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Results: 26149
NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.
T Schwerd, RV Bryant, S Pandey, M Capitani, L Meran, J-B Cazier, J Jung, K Mondal, M Parkes, CG Mathew, K Fiedler, DJ McCarthy, WGS500 Consortium, Oxford IBD cohort study investigators, COLORS in IBD group investigators, UK IBD Genetics Consortium, PB Sullivan, A Rodrigues, SPL Travis, C Moore, J Sambrook, WH Ouwehand, DJ Roberts, J Danesh, INTERVAL Study, RK Russell, DC Wilson, JR Kelsen, R Cornall, LA Denson, S Kugathasan, UG Knaus, EG Serra, CA Anderson, RH Duerr, D Pb McGovern, J Cho, F Powrie, V Sw Li, AM Muise, HH Uhlig
Feb 05, 2018
Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel hemizygous defect in NOX1 encoding NAPDH oxidase 1...
Animals Child Child Preschool Colon Genes Modifier Genetic Association Studies Genetic Predisposition to Disease Genome Genotype High-Throughput Nucleotide Sequencing Host-Pathogen Interactions Humans Inflammatory Bowel Diseases Male Mice Mice Inbred C57BL Mutation Missense NADPH Oxidase 1 Polymorphism Single Nucleotide Reactive Oxygen Species
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease
Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators, Tim Raine, Miles Parkes, UK IBD Bioresource Investigators
Jul 20, 2020
OBJECTIVE: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date...
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M Croft, Carsten Posovszky, Astor Rodrigues, Richard K Russell, Farah Barakat, Marcus KH Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C Matte, Kimberly C Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A Baeumler, Tudor A Fulga, Eli M Carrami, Ahmed Ahmed, Rachel Wilson, Jeffrey C Barrett, Abdul Elkadri, Anne M Griffiths, COLORS in IBD group investigators, Oxford IBD cohort study investigators, INTERVAL Study, Swiss IBD cohort investigators, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Scott B Snapper, Neil Shah, Aleixo M Muise, David C Wilson, Holm H Uhlig, Carl A Anderson
Jan 31, 2020
Adult Age of Onset Case-Control Studies Child Child Preschool Cohort Studies Female Genes Recessive Genetic Predisposition to Disease genetic variation Humans Infant Infant Newborn Inflammatory Bowel Diseases Loss of Function Mutation Male Mosaicism Multifactorial Inheritance Mutation NADPH Oxidase 2 Pedigree Primary Immunodeficiency Diseases Risk Factors Exome Sequencing
Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.
Maria Laura Santoru, Cristina Piras, Antonio Murgia, Vanessa Palmas, Tania Camboni, Sonia Liggi, Ivan Ibba, Maria Antonia Lai, Sandro Orrù, Sylvain Blois, Anna Lisa Loizedda, Julian Leether Griffin, Paolo Usai, Pierluigi Caboni, Luigi Atzori, Aldo Manzin
Jun 15, 2018
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change...
Inability to get up after falling, subsequent time on floor, and summoning help
OBJECTIVES: To describe the incidence and extent of lying on the floor for a long time after being unable to get up from a fall among people aged over 90; to explore their use of call alarm systems in these circumstances....
Highlights in IBD Epidemiology and Its Natural History in the Paediatric Age.
Background. The number of patients of all age brackets diagnosed with Inflammatory Bowel Disease (IBD) has risen dramatically worldwide over the past 50 years. IBD's changing epidemiology suggests that environmental factors play...
Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis
Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith, Neil McHugh
Jan 12, 2018
Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data...
Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis
Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith, Neil McHugh
Jan 12, 2018
Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data...
Place of death for the 'oldest old'
Jane Fleming, Jun Zhao, Morag Farquhar, Carol Brayne, Stephen Barclay, Cambridge City over-75s Cohort (CC75C) study collaboration
Mar 01, 2019
BACKGROUND: Deaths are rising fastest among the oldest old but data on their transitions in place of care at the end of life are scarce. AIM: To examine the place of residence or care of > or =85 year-olds less than a year...
Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
Ahmed N Hegazy, Nathaniel R West, Michael JT Stubbington, Emily Wendt, Kim IM Suijker, Angeliki Datsi, Sebastien This, Camille Danne, Suzanne Campion, Sylvia H Duncan, Benjamin MJ Owens, Holm H Uhlig, Andrew McMichael, Oxford IBD Cohort Investigators, Andreas Bergthaler, Sarah A Teichmann, Satish Keshav, Fiona Powrie
May 14, 2019
BACKGROUND & AIMS: Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactions in humans. We investigated responses of...
Cytokines immune regulation Microbiota Tissue-resident Memory T cells Bacteria CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Case-Control Studies Cell Line Colitis Ulcerative Crohn Disease Gastrointestinal Microbiome Host-Pathogen Interactions Humans Immunity mucosal Immunologic Memory Interleukin-17 Intestines Phenotype Receptors Antigen T-Cell alpha-beta Th17 Cells
Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab.
Nicholas A Kennedy, James R Goodhand, Claire Bewshea, Rachel Nice, Desmond Chee, Simeng Lin, Neil Chanchlani, Jeffrey Butterworth, Rachel Cooney, Nicholas M Croft, Ailsa L Hart, Peter M Irving, Klaartje B Kok, Christopher A Lamb, Jimmy K Limdi, Jonathan Macdonald, Dermot PB McGovern, Shameer J Mehta, Charles D Murray, Kamal V Patel, Richard Cg Pollok, Timothy Raine, Richard K Russell, Christian P Selinger, Philip J Smith, Jack Bowden, Timothy J McDonald, Charlie W Lees, Shaji Sebastian, Nicholas Powell, Tariq Ahmad, Contributors to the CLARITY IBD study
Mar 23, 2021
OBJECTIVE: Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following pneumococcal, influenza and viral hepatitis vaccination and increase the risk of serious respiratory infections. We sought to determine...
covid-19 Autoimmune Disease CLARITY inflammatory bowel disease inflammatory diseases Infliximab vedoluzimab Adult Antibodies Monoclonal Humanized Antibodies Viral Antibody Formation covid-19 Female Gastrointestinal Agents Humans Inflammatory Bowel Diseases Infliximab Male Middle Aged Prospective Studies SARS-CoV-2 Serologic Tests United Kingdom
Sources of excess steroid prescriptions and clinical adverse outcomes associated with steroid excess in patients with inflammatory bowel disease
Konstantina Rosiou, Jenelyn Carbonell, Vivien Dolby, Niloufar Monfared, Tim Raine, Christian P Selinger
May 25, 2022
BACKGROUND: Corticosteroids remain important for managing inflammatory bowel disease (IBD) flares. Steroid excess, however, may be a marker of poor care. Patients access steroid prescriptions from primary (General Practitioners...
COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP)
James L Alexander, Zhigang Liu, Diana Muñoz Sandoval, Catherine Reynolds, Hajir Ibraheim, Sulak Anandabaskaran, Aamir Saifuddin, Rocio Castro Seoane, Nikhil Anand, Rachel Nice, Claire Bewshea, Andrea D'Mello, Laura Constable, Gareth R Jones, Sharmili Balarajah, Francesca Fiorentino, Shaji Sebastian, Peter M Irving, Lucy C Hicks, Horace RT Williams, Alexandra J Kent, Rachel Linger, Miles Parkes, Klaartje Kok, Kamal V Patel, Julian P Teare, Daniel M Altmann, James R Goodhand, Ailsa L Hart, Charlie W Lees, Rosemary J Boyton, Nicholas A Kennedy, Tariq Ahmad, Nick Powell, VIP study investigators
Oct 12, 2022
BACKGROUND: COVID-19 vaccine-induced antibody responses are reduced in patients with inflammatory bowel disease (IBD) taking anti-TNF or tofacitinib after two vaccine doses. We sought to assess whether immunosuppressive...
The relationship between back pain and mortality in older adults varies with disability and gender
RE Docking, J Fleming, C Brayne, J Zhao, GJ Macfarlane, GT Jones, Cambridge City over-75s Cohort (CC75C) study collaboration
Jan 29, 2020
BACKGROUND: This study aims to determine whether older adults reporting back pain (BP) are at increased risk of premature mortality, specifically, to examine the association with disabling/non-disabling pain separately. METHODS...
Analysis of Cardio-Cerebral Crosstalk Events in an Adult Cohort from the CENTER-TBI Study.
Giovanna Maria Dimitri, Erta Beqiri, Marek Czosnyka, Ari Ercole, Peter Smielewski, Pietro Lio, CENTER-TBI High Resolution Substudy Participants and Investigators
Apr 17, 2020
OBJECTIVE: In a previous study, we observed the presence of simultaneous increases in intracranial pressure (ICP) and the heart rate (HR), which we denominated cardio-cerebral crosstalk (CC), and we related the number of such...
Somatic Evolution in Non-neoplastic IBD-Affected Colon.
Sigurgeir Olafsson, Rebecca E McIntyre, Tim Coorens, Timothy Butler, Hyunchul Jung, Philip S Robinson, Henry Lee-Six, Mathijs A Sanders, Kenneth Arestang, Claire Dawson, Monika Tripathi, Konstantina Strongili, Yvette Hooks, Michael R Stratton, Miles Parkes, Inigo Martincorena, Tim Raine, Peter J Campbell, Carl A Anderson
Jan 18, 2021
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts...
Crohn's Disease IL17 PIGR ZC3H12A inflammatory bowel disease intestinal epithelia Mutation Rate mutational signatures somatic mutations Ulcerative colitis Adult Aged Aged 80 and over aging Clonal Evolution Colitis Colitis Ulcerative Crohn Disease DNA-Binding Proteins Epithelial Cells F-Box-WD Repeat-Containing Protein 7 Female Humans INDEL Mutation Inflammatory Bowel Diseases Interleukin-17 Intestinal Mucosa Male Middle Aged Mutation Rate Phylogeny Point Mutation Receptors Cell Surface Ribonucleases Toll-Like Receptors Transcription Factors whole genome sequencing
Early PREdiction of Severe Sepsis (ExPRES-Sepsis) study
Deepankar Datta, Andrew Conway Morris, Jean Antonelli, Noel Warner, Kenneth Alun Brown, John Wright, A John Simpson, Jillian Rennie, Gillian Hulme, Sion Marc Lewis, Tracey Anne Mare, Sharon Cookson, Christopher John Weir, Ian Dimmick, Jim Keenan, Adriano Giorgio Rossi, Manu Shankar-Hari, Timothy S Walsh, ExPRES Sepsis Investigators
Jul 18, 2018
INTRODUCTION: Sepsis is an acute illness resulting from infection and the host immune response. Early identification of individuals at risk of developing life-threatening severe sepsis could enable early triage and treatment...
IBD considerations in spondyloarthritis.
Spondyloarthritis (SpA) may be regarded a family of auto-inflammatory conditions with inflammation focused on the joints. These form part of a wider family of immune-mediated inflammatory diseases, which include inflammatory...
Study protocol. A prospective cohort study of unselected primiparous women
Dharmintra Pasupathy, Alison Dacey, Emma Cook, D Stephen Charnock-Jones, Ian R White, Gordon CS Smith
Jun 16, 2011
BACKGROUND: There have been dramatic changes in the approach to screening for aneuploidy over the last 20 years. However, the approach to screening for other complications of pregnancy such as intra-uterine growth restriction...
Place of death and end-of-life transitions experienced by very old people with differing cognitive status
Anouk J Perrels, Jane Fleming, Jun Zhao, Stephen Barclay, Morag Farquhar, Hilde M Buiting, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 14, 2019
BACKGROUND: Despite fast-growing 'older old' populations, 'place of care' trajectories for very old people approaching death with or without dementia are poorly described and understood. AIM: To explore end-of-life transitions...
80 and over COGNITIVE IMPAIRMENT Aged Delivery of Health Care Dementia Frail Elderly Homes for the Aged Nursing Homes Patient Transfer residential characteristics Terminal Care Aged 80 and over Cognition Disorders Cohort Studies Female Hospital Mortality Humans Male Nursing Homes Terminal Care Terminally Ill United Kingdom
Moving towards more patient-centred clinical trials in IBD.
Declining recruitment rates in inflammatory bowel disease (IBD) trials have resulted in calls to modify the conduct of trials in IBD in order to make them more efficient and patient centred. Here, we propose a number of...
covid-19 Clinical Trials as Topic Humans Inflammatory Bowel Diseases Informed Consent Patient Acceptance of Health Care Patient Outcome Assessment Patient Reported Outcome Measures patient satisfaction Patient Selection Patient-Centered Care SARS-CoV-2 Self-testing Telemedicine Therapeutic Equipoise
COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP)
James L Alexander, Nicholas A Kennedy, Hajir Ibraheim, Sulak Anandabaskaran, Aamir Saifuddin, Rocio Castro Seoane, Zhigang Liu, Rachel Nice, Claire Bewshea, Andrea D'Mello, Laura Constable, Gareth R Jones, Sharmili Balarajah, Francesca Fiorentino, Shaji Sebastian, Peter M Irving, Lucy C Hicks, Horace RT Williams, Alexandra J Kent, Rachel Linger, Miles Parkes, Klaartje Kok, Kamal V Patel, Julian P Teare, Daniel M Altmann, Rosemary J Boyton, James R Goodhand, Ailsa L Hart, Charlie W Lees, Tariq Ahmad, Nick Powell, VIP study investigators
Mar 09, 2022
BACKGROUND: The effects that therapies for inflammatory bowel disease (IBD) have on immune responses to SARS-CoV-2 vaccination are not yet fully known. Therefore, we sought to determine whether COVID-19 vaccine-induced antibody...
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