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A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS)
Rachel Harwood, Benjamin Allin, Christine E Jones, Elizabeth Whittaker, Padmanabhan Ramnarayan, Athimalaipet V Ramanan, Musa Kaleem, Robert Tulloh, Mark J Peters, Sarah Almond, Peter J Davis, Michael Levin, Andrew Tometzki, Saul N Faust, Marian Knight, Simon Kenny, PIMS-TS National Consensus Management Study Group
Dec 15, 2020
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a novel condition that was first reported in April, 2020. We aimed to develop a national consensus management pathway for the UK to...
The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.
Emma J Crosbie, Neil AJ Ryan, Mark J Arends, Tjalling Bosse, John Burn, Joanna M Cornes, Robin Crawford, Diana Eccles, Ian M Frayling, Sadaf Ghaem-Maghami, Heather Hampel, Noah D Kauff, Henry C Kitchener, Sarah J Kitson, Ranjit Manchanda, Raymond FT McMahon, Kevin J Monahan, Usha Menon, Pål Møller, Gabriela Möslein, Adam Rosenthal, Peter Sasieni, Mourad W Seif, Naveena Singh, Pauline Skarrott, Tristan M Snowsill, Robert Steele, Marc Tischkowitz, Manchester International Consensus Group, D Gareth Evans
Feb 07, 2020
PURPOSE: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with...
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome
Frédéric Brioude, Jennifer M Kalish, Alessandro Mussa, Alison C Foster, Jet Bliek, Giovanni Battista Ferrero, Susanne E Boonen, Trevor Cole, Robert Baker, Monica Bertoletti, Guido Cocchi, Carole Coze, Maurizio De Pellegrin, Khalid Hussain, Abdulla Ibrahim, Mark D Kilby, Malgorzata Krajewska-Walasek, Christian P Kratz, Edmund J Ladusans, Pablo Lapunzina, Yves Le Bouc, Saskia M Maas, Fiona MacDonald, Katrin Õunap, Licia Peruzzi, Sylvie Rossignol, Silvia Russo, Caroleen Shipster, Agata Skórka, Katrina Tatton-Brown, Jair Tenorio, Chiara Tortora, Karen Grønskov, Irène Netchine, Raoul C Hennekam, Dirk Prawitt, Zeynep Tümer, Thomas Eggermann, Deborah JG Mackay, Andrea Riccio, Eamonn R Maher
Jul 02, 2018
Beckwith-Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth, macroglossia, abdominal wall defects, neonatal hypoglycaemia, lateralized...
Prioritised challenges in the management of acute knee dislocations are stiffness, obesity, treatment delays and associated limb-threatening injuries
Michael Held, Robert C Schenck, Vikas Khanduja, Túlio Vinícius de Oliveira Campos, Sachin Tapasvi, Andy Williams, Wai Pan Yau, Christopher Harner, Authorship group ‘Knee surgery in LRS’
Mar 09, 2021
OBJECTIVES: Heterogeneous patient factors and injury mechanisms result in a great variety of injury patterns encountered in knee dislocations (KD). Attempts to improve outcome can focus on a wide range of challenges. The aim of...
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
UKCGG Consensus Group guidelines for the management of patients with constitutional TP53 pathogenic variants.
Impact of COVID-19 pandemic on surgical neuro-oncology multi-disciplinary team decision making
Stephen John Price, Alexis Joannides, Puneet Plaha, Fardad Taghizadeh Afshari, Erminia Albanese, Neil U Barua, Huan Wee Chan, Giles Critchley, Thomas Flannery, Daniel M Fountain, Ryan K Mathew, Rory J Piper, Michael TC Poon, Chittoor Rajaraman, Ola Rominiyi, Stuart Smith, Georgios Solomou, Anna Solth, Surash Surash, Victoria Wykes, Colin Watts, Helen Bulbeck, Peter Hutchinson, Michael D Jenkinson, COVID-CNSMDT study group
Aug 17, 2020
OBJECTIVES: Pressures on healthcare systems due to COVID-19 has impacted patients without COVID-19 with surgery disproportionally affected. This study aims to understand the impact on the initial management of patients with...
Cerebrovascular Autoregulation Monitoring in the Management of Adult Severe Traumatic Brain Injury
B Depreitere, G Citerio, M Smith, P David Adelson, MJ Aries, TP Bleck, P Bouzat, R Chesnut, V De Sloovere, M Diringer, J Dureanteau, A Ercole, G Hawryluk, C Hawthorne, R Helbok, SP Klein, JO Neumann, C Robba, L Steiner, N Stocchetti, FS Taccone, A Valadka, S Wolf, FA Zeiler, G Meyfroidt
Dec 23, 2020
BACKGROUND: Several methods have been proposed to measure cerebrovascular autoregulation (CA) in traumatic brain injury (TBI), but the lack of a gold standard and the absence of prospective clinical data on risks, impact on care...
Cerebrovascular Autoregulation Monitoring in the Management of Adult Severe Traumatic Brain Injury
B. Depreitere, G. Citerio, M. Smith, P. David Adelson, M. J. Aries, T. P. Bleck, P. Bouzat, R. Chesnut, V. De Sloovere, M. Diringer, J. Dureanteau, A. Ercole, G. Hawryluk, C. Hawthorne, R. Helbok, S. P. Klein, J. O. Neumann, C. Robba, L. Steiner, N. Stocchetti, F. S. Taccone, A. Valadka, S. Wolf, F. A. Zeiler, G. Meyfroidt
Jun 05, 2021
Abstract: Background: Several methods have been proposed to measure cerebrovascular autoregulation (CA) in traumatic brain injury (TBI), but the lack of a gold standard and the absence of prospective clinical data on risks...
Factors associated with inappropriate prescribing among older adults with complex care needs who have undergone the interRAI assessment
Aim To identify factors associated with prescribing potentially inappropriate medications (PIMs) in older adults (≥ 65 years) with complex care needs, who have undertaken a comprehensive geriatric risk...
Factors associated with inappropriate prescribing among older adults with complex care needs who have undergone the interRAI assessment
Aim To identify factors associated with prescribing potentially inappropriate medications (PIMs) in older adults (≥ 65 years) with complex care needs, who have undertaken a comprehensive geriatric risk...
Diagnosing cancer in primary care
Ruth Swann, Sean McPhail, Jana Witt, Brian Shand, Gary A Abel, Sara Hiom, Jem Rashbass, Georgios Lyratzopoulos, Greg Rubin, National Cancer Diagnosis Audit Steering Group
Mar 07, 2018
BACKGROUND: Continual improvements in diagnostic processes are needed to minimise the proportion of patients with cancer who experience diagnostic delays. Clinical audit is a means of achieving this. AIM: To characterise key...
The National Institute for Health Research
V Goh, National Institute for Health Research Clinical Research Network Imaging Network Steering Group, Royal College of Radiologists' Academic Committee
Oct 01, 2019
Since the inception of the National Institute for Health Research (NIHR) in 2006, the landscape for the delivery of clinical research within the National Health Service (NHS) has been transformed. Clinical radiology has...
Pituitary Society Delphi Survey
Nicholas A Tritos, Pouneh K Fazeli, Ann McCormack, Susana M Mallea-Gil, Maria M Pineyro, Mirjam Christ-Crain, Stefano Frara, Artak Labadzhyan, Adriana G Ioachimescu, Ilan Shimon, Yutaka Takahashi, Mark Gurnell, Maria Fleseriu, “Pituitary Society Delphi Collaborative Group”
Feb 07, 2022
PURPOSE: In adults and children, transsphenoidal surgery (TSS) represents the cornerstone of management for most large or functioning sellar lesions with the exception of prolactinomas. Endocrine evaluation and management are an...
Consensus-based statements for the management of mitochondrial stroke-like episodes.
Yi Shiau Ng, Laurence A Bindoff, Gráinne S Gorman, Rita Horvath, Thomas Klopstock, Michelangelo Mancuso, Mika H Martikainen, Robert McFarland, Victoria Nesbitt, Robert DS Pitceathly, Andrew M Schaefer, Doug M Turnbull
Mar 02, 2020
Background: Focal-onset seizures and encephalopathy are prominent features of a stroke-like episode, which is a severe neurological manifestation associated with subtypes of mitochondrial disease. Despite more than 30 years of...
WSES consensus conference guidelines
Edoardo Picetti, Sandra Rossi, Fikri M Abu-Zidan, Luca Ansaloni, Rocco Armonda, Gian Luca Baiocchi, Miklosh Bala, Zsolt J Balogh, Maurizio Berardino, Walter L Biffl, Pierre Bouzat, Andras Buki, Marco Ceresoli, Randall M Chesnut, Osvaldo Chiara, Giuseppe Citerio, Federico Coccolini, Raul Coimbra, Salomone Di Saverio, Gustavo P Fraga, Deepak Gupta, Raimund Helbok, Peter J Hutchinson, Andrew W Kirkpatrick, Takahiro Kinoshita, Yoram Kluger, Ari Leppaniemi, Andrew I R Maas, Ronald V Maier, Francesco Minardi, Ernest E Moore, John A Myburgh, David O Okonkwo, Yasuhiro Otomo, Sandro Rizoli, Andres M Rubiano, Juan Sahuquillo, Massimo Sartelli, Thomas M Scalea, Franco Servadei, Philip F Stahel, Nino Stocchetti, Fabio S Taccone, Tommaso Tonetti, George Velmahos, Dieter Weber, Fausto Catena
Jan 06, 2020
The acute phase management of patients with severe traumatic brain injury (TBI) and polytrauma represents a major challenge. Guidelines for the care of these complex patients are lacking, and worldwide variability in clinical...
Multidisciplinary management of acromegaly
Andrea Giustina, Garni Barkhoudarian, Albert Beckers, Anat Ben-Shlomo, Nienke Biermasz, Beverly Biller, Cesar Boguszewski, Marek Bolanowski, Jens Bollerslev, Vivien Bonert, Marcello D Bronstein, Michael Buchfelder, Felipe Casanueva, Philippe Chanson, David Clemmons, Maria Fleseriu, Anna Maria Formenti, Pamela Freda, Monica Gadelha, Eliza Geer, Mark Gurnell, Anthony P Heaney, Ken KY Ho, Adriana G Ioachimescu, Steven Lamberts, Edward Laws, Marco Losa, Pietro Maffei, Adam Mamelak, Moises Mercado, Mark Molitch, Pietro Mortini, Alberto M Pereira, Stephan Petersenn, Kalmon Post, Manuel Puig-Domingo, Roberto Salvatori, Susan L Samson, Ilan Shimon, Christian Strasburger, Brooke Swearingen, Peter Trainer, Mary L Vance, John Wass, Margaret E Wierman, Kevin CJ Yuen, Maria Chiara Zatelli, Shlomo Melmed
Sep 02, 2020
The 13th Acromegaly Consensus Conference was held in November 2019 in Fort Lauderdale, Florida, and comprised acromegaly experts including endocrinologists and neurosurgeons who considered optimal approaches for...
The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study)
Lewis A Hall, Siobhan C McKay, James Halle-Smith, Joshua Soane, Daniel-Clement Osei-Bordom, Lesley Goodburn, Laura Magill, Thomas Pinkney, Ganesh Radhakrishna, Juan W Valle, Pippa Corrie, Keith J Roberts, CONTACT Study Group
Apr 17, 2023
INTRODUCTION: CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: The treatment...
The screening and management of pituitary dysfunction following traumatic brain injury in adults
Chin Lik Tan, Seyed Alireza Alavi, Stephanie E Baldeweg, Antonio Belli, Alan Carson, Claire Feeney, Anthony P Goldstone, Richard Greenwood, David K Menon, Helen L Simpson, Andrew A Toogood, Mark Gurnell, Peter J Hutchinson
Jun 27, 2018
Pituitary dysfunction is a recognised, but potentially underdiagnosed complication of traumatic brain injury (TBI). Post-traumatic hypopituitarism (PTHP) can have major consequences for patients physically, psychologically...
Management pituitary dysfunction screening Traumatic brain injury Adrenal Insufficiency Adult Brain Injuries Traumatic Early Diagnosis Early Medical Intervention Female Follow-Up Studies Humans hypopituitarism Inappropriate ADH Syndrome Male Mass Screening Patient Admission Pituitary Function Tests Pituitary Gland Anterior United Kingdom
Cancer Variant Interpretation Group UK (CanVIG-UK)
Alice Garrett, Alison Callaway, Miranda Durkie, Cankut Cubuk, Mary Alikian, George J Burghel, Rachel Robinson, Louise Izatt, Sabrina Talukdar, Lucy Side, Treena Cranston, Sheila Palmer-Smith, Diana Baralle, Ian R Berry, James Drummond, Andrew J Wallace, Gail Norbury, Diana M Eccles, Sian Ellard, Fiona Lalloo, D Gareth Evans, Emma Woodward, Marc Tischkowitz, Helen Hanson, Clare Turnbull, CanVIG-UK
Mar 16, 2020
Advances in technology have led to a massive expansion in the capacity for genomic analysis, with a commensurate fall in costs. The clinical indications for genomic testing have evolved markedly; the volume of clinical...
UK clinical guideline for the prevention and treatment of osteoporosis
J Compston, A Cooper, C Cooper, N Gittoes, C Gregson, N Harvey, S Hope, JA Kanis, EV McCloskey, KES Poole, DM Reid, P Selby, F Thompson, A Thurston, N Vine, National Osteoporosis Guideline Group (NOGG)
Sep 11, 2017
INTRODUCTION: In 2008, the UK National Osteoporosis Guideline Group (NOGG) produced a guideline on the prevention and treatment of osteoporosis, with an update in 2013. This paper presents a major update of the guideline, the...
A New Approach for Fairness Increment of Consensus-Driven Group Recommender Systems Based on Choquet Integral
It has been witnessed in recent years for the rising of Group recommender systems (GRSs) in most e-commerce and tourism applications like Booking.com, Traveloka.com, Amazon, etc. One of the most concerned problems in GRSs is to...
Published by: IGI Global Scientific Publishing
WSES consensus conference guidelines
Edoardo Picetti, Sandra Rossi, Fikri M Abu-Zidan, Luca Ansaloni, Rocco Armonda, Gian Luca Baiocchi, Miklosh Bala, Zsolt J Balogh, Maurizio Berardino, Walter L Biffl, Pierre Bouzat, Andras Buki, Marco Ceresoli, Randall M Chesnut, Osvaldo Chiara, Giuseppe Citerio, Federico Coccolini, Raul Coimbra, Salomone Di Saverio, Gustavo P Fraga, Deepak Gupta, Raimund Helbok, Peter J Hutchinson, Andrew W Kirkpatrick, Takahiro Kinoshita, Yoram Kluger, Ari Leppaniemi, Andrew IR Maas, Ronald V Maier, Francesco Minardi, Ernest E Moore, John A Myburgh, David O Okonkwo, Yasuhiro Otomo, Sandro Rizoli, Andres M Rubiano, Juan Sahuquillo, Massimo Sartelli, Thomas M Scalea, Franco Servadei, Philip F Stahel, Nino Stocchetti, Fabio S Taccone, Tommaso Tonetti, George Velmahos, Dieter Weber, Fausto Catena
Nov 28, 2020
The acute phase management of patients with severe traumatic brain injury (TBI) and polytrauma represents a major challenge. Guidelines for the care of these complex patients are lacking, and worldwide variability in clinical...
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