
Alzheimer’s disease Apolipoprotein E Dementia Microglia neuropathology Aged Aged 80 and over Alzheimer Disease Antigens CD Antigens Differentiation Myelomonocytic Calcium-Binding Proteins Cohort Studies Cytokines DNA-Binding Proteins Dementia Diagnosis Female HLA-DR Antigens Humans Male Mental Status Schedule Methionine Sulfoxide Reductases Microfilament Proteins Microglia Neuropsychological Tests Receptors IgG
What determines the self-rated health of older individuals with stroke compared to other older individuals? A cross-sectional analysis of the Medical Research Council Cognitive Function and Aging Study.
BACKGROUND: Poor self-rated health has been associated with poorer objective health outcomes across a range of conditions including stroke. Identification of factors associated with poor self-rated health in stroke survivors has...
A comparison over 2 decades of disability-free life expectancy at age 65 years for those with long-term conditions in England
Holly Q Bennett, Andrew Kingston, Ilianna Lourida, Louise Robinson, Lynne Corner, Carol Brayne, Fiona E Matthews, Carol Jagger, Cognitive Function and Ageing Studies collaboration
Mar 15, 2022
BACKGROUND: Previous research has examined the improvements in healthy years if different health conditions are eliminated, but often with cross-sectional data, or for a limited number of conditions. We used longitudinal data to...
Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies
Rachel Waller, Ruth Narramore, Julie E. Simpson, Paul R. Heath, Nikita Verma, Megan Tinsley, Jordan R. Barnes, Hanna T. Haris, Frances E. Henderson, Fiona E. Matthews, Connor D. Richardson, Carol Brayne, Paul G. Ince, Raj N. Kalaria, Stephen B. Wharton, CFAS
May 27, 2021
Abstract: White matter lesions (WML) are common in the ageing brain, often arising in a field effect of diffuse white matter abnormality. Although WML are associated with cerebral small vessel disease (SVD) and Alzheimer’s...
RESEARCH ARTICLE RESEARCH ARTICLES Dementia epidemiological neuropathology Neuroinflammation Small vessel disease white matter lesions
Published by: Brain Pathology
A comparison over 2 decades of disability-free life expectancy at age 65 years for those with long-term conditions in England
Holly Q Bennett, Andrew Kingston, Ilianna Lourida, Louise Robinson, Lynne Corner, Carol Brayne, Fiona E Matthews, Carol Jagger, Cognitive Function and Ageing Studies collaboration
Apr 19, 2022
BACKGROUND: Previous research has examined the improvements in healthy years if different health conditions are eliminated, but often with cross-sectional data, or for a limited number of conditions. We used longitudinal data to...
Accuracy of death certification of dementia in population-based samples of older people
Lu Gao, Rowan Calloway, Emily Zhao, Carol Brayne, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Collaboration
Jul 10, 2018
BACKGROUND: death certification data are routinely collected in most developed countries. Coded causes of death are a readily accessible source and have the potential advantage of providing complete follow-up, but with...
Increasing prevalence of anticholinergic medication use in older people in England over 20 years
Carlota M Grossi, Kathryn Richardson, George M Savva, Chris Fox, Antony Arthur, Yoon K Loke, Nicholas Steel, Carol Brayne, Fiona E Matthews, Louise Robinson, Phyo K Myint, Ian D Maidment
Aug 02, 2021
BACKGROUND: Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Here we estimate the prevalence of anticholinergic use in...
Epidemiological pathology of Aβ deposition in the ageing brain in CFAS
Aβ-amyloid deposition is a key feature of Alzheimer's disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships to dementia. Thal...
Epidemiological pathology of Aβ deposition in the ageing brain in CFAS
Abstract: Aβ-amyloid deposition is a key feature of Alzheimer’s disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships to...
Epidemiological pathology of Aβ deposition in the ageing brain in CFAS
SB Wharton, D Wang, C Parikh, FE Matthews, C Brayne, Pg Ince, Cognitive Function and Ageing Neuropathology Study Group
Jan 10, 2020
Aβ-amyloid deposition is a key feature of Alzheimer's disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships to dementia. Thal...
Disseminated $\textit{Mycobacterium malmoense}$ and $\textit{Salmonella}$ Infections Associated with a Novel Variant in $\textit{NFKBIA}$
E Staples, B Morillo-Gutierrez, J Davies, D Petersheim, M Massaad, M Slatter, D Dimou, R Doffinger, S Hackett, D Kumararatne, J Hadfield, MD Eldridge, RS Geha, M Abinun, JED Thaventhiran
May 05, 2017
JEDT is supported by a MRC Clinician Scientist Fellowship (MR/L006197/1). This work has been funded by BRC III PPG funding and by grant number 1R21AI124101-01 “Mechanisms of disease in patients with IκBα mutations” in RG’s...
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