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Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
Amit V Khera, Hong-Hee Won, Gina M Peloso, Colm O'Dushlaine, Dajiang Liu, Nathan O Stitziel, Pradeep Natarajan, Akihiro Nomura, Connor A Emdin, Namrata Gupta, Ingrid B Borecki, Rosanna Asselta, Stefano Duga, Piera Angelica Merlini, Adolfo Correa, Thorsten Kessler, James G Wilson, Matthew J Bown, Alistair S Hall, Peter S Braund, David J Carey, Michael F Murray, H Lester Kirchner, Joseph B Leader, Daniel R Lavage, J Neil Manus, Dustin N Hartzel, Nilesh J Samani, Heribert Schunkert, Jaume Marrugat, Roberto Elosua, Ruth McPherson, Martin Farrall, Hugh Watkins, Eric S Lander, Daniel J Rader, John Danesh, Diego Ardissino, Stacey Gabriel, Cristen Willer, Gonçalo R Abecasis, Danish Saleheen, Frederick E Dewey, Sekar Kathiresan, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium Myocardial Infarction Genetics Consortium
Jun 25, 2018
IMPORTANCE: The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene (LPL) lead to lifelong deficiency in enzymatic...
Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.
Matthias Kohlhauer, Sam Dawkins, Ana SH Costa, Regent Lee, Timothy Young, Victoria R Pell, Robin P Choudhury, Adrian P Banning, Rajesh K Kharbanda, Oxford Acute Myocardial Infarction (OxAMI) Study, Kourosh Saeb-Parsy, Michael P Murphy, Christian Frezza, Thomas Krieg, Keith M Channon
May 30, 2018
BACKGROUND: Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to...
Ischemia–reperfusion injury Mitochondria Myocardial Ischemia myocardial metabolism Adult Aged Aged 80 and over Biomarkers Coronary Angiography Female Follow-Up Studies Humans Magnetic Resonance Imaging Cine Male Middle Aged Myocardial Reperfusion Injury Myocardium Percutaneous Coronary Intervention Prognosis Retrospective Studies ST Elevation Myocardial Infarction Succinic Acid Time Factors
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
68Ga-DOTATATE PET Identifies Residual Myocardial Inflammation and Bone Marrow Activation After Myocardial Infarction.
Jason M Tarkin, Claudia Calcagno, Marc R Dweck, Nicholas R Evans, Mohammed M Chowdhury, Deepa Gopalan, David E Newby, Zahi A Fayad, Martin R Bennett, James HF Rudd
Mar 04, 2019
Myocardial infarction (MI) healing occurs in two phases: first an inflammatory phase, where clearance of necrotic debris occurs, followed by a reparative phase characterized by angiogenesis, granulation tissue formation and...
Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction
OBJECTIVE: To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction. DESIGN: Two sample mendelian randomisation study using genetic variants as instrumental...
Adult Aged Biological Specimen Banks Female Genetic Pleiotropy genetic variation Genome-Wide Association Study Heart Failure Humans Male Mendelian Randomization Analysis Middle Aged Myocardial Infarction Odds Ratio Randomized Controlled Trials as Topic Risk Factors Testosterone Thromboembolism United Kingdom White People
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
Derek Klarin, Scott M Damrauer, Kelly Cho, Yan V Sun, Tanya M Teslovich, Jacqueline Honerlaw, David R Gagnon, Scott L DuVall, Jin Li, Gina M Peloso, Mark Chaffin, Aeron M Small, Jie Huang, Hua Tang, Julie A Lynch, Yuk-Lam Ho, Dajiang J Liu, Connor A Emdin, Alexander H Li, Jennifer E Huffman, Jennifer S Lee, Pradeep Natarajan, Rajiv Chowdhury, Danish Saleheen, Marijana Vujkovic, Aris Baras, Saiju Pyarajan, Emanuele Di Angelantonio, Benjamin M Neale, Aliya Naheed, Amit V Khera, John Danesh, Kyong-Mi Chang, Gonçalo Abecasis, Cristen Willer, Frederick E Dewey, David J Carey, Global Lipids Genetics Consortium, Myocardial Infarction Genetics (MIGen) Consortium, Geisinger-Regeneron DiscovEHR Collaboration, VA Million Veteran Program, John Concato, J Michael Gaziano, Christopher J O'Donnell, Philip S Tsao, Sekar Kathiresan, Daniel J Rader, Peter WF Wilson, Themistocles L Assimes
Sep 08, 2018
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a...
PET Imaging of Post-infarct Myocardial Inflammation.
PURPOSE OF REVIEW: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. RECENT FINDINGS: Dysregulated immune responses after myocardial infarction are associated...
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
MRI-based strain measurements reflect morphological changes following myocardial infarction
Doyin Odunmbaku-Mansell, Eva Sammut, V. D. Bruno, Raimondo Ascione, Jonathan C.L. Rodrigues, H S Gill, Katharine Fraser, Andrew Cookson
Jan 31, 2023
In a porcine experimental model of myocardial infarction, a localised, layer-specific, circumferential left ventricular strain metric has been shown to indicate chronic changes in ventricular function post-infarction more...
PET Imaging of Post-infarct Myocardial Inflammation
Abstract: Purpose of Review: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings: Dysregulated immune responses after myocardial infarction are...
PET Imaging of Post-infarct Myocardial Inflammation
Abstract: Purpose of Review: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings: Dysregulated immune responses after myocardial infarction are...
Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function After Myocardial Infarction Through Kynurenine.
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, José Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sébastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sébastien Silvestre, Soraya Taleb
Dec 07, 2020
BACKGROUND: Ischemic cardiovascular diseases, particularly acute myocardial infarction (MI), is one of the leading causes of mortality worldwide. Indoleamine 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-limiting step of...
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
NO Stitziel, AV Khera, X Wang, AJ Bierhals, AC Vourakis, AE Sperry, P Natarajan, D Klarin, CA Emdin, SM Zekavat, A Nomura, J Erdmann, H Schunkert, NJ Samani, WE Kraus, SH Shah, B Yu, E Boerwinkle, DJ Rader, N Gupta, PM Frossard, A Rasheed, J Danesh, ES Lander, S Gabriel, D Saleheen, K Musunuru, S Kathiresan, PROMIS and Myocardial Infarction Genetics Consortium Investigators
Oct 30, 2017
Background
Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether...
MRI-based strain measurements reflect morphological changes following myocardial infarction
Doyin Odunmbaku-Mansell, Eva Sammut, V. D. Bruno, Raimondo Ascione, Jonathan C.L. Rodrigues, H S Gill, Katharine Fraser, Andrew Cookson
Jan 31, 2023
In a porcine experimental model of myocardial infarction, a localised, layer-specific, circumferential left ventricular strain metric has been shown to indicate chronic changes in ventricular function post-infarction more...
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
Doyin Odunmbaku-Mansell, V. D. Bruno, Eva Sammut, Amedeo Chiribiri, Thomas Johnson, I Khaliulin, Daniel Baz Lopez, H S Gill, Katharine Fraser, M Murphy, T Krieg, M. S. Suleiman, S George, Raimondo Ascione, Andrew Cookson
Sep 15, 2021
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance...
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model.
DS Mansell, VD Bruno, E Sammut, A Chiribiri, T Johnson, I Khaliulin, D Baz Lopez, HS Gill, KH Fraser, M Murphy, T Krieg, MS Suleiman, S George, R Ascione, AN Cookson
Oct 08, 2021
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance...
Animals Biomarkers Computational Biology Data analysis Data Interpretation Statistical Disease Models Animal Disease Susceptibility Female Image Processing Computer-Assisted Magnetic Resonance Imaging Myocardial Infarction Myocardium Proteome Proteomics Reproducibility of Results Swine Translational Research Biomedical Ventricular Function Left Ventricular Remodeling
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
Doyin Odunmbaku-Mansell, V. D. Bruno, Eva Sammut, Amedeo Chiribiri, Thomas Johnson, I Khaliulin, Daniel Baz Lopez, H S Gill, Katharine Fraser, M Murphy, T Krieg, M. S. Suleiman, S George, Raimondo Ascione, Andrew Cookson
Sep 15, 2021
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance...
Predicting risk of cardiovascular events 1 to 3 years post-myocardial infarction using a global registry.
Stuart J Pocock, David Brieger, John Gregson, Ji Y Chen, Mauricio G Cohen, Shaun G Goodman, Christopher B Granger, Richard Grieve, Jose C Nicolau, Tabassome Simon, Dirk Westermann, Satoshi Yasuda, Katarina Hedman, Kirsten L Rennie, Karolina Andersson Sundell, TIGRIS Study Investigators
Jan 16, 2020
BACKGROUND: Risk prediction tools are lacking for patients with stable disease some years after myocardial infarction (MI). HYPOTHESIS: A practical long-term cardiovascular risk index can be developed. METHODS: The long-Term...
Fulminant immune-mediated necrotising myopathy (IMNM) mimicking myocardial infarction with non-obstructive coronary arteries (MINOCA)
A 74-year-old man, with inflammatory arthritis, recently commenced on adalimumab, presented with a 4-week history of left-sided chest pain, malaise and shortness of breath. Admission ECG showed age-indeterminate left bundle...
Fulminant immune-mediated necrotising myopathy (IMNM) mimicking myocardial infarction with non-obstructive coronary arteries (MINOCA)
A 74-year-old man, with inflammatory arthritis, recently commenced on adalimumab, presented with a 4-week history of left-sided chest pain, malaise and shortness of breath. Admission ECG showed age-indeterminate left bundle...
Novel Approach for Assessing Postinfarct Myocardial Injury and Inflammation Using Hybrid Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging.
Andrej Ćorović, Deepa Gopalan, Christopher Wall, Marta Peverelli, Stephen P Hoole, Patrick A Calvert, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Martin R Bennett, James HF Rudd, Jason M Tarkin
Feb 17, 2023
Post-infarct inflammation and its resolution modulate ischemic injury after myocardial infarction (MI). While cardiac magnetic resonance imaging (MRI) is useful for assessing ventricular function, viability and structural...
The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction.
Ziwen Li, Emmanouil G Solomonidis, Marco Meloni, Richard S Taylor, Rodger Duffin, Ross Dobie, Marlene S Magalhaes, Beth EP Henderson, Pieter A Louwe, Gabriela D'Amico, Kairbaan M Hodivala-Dilke, Ajay M Shah, Nicholas L Mills, Benjamin D Simons, Gillian A Gray, Neil C Henderson, Andrew H Baker, Mairi Brittan
Jun 10, 2019
AIMS: A better understanding of the pathways that regulate regeneration of the coronary vasculature is of fundamental importance for the advancement of strategies to treat patients with heart disease. Here, we aimed to...
Cell Proliferation Endothelial Cells Lineage tracing Myocardial Infarction single-cell RNA sequencing Therapeutic angiogenesis Animals Cell Proliferation Endothelial Cells Gene Expression Profiling Humans Mice Mice Transgenic Myocardial Infarction Myocardium Neovascularization Physiologic Single-Cell Analysis Transcriptome
Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction.
Ting-Ting Tang, Yuan-Yuan Li, Jing-Jing Li, Ke Wang, Yue Han, Wen-Yong Dong, Zheng-Feng Zhu, Ni Xia, Shao-Fang Nie, Min Zhang, Zhi-Peng Zeng, Bing-Jie Lv, Jiao Jiao, Heng Liu, Zong-Shu Xian, Xiang-Ping Yang, Yu Hu, Yu-Hua Liao, Qing Wang, Xin Tu, Ziad Mallat, Yu Huang, Guo-Ping Shi, Xiang Cheng
Nov 22, 2018
Interleukin (IL)-22 regulates tissue inflammation and repair. Here we report participation of the liver in IL-22-mediated cardiac repair after acute myocardial infarction (MI). Methods: We induced experimental MI in mice by...
Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor.
Kiave-Yune Howangyin, Ivana Zlatanova, Cristina Pinto, Anta Ngkelo, Clément Cochain, Marie Rouanet, José Vilar, Mathilde Lemitre, Christian Stockmann, Bernd K Fleischmann, Ziad Mallat, Jean-Sébastien Silvestre
Jun 21, 2018
BACKGROUND: In infarcted heart, improper clearance of dying cells by activated neighboring phagocytes may precipitate the transition to heart failure. We analyzed the coordinated role of 2 major mediators of efferocytosis, the...
Inflammation MACROPHAGES Myocardial Infarction myocarditis Neovascularization Physiologic Animals Antigens surface MACROPHAGES Mice Mice Inbred C57BL Mice Knockout Mice Transgenic Milk Proteins Myocardial Infarction Phagocytosis Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases Vascular Endothelial Growth Factor A Ventricular Remodeling c-Mer Tyrosine Kinase
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