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The mail goal of this paper is to research usefulness and satisfaction with the ERP (Enterprise Resource Planning) system from the end users' point of view in companies in Bosnia and Herzegovina (BiH). The research was conducted...

Electronic Services & Service Science Business and Management Electronic Services

Evaluating the subjective playing experience and engagement in learning is important in the design of advanced learning technologies (ALTs) that respond to the learners' cognitive and emotional states. This article addresses...

Gaming Media and Communications Digital Media Computer Science and Information Technology Social Sciences and Humanities

BACKGROUND: Over the last decade sensitivity analysis techniques have been shown to be very useful to analyse complex and high dimensional Systems Biology models. However, many of the currently available toolboxes have either...

Dynamical systems Gene Regulatory Networks Mathematical models Perturbation theory Signalling systems Models Biological Signal Transduction Software Systems Biology

Evaluating the subjective playing experience and engagement in learning is important in the design of advanced learning technologies (ALTs) that respond to the learners' cognitive and emotional states. This article addresses...

Education Curriculum Development and Instructional Design Gaming in Education

Novel symmetrical bis-pyrrolo[2,3-d]pyrimidines and bis-purines and their monomers were synthesized and evaluated for their antiproliferative activity in human lung adenocarcinoma (A549), cervical carcinoma (HeLa), ductal...

pyrrolo[2 3-d]pyrimidines purine DFT calculations ULTRASOUND antiproliferative activity pancreatic adenocarcinoma Apoptosis

Novel symmetrical bis-pyrrolo[2,3-d]pyrimidines and bis-purines and their monomers were synthesized and evaluated for their antiproliferative activity in human lung adenocarcinoma (A549), cervical carcinoma (HeLa), ductal...

DFT calculations antiproliferative activity Apoptosis pancreatic adenocarcinoma purine pyrrolo[2 3-d]pyrimidines ULTRASOUND A549 Cells Antineoplastic Agents Cell Line Tumor Cell Proliferation Cell Survival Cycloaddition Reaction density functional theory Drug Screening Assays Antitumor HeLa Cells Humans Pyrimidines Pyrroles

Individual plant cells have a genetic circuit, the circadian clock, that times key processes to the day-night cycle. These clocks are aligned to the day-night cycle by multiple environmental signals that vary across the plant....

Arabidopsis Arabidopsis Proteins Circadian Clocks Circadian Rhythm Gene Expression Regulation Plant Gene Regulatory Networks Organ Specificity Photoperiod Seedlings Signal Transduction Transcription Factors

Comparative Effectiveness Research Clinical Trials and Supportive Activities Digestive Diseases Clinical Research Rare Diseases

Background and study aims  The standard radiofrequency ablation (RFA) protocol for Barrett's esophagus (BE) encompasses an intermediary cleaning phase between two ablation sessions. A simplified protocol omitting the cleaning...

The Arabidopsis circadian clock orchestrates gene regulation across the day/night cycle. Although a multiple feedback loop circuit has been shown to generate the 24-hr rhythm, it remains unclear how robust the clock is in...

A. thaliana cell-to-cell coupling circadian clock Computational Biology plant biology single cell Systems Biology Time-lapse microscopy Arabidopsis Cells Circadian Clocks Gene Expression Regulation Plant Gene Regulatory Networks Seedlings

The Cuckoos have a long history of difficult classification. The species of this order have been the subject of several studies based on osteology, behavior, ecology, morphology and molecular data. Despite this, the relationship...

Animals Biological Evolution Birds Chromosome Mapping Chromosome Painting Chromosomes evolution Molecular Female In Situ Hybridization Fluorescence Karyotype Male Phylogeny Species Specificity Synteny

BACKGROUND: The Notch pathway is frequently activated in cancer. Pathway inhibition by γ-secretase inhibitors has been shown to be effective in pre-clinical models of pancreatic cancer, in combination with gemcitabine. METHODS...

Adult Aged Amyloid Precursor Protein Secretases Antineoplastic Combined Chemotherapy Protocols Bayes Theorem Benzene Derivatives Carcinoma Pancreatic Ductal Deoxycytidine Drug Administration Schedule Female Humans Infusions Intravenous Male Middle Aged Pancreatic Neoplasms Propionates Receptors Notch Signal Transduction Sulfones Gemcitabine

The Cuckoos have a long history of difficult classification. The species of this order have been the subject of several studies based on osteology, behavior, ecology, morphology and molecular data. Despite this, the relationship...

RESEARCH ARTICLE Biology and life sciences Research and analysis methods Computer and information sciences