Search
Results: 26062
Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.
Matthias Kohlhauer, Sam Dawkins, Ana SH Costa, Regent Lee, Timothy Young, Victoria R Pell, Robin P Choudhury, Adrian P Banning, Rajesh K Kharbanda, Oxford Acute Myocardial Infarction (OxAMI) Study, Kourosh Saeb-Parsy, Michael P Murphy, Christian Frezza, Thomas Krieg, Keith M Channon
May 30, 2018
BACKGROUND: Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to...
Ischemia–reperfusion injury Mitochondria Myocardial Ischemia myocardial metabolism Adult Aged Aged 80 and over Biomarkers Coronary Angiography Female Follow-Up Studies Humans Magnetic Resonance Imaging Cine Male Middle Aged Myocardial Reperfusion Injury Myocardium Percutaneous Coronary Intervention Prognosis Retrospective Studies ST Elevation Myocardial Infarction Succinic Acid Time Factors
68Ga-DOTATATE PET Identifies Residual Myocardial Inflammation and Bone Marrow Activation After Myocardial Infarction.
Jason M Tarkin, Claudia Calcagno, Marc R Dweck, Nicholas R Evans, Mohammed M Chowdhury, Deepa Gopalan, David E Newby, Zahi A Fayad, Martin R Bennett, James HF Rudd
Mar 04, 2019
Myocardial infarction (MI) healing occurs in two phases: first an inflammatory phase, where clearance of necrotic debris occurs, followed by a reparative phase characterized by angiogenesis, granulation tissue formation and...
Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction
OBJECTIVE: To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction. DESIGN: Two sample mendelian randomisation study using genetic variants as instrumental...
Adult Aged Biological Specimen Banks Female Genetic Pleiotropy genetic variation Genome-Wide Association Study Heart Failure Humans Male Mendelian Randomization Analysis Middle Aged Myocardial Infarction Odds Ratio Randomized Controlled Trials as Topic Risk Factors Testosterone Thromboembolism United Kingdom White People
Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function After Myocardial Infarction Through Kynurenine.
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, José Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sébastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sébastien Silvestre, Soraya Taleb
Dec 07, 2020
BACKGROUND: Ischemic cardiovascular diseases, particularly acute myocardial infarction (MI), is one of the leading causes of mortality worldwide. Indoleamine 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-limiting step of...
Predicting risk of cardiovascular events 1 to 3 years post-myocardial infarction using a global registry.
Stuart J Pocock, David Brieger, John Gregson, Ji Y Chen, Mauricio G Cohen, Shaun G Goodman, Christopher B Granger, Richard Grieve, Jose C Nicolau, Tabassome Simon, Dirk Westermann, Satoshi Yasuda, Katarina Hedman, Kirsten L Rennie, Karolina Andersson Sundell, TIGRIS Study Investigators
Jan 16, 2020
BACKGROUND: Risk prediction tools are lacking for patients with stable disease some years after myocardial infarction (MI). HYPOTHESIS: A practical long-term cardiovascular risk index can be developed. METHODS: The long-Term...
MRI-based strain measurements reflect morphological changes following myocardial infarction
Doyin Odunmbaku-Mansell, Eva Sammut, V. D. Bruno, Raimondo Ascione, Jonathan C.L. Rodrigues, H S Gill, Katharine Fraser, Andrew Cookson
Jan 31, 2023
In a porcine experimental model of myocardial infarction, a localised, layer-specific, circumferential left ventricular strain metric has been shown to indicate chronic changes in ventricular function post-infarction more...
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
Doyin Odunmbaku-Mansell, V. D. Bruno, Eva Sammut, Amedeo Chiribiri, Thomas Johnson, I Khaliulin, Daniel Baz Lopez, H S Gill, Katharine Fraser, M Murphy, T Krieg, M. S. Suleiman, S George, Raimondo Ascione, Andrew Cookson
Sep 15, 2021
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance...
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model.
DS Mansell, VD Bruno, E Sammut, A Chiribiri, T Johnson, I Khaliulin, D Baz Lopez, HS Gill, KH Fraser, M Murphy, T Krieg, MS Suleiman, S George, R Ascione, AN Cookson
Oct 08, 2021
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance...
Animals Biomarkers Computational Biology Data analysis Data Interpretation Statistical Disease Models Animal Disease Susceptibility Female Image Processing Computer-Assisted Magnetic Resonance Imaging Myocardial Infarction Myocardium Proteome Proteomics Reproducibility of Results Swine Translational Research Biomedical Ventricular Function Left Ventricular Remodeling
PET Imaging of Post-infarct Myocardial Inflammation.
PURPOSE OF REVIEW: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. RECENT FINDINGS: Dysregulated immune responses after myocardial infarction are associated...
Cognitive Decline in Older Patients With Non- ST Elevation Acute Coronary Syndrome.
Sophie Z Gu, Benjamin Beska, Danny Chan, Dermot Neely, Jonathan A Batty, Jennifer Adams-Hall, Helen Mossop, Weiliang Qiu, Vijay Kunadian
Mar 12, 2020
Background Dementia is a growing health burden of an aging population. This study aims to evaluate the prevalence of cognitive impairment and the predictors of cognitive decline at 1 year in older patients with non-ST-elevation...
Cognition COGNITIVE IMPAIRMENT Coronary Artery Disease non‐ST‐segment–elevation acute coronary syndrome Acute Coronary Syndrome Aged Aged 80 and over Cognitive Dysfunction Coronary Angiography Electrocardiography Female Follow-Up Studies Humans Male prevalence Prognosis Prospective Studies Risk Factors United Kingdom
Fulminant immune-mediated necrotising myopathy (IMNM) mimicking myocardial infarction with non-obstructive coronary arteries (MINOCA)
A 74-year-old man, with inflammatory arthritis, recently commenced on adalimumab, presented with a 4-week history of left-sided chest pain, malaise and shortness of breath. Admission ECG showed age-indeterminate left bundle...
MRI-based strain measurements reflect morphological changes following myocardial infarction
Doyin Odunmbaku-Mansell, Eva Sammut, V. D. Bruno, Raimondo Ascione, Jonathan C.L. Rodrigues, H S Gill, Katharine Fraser, Andrew Cookson
Jan 31, 2023
In a porcine experimental model of myocardial infarction, a localised, layer-specific, circumferential left ventricular strain metric has been shown to indicate chronic changes in ventricular function post-infarction more...
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
Doyin Odunmbaku-Mansell, V. D. Bruno, Eva Sammut, Amedeo Chiribiri, Thomas Johnson, I Khaliulin, Daniel Baz Lopez, H S Gill, Katharine Fraser, M Murphy, T Krieg, M. S. Suleiman, S George, Raimondo Ascione, Andrew Cookson
Sep 15, 2021
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance...
Fulminant immune-mediated necrotising myopathy (IMNM) mimicking myocardial infarction with non-obstructive coronary arteries (MINOCA)
A 74-year-old man, with inflammatory arthritis, recently commenced on adalimumab, presented with a 4-week history of left-sided chest pain, malaise and shortness of breath. Admission ECG showed age-indeterminate left bundle...
Novel Approach for Assessing Postinfarct Myocardial Injury and Inflammation Using Hybrid Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging.
Andrej Ćorović, Deepa Gopalan, Christopher Wall, Marta Peverelli, Stephen P Hoole, Patrick A Calvert, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Martin R Bennett, James HF Rudd, Jason M Tarkin
Feb 17, 2023
Post-infarct inflammation and its resolution modulate ischemic injury after myocardial infarction (MI). While cardiac magnetic resonance imaging (MRI) is useful for assessing ventricular function, viability and structural...
Are there gender differences in acute management and secondary prevention of acute coronary syndromes in Barbados? A cohort study.
Natasha Sobers, Angela Mc Rose, T Alafia Samuels, Julia Critchley, Melissa Abed, Ian Hambleton, Arianne Harvey, Nigel Unwin
Feb 14, 2019
OBJECTIVES: In Barbados, high case fatality rates have been reported after myocardial infarction (MI) with higher rates in women than men. To explore this inequality, we examined documented pharmacological interventions for...
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Icia Santos-Zas, Jeremie Lemarié, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bizé, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, José Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sébastien Silvestre, Hafid Ait-Oufella
Mar 16, 2021
Acute myocardial infarction is a common condition responsible for heart failure and sudden death. Here, we show that following acute myocardial infarction in mice, CD8+ T lymphocytes are recruited and activated in the ischemic...
PET Imaging of Post-infarct Myocardial Inflammation
Abstract: Purpose of Review: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings: Dysregulated immune responses after myocardial infarction are...
PET Imaging of Post-infarct Myocardial Inflammation
Abstract: Purpose of Review: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings: Dysregulated immune responses after myocardial infarction are...
Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction.
Ting-Ting Tang, Yuan-Yuan Li, Jing-Jing Li, Ke Wang, Yue Han, Wen-Yong Dong, Zheng-Feng Zhu, Ni Xia, Shao-Fang Nie, Min Zhang, Zhi-Peng Zeng, Bing-Jie Lv, Jiao Jiao, Heng Liu, Zong-Shu Xian, Xiang-Ping Yang, Yu Hu, Yu-Hua Liao, Qing Wang, Xin Tu, Ziad Mallat, Yu Huang, Guo-Ping Shi, Xiang Cheng
Nov 22, 2018
Interleukin (IL)-22 regulates tissue inflammation and repair. Here we report participation of the liver in IL-22-mediated cardiac repair after acute myocardial infarction (MI). Methods: We induced experimental MI in mice by...
Deepwater Horizon oil spill exposures and nonfatal myocardial infarction in the GuLF STUDY.
Jean Strelitz, Lawrence S Engel, Richard K Kwok, Aubrey K Miller, Aaron Blair, Dale P Sandler
Jul 17, 2019
BACKGROUND: Workers involved in the response and clean-up of the 2010 Deepwater Horizon oil spill faced possible exposures to crude oil, burning oil, dispersants and other pollutants in addition to physical and emotional stress....
Deepwater Horizon Disaster epidemiology Myocardial Infarction Oil spill Adult Aged Cohort Studies Female Gulf of Mexico Humans Incidence Male Middle Aged Myocardial Infarction occupational exposure Petroleum Petroleum Pollution Prospective Studies Self Report Southeastern United States Water Pollutants Chemical Young Adult
Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb.
David Köhler, Tiago Granja, Julia Volz, Michael Koeppen, Harald F Langer, Georg Hansmann, Ekaterina Legchenko, Tobias Geisler, Tamam Bakchoul, Claudia Eggstein, Helene A Häberle, Bernhard Nieswandt, Peter Rosenberger
May 04, 2020
Myocardial ischemia is one of the leading health problems worldwide. Therapy consists of the restitution of coronary perfusion which is followed by myocardial inflammation. Platelet-neutrophil interaction is a crucial process...
Adolescent Adult Aged Aged 80 and over Animals Antigens CD Blood Platelets Coronary Vessels Disease Models Animal Erythrocytes Female GPI-Linked Proteins Humans Male Mice Mice Knockout Middle Aged Myocardial Infarction Myocardial Reperfusion Injury Myocardium Platelet Glycoprotein GPIb-IX Complex Prospective Studies Semaphorins Thrombosis Young Adult
Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction.
Xian Yu, Stephen A Newland, Tian X Zhao, Yuning Lu, Andrew S Sage, Yanyi Sun, Rouchelle S Sriranjan, Marcella Kl Ma, Brian YH Lam, Meritxell Nus, James E Harrison, Simon J Bond, Xiang Cheng, Jean-Sébastien Silvestre, James HF Rudd, Joseph Cheriyan, Ziad Mallat
Jul 20, 2021
BACKGROUND: Innate lymphoid cells type 2 (ILC2s) play critical homeostatic functions in peripheral tissues. ILC2s reside in perivascular niches and limit atherosclerosis development. OBJECTIVES: ILC2s also reside in the...
The role of Glucagon-Like Peptide 1 Loading on periprocedural myocardial infarction During elective PCI (GOLD-PCI study)
Joel P Giblett, Sophie Clarke, Tian Zhao, Liam M McCormick, Denise M Braganza, Cameron G Densem, Michael O'Sullivan, David Adlam, Sarah C Clarke, Jo Steele, Sarah Fielding, Nick EJ West, Sofia S Villar, Stephen P Hoole
Aug 07, 2019
BACKGROUND
The incretin hormone glucagon-like peptide 1 (GLP-1) has been shown to protect against lethal ischemia-reperfusion injury in animal models and against nonlethal ischemia reperfusion injury in humans. Furthermore...
Aged Biomarkers Coronary Angiography Dose-Response Relationship Drug Double-Blind Method Elective Surgical Procedures Female Follow-Up Studies Glucagon-Like Peptide 1 Humans Infusions Intravenous Male Myocardial Infarction Myocardial Reperfusion Injury Peptide Fragments Percutaneous Coronary Intervention Preoperative Period Retrospective Studies Treatment Outcome Troponin I
|
|< |
< |
1 |