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Results: 14004
Diagnosing cancer in primary care
Ruth Swann, Sean McPhail, Jana Witt, Brian Shand, Gary A Abel, Sara Hiom, Jem Rashbass, Georgios Lyratzopoulos, Greg Rubin, National Cancer Diagnosis Audit Steering Group
Mar 07, 2018
BACKGROUND: Continual improvements in diagnostic processes are needed to minimise the proportion of patients with cancer who experience diagnostic delays. Clinical audit is a means of achieving this. AIM: To characterise key...
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
ENT audit and research in the era of trainee collaboratives.
Matthew E Smith, John Hardman, Matthew Ellis, Richard J Williams, The UK National ENT Trainee Research Network INTEGRATE
Sep 20, 2018
Large surgical audits and research projects are complex and costly to deliver, but increasingly surgical trainees are delivering these projects within formal collaboratives and research networks. Surgical trainee collaboratives...
How do primary care doctors in England and Wales code and manage people with chronic kidney disease? Results from the National Chronic Kidney Disease Audit.
Lois G Kim, Faye Cleary, David C Wheeler, Ben Caplin, Dorothea Nitsch, Sally A Hull, UK National Chronic Kidney Disease Audit
Dec 07, 2017
BACKGROUND: In the UK, primary care records are electronic and require doctors to ascribe disease codes to direct care plans and facilitate safe prescribing. We investigated factors associated with coding of chronic kidney...
The National Institute for Health Research
V Goh, National Institute for Health Research Clinical Research Network Imaging Network Steering Group, Royal College of Radiologists' Academic Committee
Oct 01, 2019
Since the inception of the National Institute for Health Research (NIHR) in 2006, the landscape for the delivery of clinical research within the National Health Service (NHS) has been transformed. Clinical radiology has...
Profiling for primary-care presentation, investigation and referral for liver cancers
BACKGROUND AND AIM: The incidence of liver cancer across Europe is increasing. There is a lack of evidence within the current literature on the identification and investigation of liver cancer within primary care. We aimed to...
The nature and frequency of abdominal symptoms in cancer patients and their associations with time to help-seeking
Minjoung Monica Koo, Christian von Wagner, Gary A Abel, Sean McPhail, William Hamilton, Greg P Rubin, Georgios Lyratzopoulos
Jun 25, 2018
BACKGROUND: Raising awareness of possible cancer symptoms is important for timely help-seeking; recent campaigns have focused on symptom groups (such as abdominal symptoms) rather than individual alarm symptoms associated with...
Best practice in Active Surveillance for men with prostate cancer
Samuel WD Merriel, Liz Hetherington, Andrew Seggie, Joanna T Castle, William Cross, Monique J Roobol, Vincent Gnanapragasam, Caroline M Moore, Prostate Cancer UK Expert Reference Group on Active Surveillance
Apr 04, 2019
OBJECTIVES: To develop a consensus statement on current best practice of active surveillance (AS) in the UK, informed by patients and clinical experts. SUBJECTS AND METHODS: A consensus statement was drafted on the basis of...
Cancer Variant Interpretation Group UK (CanVIG-UK)
Alice Garrett, Alison Callaway, Miranda Durkie, Cankut Cubuk, Mary Alikian, George J Burghel, Rachel Robinson, Louise Izatt, Sabrina Talukdar, Lucy Side, Treena Cranston, Sheila Palmer-Smith, Diana Baralle, Ian R Berry, James Drummond, Andrew J Wallace, Gail Norbury, Diana M Eccles, Sian Ellard, Fiona Lalloo, D Gareth Evans, Emma Woodward, Marc Tischkowitz, Helen Hanson, Clare Turnbull, CanVIG-UK
Mar 16, 2020
Advances in technology have led to a massive expansion in the capacity for genomic analysis, with a commensurate fall in costs. The clinical indications for genomic testing have evolved markedly; the volume of clinical...
Presenting symptoms of cancer and stage at diagnosis
Minjoung Monica Koo, Ruth Swann, Sean McPhail, Gary A Abel, Lucy Elliss-Brookes, Greg P Rubin, Georgios Lyratzopoulos
Feb 07, 2020
BACKGROUND: Early diagnosis interventions such as symptom awareness campaigns increasingly form part of global cancer control strategies. However, these strategies will have little impact in improving cancer outcomes if the...
Risk factors for the development of invasive cancer in unresected ductal carcinoma in situ.
Anthony J Maxwell, Karen Clements, Bridget Hilton, David J Dodwell, Andrew Evans, Olive Kearins, Sarah E Pinder, Jeremy Thomas, Matthew G Wallis, Alastair M Thompson, Sloane Project Steering Group
Feb 18, 2019
BACKGROUND: The natural history of ductal carcinoma in situ (DCIS) remains uncertain. The risk factors for the development of invasive cancer in unresected DCIS are unclear. METHODS: Women diagnosed with DCIS on needle biopsy...
Breast Cancer DCIS Endocrine therapy invasion Microcalcification SURGERY Adult Age Factors Aged Aged 80 and over Biopsy Needle Breast Carcinoma In Situ Breast Neoplasms Calcinosis Carcinoma Intraductal Noninfiltrating Disease Progression Female Humans Middle Aged Neoplasm Grading Neoplasm Invasiveness Prognosis Registries Risk Factors
Survival and disease characteristics of de novo versus recurrent metastatic breast cancer in a cohort of young patients.
Hayley S McKenzie, Tom Maishman, Peter Simmonds, Lorraine Durcan, POSH Steering Group, Diana Eccles, Ellen Copson
Nov 03, 2020
BACKGROUND: It is not clear how the pathology, presentation and outcome for patients who present with de novo metastatic breast cancer (dnMBC) compare with those who later develop distant metastases. DnMBC is uncommon in younger...
Current opportunities to catalyze research in nutrition and cancer prevention – an interdisciplinary perspective
The Cancer Research UK - Ludwig Cancer Research Nutrition and Cancer Prevention Collaborative Group
Jul 31, 2019
Cancer Research UK and Ludwig Cancer Research convened an inaugural international Cancer Prevention and Nutrition Conference in London on December 3–4, 2018. Much of the discussion focused on the need for systematic...
cancer prevention Developmental origins Diet EPIDEMIOLOGY epigenetics interdisciplinary metabolism Nutrition obesity physical activity Public Health Biomedical Research Body Weight Congresses as Topic Diet Exercise food Humans Interdisciplinary Communication Interdisciplinary Research Neoplasms Nutrition Therapy Nutritional Status obesity Risk Factors United Kingdom
Menopausal hormone use and ovarian cancer risk
Collaborative Group On Epidemiological Studies Of Ovarian Cancer, V Beral, K Gaitskell, C Hermon, K Moser, G Reeves, R Peto
Sep 21, 2018
BACKGROUND: Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or...
Computer-assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.
Lavinia Ferrante di Ruffano, Yemisi Takwoingi, Jacqueline Dinnes, Naomi Chuchu, Susan E Bayliss, Clare Davenport, Rubeta N Matin, Kathie Godfrey, Colette O'Sullivan, Abha Gulati, Sue Ann Chan, Alana Durack, Susan O'Connell, Matthew D Gardiner, Jeffrey Bamber, Jonathan J Deeks, Hywel C Williams, Cochrane Skin Cancer Diagnostic Test Accuracy Group
Feb 15, 2019
BACKGROUND: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high-risk skin cancers...
Prostate cancer in South Africa
Prostate cancer is one of the most common male cancers globally; however little is known about prostate cancer in Africa. Incidence data for prostate cancer in South Africa (SA) from the pathology based National Cancer Registry...
The B-MaP-C study
Alona Courtney, Rachel O'Connell, Tim Rattay, Baek Kim, Ramsey I Cutress, Cliona C Kirwan, Ashu Gandhi, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Rajiv V Dave
Sep 14, 2020
Introduction: Approximately 55,000 women in the United Kingdom are diagnosed with new breast cancer annually. Since emerging in December 2019, SARS-CoV-2 (coronavirus disease 2019, COVID-19) has become a global pandemic...
Hematologic malignancies in South Africa 2000-2006
Sara J Schonfeld, Friederike Erdmann, Tracey Wiggill, Elvira Singh, Patricia Kellett, Chantal Babb, Joachim Schüz
Apr 16, 2018
Little is known about the incidence patterns of hematologic malignancies in Sub-Saharan Africa, including South Africa. We estimated incidence rates of pathology-confirmed adult cases of leukemia, myeloma and related diseases...
A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS)
Rachel Harwood, Benjamin Allin, Christine E Jones, Elizabeth Whittaker, Padmanabhan Ramnarayan, Athimalaipet V Ramanan, Musa Kaleem, Robert Tulloh, Mark J Peters, Sarah Almond, Peter J Davis, Michael Levin, Andrew Tometzki, Saul N Faust, Marian Knight, Simon Kenny, PIMS-TS National Consensus Management Study Group
Dec 15, 2020
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a novel condition that was first reported in April, 2020. We aimed to develop a national consensus management pathway for the UK to...
Introduction to the National Cancer Imaging Translational Accelerator (NCITA)
MA McAteer, JPB O'Connor, DM Koh, HY Leung, SJ Doran, M Jauregui-Osoro, N Muirhead, C Brew-Graves, ER Plummer, E Sala, T Ng, EO Aboagye, GS Higgins, S Punwani
Oct 04, 2021
The National Cancer Imaging Translational Accelerator (NCITA) is creating a UK national coordinated infrastructure for accelerated translation of imaging biomarkers for clinical use. Through the development of standardised...
Conceptual Framework to Guide Early Diagnosis Programs for Symptomatic Cancer as Part of Global Cancer Control.
Minjoung Monica Koo, Karla Unger-Saldaña, Amos D Mwaka, Marilys Corbex, Ophira Ginsburg, Fiona M Walter, Natalia Calanzani, Jennifer Moodley, Greg P Rubin, Georgios Lyratzopoulos
Jan 22, 2021
Diagnosing cancer earlier can enable timely treatment and optimize outcomes. Worldwide, national cancer control plans increasingly encompass early diagnosis programs for symptomatic patients, commonly comprising awareness...
Risk stratification for prostate cancer management
M. G. Parry, T. E. Cowling, A. Sujenthiran, J. Nossiter, B. Berry, P. Cathcart, A. Aggarwal, H. Payne, J. van der Meulen, N. W. Clarke, V. J. Gnanapragasam
May 28, 2021
Abstract: Background: The five-tiered Cambridge Prognostic Group (CPG) classification is a better predictor of prostate cancer-specific mortality than the traditional three-tiered classification (low, intermediate, and high...
Risk stratification for prostate cancer management
M. G. Parry, T. E. Cowling, A. Sujenthiran, J. Nossiter, B. Berry, P. Cathcart, A. Aggarwal, H. Payne, J. van der Meulen, N. W. Clarke, V. J. Gnanapragasam
Jun 06, 2020
Abstract: Background: The five-tiered Cambridge Prognostic Group (CPG) classification is a better predictor of prostate cancer-specific mortality than the traditional three-tiered classification (low, intermediate, and high...
Introduction to the National Cancer Imaging Translational Accelerator (NCITA)
M A McAteer, J P B O'Connor, D M Koh, H Y Leung, S J Doran, M Jauregui-Osoro, N Muirhead, C Brew-Graves, E R Plummer, E Sala, T Ng, E O Aboagye, G S Higgins, S Punwani
Aug 28, 2021
The National Cancer Imaging Translational Accelerator (NCITA) is creating a UK national coordinated infrastructure for accelerated translation of imaging biomarkers for clinical use. Through the development of standardised...
Published by: British journal of cancer
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