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Role of Readiness to Change in the Relationship Between Workforce Agility and Digital Transformation
This paper uses dynamic capabilities theory to explore the role of readiness to change as mediator in the intricate relationship between workforce agility and digital transformation. A total of 161 usable responses were gathered...
Published by: IGI Global Scientific Publishing
Synthesis and in vitro antimicrobial SAR of benzyl and phenyl guanidine and aminoguanidine hydrazone derivatives
A series of benzyl, phenyl guanidine and aminoguandine hydrazone derivatives was designed and in vitro antibacterial activities against two different bacterial strains (Staphylococcus aureus and Escherichia coli) were...
antimicrobial activity benzyl aminoguanidine hydrazone benzyl guanidine guanylation methicillin-resistant Staphylococcus aureus (MRSA) /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1601 name=Chemistry (miscellaneous) /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry
Consumer Engagement Through Conditional Promotions
This paper investigates consumers' response to conditional promotions (CP) offered in an offline retail store. Using qualitative research inquiry, we decipher the consumer decision-making process by finding the linkages between...
Published by: IGI Global Scientific Publishing
Parametric Model for Flora Detection in Middle Himalayas
Plant detection forms an integral part of the life of the forest guards, researchers, and students in the field of botany and for common people also who are curious about knowing a plant. But detecting plants suffer a major...
Published by: IGI Global Scientific Publishing
Synthesis and in vitro antimicrobial SAR of benzyl and phenyl guanidine and aminoguanidine hydrazone derivatives
A series of benzyl, phenyl guanidine and aminoguandine hydrazone derivatives was designed and in vitro antibacterial activities against two different bacterial strains (Staphylococcus aureus and Escherichia coli) were...
antimicrobial activity benzyl aminoguanidine hydrazone benzyl guanidine guanylation methicillin-resistant Staphylococcus aureus (MRSA) /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1601 name=Chemistry (miscellaneous) /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry
Purchase Behavior of Generation Z for New-Brand Beauty Products
Consumers get innumerable product options, making it crucial to study their selection among brands v/s new brands. The study explores how in a post covid world, the online purchase behavior of Generation Z female consumers is...
Published by: IGI Global Scientific Publishing
Thematic issue of the Second combined Bio-ontologies and Phenotypes Workshop.
Karin Verspoor, Anika Oellrich, Nigel Collier, Tudor Groza, Philippe Rocca-Serra, Larisa Soldatova, Michel Dumontier, Nigam Shah
May 03, 2019
This special issue covers selected papers from the 18th Bio-Ontologies Special Interest Group meeting and Phenotype Day, which took place at the Intelligent Systems for Molecular Biology (ISMB) conference in Dublin in 2015. The...
Performance Accretion in Delay Compensation of Networked Control System Using Markov Approach-Based Randomness Estimation in Smith Predictor
By the second decade of the 21st century, there has been a multi-faceted technological development in the field of networked control system (NCS). This progression in NCS has not only revealed its significant applications in...
Published by: IGI Global Scientific Publishing
Alleviation of Delay in Tele-Surgical Operations Using Markov Approach-Based Smith Predictor
The acceptance of tele-robotics and teleoperations through networked control system (NCS) is increasing day-by-day. NCS involves the feedback control loop system wherein the control components such as actuators and sensors are...
Published by: IGI Global Scientific Publishing
Two Decades of Research on Consumer Behaviour and Analytics
Mitchell Ross, Sara Quach, Achint Nigam, Vijay Pereira, Nirma Jayawardena, Abhishek Behl, Park Thaichon, Thanh Le
Jan 01, 2022
The present study is a systematic literature review that identifies the context of consumer behaviour and analytics in business to forecast the future of consumer behaviour with changing business trends through TCCM (theory...
Published by: IGI Global Scientific Publishing
Critical IT Project Management Competencies
Academic computing curricula generally focus on teaching the specific technological skills expected of new graduates in their disciplines. Yet when it comes to hiring these graduates, behavioral skills (also called soft skills)...
Published by: IGI Global Scientific Publishing
Exploring Customer Engagement on Social Networking Sites
The growth in popularity of social media and its perfunctory use by individuals throughout the day has sprouted the need to study Customer Engagement (CE) on Social Networking Sites (SNSs) from the consumer’s lens. To understand...
Published by: IGI Global Scientific Publishing
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
Siddhartha Jaiswal, Pradeep Natarajan, Alexander J Silver, Christopher J Gibson, Alexander G Bick, Eugenia Shvartz, Marie McConkey, Namrata Gupta, Stacey Gabriel, Diego Ardissino, Usman Baber, Roxana Mehran, Valentin Fuster, John Danesh, Philippe Frossard, Danish Saleheen, Olle Melander, Galina K Sukhova, Donna Neuberg, Peter Libby, Sekar Kathiresan, Benjamin L Ebert
Nov 28, 2017
Dovetailing biology and chemistry
David P Hill, Nico Adams, Mike Bada, Colin Batchelor, Tanya Z Berardini, Heiko Dietze, Harold J Drabkin, Marcus Ennis, Rebecca E Foulger, Midori A Harris, Janna Hastings, Namrata S Kale, Paula de Matos, Christopher J Mungall, Gareth Owen, Paola Roncaglia, Christoph Steinbeck, Steve Turner, Jane Lomax
May 06, 2020
BACKGROUND: The Gene Ontology (GO) facilitates the description of the action of gene products in a biological context. Many GO terms refer to chemical entities that participate in biological processes. To facilitate accurate and...
Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.
Connor A Emdin, Amit V Khera, Derek Klarin, Pradeep Natarajan, Seyedeh M Zekavat, Akihiro Nomura, Mary Haas, Krishna Aragam, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Padhraig Gormley, Aarno Palotie, Nathan O Stitziel, Namrata Gupta, John Danesh, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Jan 19, 2018
BACKGROUND: Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for...
cardiovascular disease Genetics Nitric oxide nitric oxide synthase blood pressure Coronary Disease Genetic Association Studies Genetic Predisposition to Disease Humans Mutation Nitric oxide Nitric Oxide Synthase Type III Peripheral Arterial Disease Phenotype Polymorphism Single Nucleotide Protective factors Risk Factors Signal Transduction Soluble Guanylyl Cyclase stroke
Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.
Paul J McLaren, Sara L Pulit, Deepti Gurdasani, Istvan Bartha, Patrick R Shea, Cristina Pomilla, Namrata Gupta, Effrossyni Gkrania-Klotsas, Elizabeth H Young, Norbert Bannert, Julia Del Amo, M John Gill, Jill Gilmour, Paul Kellam, Anthony D Kelleher, Anders Sönnerborg, Robert Zangerle, Frank A Post, Martin Fisher, David W Haas, Bruce D Walker, Kholoud Porter, David B Goldstein, Manjinder S Sandhu, Paul IW de Bakker, Jacques Fellay
Apr 05, 2019
Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought to...
HIV host dependency factors HIV-1 control HIV-1 progression Exome Sequencing host genetics of infection Adult Female Genetic Predisposition to Disease genetic variation Genotype HIV Infections HIV-1 Host-Pathogen Interactions Humans Male Middle Aged Polymorphism Single Nucleotide Viral Load Whole exome sequencing
Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease.
Akihiro Nomura, Connor A Emdin, Hong Hee Won, Gina M Peloso, Pradeep Natarajan, Diego Ardissino, John Danesh, Heribert Schunkert, Adolfo Correa, Matthew J Bown, Nilesh J Samani, Jeanette Erdmann, Ruth McPherson, Hugh Watkins, Danish Saleheen, Roberto Elosua, Masa-Aki Kawashiri, Hayato Tada, Namrata Gupta, Svati H Shah, Daniel J Rader, Stacey Gabriel, Amit V Khera, Sekar Kathiresan
Dec 17, 2020
Coronary Artery Disease Lipids Odds Ratio Pedigree prevalence ATP Binding Cassette Transporter Subfamily G Member 5 ATP Binding Cassette Transporter Subfamily G Member 8 Adult Case-Control Studies Cholesterol LDL Coronary Artery Disease Female Heterozygote Humans Hypercholesterolemia Intestinal Diseases Lipid Metabolism Inborn Errors Lipoproteins Loss of Function Mutation Male Middle Aged Odds Ratio Phytosterols Risk Factors Sitosterols
An informatics consult approach for generating clinical evidence for treatment decisions.
Alvina G Lai, Wai Hoong Chang, Constantinos A Parisinos, Michail Katsoulis, Ruth M Blackburn, Anoop D Shah, Vincent Nguyen, Spiros Denaxas, George Davey Smith, Tom R Gaunt, Krishnarajah Nirantharakumar, Murray P Cox, Donall Forde, Folkert W Asselbergs, Steve Harris, Sylvia Richardson, Reecha Sofat, Richard JB Dobson, Aroon Hingorani, Riyaz Patel, Jonathan Sterne, Amitava Banerjee, Alastair K Denniston, Simon Ball, Neil J Sebire, Nigam H Shah, Graham R Foster, Bryan Williams, Harry Hemingway
Nov 22, 2021
BACKGROUND: An Informatics Consult has been proposed in which clinicians request novel evidence from large scale health data resources, tailored to the treatment of a specific patient. However, the availability of such...
An informatics consult approach for generating clinical evidence for treatment decisions
Alvina G. Lai, Wai Hoong Chang, Constantinos A. Parisinos, Michail Katsoulis, Ruth M. Blackburn, Anoop D. Shah, Vincent Nguyen, Spiros Denaxas, George Davey Smith, Tom R. Gaunt, Krishnarajah Nirantharakumar, Murray P. Cox, Donall Forde, Folkert W. Asselbergs, Steve Harris, Sylvia Richardson, Reecha Sofat, Richard J. B. Dobson, Aroon Hingorani, Riyaz Patel, Jonathan Sterne, Amitava Banerjee, Alastair K. Denniston, Simon Ball, Neil J. Sebire, Nigam H. Shah, Graham R. Foster, Bryan Williams, Harry Hemingway
Oct 13, 2021
Abstract: Background: An Informatics Consult has been proposed in which clinicians request novel evidence from large scale health data resources, tailored to the treatment of a specific patient. However, the availability of such...
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 16, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease.
Connor A Emdin, Amit V Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M Zekavat, Akihiro Nomura, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H Lichtman, Gail D'Onofrio, Jennifer Mattera, John A Spertus, Wayne H-H Sheu, Kent D Taylor, Bruce M Psaty, Stephen S Rich, Wendy Post, Jerome I Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Jun 13, 2018
Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted...
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Connor A. Emdin, Mary E. Haas, Amit V. Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 05, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels
Connor A Emdin, Amit V Khera, Pradeep Natarajan, Derek Klarin, Hong-Hee Won, Gina M Peloso, Nathan O Stitziel, Akihiro Nomura, Seyedeh M Zekavat, Alexander G Bick, Namrata Gupta, Rosanna Asselta, Stefano Duga, Piera Angelica Merlini, Adolfo Correa, Thorsten Kessler, James G Wilson, Matthew J Bown, Alistair S Hall, Peter S Braund, Nilesh J Samani, Heribert Schunkert, Jaume Marrugat, Roberto Elosua, Ruth McPherson, Martin Farrall, Hugh Watkins, Cristen Willer, Gonçalo R Abecasis, Janine F Felix, Ramachandran S Vasan, Eric Lander, Daniel J Rader, John Danesh, Diego Ardissino, Stacey Gabriel, Danish Saleheen, Sekar Kathiresan, CHARGE–Heart Failure Consortium, CARDIOGRAM Exome Consortium
Nov 20, 2017
The future of metabolomics in ELIXIR.
Merlijn van Rijswijk, Charlie Beirnaert, Christophe Caron, Marta Cascante, Victoria Dominguez, Warwick B Dunn, Timothy MD Ebbels, Franck Giacomoni, Alejandra Gonzalez-Beltran, Thomas Hankemeier, Kenneth Haug, Jose L Izquierdo-Garcia, Rafael C Jimenez, Fabien Jourdan, Namrata Kale, Maria I Klapa, Oliver Kohlbacher, Kairi Koort, Kim Kultima, Gildas Le Corguillé, Pablo Moreno, Nicholas K Moschonas, Steffen Neumann, Claire O'Donovan, Martin Reczko, Philippe Rocca-Serra, Antonio Rosato, Reza M Salek, Susanna-Assunta Sansone, Venkata Satagopam, Daniel Schober, Ruth Shimmo, Rachel A Spicer, Ola Spjuth, Etienne A Thévenot, Mark R Viant, Ralf JM Weber, Egon L Willighagen, Gianluigi Zanetti, Christoph Steinbeck
Jan 19, 2018
Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for...
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