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Association Between the Probability of Autism Spectrum Disorder and Normative Sex-Related Phenotypic Diversity in Brain Structure.
Christine Ecker, Derek S Andrews, Christina M Gudbrandsen, Andre F Marquand, Cedric E Ginestet, Eileen M Daly, Clodagh M Murphy, Meng-Chuan Lai, Michael V Lombardo, Amber NV Ruigrok, Edward T Bullmore, John Suckling, Steven Cr Williams, Simon Baron-Cohen, Michael C Craig, Declan GM Murphy, Medical Research Council Autism Imaging Multicentre Study (MRC AIMS) Consortium
Aug 16, 2017
IMPORTANCE: Autism spectrum disorder (ASD) is 2 to 5 times more common in male individuals than in female individuals. While the male preponderant prevalence of ASD might partially be explained by sex differences in clinical...
Medical Research Council Autism Imaging Multicentre Study (MRC AIMS) Consortium Cerebral Cortex Humans Image Interpretation Computer-Assisted Magnetic Resonance Imaging Image Enhancement Multivariate Analysis Models Statistical Risk Factors Case-Control Studies Cross-Sectional Studies Sex Characteristics Phenotype Reference Values Adolescent Adult Female Male Young Adult white matter Gray Matter Autism spectrum disorder
Cohort differences in disease and disability in the young-old
Carol Jagger, Ruth J Matthews, Fiona E Matthews, Nicola A Spiers, Judith Nickson, Eugene S Paykel, Felicia A Huppert, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS)
Jun 14, 2011
BACKGROUND: Projections of health and social care need are highly sensitive to assumptions about cohort trends in health and disability. We use a repeated population-based cross-sectional study from the Cambridgeshire centre of...
An investigation of whether factors associated with short-term attrition change or persist over ten years
Fiona E Matthews, Mark Chatfield, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study
Jun 16, 2011
EU-AIMS Longitudinal European Autism Project (LEAP)
Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K Buitelaar, Eva Loth, Declan GM Murphy, Will Spooren, Sven Bölte, EU-AIMS LEAP group
May 09, 2019
EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has...
Microinfarcts in an older population-representative brain donor cohort (MRC CFAS)
Pg Ince, T Minett, G Forster, C Brayne, SB Wharton, Medical Research Council Cognitive Function and Ageing Neuropathology Study
Aug 13, 2018
INTRODUCTION: Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship with dementia, mobility and cerebrovascular disease in an older...
The National Institute for Health Research
V Goh, National Institute for Health Research Clinical Research Network Imaging Network Steering Group, Royal College of Radiologists' Academic Committee
Oct 01, 2019
Since the inception of the National Institute for Health Research (NIHR) in 2006, the landscape for the delivery of clinical research within the National Health Service (NHS) has been transformed. Clinical radiology has...
Regional differences in multidimensional aspects of health
Fiona E Matthews, Laura L Miller, Carol Brayne, Carol Jagger, Medical Research Council Cognitive Function and Aging Study (MRC CFAS)
Jun 16, 2011
Activities of Daily Living Aged Aged 80 and over Attitude to Health Cognition Disorders Cohort Studies Female Geography Geriatric Assessment Health Surveys Humans Life Change Events Life Expectancy Male Prospective Studies Quality of life Rural Health Self Concept Socioeconomic Factors United Kingdom Urban Health
Dementia before death in ageing societies--the promise of prevention and the reality.
Carol Brayne, Lu Gao, Michael Dewey, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Study Investigators
Jul 10, 2018
BACKGROUND: Dementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions. Given population increases in longevity it is important to...
Gray matter covariations and core symptoms of autism
Ting Mei, Alberto Llera, Dorothea L Floris, Natalie J Forde, Julian Tillmann, Sarah Durston, Carolin Moessnang, Tobias Banaschewski, Rosemary J Holt, Simon Baron-Cohen, Annika Rausch, Eva Loth, Flavio Dell'Acqua, Tony Charman, Declan GM Murphy, Christine Ecker, Christian F Beckmann, Jan K Buitelaar, EU-AIMS LEAP group
Dec 07, 2020
BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of...
External validation and recalibration of an incidental meningioma prognostic model - IMPACT
Abdurrahman I Islim, Christopher P Millward, Rory J Piper, Daniel M Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J Mills, Andrew R Brodbelt, Ryan K Mathew, Thomas Santarius, Michael D Jenkinson, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC) IMPACT Study Investigators
Feb 19, 2022
INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an...
External validation and recalibration of an incidental meningioma prognostic model - IMPACT
Abdurrahman I Islim, Christopher P Millward, Rory J Piper, Daniel M Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J Mills, Andrew R Brodbelt, Ryan K Mathew, Thomas Santarius, Michael D Jenkinson, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC) IMPACT Study Investigators
Jan 28, 2022
INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an...
The neuropsychology of male adults with high-functioning autism or asperger syndrome.
C Ellie Wilson, Francesca Happé, Sally J Wheelwright, Christine Ecker, Michael V Lombardo, Patrick Johnston, Eileen Daly, Clodagh M Murphy, Debbie Spain, Meng-Chuan Lai, Bhismadev Chakrabarti, Disa A Sauter, MRC AIMS Consortium, Simon Baron-Cohen, Declan GM Murphy
Jan 23, 2018
Autism Spectrum Disorder (ASD) is diagnosed on the basis of behavioral symptoms, but cognitive abilities may also be useful in characterizing individuals with ASD. One hundred seventy-eight high-functioning male adults, half...
Autism spectrum disorder autistic subtypes autistic symptomatology cognitive profiles comorbid psychopathology support vector machine classification Adolescent Adult Asperger Syndrome Autistic Disorder Cognition Executive Function Humans Intelligence Intelligence Tests London Male Neuropsychological Tests Severity of Illness Index Social Behavior Young Adult
The Built Environment and Cognitive Disorders
Y-T Wu, AM Prina, A Jones, FE Matthews, C Brayne, Medical Research Council Cognitive Function and Ageing Study Collaboration
Aug 16, 2017
Frontal networks in adults with autism spectrum disorder.
Marco Catani, Flavio Dell'Acqua, Sanja Budisavljevic, Henrietta Howells, Michel Thiebaut de Schotten, Seán Froudist-Walsh, Lucio D'Anna, Abigail Thompson, Stefano Sandrone, Edward T Bullmore, John Suckling, Simon Baron-Cohen, Michael V Lombardo, Sally J Wheelwright, Bhismadev Chakrabarti, Meng-Chuan Lai, Amber NV Ruigrok, Alexander Leemans, Christine Ecker, Mrc Aims Consortium, Michael C Craig, Declan GM Murphy
Aug 09, 2017
It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum...
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne, MRC Cognitive Function and Ageing Study
Jul 10, 2018
BACKGROUND: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate...
Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project.
Julian Tillmann, Antonia San José Cáceres, Chris H Chatham, Daisy Crawley, Rosemary Holt, Bethany Oakley, Tobias Banaschewski, Simon Baron-Cohen, Sven Bölte, Jan K Buitelaar, Sarah Durston, Lindsay Ham, Eva Loth, Emily Simonoff, Will Spooren, Declan G Murphy, Tony Charman, EU-AIMS LEAP group
May 03, 2019
Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced...
adaptive functioning Autism spectrum disorder intellectual functioning psychiatric symptoms symptom severity Activities of Daily Living Adolescent Adult Age Factors Autism spectrum disorder Child Cohort Studies Europe Female Humans Intelligence Longitudinal Studies Male Phenotype Severity of Illness Index Sex Factors Young Adult
Community environment, cognitive impairment and dementia in later life
Yu-Tzu Wu, A Matthew Prina, Andrew P Jones, Linda E Barnes, Fiona E Matthews, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study
Aug 11, 2015
Accuracy of death certification of dementia in population-based samples of older people
Lu Gao, Rowan Calloway, Emily Zhao, Carol Brayne, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Collaboration
Jul 10, 2018
BACKGROUND: death certification data are routinely collected in most developed countries. Coded causes of death are a readily accessible source and have the potential advantage of providing complete follow-up, but with...
Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time
Fiona Matthews, Riccardo Marioni, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study
Jan 10, 2013
Neural self-representation in autistic women and association with 'compensatory camouflaging'.
Meng-Chuan Lai, Michael V Lombardo, Bhismadev Chakrabarti, Amber NV Ruigrok, Edward T Bullmore, John Suckling, Bonnie Auyeung, Francesca Happé, Peter Szatmari, Simon Baron-Cohen, MRC AIMS Consortium
Dec 03, 2018
Prior work has revealed sex/gender-dependent autistic characteristics across behavioural and neural/biological domains. It remains unclear whether and how neural sex/gender differences are related to behavioural sex/gender...
Adult autism camouflaging compensation functional magnetic resonance imaging Gender Heterogeneity Mentalizing Self sex Adolescent Adult Autistic Disorder Brain Case-Control Studies Female Functional Neuroimaging Humans Magnetic Resonance Imaging Male mentalization Middle Aged Self Concept Sex Factors Social Behavior Young Adult
Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood.
Anke Bletsch, Tim Schäfer, Caroline Mann, Derek S Andrews, Eileen Daly, Maria Gudbrandsen, Amber NV Ruigrok, Robert Dallyn, Rafael Romero-Garcia, Meng-Chuan Lai, Michael V Lombardo, Michael C Craig, John Suckling, Edward T Bullmore, Simon Baron-Cohen, MRC AIMS Consortium, Declan GM Murphy, Flavio Dell'Acqua, Christine Ecker
Nov 09, 2020
Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more recently...
Enhancement of indirect functional connections with shortest path length in the adult autistic brain.
Xiaonan Guo, Tiago Simas, Meng-Chuan Lai, Michael V Lombardo, Bhismadev Chakrabarti, Amber NV Ruigrok, Edward T Bullmore, Simon Baron-Cohen, Huafu Chen, John Suckling, MRC AIMS Consortium
Sep 16, 2019
Autism is a neurodevelopmental condition characterized by atypical brain functional organization. Here we investigated the intrinsic indirect (semi-metric) connectivity of the functional connectome associated with autism....
A comparison of health expectancies over two decades in England
Carol Jagger, Fiona E Matthews, Pia Wohland, Tony Fouweather, Blossom CM Stephan, Louise Robinson, Antony Arthur, Carol Brayne, Medical Research Council Cognitive Function and Ageing Collaboration
Nov 09, 2018
BACKGROUND: Whether rises in life expectancy are increases in good-quality years is of profound importance worldwide, with population ageing. We investigate how various health expectancies have changed in England between 1991...
Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening.
SG Thompson, HA Ashton, L Gao, MJ Buxton, RAP Scott, Multicentre Aneurysm Screening Study (MASS) Group
Jan 27, 2020
BACKGROUND: The long-term effects of abdominal aortic aneurysm (AAA) screening were investigated in extended follow-up from the UK Multicentre Aneurysm Screening Study (MASS) randomized trial. METHODS: A population-based sample...
In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder.
Derek Sayre Andrews, Thomas A Avino, Maria Gudbrandsen, Eileen Daly, Andre Marquand, Clodagh M Murphy, Meng-Chuan Lai, Michael V Lombardo, Amber NV Ruigrok, Steven C Williams, Edward T Bullmore, The Mrc Aims Consortium, John Suckling, Simon Baron-Cohen, Michael C Craig, Declan GM Murphy, Christine Ecker
Aug 17, 2017
Atypical cortical organization and reduced integrity of the gray-white matter boundary have been reported by postmortem studies in individuals with autism spectrum disorder (ASD). However, there are no in vivo studies that...
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