Search
Results: 96617
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
Xueyi Shen, David M Howard, Mark J Adams, W David Hill, Toni-Kim Clarke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ian J Deary, Heather C Whalley, Andrew M McIntosh
May 08, 2021
Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a...
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Till FM Andlauer, Jose Guzman-Parra, Fabian Streit, Jana Strohmaier, Maria José González, Susana Gil Flores, Francisco J Cabaleiro Fabeiro, Francisco Del Río Noriega, Fermin Perez Perez, Jesus Haro González, Guillermo Orozco Diaz, Yolanda de Diego-Otero, Berta Moreno-Küstner, Georg Auburger, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffmann, Josef Frank, Jerome C Foo, Jens Treutlein, Stephanie H Witt, Sven Cichon, Manolis Kogevinas, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Fabio Rivas, Fermín Mayoral, Bertram Müller-Myhsok, Andreas J Forstner, Markus M Nöthen, Marcella Rietschel
Mar 22, 2021
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD...
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes
BP Prins, A Abbasi, A Wong, A Vaez, I Nolte, N Franceschini, PE Stuart, J Guterriez Achury, V Mistry, JP Bradfield, AM Valdes, J Bras, A Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, C Lu, B Han, S Raychaudhuri, S Bevan, MD Mayes, LC Tsoi, E Evangelou, RP Nair, SFA Grant, C Polychronakos, TRD Radstake, DA van Heel, ML Dunstan, NW Wood, A Al-Chalabi, A Dehghan, H Hakonarson, HS Markus, JT Elder, J Knight, DE Arking, TD Spector, BPC Koeleman, CM van Duijn, J Martin, AP Morris, RK Weersma, C Wijmenga, PB Munroe, JRB Perry, JG Pouget, Y Jamshidi, H Snieder, BZ Alizadeh
Jan 30, 2017
BACKGROUND: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. METHODS AND FINDINGS: We performed Mendelian...
Transdiagnostic and Illness-Specific Functional Dysconnectivity Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder.
Chu-Chung Huang, Qiang Luo, Lena Palaniyappan, Albert C Yang, Chia-Chun Hung, Kun-Hsien Chou, Chun-Yi Zac Lo, Mu-N Liu, Shih-Jen Tsai, Deanna M Barch, Jianfeng Feng, Ching-Po Lin, Trevor W Robbins
Jul 07, 2020
BACKGROUND: Mental disorders are typically defined as distinct diagnostic entities, but similar patterns of clinical and cognitive impairments are frequently found across diagnostic groups. We investigated whether these...
Surveillance recommendations for DICER1 pathogenic variant carriers
Jette J Bakhuizen, Helen Hanson, Karin van der Tuin, Fiona Lalloo, Marc Tischkowitz, Karin Wadt, Marjolijn CJ Jongmans, SIOPE Host Genome Working Group, CanGene-CanVar Clinical Guideline Working Group, Expert Network Members
Oct 01, 2021
DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging because uncertainty exists about the clinical efficacy of surveillance...
Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder.
Yan-Yu Wang, Yi Wang, Ying-Min Zou, Ke Ni, Xue Tian, Hong-Wei Sun, Simon SY Lui, Eric FC Cheung, John Suckling, Raymond CK Chan
Jun 21, 2018
BACKGROUND: Although Theory of Mind (ToM) impairment has been observed in patients with a wide range of mental disorders, the similarity and uniqueness of these deficits across diagnostic groups has not been thoroughly...
The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs
Typhoid fever is estimated to cause between 11.9-26.9 million infections globally each year with 129,000-216,510 deaths. Access to improved water sources have reduced disease incidence in parts of the world but the use of...
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
Importance: Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well...
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher...
Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.
MD Hettwer, S Larivière, BY Park, OA van den Heuvel, L Schmaal, OA Andreassen, CRK Ching, M Hoogman, J Buitelaar, D van Rooij, DJ Veltman, DJ Stein, B Franke, TGM van Erp, ENIGMA ADHD Working Group, ENIGMA Autism Working Group, ENIGMA Bipolar Disorder Working Group, ENIGMA Major Depression Working Group, ENIGMA OCD Working Group, ENIGMA Schizophrenia Working Group, N Jahanshad, PM Thompson, SI Thomopoulos, RAI Bethlehem, BC Bernhardt, SB Eickhoff, SL Valk
Nov 15, 2022
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.
John J Cole, Alison McColl, Robin Shaw, Mary-Ellen Lynall, Philip J Cowen, Peter de Boer, Wayne C Drevets, Neil Harrison, Carmine Pariante, Linda Pointon, NIMA Consortium, Carl Goodyear, Edward Bullmore, Jonathan Cavanagh
Jun 04, 2021
The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation forthe variance in this heterogeneous condition. Peripheral blood...
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher...
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
Importance: Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well...
A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank
Beate Leppert, Louise A. C. Millard, Lucy Riglin, George Davey Smith, Anita Thapar, Kate Tilling, Esther Walton, Evie Stergiakouli
May 11, 2020
Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric...
Toward an Extended Definition of Major Depressive Disorder Symptomatology
Nayra A Martin-Key, Dan-Mircea Mirea, Tony Olmert, Jason Cooper, Sung Yeon Sarah Han, Giles Barton-Owen, Lynn Farrag, Emily Bell, Pawel Eljasz, Daniel Cowell, Jakub Tomasik, Sabine Bahn
Jan 06, 2022
BACKGROUND: Diagnosing major depressive disorder (MDD) is challenging, with diagnostic manuals failing to capture the wide range of clinical symptoms that are endorsed by individuals with this condition. OBJECTIVE: This study...
A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank
Beate Leppert, Louise A. C. Millard, Lucy Riglin, George Davey Smith, Anita Thapar, Kate Tilling, Esther Walton, Evie Stergiakouli
May 11, 2020
Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric...
Discrimination in the workplace, reported by people with major depressive disorder
EPM Brouwers, J Mathijssen, T Van Bortel, L Knifton, K Wahlbeck, C Van Audenhove, N Kadri, Ch Chang, BR Goud, D Ballester, LF Tófoli, R Bello, MF Jorge-Monteiro, H Zäske, I Milaćić, A Uçok, C Bonetto, A Lasalvia, G Thornicroft, J Van Weeghel, ASPEN/INDIGO Study Group*
Feb 27, 2019
OBJECTIVE: Whereas employment has been shown to be beneficial for people with Major Depressive Disorder (MDD) across different cultures, employers' attitudes have been shown to be negative towards workers with MDD. This may form...
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
Raffaele Ferrari, Yunpeng Wang, Jana Vandrovcova, Sebastian Guelfi, Aree Witeolar, Celeste M Karch, Andrew J Schork, Chun C Fan, James B Brewer, International FTD-Genomics Consortium (IFGC), International Parkinson's Disease Genomics Consortium (IPDGC), International Genomics of Alzheimer's Project (IGAP), Parastoo Momeni, Gerard D Schellenberg, William P Dillon, Leo P Sugrue, Christopher P Hess, Jennifer S Yokoyama, Luke W Bonham, Gil D Rabinovici, Bruce L Miller, Ole A Andreassen, Anders M Dale, John Hardy, Rahul S Desikan
Feb 06, 2018
BACKGROUND: Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders...
The Gene Ontology's Reference Genome Project
The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a...
Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.
MD Hettwer, S Larivière, BY Park, OA van den Heuvel, L Schmaal, OA Andreassen, CRK Ching, M Hoogman, J Buitelaar, D van Rooij, DJ Veltman, DJ Stein, B Franke, TGM van Erp, ENIGMA ADHD Working Group, ENIGMA Autism Working Group, ENIGMA Bipolar Disorder Working Group, ENIGMA Major Depression Working Group, ENIGMA OCD Working Group, ENIGMA Schizophrenia Working Group, N Jahanshad, PM Thompson, SI Thomopoulos, RAI Bethlehem, BC Bernhardt, SB Eickhoff, SL Valk
Dec 13, 2022
Modifiable pathways in Alzheimer's disease
Susanna C Larsson, Matthew Traylor, Rainer Malik, Martin Dichgans, Stephen Burgess, Hugh S Markus, on behalf of the International Genomics of Alzheimer’s Project CoSTREAM Consortium
Mar 07, 2018
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease. DESIGN: Mendelian randomisation...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Mar 27, 2020
The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 14, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 26, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC)
Keiji Fukuda, Direk Limmathurotsakul, Iruka N Okeke, Nandini Shetty, Rogier van Doorn, Nicholas A Feasey, Francesca Chiara, Ghada Zoubiane, Tim Jinks, Julian Parkhill, Jean Patel, Stuart WJ Reid, Alison H Holmes, Sharon J Peacock, Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC)
Nov 05, 2018
In recognition of the central importance of surveillance and epidemiology in the control of antimicrobial resistance and the need to strengthen surveillance at all levels, Wellcome has brought together a new international expert...
|
|< |
< |
1 |